Icosapent Ethyl Effects on Fatty Acid Profiles in Statin-Treated Patients With High Triglycerides: The Randomized, Placebo-controlled ANCHOR Study
ConclusionsIcosapent ethyl 4 g/day significantly increased EPA and produced other potentially beneficial shifts in fatty acids in plasma and RBCs versus placebo.Trial RegistrationClinicalTrials.gov Identifier, NCT01047501FundingAmarin Pharma Inc.Plain Language SummaryPlain language summary available for this article. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - February 20, 2019 Category: Cardiology Source Type: research
PPAR- δ and erucic acid in multiple sclerosis and Alzheimer's Disease. Likely benefits in terms of immunity and metabolism.
PPAR-δ and erucic acid in multiple sclerosis and Alzheimer's Disease. Likely benefits in terms of immunity and metabolism.
Int Immunopharmacol. 2019 Feb 07;69:245-256
Authors: Altinoz MA, Ozpinar A
Abstract
The transcription factor, PPARδ is involved in suppressing inflammation, stimulating oligodendroglial biogenesis and myelination. Furthermore, activation of PPARδ directly protects mitochondria against noxious stimuli and stimulates biogenesis of new mitochondria. PPARδ activation directly inhibits neuronal cell death and reduces both the level and neurotoxicity of Amyloid-...
Source: International Immunopharmacology - February 7, 2019 Category: Allergy & Immunology Authors: Altinoz MA, Ozpinar A Tags: Int Immunopharmacol Source Type: research
Erucic acid, a component of Lorenzo's oil and PPAR- δ ligand modifies C6 glioma growth and toxicity of doxorubicin. Experimental data and a comprehensive literature analysis.
CONCLUSIONS: Both the antitumor and cardiac effects of EA may associate with the cell-to-cell contact mechanisms. Combining systemic EA with intrathecal DOX-chemotherapy via Ommaya reservoirs may reduce DOX concentrations in systemic circulation, hinder toxic interactions with EA and induce selective kill of glioma cells.
PMID: 30142312 [PubMed - indexed for MEDLINE] (Source: Chemico-Biological Interactions)
Source: Chemico-Biological Interactions - September 16, 2018 Category: Molecular Biology Authors: Altinoz MA, Bilir A, Elmaci İ Tags: Chem Biol Interact Source Type: research
Erucic acid, a component of Lorenzo's oil and PPAR-δ ligand modifies C6 glioma growth and toxicity of doxorubicin. Experimental data and a comprehensive literature analysis
ConclusionsBoth the antitumor and cardiac effects of EA may associate with the cell-to-cell contact mechanisms. Combining systemic EA with intrathecal DOX-chemotherapy via Ommaya reservoirs may reduce DOX concentrations in systemic circulation, hinder toxic interactions with EA and induce selective kill of glioma cells. (Source: Chemico Biological Interactions)
Source: Chemico Biological Interactions - August 23, 2018 Category: Biochemistry Source Type: research
Comparison of liver function tests abnormality – using two distinct parenteral nutrition (PN) lipid emulsions
Rationale: An important side effect of PN is liver function tests (LFT) abnormalities. In recent years, new PN solutions are marketed. There is lack of direct comparison between the newer and older solutions. In our hospital, up to July 2014 an MCT/LCT (ML) (Lipofundin) containing solution was prescribed, thereafter a transition was made to an LCT/MCT/Omega-9/Omega-3 (SMOF-Kabiven) (SMOF) containing solution. The aim of this study is to compare the occurrence of LFT abnormalities between the two lipid formulations. (Source: Clinical Nutrition)
Source: Clinical Nutrition - August 22, 2018 Category: Nutrition Authors: I. Elad, H. Bar-Yoseph, T. Saadi, I. Papier, J. Khuri, D. Hochstein, G. Rozen, I. Chermesh Source Type: research
Circulating oleic acid levels are related to greater risks of cardiovascular events and all-cause mortality: the Multi-Ethnic Study of Atherosclerosis
Limited evidence has suggested that circulating levels of the omega-9 fatty acid, oleic acid, may be related to greater risks of adverse cardiovascular outcomes. (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - August 16, 2018 Category: Lipidology Authors: Brian T. Steffen, Daniel Duprez, Moyses Szklo, Weihua Guan, Michael Y. Tsai Source Type: research
FFA4 (GPR120) as a fatty acid sensor involved in appetite control, insulin sensitivity and inflammation regulation
Publication date: Available online 12 October 2017Source: Molecular Aspects of MedicineAuthor(s): Dong-Soon ImAbstractUnsaturated long-chain fatty acids have been suggested to be beneficial in the context of cardiovascular disorders based in epidemiologic studies conducted in Greenland and Mediterranean. DHA and EPA are omega-3 polyunsaturated fatty acids that are plentiful in fish oil, and oleic acid is an omega-9 monounsaturated fatty acid, rich in olive oil. Dietary intake of these unsaturated long-chain fatty acids have been associated with insulin sensitivity and weight loss, which contrasts with the impairment of ins...
Source: Molecular Aspects of Medicine - July 11, 2018 Category: Molecular Biology Source Type: research
Vesicular nanostructures composed of oleic acid and phosphatidylcholine: Effect of pH and molar ratio.
Abstract
Phospholipids and fatty acids are the main building blocks of biological membranes. Oleic acid is a monounsaturated omega-9 fatty acid commonly found in many natural sources. Its characteristic kinked structure grants this molecule with a great number of biological properties. To better understand the role that this kind of fatty acids play into phospholipid membranes, nanostructured systems formed with hydrogenated soy phosphatidylcholine and oleic acid were studied in this work by means of cryo-electron microscopy, dynamic light scattering and differential scanning calorimetry. Differences conce...
Source: Chemistry and Physics of Lipids - April 18, 2018 Category: Lipidology Authors: Talló K, Moner V, Cabo M, Cócera M, López O Tags: Chem Phys Lipids Source Type: research
Oleic acid in the modulation of oocyte and preimplantation embryo development.
Abstract
Potential reproductive effects are considered as the major aspect of biomolecules functionality in an organism. The recent identification of differential patterns of fatty acids across ovarian follicles and their association with levels of sexual maturity highlights the importance of these biomolecules. It is well known that fatty acids are highly diverse in terms of their functional properties. Oleic acid is chemically classified as an unsaturated omega-9 fatty acid. Besides serving as an important energy source, oleic acid is involved in metabolic and structural roles. Free and esterified oleic ...
Source: Zygote - December 15, 2017 Category: Reproduction Medicine Authors: Fayezi S, Leroy JLMR, Ghaffari Novin M, Darabi M Tags: Zygote Source Type: research
FFA4 (GPR120) as a fatty acid sensor involved in appetite control, insulin sensitivity and inflammation regulation
Publication date: Available online 12 October 2017 Source:Molecular Aspects of Medicine Author(s): Dong-Soon Im Unsaturated long-chain fatty acids have been suggested to be beneficial in the context of cardiovascular disorders based in epidemiologic studies conducted in Greenland and Mediterranean. DHA and EPA are omega-3 polyunsaturated fatty acids that are plentiful in fish oil, and oleic acid is an omega-9 monounsaturated fatty acid, rich in olive oil. Dietary intake of these unsaturated long-chain fatty acids have been associated with insulin sensitivity and weight loss, which contrasts with the impairment of insuli...
Source: Molecular Aspects of Medicine - October 12, 2017 Category: Molecular Biology Source Type: research
The role of Omega-3 and Omega-9 fatty acids for the treatment of neuropathic pain after neurotrauma
This article is part of a Special Issue entitled: Membrane Lipid Therapy: Drugs Targeting Biomembranes edited by Pablo Escríba-Ruíz. (Source: Biochimica et Biophysica Acta (BBA) Biomembranes)
Source: Biochimica et Biophysica Acta (BBA) Biomembranes - May 9, 2017 Category: Biochemistry Source Type: research
The role of Omega-3 and Omega-9 fatty acids for the treatment of neuropathic pain after neurotrauma.
This article is part of a Special Issue entitled: Membrane Lipid Therapy: Drugs Targeting Biomembranes edited by Pablo Escríba-Ruíz.
PMID: 28495596 [PubMed - as supplied by publisher] (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - May 8, 2017 Category: Biochemistry Authors: Galán-Arriero I, Serrano-Muñoz D, Gómez-Soriano J, Goicoechea C, Taylor J, Velasco A, Ávila-Martín G Tags: Biochim Biophys Acta Source Type: research
Lipid Emulsions Containing Medium Chain Triacylglycerols Blunt Bradykinin-Induced Endothelium-Dependent Relaxation in Porcine Coronary Artery Rings
AbstractLipid emulsions for parenteral nutrition are used to provide calories and essential fatty acids for patients. They have been associated with hypertriglyceridemia, hypercholesterolemia, and metabolic stress, which may promote the development of endothelial dysfunction in patients. The aim of the present study was to determine whether five different industrial lipid emulsions may affect the endothelial function of coronary arteries. Porcine coronary artery rings were incubated with lipid emulsions 0.5, 1, or 2% (v/v) for 30 min before the determination of vascular reactivity in organ chambers and the level of oxida...
Source: Lipids - January 1, 2017 Category: Lipidology Source Type: research
Individual omega-9 monounsaturated fatty acids and mortality —The Ludwigshafen Risk and Cardiovascular Health Study
The association of polyunsaturated omega-3 and omega-6 fatty acids with mortality has been extensively studied. Far less is known about the association of omega-9 monounsaturated fatty acids (omega-9 MUFA) with mortality. (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - November 8, 2016 Category: Lipidology Authors: Graciela E. Delgado, Bernhard K. Kr ämer, Stefan Lorkowski, Winfried März, Clemens von Schacky, Marcus E. Kleber Tags: Original Contribution Source Type: research
