Antibiotics for treatment of leptospirosis
CONCLUSIONS: As the certainty of evidence is very low, we do not know if antibiotics provide little to no effect on all-cause mortality, serious adverse events, or adverse events considered non-serious. There is a lack of definitive rigorous data from randomised trials to support the use of antibiotics for treating leptospirosis infection, and the absence of trials reporting data on clinically relevant outcomes further adds to this limitation.PMID:38483092 | PMC:PMC10938876 | DOI:10.1002/14651858.CD014960.pub2 (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - March 14, 2024 Category: General Medicine Authors: Tin Zar Win Su Myat Han Tansy Edwards Hsu Thinzar Maung David M Brett-Major Chris Smith Nathaniel Lee Source Type: research
Antibiotic prophylaxis for leptospirosis
CONCLUSIONS: We do not know if antibiotics versus placebo or another antibiotic has little or have no effect on all-cause mortality or leptospirosis infection because the certainty of evidence is low or very low. We do not know if antibiotics versus placebo may increase the overall risk of non-serious adverse events because of very low-certainty evidence. We lack definitive rigorous data from randomised trials to support the use of antibiotics for the prophylaxis of leptospirosis infection. We lack trials reporting data on clinically relevant outcomes.PMID:38483067 | PMC:PMC10938880 | DOI:10.1002/14651858.CD014959.pub2 (So...
Source: Cochrane Database of Systematic Reviews - March 14, 2024 Category: General Medicine Authors: Tin Zar Win Tanaraj Perinpanathan Patrick Mukadi Chris Smith Tansy Edwards Su Myat Han Hsu Thinzar Maung David M Brett-Major Nathaniel Lee Source Type: research
Hemadsorption extracorporeal therapy removes cytokines ex vivo in horses
Am J Vet Res. 2024 Mar 18:1-8. doi: 10.2460/ajvr.24.01.0022. Online ahead of print.ABSTRACTOBJECTIVE: Plasma cytokine adsorption has shown benefit as an adjunctive therapy in human sepsis but has yet to be investigated in horses. We hypothesized that ex vivo filtration of equine plasma with a novel cytokine adsorption device would significantly reduce concentrations of lipopolysaccharide-stimulated cytokines. We also hypothesized that the device would adsorb medications commonly used to treat sepsis.ANIMALS: 8 horses owned by North Carolina State University.METHODS: Four liters of heparinized whole blood was collected from...
Source: American Journal of Veterinary Research - March 14, 2024 Category: Veterinary Research Authors: Kallie J Hobbs Jennifer L Davis Bethanie L Cooper Yu Ueda Megan J Burke M Katie Sheats Source Type: research
Hemadsorption extracorporeal therapy removes cytokines ex vivo in horses
Am J Vet Res. 2024 Mar 18:1-8. doi: 10.2460/ajvr.24.01.0022. Online ahead of print.ABSTRACTOBJECTIVE: Plasma cytokine adsorption has shown benefit as an adjunctive therapy in human sepsis but has yet to be investigated in horses. We hypothesized that ex vivo filtration of equine plasma with a novel cytokine adsorption device would significantly reduce concentrations of lipopolysaccharide-stimulated cytokines. We also hypothesized that the device would adsorb medications commonly used to treat sepsis.ANIMALS: 8 horses owned by North Carolina State University.METHODS: Four liters of heparinized whole blood was collected from...
Source: American Journal of Veterinary Research - March 14, 2024 Category: Veterinary Research Authors: Kallie J Hobbs Jennifer L Davis Bethanie L Cooper Yu Ueda Megan J Burke M Katie Sheats Source Type: research
Hemadsorption extracorporeal therapy removes cytokines ex vivo in horses
Am J Vet Res. 2024 Mar 18:1-8. doi: 10.2460/ajvr.24.01.0022. Online ahead of print.ABSTRACTOBJECTIVE: Plasma cytokine adsorption has shown benefit as an adjunctive therapy in human sepsis but has yet to be investigated in horses. We hypothesized that ex vivo filtration of equine plasma with a novel cytokine adsorption device would significantly reduce concentrations of lipopolysaccharide-stimulated cytokines. We also hypothesized that the device would adsorb medications commonly used to treat sepsis.ANIMALS: 8 horses owned by North Carolina State University.METHODS: Four liters of heparinized whole blood was collected from...
Source: American Journal of Veterinary Research - March 14, 2024 Category: Veterinary Research Authors: Kallie J Hobbs Jennifer L Davis Bethanie L Cooper Yu Ueda Megan J Burke M Katie Sheats Source Type: research
Outpatient parenteral antimicrobial therapy (OPAT) in Germany: insights and clinical outcomes from the K-APAT cohort study
ConclusionThe study demonstrates that OPAT can be safely conducted in Germany. In preparation for its broader implementation, crucial next steps include creating medical guidelines, fostering interdisciplinary and inter-sectoral communication, as well as creating financial and structural regulations that facilitate and encourage the adoption of OPAT.Trial registration numberNCT04002453. (Source: Infection)
Source: Infection - March 13, 2024 Category: Infectious Diseases Source Type: research
Serotype distribution and antimicrobial resistance of pediatric Streptococcus pneumoniae isolated from inpatients and outpatients at Beijing Children's Hospital
CONCLUSIONS: Pneumococcal vaccine-related serotypes are prevalent among both inpatients and outpatients, especially among inpatients, who exhibit more severe antibiotic resistance. Therefore, universal immunization with PCV13 would decrease the hospitalization rate due to S. pneumoniae and the antibiotic resistance rate of S. pneumoniae.PMID:38471654 | DOI:10.1016/j.bjid.2024.103734 (Source: Braz J Infect Dis)
Source: Braz J Infect Dis - March 12, 2024 Category: Infectious Diseases Authors: Shuang Lyu Wei Shi Fang Dong Bao Ping Xu Gang Liu Quan Wang Kai Hu Yao Yong Hong Yang Source Type: research
Serotype distribution and antimicrobial resistance of pediatric Streptococcus pneumoniae isolated from inpatients and outpatients at Beijing Children's Hospital
CONCLUSIONS: Pneumococcal vaccine-related serotypes are prevalent among both inpatients and outpatients, especially among inpatients, who exhibit more severe antibiotic resistance. Therefore, universal immunization with PCV13 would decrease the hospitalization rate due to S. pneumoniae and the antibiotic resistance rate of S. pneumoniae.PMID:38471654 | DOI:10.1016/j.bjid.2024.103734 (Source: Braz J Infect Dis)
Source: Braz J Infect Dis - March 12, 2024 Category: Infectious Diseases Authors: Shuang Lyu Wei Shi Fang Dong Bao Ping Xu Gang Liu Quan Wang Kai Hu Yao Yong Hong Yang Source Type: research
Multisite primary care led amoxicillin challenge pathway to safely remove penicillin allergy label
ConclusionsOur study demonstrates a pediatric specific screener and pathway for pediatric providers to safely remove penicillin allergy labels following latest allergy practice parameters. (Source: Drugs and Therapy Perspectives)
Source: Drugs and Therapy Perspectives - March 10, 2024 Category: Drugs & Pharmacology Source Type: research
One pot fabrication of diamino naphthalene -AuNPs decorated graphene nanoplatform for the MRSA detection in the biological sample
Bioelectrochemistry. 2024 Feb 28;157:108674. doi: 10.1016/j.bioelechem.2024.108674. Online ahead of print.ABSTRACTEarly monitoring of MRSA can effectively mitigate the disease risk by using Penicillin-binding protein 2a (PbP2a) biomarker. Diamino naphthalene-AuNPs decorated graphene (AuNPsGO-DN) nanocomposite was synthesized for a rapid and sensitive immunosensor detecting PbP2a. The synthesized AuNPsGO-DN nanocomposites were characterized by field emission scanning electron microscopy (FE-SEM), energy-dispersive X-ray spectroscopy (SEM-EDX), Fourier transform infrared spectroscopy (FT-IR), Raman spectroscopy, and X-ray di...
Source: Bioelectrochemistry - March 9, 2024 Category: Biochemistry Authors: Ruchika Chauhan Zondi Nate Blessing Ike Darko Kwabena Adu John Alake Atal A S Gill Lungelo Miya Neeta Bachheti Thapliyal Rajshekhar Karpoormath Source Type: research
One pot fabrication of diamino naphthalene -AuNPs decorated graphene nanoplatform for the MRSA detection in the biological sample
Bioelectrochemistry. 2024 Feb 28;157:108674. doi: 10.1016/j.bioelechem.2024.108674. Online ahead of print.ABSTRACTEarly monitoring of MRSA can effectively mitigate the disease risk by using Penicillin-binding protein 2a (PbP2a) biomarker. Diamino naphthalene-AuNPs decorated graphene (AuNPsGO-DN) nanocomposite was synthesized for a rapid and sensitive immunosensor detecting PbP2a. The synthesized AuNPsGO-DN nanocomposites were characterized by field emission scanning electron microscopy (FE-SEM), energy-dispersive X-ray spectroscopy (SEM-EDX), Fourier transform infrared spectroscopy (FT-IR), Raman spectroscopy, and X-ray di...
Source: Bioelectrochemistry - March 9, 2024 Category: Biochemistry Authors: Ruchika Chauhan Zondi Nate Blessing Ike Darko Kwabena Adu John Alake Atal A S Gill Lungelo Miya Neeta Bachheti Thapliyal Rajshekhar Karpoormath Source Type: research
One pot fabrication of diamino naphthalene -AuNPs decorated graphene nanoplatform for the MRSA detection in the biological sample
Bioelectrochemistry. 2024 Feb 28;157:108674. doi: 10.1016/j.bioelechem.2024.108674. Online ahead of print.ABSTRACTEarly monitoring of MRSA can effectively mitigate the disease risk by using Penicillin-binding protein 2a (PbP2a) biomarker. Diamino naphthalene-AuNPs decorated graphene (AuNPsGO-DN) nanocomposite was synthesized for a rapid and sensitive immunosensor detecting PbP2a. The synthesized AuNPsGO-DN nanocomposites were characterized by field emission scanning electron microscopy (FE-SEM), energy-dispersive X-ray spectroscopy (SEM-EDX), Fourier transform infrared spectroscopy (FT-IR), Raman spectroscopy, and X-ray di...
Source: Bioelectrochemistry - March 9, 2024 Category: Biochemistry Authors: Ruchika Chauhan Zondi Nate Blessing Ike Darko Kwabena Adu John Alake Atal A S Gill Lungelo Miya Neeta Bachheti Thapliyal Rajshekhar Karpoormath Source Type: research
Secondary syphilis presenting as fever of unknown origin
Image of patient's maculopapular syphilitic rash on palmar surface of his hand, which developed about 8  weeks into his fever. Key Clinical MessageA thirty-eight year-old male presented with a seven-week history of persistent fever accompanied by recurrent night sweats, chills, arthralgias, headache, and chest tightness.Initial laboratory testing showed non-specific elevation of inflammatory markers, but was otherwise unremarkable.A palmar rash developed one week later, prompting testing for syphilis. Fluorescent treponemal antibody absorption (FTA-ABS) and rapid plasma reagin (RPR) tests were both positive.Penicillin G ...
Source: Clinical Case Reports - March 9, 2024 Category: General Medicine Authors: Hannah Eloise Wilding,
Amy Hays Tags: CASE REPORT Source Type: research
Clinical and microbiological profile of Viridans group streptococcal bacteraemia; experience from South India
CONCLUSIONS: VGS are an important cause of bacteraemia and was associated with 19% mortality in our study. High rates of penicillin and ceftriaxone resistance are a reason of concern. Molecular diagnostics like matrix assisted laser desorption ionization-time of flight (MALDI-TOF) identification must be increasingly applied for species identification considering that a substantial number of isolates were not identified to species level.PMID:38456022 | PMC:PMC10917554 | DOI:10.53854/liim-3201-5 (Source: Infezioni in Medicina)
Source: Infezioni in Medicina - March 8, 2024 Category: Infectious Diseases Authors: Rajalakshmi Arjun Vettakkara Kandy Muhammed Niyas Febeena Hussain Sandeep Surendran Viji Mohan Source Type: research
