Cancers, Vol. 16, Pages 1590: Unsaturated Fatty Acid Synthesis Is Associated with Worse Survival and Is Differentially Regulated by MYCN and Tumor Suppressor microRNAs in Neuroblastoma
John T. Powers
MYCN amplification (MNA) and disruption of tumor suppressor microRNA (TSmiR) function are key drivers of poor outcomes in neuroblastoma (NB). While MYCN and TSmiRs regulate glucose metabolism, their role in de novo fatty acid synthesis (FAS) and unsaturated FAS (UFAS) remains poorly understood. Here, we show that FAS and UFAS (U/FAS) genes FASN, ELOVL6, SCD, FADS2, and FADS1 are upregulated in high-risk (HR) NB and that their expression is associated with lower overall survival. RNA-Seq analysis of human NB cell lines revealed parallel U/FAS gene expression patterns. Consistent with this, we found tha...
Source: Cancers - April 21, 2024 Category: Cancer & Oncology Authors: Dennis A. Sheeter Secilia Garza Hui Gyu Park Lorraine-Rana E. Benhamou Niharika R. Badi Erika C. Espinosa Kumar S. D. Kothapalli J. Thomas Brenna John T. Powers Tags: Article Source Type: research
Evaluating the renoprotective effects of omega-3-6-9 against cisplatin-induced nephrotoxicity in mice
This study explored the renoprotective potential of omega-3-6-9 when co-administered with cisplatin in a mice model. We divided adult mice into five groups: a control group received 0.5 ml of liquid paraffin; a cisplatin-only group; two groups were treated with low (50 mg/kg) and high (100 mg/kg) doses of omega-3-6-9 plus cisplatin; and a final group received vitamin E before cisplatin administration. The administration of omega-3-6-9 significantly decreased pro-inflammatory modulators and kidney function markers such as TNF-α, IL-1β, blood urea nitrogen, and creatinine, indicating potential renoprotective effects. Our r...
Source: Journal of Medicine and Life - April 8, 2024 Category: General Medicine Authors: Saja Kareem Abd Alhusen Ali Faris Hasan Source Type: research
Lipidomics of triglyceride-rich lipoproteins derived from hyperlipidemic patients on inflammation
CONCLUSIONS: High TRL-TG levels are associated with a higher systemic inflammatory status and increased particle concentrations. In vitro, higher particle numbers increase proinflammatory cytokine secretion, with cholesterol and phospholipid-rich TRL being more proinflammatory.PMID:38010694 | DOI:10.1111/eci.14132 (Source: Atherosclerosis)
Source: Atherosclerosis - November 27, 2023 Category: Cardiology Authors: Juan Moreno-Vedia D ídac Llop Ricardo Rodr íguez-Calvo N úria Plana N úria Amigó Roser Rosales Yaiza Esteban Llu ís Masana Daiana Ibarretxe Josefa Girona Source Type: research
Examination of Serum Metabolome Altered by Dietary Carbohydrate, Milk Protein, and Soy Protein Interventions Identified Novel Metabolites Associated with Blood Pressure: The ProBP Trial
ConclusionsThe study identifies molecular signatures of dietary interventions.Erucate (22:1n9) increases systolic BP. Acylcholine enhances and cheese intake reduces the BP lowering effect of soy protein supplement. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - August 31, 2023 Category: Food Science Authors: Li Changwei,
Joshua D. Bundy,
Ling Tian,
Ruiyuan Zhang,
Jing Chen,
Tanika N. Kelly,
Jiang He Tags: Research Article Source Type: research
Neuroinflammation and hypersensitivity evidenced by the acute and 28-DAY repeated dose toxicity tests of ostrich oil in mice
This study presents the chromatographic profile of a commercially available OO and its acute and 28-day repeated dose in vivo toxicological profiles. OO anti-inflammatory and antinociceptive effects were also investigated. Omega-9 (ω-9; oleic acid; 34.6%) and -6 (linoleic acid; 14.9%) were detected as OO main constituents. A high single dose of the OO (2 g/kg of ω-9) demonstrated no or low acute toxicity. However, when orally treated with OO (30-300 mg/kg of ω-9) for 28 consecutive days, mice exhibited altered locomotor and exploratory activities, hepatic damage, and increased hindpaw sensitivity accompanied by increase...
Source: Food and Chemical Toxicology - May 27, 2023 Category: Food Science Authors: Jose Roberto Santin Mainara Adriane Tesser Kopp Thiago Patr ício Correa J éssica Melato Larissa Benvenutti Roberta Nunes Fernanda Capitanio Goldoni Yasmin Beatrisse Klein Patel Jade Andr é de Souza Suzany Hellen da Silva Soczek Elizabeth Soares Fernand Source Type: research
Neuroinflammation and hypersensitivity evidenced by the acute and 28-DAY repeated dose toxicity tests of ostrich oil in mice
This study presents the chromatographic profile of a commercially available OO and its acute and 28-day repeated dose in vivo toxicological profiles. OO anti-inflammatory and antinociceptive effects were also investigated. Omega-9 (ω-9; oleic acid; 34.6%) and -6 (linoleic acid; 14.9%) were detected as OO main constituents. A high single dose of the OO (2 g/kg of ω-9) demonstrated no or low acute toxicity. However, when orally treated with OO (30-300 mg/kg of ω-9) for 28 consecutive days, mice exhibited altered locomotor and exploratory activities, hepatic damage, and increased hindpaw sensitivity accompanied by increase...
Source: Food and Chemical Toxicology - May 27, 2023 Category: Food Science Authors: Jose Roberto Santin Mainara Adriane Tesser Kopp Thiago Patr ício Correa J éssica Melato Larissa Benvenutti Roberta Nunes Fernanda Capitanio Goldoni Yasmin Beatrisse Klein Patel Jade Andr é de Souza Suzany Hellen da Silva Soczek Elizabeth Soares Fernand Source Type: research
Erucic Acid: A Possible Therapeutic Agent for Neurodegenerative Diseases
Curr Mol Med. 2023 May 9. doi: 10.2174/1566524023666230509123536. Online ahead of print.ABSTRACTNeurodegenerative disorders are among the most common life-threatening disorders among the elderly worldwide and are marked by neuronal death in the brain and spinal cord. Several studies have demonstrated the beneficial role of dietary fatty acids in different brain disorders. This is due to their neurotrophic, antioxidant, and anti-inflammatory properties. Furthermore, extensive evidence shows that an unbalanced intake of certain dietary fatty acids increases the risk of neuropsychiatric diseases. Several research has been don...
Source: Molecular Medicine - May 11, 2023 Category: Molecular Biology Authors: Ahsas Goyal Nandini Dubey Aanchal Verma Anant Agrawal Source Type: research
Erucic Acid: A Possible Therapeutic Agent for Neurodegenerative Diseases
Curr Mol Med. 2023 May 9. doi: 10.2174/1566524023666230509123536. Online ahead of print.ABSTRACTNeurodegenerative disorders are among the most common life-threatening disorders among the elderly worldwide and are marked by neuronal death in the brain and spinal cord. Several studies have demonstrated the beneficial role of dietary fatty acids in different brain disorders. This is due to their neurotrophic, antioxidant, and anti-inflammatory properties. Furthermore, extensive evidence shows that an unbalanced intake of certain dietary fatty acids increases the risk of neuropsychiatric diseases. Several research has been don...
Source: Current Molecular Medicine - May 11, 2023 Category: Molecular Biology Authors: Ahsas Goyal Nandini Dubey Aanchal Verma Anant Agrawal Source Type: research
