Individual Omega-9 Monounsaturated Fatty Acids and Mortality – The Ludwigshafen Risk and Cardiovascular Health Study
The association of polyunsaturated omega-3 and omega-6 fatty acids with mortality has been extensively studied. Far less is known about the association of omega-9 monounsaturated fatty acids (omega-9 MUFA) with mortality. (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - November 8, 2016 Category: Lipidology Authors: Graciela E. Delgado, Bernhard K. Kr ämer, Stefan Lorkowski, Winfried März, Clemens von Schacky, Marcus E. Kleber Source Type: research
Reduction of Platelet Aggregation From Ingestion of Oleic and Linoleic Acids Found in Vitis vinifera and Arachis hypogaea Oils
This study was performed using a pre–post test design, with a control group, and double blind. The effects of the consumption of grape seed and peanut oils were measured for platelet aggregation in clinical and laboratory tests in 30 healthy subjects. In addition to this group, a control group of 4 health subjects received no treatment with oils, just 500 mg oral administration acetylsalicylic acid for 7 days. Platelet aggregation was assessed by the Born turbidimetric method, using 3 different concentrations of adenosine diphosphate as agonists (2, 54; 1, 17; and 0, 58 μM). The study subjects had very similar results; ...
Source: American Journal of Therapeutics - November 1, 2016 Category: Drugs & Pharmacology Tags: Original Articles Source Type: research
P08.03 Erucic acid, a component of Lorenzos oil used in treatment of adrenoleukodystrophy, acts antineoplastic in C6 glioma cell culture
Conclusions:EA reduces glial tumor growth in vitro and its cardiac toxicity - if ever exists at low applicable doses - is not due to mitochondrial injury. It may be a novel biological modifier to enhance chemotherapy-efficacy in glial tumor treatment. (Source: Neuro-Oncology)
Source: Neuro-Oncology - September 20, 2016 Category: Cancer & Oncology Authors: Altinoz, M. A., Bilir, A., Bolukbasi, F. H., Sari, R., Yazici, Z., Elmaci, I. Tags: P08 Glioblastom and Anaplastic gliomas Source Type: research
Estudio comparativo de la eficacia y seguridad de una nutrici ón parenteral formulada con dos lípidos distintos: SMOFlipid® frente a Clinoleic®. Estudio preliminar.
Estudio comparativo de la eficacia y seguridad de una nutrición parenteral formulada con dos lípidos distintos: SMOFlipid® frente a Clinoleic®. Estudio preliminar.
Nutr Hosp. 2016;33(3):252
Authors: Martínez-Lozano Aranaga F, Palacios Vales P, Serrano Navarro JM, Caballero Requejo C, Gómez Ramos MJ, Sánchez Álvarez C
Abstract
Introducción: la composición lipídica de las fórmulas de nutrición parenteral (NP) se postula como posible factor de evolución clínica.Objetivo: evaluar las diferencias en eficacia y seguridad de dos emulsiones lipídicas en NP.Material y méto...
Source: Nutricion Hospitalaria - August 12, 2016 Category: Nutrition Authors: Martínez-Lozano Aranaga F, Palacios Vales P, Serrano Navarro JM, Caballero Requejo C, Gómez Ramos MJ, Sánchez Álvarez C Tags: Nutr Hosp Source Type: research
[Not Available].
Abstract
Introducción: la composición lipídica de las fórmulas de nutrición parenteral (NP) se postula como posible factor de evolución clínica.Objetivo: evaluar las diferencias en eficacia y seguridad de dos emulsiones lipídicas en NP.Material y métodos: estudio clínico prospectivo de pacientes posquirúrgicos sometidos a NP durante más de 7 días en un periodo de 2 años. Se administraron de forma indistinta 2 tipos de emulsiones lipídicas: enriquecida con ácidos grasos omega 3 (SMOFlipid Fresenius Kabi®) o con ácido oleico omega 9 (Clinoleic Baxter®). Se analizaron variables epidemiol...
Source: Nutricion Hospitalaria - July 25, 2016 Category: Nutrition Authors: Martínez-Lozano Aranaga F, Palacios Vales P, Serrano Navarro JM, Caballero Requejo C, Gómez Ramos MJ, Sánchez Álvarez C Tags: Nutr Hosp Source Type: research
The memory-enhancing effect of erucic acid on scopolamine-induced cognitive impairment in mice
Publication date: Available online 15 January 2016 Source:Pharmacology Biochemistry and Behavior Author(s): Eunji Kim, Hae Ju Ko, Se Jin Jeon, Sunhee Lee, Hyung Eun Lee, Ha Neul Kim, Eun-Rhan Woo, Jong Hoon Ryu Erucic acid is a monounsaturated omega-9 fatty acid isolated from the seed of Raphanus sativus L. that is known to normalize the accumulation of very long chain fatty acids in the brains of patients suffering from X-linked adrenoleukodystrophy. Here, we investigated whether erucic acid enhanced cognitive function or ameliorated scopolamine-induced memory impairment using the passive avoidance, Y-...
Source: Pharmacology Biochemistry and Behavior - January 15, 2016 Category: Biochemistry Source Type: research
Circulating Eicosapentaenoic Acid to Oleic Acid Ratio and Risk for Cardiovascular Events in Patients with Coronary Artery Disease: A Sub-analysis of the SHINANO registry
Conclusions We demonstrated that the EPA/OA ratio predicted MACE in patients with CAD who underwent PCI. (Source: IJC Metabolic and Endocrine)
Source: IJC Metabolic and Endocrine - November 10, 2015 Category: Endocrinology Source Type: research
Substrate specificity of Mortierella alpina Δ9‐III fatty acid desaturase and its value for the production of omega‐9 MUFA
The fatty acid desaturase (FADS9‐III) gene from M. alpina ATCC 32222 was cloned and overexpressed in a homologous system. Lipid analysis via GC‐MS revealed that the Δ9‐III fatty acid desaturase had moderate activity with palmitic acid (C16:0) and stearic acid (C18:0) as substrates. Palmitoleic acid (C16:1) and oleic acid (C18:1) contents increased 4.0‐ and 1.94‐fold in the FADS9‐III overexpression clones compared to the wild‐type strain. Low temperature (12°C) significantly improved the conversion ratio of C16:0 to C16:1 (9.12‐fold increase). In addition, the FADS9‐III fatty acid desaturase had specific...
Source: European Journal of Lipid Science and Technology - August 28, 2015 Category: Lipidology Authors: Guangfei Hao, Haiqin Chen, Bo Yang, Kai Du, Hongchao Wang, Zhennan Gu, Hao Zhang, Wei Chen, Yong Q. Chen Tags: Research Article Source Type: research
Diets containing alpha-linolenic (omega 3) or oleic (omega 9) fatty acids rescues obese mice from insulin resistance.
Abstract
Subclinical systemic inflammation is a hallmark of obesity and insulin resistance. The results obtained from a number of experimental studies suggest that targeting different components of the inflammatory machinery may result in the improvement of the metabolic phenotype. Unsaturated fatty acids exert anti-inflammatory activity through several distinct mechanisms. Here, we tested the capacity of omega-3 (ω3) and omega-9 (ω9) fatty acids, directly from their food matrix, to exert anti-inflammatory activity through the GPR120 and GPR40 pathways. GPR120 was activated in liver, skeletal muscle and ...
Source: Endocrinology - August 17, 2015 Category: Endocrinology Authors: Oliveira V, Marinho R, Vitorino D, Santos GA, Moraes JC, Dragano N, Sartori-Cintra A, Pereira L, Catharino RR, da Silva AS, Ropelle ER, Pauli JR, De Souza CT, Velloso LA, Cintra DE Tags: Endocrinology Source Type: research
Characterization of the substrate specificity of Mortierella alpina Δ9‐III fatty acid desaturase and its value for the production of omega‐9 MUFA
The FADS9‐III gene from M. alpina ATCC 32222 was cloned and overexpressed in a homologous system. Lipid analysis via GC‐MS revealed that the Δ9‐III fatty acid desaturase had moderate activity with palmitic acid (C16:0) and stearic acid (C18:0) as substrates. Palmitoleic acid (C16:1) and oleic acid (C18:1) contents increased 4.0‐ and 1.94‐fold in the FADS9‐III overexpression clones compared to the wild‐type strain. Low temperature (12°C) significantly improved the conversion ratio of C16:0 to C16:1 (9.12‐fold increase). In addition, the FADS9‐III fatty acid desaturase had specific activity at the ω9 pos...
Source: European Journal of Lipid Science and Technology - July 1, 2015 Category: Lipidology Authors: Guangfei Hao, Haiqin Chen, Bo Yang, Kai Du, Hongchao Wang, Zhennan Gu, Hao Zhang, Wei Chen, Yong Q. Chen Tags: Research Article Source Type: research
Oil mixes omega 9, 6 and 3, enriched with seaweed, promoted reduction of thermal burned modulating NF-kB and Ki-67.
CONCLUSION: Rats received oil mix in which the source of ω3 (ALA+DHA of seaweed) showed inhibition of NF-κB, increase in cell proliferation, and reduction the extension of thermal lesion.
PMID: 26108032 [PubMed - in process] (Source: Acta Cirurgica Brasileira)
Source: Acta Cirurgica Brasileira - June 1, 2015 Category: Surgery Authors: Campelo AP, Campelo MW, Brito GA, Jamacaru FV, Leitão RF, Vasconcelos PR Tags: Acta Cir Bras Source Type: research
Fatty acids as modulators of neutrophil recruitment, function and survival.
Abstract
Neutrophils are well-known to act in the destruction of invading microorganisms. They have also been implicated in the activation of other immune cells including B- and T-lymphocytes and in the resolution of inflammation and tissue regeneration. Neutrophils are produced in the bone marrow and released into the circulation from where they migrate to tissues to perform their effector functions. Neutrophils are in constant contact with fatty acids that can modulate their function, activation and fate (survival or cell death) through different mechanisms. In this review, the effects of fatty acids per...
Source: European Journal of Pharmacology - May 15, 2015 Category: Drugs & Pharmacology Authors: Hosana GR, Takeo Sato F, Curi R, Vinolo MA Tags: Eur J Pharmacol Source Type: research
Modulation of endothelial cell integrity and inflammatory activation by commercial lipid emulsions
Conclusions:
Lipid emulsions are readily incorporated and stored in the form of triacylglycerols. Soybean oil-based, olive oil-predominant and fish-oil based LEs differentially affected endothelial cell integrity. Importantly, these three LEs were capable of suppressing endothelial cell inflammatory response despite their fatty acid content. (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - February 18, 2015 Category: Lipidology Authors: Kevin HarveyZhidong XuThomas PavlinaGary ZalogaRafat Siddiqui Source Type: research
Lipid Emulsions Differentially Affect LPS-Induced Acute Monocytes Inflammation: In Vitro Effects on Membrane Remodeling and Cell Viability
Abstract
The aim of this study was to assess how lipid emulsions for parenteral nutrition affect lipopolysaccharide (LPS)-induced acute monocyte inflammation in vitro. An 18 h long LPS induced human monocyte leukemia cell stimulation was performed and the cell-growth medium was supplemented with three different industrial lipid emulsions: Intralipid®, containing long-chain triglycerides (LCT—soybean oil); Medialipid®, containing LCT (soybean oil) and medium-chain triglycerides (MCT—coconut oil); and SMOFlipid®, containing LCT, MCT, omega-9 and -3 (soybean, coconut, olive and fish oils). Cell vi...
Source: Lipids - October 23, 2014 Category: Lipidology Source Type: research
Mediterranean-style diet reduces metabolic syndrome components in obese children and adolescents with obesity
Conclusion:
The MSD improves the BMI, glucose and lipid profile in children and adolescents with obesity and any MetS component. (Source: BMC Pediatrics - Latest articles)
Source: BMC Pediatrics - Latest articles - July 5, 2014 Category: Pediatrics Authors: Lubia Velázquez-LópezGerardo Santiago-DíazJulia Nava-HernándezAbril Muñoz-TorresPatricia Medina-BravoMargarita Torres-Tamayo Source Type: research
