The roles of iron and HFE genotype in neurological diseases
Publication date: Available online 9 July 2020Source: Molecular Aspects of MedicineAuthor(s): Yunsung Kim, James R. Connor (Source: Molecular Aspects of Medicine)
Source: Molecular Aspects of Medicine - July 10, 2020 Category: Molecular Biology Source Type: research

Oral iron supplementation in iron-deficient women: How much and how often?
Publication date: Available online 7 July 2020Source: Molecular Aspects of MedicineAuthor(s): Nicole U. Stoffel, Hanna K. von Siebenthal, Diego Moretti, Michael B. Zimmermann (Source: Molecular Aspects of Medicine)
Source: Molecular Aspects of Medicine - July 8, 2020 Category: Molecular Biology Source Type: research

Iron overload and its impact on outcome of patients with hematological diseases
Publication date: Available online 1 July 2020Source: Molecular Aspects of MedicineAuthor(s): Georg-Nikolaus Franke, Anne Sophie Kubasch, Michael Cross, Vladan Vucinic, Uwe Platzbecker (Source: Molecular Aspects of Medicine)
Source: Molecular Aspects of Medicine - July 1, 2020 Category: Molecular Biology Source Type: research

Basics and principles of cellular and systemic iron homeostasis
Publication date: Available online 18 June 2020Source: Molecular Aspects of MedicineAuthor(s): Angeliki Katsarou, Kostas Pantopoulos (Source: Molecular Aspects of Medicine)
Source: Molecular Aspects of Medicine - June 19, 2020 Category: Molecular Biology Source Type: research

The NAIP/NLRC4 inflammasome in infection and pathology
Publication date: Available online 1 June 2020Source: Molecular Aspects of MedicineAuthor(s): Renate Bauer, Isabella Rauch (Source: Molecular Aspects of Medicine)
Source: Molecular Aspects of Medicine - June 2, 2020 Category: Molecular Biology Source Type: research

Iron in infection and immunity
Publication date: Available online 24 May 2020Source: Molecular Aspects of MedicineAuthor(s): Manfred Nairz, Günter Weiss (Source: Molecular Aspects of Medicine)
Source: Molecular Aspects of Medicine - May 26, 2020 Category: Molecular Biology Source Type: research

Intravenous iron supplementation therapy
Publication date: Available online 19 May 2020Source: Molecular Aspects of MedicineAuthor(s): Benedikt Schaefer, Eva Meindl, Sonja Wagner, Herbert Tilg, Heinz Zoller (Source: Molecular Aspects of Medicine)
Source: Molecular Aspects of Medicine - May 20, 2020 Category: Molecular Biology Source Type: research

The changing landscape of iron deficiency
Publication date: Available online 14 May 2020Source: Molecular Aspects of MedicineAuthor(s): Clara Camaschella, Domenico Girelli (Source: Molecular Aspects of Medicine)
Source: Molecular Aspects of Medicine - May 15, 2020 Category: Molecular Biology Source Type: research

NLRP6 inflammasome
Publication date: Available online 6 May 2020Source: Molecular Aspects of MedicineAuthor(s): Runzhi Li, Shu Zhu (Source: Molecular Aspects of Medicine)
Source: Molecular Aspects of Medicine - May 6, 2020 Category: Molecular Biology Source Type: research

To protect or adversely affect? The dichotomous role of the NLRP1 inflammasome in human disease
Publication date: Available online 28 April 2020Source: Molecular Aspects of MedicineAuthor(s): Juselyn D. Tupik, Margaret A. Nagai-Singer, Irving C. Allen (Source: Molecular Aspects of Medicine)
Source: Molecular Aspects of Medicine - April 30, 2020 Category: Molecular Biology Source Type: research

Iron: The cancer connection
Publication date: Available online 25 April 2020Source: Molecular Aspects of MedicineAuthor(s): Suzy V. Torti, Frank M. Torti (Source: Molecular Aspects of Medicine)
Source: Molecular Aspects of Medicine - April 25, 2020 Category: Molecular Biology Source Type: research

Editorial Board
Publication date: April 2020Source: Molecular Aspects of Medicine, Volume 72Author(s): (Source: Molecular Aspects of Medicine)
Source: Molecular Aspects of Medicine - April 11, 2020 Category: Molecular Biology Source Type: research

Editorial Board
Publication date: February 2020Source: Molecular Aspects of Medicine, Volume 71Author(s): (Source: Molecular Aspects of Medicine)
Source: Molecular Aspects of Medicine - February 16, 2020 Category: Molecular Biology Source Type: research

Mitochondrial functions and rare diseases
Publication date: Available online 3 February 2020Source: Molecular Aspects of MedicineAuthor(s): L. Dard, W. Blanchard, C. Hubert, D. Lacombe, R. RossignolAbstractMitochondria are dynamic cellular organelles responsible for a large variety of biochemical processes as energy transduction, REDOX signaling, the biosynthesis of hormones and vitamins, inflammation or cell death execution. Cell biology studies established that 1158 human genes encode proteins localized to mitochondria, as registered in MITOCARTA. Clinical studies showed that a large number of these mitochondrial proteins can be altered in expression and functio...
Source: Molecular Aspects of Medicine - February 4, 2020 Category: Molecular Biology Source Type: research

Integrating circulating miRNA analysis in the clinical management of lung cancer: Present or future?
Publication date: Available online 17 January 2020Source: Molecular Aspects of MedicineAuthor(s): Rita Lampignano, Vera Kloten, Thomas Krahn, Thomas SchlangeAbstractLiquid biopsy holds great promise to complement traditional analysis on cancerous tissue during clinical management of cancer: screening of patients, (early) disease diagnosis, prognosis, therapy selection as well as early response to treatment and disease monitoring. Among emerging circulating biomarkers, cell-free miRNA (cfmiRNA) may have potential in detecting lung cancer and following the course of the disease. Furthermore, several studies highlighted the p...
Source: Molecular Aspects of Medicine - January 18, 2020 Category: Molecular Biology Source Type: research

Circulating cell-free DNA: Translating prostate cancer genomics into clinical care
Publication date: Available online 16 January 2020Source: Molecular Aspects of MedicineAuthor(s): Delila Gasi Tandefelt, Johann de BonoAbstractOnly in the past decade tremendous advances have been made in understanding prostate cancer genomics and consequently in applying new treatment strategies. As options regarding treatments are increasing so are the challenges in selecting the right treatment option for each patient and not the least, understanding the optimal time-point and sequence of applying available treatments. Critically, without reliable methods that enable sequential monitoring of evolving genotypes in indivi...
Source: Molecular Aspects of Medicine - January 17, 2020 Category: Molecular Biology Source Type: research

Macrophage activation as an archetype of mitochondrial repurposing
Publication date: Available online 16 January 2020Source: Molecular Aspects of MedicineAuthor(s): Anthony E. Jones, Ajit S. DivakaruniAbstractMitochondria are metabolic organelles essential not only for energy transduction, but also a range of other functions such as biosynthesis, ion and metal homeostasis, maintenance of redox balance, and cell signaling. A hallmark example of how mitochondria can rebalance these processes to adjust cell function is observed in macrophages. These innate immune cells are responsible for a remarkable breadth of processes including pathogen elimination, antigen presentation, debris clearance...
Source: Molecular Aspects of Medicine - January 17, 2020 Category: Molecular Biology Source Type: research

Emerging roles of β-cell mitochondria in type-2-diabetes
Publication date: Available online 7 January 2020Source: Molecular Aspects of MedicineAuthor(s): Guy Las, Marcus F. Oliveira, Orian S. ShirihaiAbstractType-2-Diabetes (T2D) is the most common metabolic disease in the world today. It erupts as a result of peripheral insulin resistance combined with hyperinsulinemia followed by suppression of insulin secretion from pancreatic β-cells. Mitochondria play a central role in β-cells by sensing glucose and also by mediating the suppression of insulin secretion in T2D. Here, we will summarize the evidence accumulated for the roles of β-cells mitochondria in T2D. We w...
Source: Molecular Aspects of Medicine - January 8, 2020 Category: Molecular Biology Source Type: research

Mitochondria: New developments in pathophysiology
Publication date: Available online 30 December 2019Source: Molecular Aspects of MedicineAuthor(s): Alicia J. Kowaltowski, Marcus F. Oliveira (Source: Molecular Aspects of Medicine)
Source: Molecular Aspects of Medicine - January 1, 2020 Category: Molecular Biology Source Type: research

Liquid biopsy analysis in cancer diagnostics
Publication date: Available online 26 December 2019Source: Molecular Aspects of MedicineAuthor(s): Daniel Andersson, Mikael Kubista, Anders Ståhlberg (Source: Molecular Aspects of Medicine)
Source: Molecular Aspects of Medicine - December 27, 2019 Category: Molecular Biology Source Type: research

Mitochondrial bioenergetics and redox dysfunctions in hypercholesterolemia and atherosclerosis
Publication date: Available online 25 December 2019Source: Molecular Aspects of MedicineAuthor(s): Helena C.F. Oliveira, Anibal E. VercesiAbstractIn the first part of this review, we summarize basic mitochondrial bioenergetics concepts showing that mitochondria are critical regulators of cell life and death. Until a few decades ago, mitochondria were considered to play essential roles only in respiration, ATP formation, non-shivering thermogenesis and a variety of metabolic pathways. However, the concept presented by Peter Mitchell regarding coupling between electron flow and ATP synthesis through the intermediary of a H+ ...
Source: Molecular Aspects of Medicine - December 26, 2019 Category: Molecular Biology Source Type: research

Mitochondrially-targeted treatment strategies
Publication date: Available online 19 December 2019Source: Molecular Aspects of MedicineAuthor(s): Luiz H.M. Bozi, Juliane C. Campos, Vanessa O. Zambelli, Nikolas D. Ferreira, Julio C.B. FerreiraAbstractDisruption of mitochondrial function is a common feature of inherited mitochondrial diseases (mitochondriopathies) and many other infectious and non-infectious diseases including viral, bacterial and protozoan infections, inflammatory and chronic pain, neurodegeneration, diabetes, obesity and cardiovascular diseases. Mitochondria therefore become an attractive target for developing new therapies. In this review we describe ...
Source: Molecular Aspects of Medicine - December 20, 2019 Category: Molecular Biology Source Type: research

Blood-based bioenergetics: An emerging translational and clinical tool
Publication date: Available online 18 December 2019Source: Molecular Aspects of MedicineAuthor(s): Andrea Braganza, Gowtham K. Annarapu, Sruti ShivaAbstractAccumulating studies demonstrate that mitochondrial genetics and function are central to determining the susceptibility to, and prognosis of numerous diseases across all organ systems. Despite this recognition, mitochondrial function remains poorly characterized in humans primarily due to the invasiveness of obtaining viable tissue for mitochondrial studies. Recent studies have begun to test the hypothesis that circulating blood cells, which can be obtained by minimally...
Source: Molecular Aspects of Medicine - December 20, 2019 Category: Molecular Biology Source Type: research

Nanoparticle-aided glycovariant assays to bridge biomarker performance and ctDNA results
Publication date: Available online 29 November 2019Source: Molecular Aspects of MedicineAuthor(s): Kamlesh Gidwani, Henna Kekki, Joonas Terävä, Tero Soukka, Karin Sundfeldt, Kim PetterssonAbstractNumerous immunoassay based cancer biomarkers established in the 1970 and 1980′ies are widely used in clinical routine. Initial expectations of biomarkers such as CEA, CA125, CA19-9, AFP to provide decisive help in the diagnosis of early stage, pre-symptomatic cancers have not been realized. Thus, they are primarily used for monitoring disease progression and occasionally being useful as prognostic indicators. This ...
Source: Molecular Aspects of Medicine - November 29, 2019 Category: Molecular Biology Source Type: research

Editorial Board
Publication date: December 2019Source: Molecular Aspects of Medicine, Volume 70Author(s): (Source: Molecular Aspects of Medicine)
Source: Molecular Aspects of Medicine - November 26, 2019 Category: Molecular Biology Source Type: research

Emerging isothermal amplification technologies for microRNA biosensing: Applications to liquid biopsies
Publication date: Available online 23 November 2019Source: Molecular Aspects of MedicineAuthor(s): Guillaume Gines, Roberta Menezes, Wenjin Xiao, Yannick Rondelez, Valerie TalyAbstractThe potential of microRNAs (miRNAs) as biomarker candidates in clinical practice for diagnosis, prognosis and treatment response prediction, especially in liquid biopsies, has led to a tremendous demand for techniques that can detect these molecules rapidly and accurately. Hence, numerous achievements have been reported recently in miRNA research. In this review, we discuss the challenges associated with the emerging field of miRNA detection,...
Source: Molecular Aspects of Medicine - November 24, 2019 Category: Molecular Biology Source Type: research

Quantification of mitochondrial DNA from peripheral tissues: Limitations in predicting the severity of neurometabolic disorders and proposal of a novel diagnostic test
Publication date: Available online 16 November 2019Source: Molecular Aspects of MedicineAuthor(s): Christos ChinopoulosAbstractNeurometabolic disorders stem from errors in metabolic processes yielding a neurological phenotype. A subset of those disorders encompasses mitochondrial abnormalities partially due to mitochondrial DNA (mtDNA) depletion. mtDNA depletion can be attributed to inheritance, spontaneous mutations or acquired from drug-related toxicities. In the armamentarium of diagnostic procedures, mtDNA quantification is a standard for disease classification. However, alterations in mtDNA obtained from peripheral ti...
Source: Molecular Aspects of Medicine - November 16, 2019 Category: Molecular Biology Source Type: research

Molecular aspects of medicine – Editorial 2019
Publication date: Available online 14 November 2019Source: Molecular Aspects of MedicineAuthor(s): George A. Calin (Source: Molecular Aspects of Medicine)
Source: Molecular Aspects of Medicine - November 16, 2019 Category: Molecular Biology Source Type: research

Targets, pitfalls and reference materials for liquid biopsy tests in cancer diagnostics
Publication date: Available online 8 November 2019Source: Molecular Aspects of MedicineAuthor(s): Edward Geeurickx, An HendrixAbstractAssessment of cell free DNA (cfDNA) and RNA (cfRNA), circulating tumor cells (CTC) and extracellular vesicles (EV) in blood or other bodily fluids can enable early cancer detection, tumor dynamics assessment, minimal residual disease detection and therapy monitoring. However, few liquid biopsy tests progress towards clinical application because results are often discordant and challenging to reproduce. Reproducibility can be enhanced by the development and implementation of standard operatin...
Source: Molecular Aspects of Medicine - November 9, 2019 Category: Molecular Biology Source Type: research

Altered expression of miR-181 affects cell fate and targets drug resistance-related mechanisms
Publication date: Available online 6 November 2019Source: Molecular Aspects of MedicineAuthor(s): Cornelia Braicu, Diana Gulei, Lajos Raduly, Antonia Harangus, Alexandru Rusu, Ioana Berindan-NeagoeAbstractMicroRNAs (miRNAs) are non-coding transcripts which regulate genetic and epigenetic events by interfering with mRNA translation. miRNAs are involved in regulation of cell fate due to their ability of interfering with physiological or pathological processes. In this review paper, we evaluate the role of miR-181 family members as prognostic or diagnostic markers or therapeutic targets in malignant pathologies in connection ...
Source: Molecular Aspects of Medicine - November 6, 2019 Category: Molecular Biology Source Type: research

Cell-free DNA in blood as a noninvasive insight into the sarcoma genome
Publication date: Available online 6 November 2019Source: Molecular Aspects of MedicineAuthor(s): Heidi Maria Namløs, Kjetil Boye, Leonardo A. Meza-ZepedaAbstractSarcomas are malignant tumors of mesenchymal origin that arise mainly from connective and supportive tissue. Sarcomas include a wide range of histological subtypes, showing a large diversity at the molecular level, from simple to highly complex karyotypes but with few recurrent somatic changes. Therapeutic decisions increasingly rely on the molecular characteristics of the individual tumor. Circulating cell-free DNA (ctDNA) is released into peripheral blood...
Source: Molecular Aspects of Medicine - November 6, 2019 Category: Molecular Biology Source Type: research

Circular RNAs: The star molecules in cancer
Publication date: Available online 31 October 2019Source: Molecular Aspects of MedicineAuthor(s): Jianhong Liu, Dongpei Li, Hui Luo, Xiao ZhuAbstractCircular RNAs (circRNAs) are a class of endogenous non-coding RNAs with a closed loop structure. These RNAs are produced by pre-mRNA through variable shear processing and are highly conserved. Such highly conserved molecules play an important role in biology, especially in cancer biology. With the development of experimental techniques such as circRNA microarray screening and high-throughput sequencing technologies, the mystery of circRNAs has gradually been unveiled and the v...
Source: Molecular Aspects of Medicine - October 31, 2019 Category: Molecular Biology Source Type: research

Circulating miRNA analysis for cancer diagnostics and therapy
Publication date: Available online 18 October 2019Source: Molecular Aspects of MedicineAuthor(s): Lukas Valihrach, Peter Androvic, Mikael KubistaAbstractSuccessful treatment of cancer depends on early diagnosis and effective monitoring of patients’ response to therapy. Traditional tools based on tumor biopsies lack the sensitivity and specificity to capture cancer development in its early phases and are not applicable for continuous monitoring. To overcome these barriers, liquid biopsies have been introduced as a minimally invasive and cost-efficient means of diagnosis with high level of specificity and sensitivity. ...
Source: Molecular Aspects of Medicine - October 20, 2019 Category: Molecular Biology Source Type: research

Neurological disorders and mitochondria
Publication date: Available online 17 October 2019Source: Molecular Aspects of MedicineAuthor(s): J.V. Cabral-Costa, A.J. KowaltowskiAbstractThe brain is highly dependent on mitochondrial energy metabolism. As a result, mitochondrial dysfunction is a central aspect of many adult-onset neurological diseases, including stroke, ALS, Alzheimer's, Huntington's, and Parkinson's diseases. We review here how different mitochondrial functions, including oxidative phosphorylation, mitochondrial dynamics, oxidant generation, cell death regulation, Ca2+ homeostasis, and proteostasis are involved in these disorders. (Source: Molecular Aspects of Medicine)
Source: Molecular Aspects of Medicine - October 18, 2019 Category: Molecular Biology Source Type: research

The role of exosomes and MYC in therapy resistance of acute myeloid leukemia: Challenges and opportunities
Publication date: Available online 14 October 2019Source: Molecular Aspects of MedicineAuthor(s): Nithya Mudgapalli, Palanisamy Nallasamy, Haritha Chava, Srinivas Chava, Anup S. Pathania, Venugopal Gunda, Santhi Gorantla, Manoj K. Pandey, Subash C. Gupta, Kishore B. ChallagundlaAbstractAcute myeloid leukemia (AML) is caused by abnormal production of white blood cells, red blood cells or platelets. The leukemia cells communicate with their microenvironment through nano-vesicle exosomes that are 30–100 nm in diameter. These nano-vesicles are released from body fluids upon fusion of an endocytic compartment with the c...
Source: Molecular Aspects of Medicine - October 16, 2019 Category: Molecular Biology Source Type: research

Emerging role of mitophagy in cardiovascular physiology and pathology
Publication date: Available online 3 October 2019Source: Molecular Aspects of MedicineAuthor(s): Pablo E. Morales, Carla Arias-Durán, Yáreni Ávalos-Guajardo, Geraldine Aedo, Hugo E. Verdejo, Valentina Parra, Sergio LavanderoAbstractHealthy mitochondrial function is imperative for most tissues, but especially those with a high energy demand. Robust evidence linking mitochondrial dysfunction with cardiovascular disease has demonstrated that mitochondrial activity is highly relevant to cardiac muscle performance. Mitochondrial homeostasis is maintained through coordination among the processes that compris...
Source: Molecular Aspects of Medicine - October 4, 2019 Category: Molecular Biology Source Type: research

Current concepts of non-coding RNA regulation of immune checkpoints in cancer
Publication date: Available online 30 September 2019Source: Molecular Aspects of MedicineAuthor(s): Maria Anna Smolle, Felix Prinz, George Adrian Calin, Martin PichlerAbstractThe discovery of immune checkpoint molecules as important regulators of immune responses in healthy individuals as well as immune escape of malignant tumours has led to profound changes in understanding, research and treatment of human cancer. Especially the introduction of immune checkpoint inhibitors in cancer therapy has set anti-cancer therapy on a novel level. With increasing experience of approved CTLA-4 and PD1/PD-L1 inhibitors and the evolutio...
Source: Molecular Aspects of Medicine - October 1, 2019 Category: Molecular Biology Source Type: research

Circulating cell-free tumor DNA analysis in pediatric cancers
Publication date: Available online 25 September 2019Source: Molecular Aspects of MedicineAuthor(s): Daniel Andersson, Henrik Fagman, Martin G. Dalin, Anders StåhlbergAbstractAnalysis of circulating cell-free tumor DNA (ctDNA) has shown promising results within several clinical applications, including cancer detection, mutation profiling, treatment monitoring and early detection of relapse. Here, we discuss the potential and limitations of ctDNA analysis in pediatric cancer detection, therapy decision making and research. Biological properties associated to ctDNA are highlighted and related to technical constraints in...
Source: Molecular Aspects of Medicine - September 27, 2019 Category: Molecular Biology Source Type: research

Epithelial keratins: Biology and implications as diagnostic markers for liquid biopsies
Publication date: Available online 25 September 2019Source: Molecular Aspects of MedicineAuthor(s): Stefan Werner, Laura Keller, Klaus PantelAbstractKeratins are essential elements of the cytoskeleton of normal and malignant epithelial cells. Because carcinomas commonly maintain their specific keratin expression pattern during malignant transformation, keratins are extensively used as tumor markers in cancer diagnosis including the detection of circulating tumor cells in blood of carcinoma patients. Interestingly, recent biological insights demonstrate that epithelial keratins should not only be considered as mere tumor ma...
Source: Molecular Aspects of Medicine - September 27, 2019 Category: Molecular Biology Source Type: research

MiR-200 family and cancer: From a meta-analysis view
Publication date: Available online 23 September 2019Source: Molecular Aspects of MedicineAuthor(s): Guo-Liang Huang, Jiancong Sun, Yan Lu, Yuke Liu, Huiyuan Cao, Huanyu Zhang, George A. CalinAbstractThe role of microRNAs (miRNAs) in cancer development was implicated as oncogene or tumor suppressor. One of the miRNA family, the miR-200 family, was mainly characterized as tumor suppressor. However, controversial results were reported. The associations between miR-200 family (consisting of five miRNAs: miR-141/200a/200b/200c/429) and cancer prognosis were inconsistent. Therefore, we conducted a meta-analysis by searching PubM...
Source: Molecular Aspects of Medicine - September 24, 2019 Category: Molecular Biology Source Type: research

The extensive role of miR-155 in malignant and non-malignant diseases
Publication date: Available online 23 September 2019Source: Molecular Aspects of MedicineAuthor(s): Diana Gulei, Lajos Raduly, Elisabetta Broseghini, Manuela Ferracin, Ioana Berindan-NeagoeAbstractMicroRNAs (miRNAs) have rapidly emerged as key molecules in cancer initiation and development, showing the capability to regulate pivotal oncogenic pathways. MiR-155 has gathered an increased attention especially in oncology, but also in non-malignanat pathologies. Nowadays, this noncoding RNA is one of the most important miRNAs in cancer, due to the extensive signaling network associated with it, implication in immune system reg...
Source: Molecular Aspects of Medicine - September 24, 2019 Category: Molecular Biology Source Type: research

Editorial Board
Publication date: October 2019Source: Molecular Aspects of Medicine, Volume 69Author(s): (Source: Molecular Aspects of Medicine)
Source: Molecular Aspects of Medicine - September 18, 2019 Category: Molecular Biology Source Type: research

Introduction to special issue – “New insights on the molecular aspects of colorectal cancer”
Publication date: October 2019Source: Molecular Aspects of Medicine, Volume 69Author(s): Sergi Castellví-Bel (Source: Molecular Aspects of Medicine)
Source: Molecular Aspects of Medicine - September 18, 2019 Category: Molecular Biology Source Type: research

Circulating tumor cell as the functional aspect of liquid biopsy to understand the metastatic cascade in solid cancer
Publication date: Available online 21 August 2019Source: Molecular Aspects of MedicineAuthor(s): Luis Enrique Cortés-Hernández, Zahra Eslami-S, Catherine Alix-PanabièresAbstractMetastasis is the main cause of death in patients with cancer. The molecular mechanisms underlying the different metastasis steps are not yet fully known, partly because most studies have been focusing only on cancer cells within the tumor. Currently, with the development of technologies for the enrichment and capture of circulating tumor cells (CTCs), it is possible to characterize cancer cells at the exact moment of metastasis...
Source: Molecular Aspects of Medicine - August 22, 2019 Category: Molecular Biology Source Type: research

Editorial Board
Publication date: August 2019Source: Molecular Aspects of Medicine, Volume 68Author(s): (Source: Molecular Aspects of Medicine)
Source: Molecular Aspects of Medicine - August 20, 2019 Category: Molecular Biology Source Type: research

Switching on the furnace: Regulation of heat production in brown adipose tissue
Publication date: Available online 5 August 2019Source: Molecular Aspects of MedicineAuthor(s): Li Li, Baoguo Li, Min Li, John R. SpeakmanAbstractEndothermy requires a source of endogenous heat production. In birds, this is derived primarily from shivering, but in mammals it is mostly non-shivering thermogenesis (NST). Brown adipose tissue (BAT) is a specialized tissue found in Eutherian mammals that is the source of most NST. Heat production in BAT depends primarily on the activity of uncoupling protein 1 (UCP1), which decouples transport of protons across the inner mitochondrial membrane from synthesis of ATP. UCP1 and h...
Source: Molecular Aspects of Medicine - August 6, 2019 Category: Molecular Biology Source Type: research

The landscape of genomic copy number alterations in colorectal cancer and their consequences on gene expression levels and disease outcome
Publication date: Available online 6 August 2019Source: Molecular Aspects of MedicineAuthor(s): Thomas Ried, Gerrit A. Meijer, David J. Harrison, Godfrey Grech, Sebastià Franch-Expósito, Romina Briffa, Beatriz Carvalho, Jordi CampsAbstractAneuploidy, the unbalanced state of the chromosome content, represents a hallmark of most solid tumors, including colorectal cancer. Such aneuploidies result in tumor specific genomic imbalances, which emerge in premalignant precursor lesions. Moreover, increasing levels of chromosomal instability have been observed in adenocarcinomas and are maintained in distant metastases...
Source: Molecular Aspects of Medicine - August 6, 2019 Category: Molecular Biology Source Type: research

Glucocorticoids and Brown Adipose Tissue: Do glucocorticoids really inhibit thermogenesis?
Publication date: Available online 27 July 2019Source: Molecular Aspects of MedicineAuthor(s): Ineke H.N. Luijten, Barbara Cannon, Jan NedergaardAbstractA reduction in the thermogenic activity of brown adipose tissue (BAT) is presently discussed as a possible determinant for the development of obesity in humans. One group of endogenous factors that could potentially affect BAT activity is the glucocorticoids (e.g. cortisol). We analyse here studies examining the effects of alterations in glucocorticoid signaling on BAT recruitment and thermogenic capacity. We find that irrespective of which manipulation of glucocorticoid s...
Source: Molecular Aspects of Medicine - July 28, 2019 Category: Molecular Biology Source Type: research

Fifty shades of brown: The functions, diverse regulation and evolution of brown adipose tissue
Publication date: Available online 22 July 2019Source: Molecular Aspects of MedicineAuthor(s): John R. Speakman (Source: Molecular Aspects of Medicine)
Source: Molecular Aspects of Medicine - July 24, 2019 Category: Molecular Biology Source Type: research

The importance of long non-coding RNAs in neuropsychiatric disorders
Publication date: Available online 19 July 2019Source: Molecular Aspects of MedicineAuthor(s): Ebrahim Hosseini, Zahra Bagheri-Hosseinabadi, Ilario De Toma, Moslem Jafarisani, Iman SadeghiAbstractIn the last decade, transcriptome analyses have discovered thousands of long non-coding RNAs (lncRNAs) which are assumed as a fundamental part of the gene regulatory networks in the cell. Intriguingly, lncRNAs are abundantly enriched in the brain, displaying elaborate spatiotemporal expression profiles and modulation. They diversely participate in the delicate regulation of the central nervous system (CNS) development including se...
Source: Molecular Aspects of Medicine - July 21, 2019 Category: Molecular Biology Source Type: research