Profile of metacaspase gene expression in Plasmodium vivax field isolates from the Brazilian Amazon
CONCLUSION: The detection of metacaspases in P. vivax blood-stage parasites reported herein, allows the inclusion of these proteases as a potential candidate drug target for vivax malaria, while further investigations are still required to evaluate the activity, role and essentiality of metacaspases in P. vivax biology.PMID:38683374 | DOI:10.1007/s11033-024-09538-x (Source: Mol Biol Cell)
Source: Mol Biol Cell - April 29, 2024 Category: Molecular Biology Authors: Carolina Moreira Blanco Hugo Amorim Dos Santos de Souza Priscilla da Costa Martins Camila Fabbri Fernanda Souza de Souza Josu é da Costa Lima-Junior Stefanie Costa Pinto Lopes Lilian Rose Pratt-Riccio Cl áudio Tadeu Daniel-Ribeiro Paulo Renato Rivas Tot Source Type: research
Profile of metacaspase gene expression in Plasmodium vivax field isolates from the Brazilian Amazon
CONCLUSION: The detection of metacaspases in P. vivax blood-stage parasites reported herein, allows the inclusion of these proteases as a potential candidate drug target for vivax malaria, while further investigations are still required to evaluate the activity, role and essentiality of metacaspases in P. vivax biology.PMID:38683374 | DOI:10.1007/s11033-024-09538-x (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 29, 2024 Category: Molecular Biology Authors: Carolina Moreira Blanco Hugo Amorim Dos Santos de Souza Priscilla da Costa Martins Camila Fabbri Fernanda Souza de Souza Josu é da Costa Lima-Junior Stefanie Costa Pinto Lopes Lilian Rose Pratt-Riccio Cl áudio Tadeu Daniel-Ribeiro Paulo Renato Rivas Tot Source Type: research
Bacteria in the blood of healthy stray dogs infested by ticks in northern Mexico
CONCLUSION: This research offers relevant information on the prevalence of tick-borne diseases as well as other potential zoonotic diseases in the blood of stray dogs parasitized by ticks in northern Mexico. New molecular biology and massive NGS techniques may play an important role in the study and documentation of bacterial profiles from animals in close proximity to humans.PMID:38680790 | PMC:PMC11055595 | DOI:10.5455/javar.2024.k757 (Source: Adv Data)
Source: Adv Data - April 29, 2024 Category: Epidemiology Authors: Fernando Mej ía García Sergio Iv án Barraza Guerrero Cristina Garc ía De la Peña David Ramiro Aguill ón Gutiérrez Quetzaly Karmy Siller Rodr íguez C ésar Alberto Meza Herrera Felipe Vaca Paniagua Clara Diaz Vel ásquez Aldo De la Cruz Montoya Lui Source Type: research
Infections and fever
Z Rheumatol. 2024 Apr 29. doi: 10.1007/s00393-024-01503-0. Online ahead of print.ABSTRACTFever can be due to infectious or noninfectious causes and results from the body's natural response to exogenous or endogenous pyrogens. Laboratory tests including complete blood count, differential blood count, C‑reactive protein, erythrocyte sedimentation rate and procalcitonin do not have sufficient sensitivity and specificity to definitively detect or rule out an infectious (bacterial, viral, parasitic) cause of fever. Blood cultures should be carried out when bacteremic or septic illnesses are suspected. Fever is not always pres...
Source: Zeitschrift fur Rheumatologie - April 29, 2024 Category: Rheumatology Authors: Stefan Schmiedel Source Type: research
Italian peninsula as a hybridization zone of Ixodes inopinatus and I. ricinus and the prevalence of tick-borne pathogens in I. inopinatus, I. ricinus, and their hybrids
Ixodes inopinatus was described from Spain on the basis of morphology and partial sequencing of 16S ribosomal DNA. However, several studies suggested that morphological differences between I. inopinatus and Ixode... (Source: Parasites and Vectors)
Source: Parasites and Vectors - April 29, 2024 Category: Microbiology Authors: Ond řej Daněk, Alena Hrbatová, Karolina Volfová, Sylvie Ševčíková, Paulina Lesiczka, Markéta Nováková, Sajjad Ghodrati, Kristyna Hrazdilova, Vincenzo Veneziano, Ettore Napoli, Domenico Otranto, Fabrizio Montarsi, Andrei Daniel Mihalca, Noureddi Tags: Research Source Type: research
Efficacy of monthly treatment with oral fluralaner (Bravecto ® 1-Month) against Tunga penetrans in dogs in Brazil: a randomized, double-blind, controlled field study
Tungiasis is a neglected tropical disease caused by the adult female sand flea (Tunga penetrans). Dogs are considered important reservoirs of T. penetrans in Brazil. The aim of this study was to determine the mon... (Source: Parasites and Vectors)
Source: Parasites and Vectors - April 29, 2024 Category: Microbiology Authors: Katharine Costa dos Santos, Paula Elisa Brand ão Guedes, George Rêgo Albuquerque, Anderson Vieira de Jesus, Anaiá da Paixão Sevá, Joana Thaisa Santos de Oliveira, Jamille Bispo de Carvalho Teixeira, Thammy Vieira Bitar, Tatiani Vitor Harvey, Sofia Na Tags: Research Source Type: research
A 11-year-old boy with Blastocystis hominis infection, presents as immune thrombocytopenia
Some causes of first-line treatment failure for ITP are often closely related to infections. But parasitic infections are rarely mentioned and easily overlooked. The case is the first to describe a boy with im... (Source: Thrombosis Journal)
Source: Thrombosis Journal - April 29, 2024 Category: Hematology Authors: Fajuan Tang, Dongqiong Xiao, Lin Chen, Xihong Li and Lina Qiao Tags: Case Report Source Type: research
Molecular diagnosis of human toxoplasmosis: the state of the art
AbstractToxoplasma gondii (T. gondii) is an obligate intracellular apicomplexan protozoan that causes toxoplasmosis. Approximately one-third of the world ’s population is currentlyT. gondii-seropositive. Although most infections are symptomless, a few can produce retinal lesions and, in immunocompromised persons or when congenitally contracted, can progress to life-threatening central nervous system disseminated infections. Therefore, quick, and precise diagnosis is a must. Molecular techniques nowadays play a crucial role in toxoplasmosis diagnosis, particularly in immunocompromised patients or congenital toxoplasmosis....
Source: Journal of Parasitic Diseases - April 29, 2024 Category: Parasitology Source Type: research
An insight into the epidemiology of foodborne zoonotic fascioliasis in small ruminants in northwestern region of Bangladesh
AbstractFascioliasis is one of the most common foodborne zoonotic infection of ruminants in Bangladesh. To estimate the prevalence and associated risk factors of fascioliasis and extent of liver damage, 825 livers of sheep and goats were randomly inspected during onsite slaughterhouse visiting in Naogaon, Natore, Rajshahi and Joypurhat districts. The overall prevalence of fascioliasis was 25.09% and significantly (P = 0.008) higher in goats (26.11%) than sheep (24.00%). During gross inspection,Fasciola infected livers were increased in size, fibrosed, fatty, multiple white or reddish necrotic foci on the parietal surfa...
Source: Journal of Parasitic Diseases - April 29, 2024 Category: Parasitology Source Type: research
Tick species diversity and potential distribution alternation of dominant ticks under different climate scenarios in Xinjiang, China
This study constructed a dataset of tick species distribution in Xinjiang for 60 years based on literature database retrieval and historical data collection (January 1963-January 2023). The distribution data were extracted, corrected, and deduplicated. The dominant tick species were selected for analysis using the MaxEnt model to assess their potential distribution in different periods under the current and BCC-CSM2.MR mode scenarios. The results indicated that there are eight genera and 48 species of ticks in 108 cities and counties of Xinjiang, withHyalomma asiaticum,Rhipicephalus turanicus,Dermacentor marginatus, andHae...
Source: PLoS Neglected Tropical Diseases - April 29, 2024 Category: Tropical Medicine Authors: Rui Ma Source Type: research
Validation of deep amplicon sequencing of < i > Dicrocoelium < /i > in small ruminants from Northern regions of Pakistan
In conclusion each sample was identified asD.dendriticum based on the proportion of MiSeq reads and validated the presence of this group of parasites in the Gilgit Baltistan and Khyber Pakhtunkhwa provinces of Pakistan. The metabarcoding deep amplicon sequencing technology and bioinformatics pathway have several potential applications, including species interactions during co-infections, identifying the host and geographical distribution ofDicrocoelium in livestock, drug therapy response evaluation and understanding of the emergence and spread of drug resistance. (Source: PLoS One)
Source: PLoS One - April 29, 2024 Category: Biomedical Science Authors: Muhammad Asim Khan Source Type: research
The Phytophthora parasitica effector AVH195 interacts with ATG8, attenuates host autophagy, and promotes biotrophic infection
Plant pathogens secrete effector proteins into host cells to suppress immune responses and manipulate fundamental cellular processes. One of these processes is autophagy, an essential recycling mechanism in eu... (Source: BMC Biology)
Source: BMC Biology - April 29, 2024 Category: Biology Authors: Serena Testi, Marie-Line Kuhn, Val érie Allasia, Pascaline Auroy, Fantao Kong, Gilles Peltier, Sophie Pagnotta, Julie Cazareth, Harald Keller and Franck Panabières Tags: Research article Source Type: research
Comparison of extracellular vesicle isolation methods for the study of exosome cargo within Toxocara canis and Toxocara cati excretory secretory (TES) products
Exp Parasitol. 2024 Apr 27;261:108765. doi: 10.1016/j.exppara.2024.108765. Online ahead of print.ABSTRACTToxocara is a genus of nematodes, which infects a variety of hosts, principally dogs and cats, with potential zoonotic risks to humans. Toxocara spp. larvae are capable of migrating throughout the host tissues, eliciting eosinophilic and granulomatous reactions, while surviving for extended periods of time, unchanged, in the host. It is postulated that larvae are capable of altering the host's immune response through the release of excretory-secretory products, containing both proteins and extracellular vesicles (EVs). ...
Source: Experimental Parasitology - April 28, 2024 Category: Parasitology Authors: Timothy K Wu Janice L Liotta Dwight D Bowman Source Type: research
Anthelmintic efficacy of an organic fraction from Guazuma ulmifolia leaves and evaluation of reactive oxidative stress on Haemonchus contortus
This study describes the anthelmintic efficacy of an organic fraction (EtOAc- F) from Guazuma ulmifolia leaves and evaluation of its reactive oxidative stress on Haemonchus contortus. The first step was to assess the anthelmintic effect of EtOAc-F at 0.0, 3.5, 7.0 and 14 mg kg of body weight (BW) in gerbil's (Meriones unguiculatus) artificially infected with H. contortus infective larvae (L3). The second step was to evaluate the preliminary toxicity after oral administration of the EtOAc-F in gerbils. Finally, the third step was to determine the relative expression of biomarkers as glutathione (GPx), catalase (CAT), and su...
Source: Experimental Parasitology - April 28, 2024 Category: Parasitology Authors: Guillermo Res éndiz-González Agust ín Olmedo-Juárez Roberto Gonz ález-Garduño Jorge Alberto Cortes Morales Manas és González Cortazar Ana Elvia S ánchez-Mendoza Mar ía Eugenia López-Arellano Cris óforo Mercado-Márquez Alejandro Lara-Bueno Ros Source Type: research
Design, in silico study, synthesis and evaluation of hybrid pyrazole substituted 1,3,5-triazine derivatives for antimalarial activity
CONCLUSION: Among the ten derivatives, compound 7J has considerable potential as an antimalarial agent, making it a viable contender for further refinement in the realm of pharmaceutical exploration, with the aim of mitigating the global malaria load.PMID:38679125 | DOI:10.1016/j.exppara.2024.108767 (Source: Experimental Parasitology)
Source: Experimental Parasitology - April 28, 2024 Category: Parasitology Authors: Pritom Borgohain Anshul Shakya Surajit Kumar Ghosh Neelutpal Gogoi Saurav Jyoti Patgiri Ipsita Pal Bhowmick Dibya Ranjan Bhattacharyya Udaya Pratap Singh Hans Raj Bhat Source Type: research
