Lipidomics of triglyceride-rich lipoproteins derived from hyperlipidemic patients on inflammation
CONCLUSIONS: High TRL-TG levels are associated with a higher systemic inflammatory status and increased particle concentrations. In vitro, higher particle numbers increase proinflammatory cytokine secretion, with cholesterol and phospholipid-rich TRL being more proinflammatory.PMID:38010694 | DOI:10.1111/eci.14132 (Source: Atherosclerosis)
Source: Atherosclerosis - November 27, 2023 Category: Cardiology Authors: Juan Moreno-Vedia D ídac Llop Ricardo Rodr íguez-Calvo N úria Plana N úria Amigó Roser Rosales Yaiza Esteban Llu ís Masana Daiana Ibarretxe Josefa Girona Source Type: research
Examination of Serum Metabolome Altered by Dietary Carbohydrate, Milk Protein, and Soy Protein Interventions Identified Novel Metabolites Associated with Blood Pressure: The ProBP Trial
ConclusionsThe study identifies molecular signatures of dietary interventions.Erucate (22:1n9) increases systolic BP. Acylcholine enhances and cheese intake reduces the BP lowering effect of soy protein supplement. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - August 31, 2023 Category: Food Science Authors: Li Changwei,
Joshua D. Bundy,
Ling Tian,
Ruiyuan Zhang,
Jing Chen,
Tanika N. Kelly,
Jiang He Tags: Research Article Source Type: research
Neuroinflammation and hypersensitivity evidenced by the acute and 28-DAY repeated dose toxicity tests of ostrich oil in mice
This study presents the chromatographic profile of a commercially available OO and its acute and 28-day repeated dose in vivo toxicological profiles. OO anti-inflammatory and antinociceptive effects were also investigated. Omega-9 (ω-9; oleic acid; 34.6%) and -6 (linoleic acid; 14.9%) were detected as OO main constituents. A high single dose of the OO (2 g/kg of ω-9) demonstrated no or low acute toxicity. However, when orally treated with OO (30-300 mg/kg of ω-9) for 28 consecutive days, mice exhibited altered locomotor and exploratory activities, hepatic damage, and increased hindpaw sensitivity accompanied by increase...
Source: Food and Chemical Toxicology - May 27, 2023 Category: Food Science Authors: Jose Roberto Santin Mainara Adriane Tesser Kopp Thiago Patr ício Correa J éssica Melato Larissa Benvenutti Roberta Nunes Fernanda Capitanio Goldoni Yasmin Beatrisse Klein Patel Jade Andr é de Souza Suzany Hellen da Silva Soczek Elizabeth Soares Fernand Source Type: research
Neuroinflammation and hypersensitivity evidenced by the acute and 28-DAY repeated dose toxicity tests of ostrich oil in mice
This study presents the chromatographic profile of a commercially available OO and its acute and 28-day repeated dose in vivo toxicological profiles. OO anti-inflammatory and antinociceptive effects were also investigated. Omega-9 (ω-9; oleic acid; 34.6%) and -6 (linoleic acid; 14.9%) were detected as OO main constituents. A high single dose of the OO (2 g/kg of ω-9) demonstrated no or low acute toxicity. However, when orally treated with OO (30-300 mg/kg of ω-9) for 28 consecutive days, mice exhibited altered locomotor and exploratory activities, hepatic damage, and increased hindpaw sensitivity accompanied by increase...
Source: Food and Chemical Toxicology - May 27, 2023 Category: Food Science Authors: Jose Roberto Santin Mainara Adriane Tesser Kopp Thiago Patr ício Correa J éssica Melato Larissa Benvenutti Roberta Nunes Fernanda Capitanio Goldoni Yasmin Beatrisse Klein Patel Jade Andr é de Souza Suzany Hellen da Silva Soczek Elizabeth Soares Fernand Source Type: research
Erucic Acid: A Possible Therapeutic Agent for Neurodegenerative Diseases
Curr Mol Med. 2023 May 9. doi: 10.2174/1566524023666230509123536. Online ahead of print.ABSTRACTNeurodegenerative disorders are among the most common life-threatening disorders among the elderly worldwide and are marked by neuronal death in the brain and spinal cord. Several studies have demonstrated the beneficial role of dietary fatty acids in different brain disorders. This is due to their neurotrophic, antioxidant, and anti-inflammatory properties. Furthermore, extensive evidence shows that an unbalanced intake of certain dietary fatty acids increases the risk of neuropsychiatric diseases. Several research has been don...
Source: Current Molecular Medicine - May 11, 2023 Category: Molecular Biology Authors: Ahsas Goyal Nandini Dubey Aanchal Verma Anant Agrawal Source Type: research
Erucic Acid: A Possible Therapeutic Agent for Neurodegenerative Diseases
Curr Mol Med. 2023 May 9. doi: 10.2174/1566524023666230509123536. Online ahead of print.ABSTRACTNeurodegenerative disorders are among the most common life-threatening disorders among the elderly worldwide and are marked by neuronal death in the brain and spinal cord. Several studies have demonstrated the beneficial role of dietary fatty acids in different brain disorders. This is due to their neurotrophic, antioxidant, and anti-inflammatory properties. Furthermore, extensive evidence shows that an unbalanced intake of certain dietary fatty acids increases the risk of neuropsychiatric diseases. Several research has been don...
Source: Molecular Medicine - May 11, 2023 Category: Molecular Biology Authors: Ahsas Goyal Nandini Dubey Aanchal Verma Anant Agrawal Source Type: research
Erucic Acid: A Possible Therapeutic Agent for Neurodegenerative Diseases
Curr Mol Med. 2023 May 9. doi: 10.2174/1566524023666230509123536. Online ahead of print.ABSTRACTNeurodegenerative disorders are among the most common life-threatening disorders among the elderly worldwide and are marked by neuronal death in the brain and spinal cord. Several studies have demonstrated the beneficial role of dietary fatty acids in different brain disorders. This is due to their neurotrophic, antioxidant, and anti-inflammatory properties. Furthermore, extensive evidence shows that an unbalanced intake of certain dietary fatty acids increases the risk of neuropsychiatric diseases. Several research has been don...
Source: Current Molecular Medicine - May 11, 2023 Category: Molecular Biology Authors: Ahsas Goyal Nandini Dubey Aanchal Verma Anant Agrawal Source Type: research
Erucic Acid: A Possible Therapeutic Agent for Neurodegenerative Diseases
Curr Mol Med. 2023 May 9. doi: 10.2174/1566524023666230509123536. Online ahead of print.ABSTRACTNeurodegenerative disorders are among the most common life-threatening disorders among the elderly worldwide and are marked by neuronal death in the brain and spinal cord. Several studies have demonstrated the beneficial role of dietary fatty acids in different brain disorders. This is due to their neurotrophic, antioxidant, and anti-inflammatory properties. Furthermore, extensive evidence shows that an unbalanced intake of certain dietary fatty acids increases the risk of neuropsychiatric diseases. Several research has been don...
Source: Molecular Medicine - May 11, 2023 Category: Molecular Biology Authors: Ahsas Goyal Nandini Dubey Aanchal Verma Anant Agrawal Source Type: research
Effect of adding lavender oil to laying quail diets on performance, egg quality, oxidative status, and fatty acid profile
This study aims to investigate the effects of lavender essential oil on performance, egg quality parameters in quails, malondialdehyde (MDA) in fresh and stored (28 days at+4 °C) eggs, and individual and total fatty acids. To this end, 100 female quails (Coturnix coturnix Japonica) which were 5 weeks old with an average weight of 224 g were used. The study lasted 45 days, including 10 days of introduction and 35 days of study. Quails were fed ad libitum with four different treatments. Four groups were formed as control groups (0g lavender essential oil/kg feed), Lav125 (125mg lavender essential oil/kg feed), Lav250 (250...
Source: Tropical Animal Health and Production - April 26, 2023 Category: Veterinary Research Source Type: research
Could dietary erucic acid lower risk of brain tumors? An epidemiological look to Chinese population with implications for prevention and treatment
AbstractErucic acid, an omega-9 monounsaturated fatty acid present in Brassicaceae plants (rapeseed and mustard oils) is highly consumed by the Chinese population and according to several global survey studies, its highest levels are encountered in the Chinese women ’s milk. Erucic acid is an activating ligand of the transcription factor PPARδ and an inhibitor of the transcriptional activity of PPARγ, which drive tumorigenesis of glioblastomas and medulloblastomas. In this theoretical review, we propose that erucic acid in diet may associate with the risk o f brain tumors. High grade brain tumors including medulloblast...
Source: Metabolic Brain Disease - June 15, 2022 Category: Neurology Source Type: research
Clinician guidelines for the treatment of psychiatric disorders with nutraceuticals and phytoceuticals: The World Federation of Societies of Biological Psychiatry (WFSBP) and Canadian Network for Mood and Anxiety Treatments (CANMAT) Taskforce
CONCLUSIONS: Based on the current data and clinician input, a range of nutraceuticals and phytoceuticals were given either a supportive recommendation or a provisional recommendation across a range of various psychiatric disorders. However several had only a weak endorsement for potential use; for a few it was not possible to reach a clear recommendation direction, largely due to mixed study findings; while some other agents showed no obvious therapeutic benefit and were clearly not recommended for use. It is the intention of these guidelines to inform psychiatric/medical, and health professional practice globally.PMID:353...
Source: The World Journal of Biological Psychiatry - March 21, 2022 Category: Psychiatry Authors: Jerome Sarris Arun Ravindran Lakshmi N Yatham Wolfgang Marx Julia J Rucklidge Roger S McIntyre Shahin Akhondzadeh Francesco Benedetti Constanza Caneo Holger Cramer Lachlan Cribb Michael de Manincor Olivia Dean Andrea Camaz Deslandes Marlene P Freeman Bang Source Type: research
Clinician guidelines for the treatment of psychiatric disorders with nutraceuticals and phytoceuticals: The World Federation of Societies of Biological Psychiatry (WFSBP) and Canadian Network for Mood and Anxiety Treatments (CANMAT) Taskforce
CONCLUSIONS: Based on the current data and clinician input, a range of nutraceuticals and phytoceuticals were given either a supportive recommendation or a provisional recommendation across a range of various psychiatric disorders. However several had only a weak endorsement for potential use; for a few it was not possible to reach a clear recommendation direction, largely due to mixed study findings; while some other agents showed no obvious therapeutic benefit and were clearly not recommended for use. It is the intention of these guidelines to inform psychiatric/medical, and health professional practice globally.PMID:353...
Source: The World Journal of Biological Psychiatry - March 21, 2022 Category: Psychiatry Authors: Jerome Sarris Arun Ravindran Lakshmi N Yatham Wolfgang Marx Julia J Rucklidge Roger S McIntyre Shahin Akhondzadeh Francesco Benedetti Constanza Caneo Holger Cramer Lachlan Cribb Michael de Manincor Olivia Dean Andrea Camaz Deslandes Marlene P Freeman Bang Source Type: research
