National Institute for Health Research (NIHR) Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Centile reference chart for resting metabolic rate through the life course
Conclusion We have developed a reference centile chart for an index of resting metabolic rate in childhood and adults, and shown its clinical utility in assessing response to therapy of an endocrine disorder during a patient’s transition from childhood to adult. (Source: Archives of Disease in Childhood)
Source: Archives of Disease in Childhood - June 19, 2023 Category: Pediatrics Authors: Watson, L., Cole, T. J., Lyons, G., Georgiou, C., Worsley, J., Carr, K., Murgatroyd, P., Moran, C., Chatterjee, K., Venables, M. Tags: Open access Original research Source Type: research

KIR-HLA interactions extend human CD8+ T cell lifespan in vivo
CONCLUSIONS Together, these data reveal an unexpectedly large effect of iKIR genotype on T cell survival.FUNDING Wellcome Trust; Medical Research Council; EU Horizon 2020; EU FP7; Leukemia and Lymphoma Research; National Institute of Health Research (NIHR) Imperial Biomedical Research Centre; Imperial College Research Fellowship; National Institutes of Health; Jefferiss Trust. (Source: Journal of Clinical Investigation)
Source: Journal of Clinical Investigation - June 15, 2023 Category: Biomedical Science Authors: Yan Zhang, Ada W.C. Yan, Lies Boelen, Linda Hadcocks, Arafa Salam, Daniel Padrosa Gispert, Loiza Spanos, Laura Mora Bitria, Neda Nemat-Gorgani, James A. Traherne, Chrissy Roberts, Danai Koftori, Graham P. Taylor, Daniel Forton, Paul J. Norman, Steven G.E. Source Type: research

Models of social prescribing to address non-medical needs in adults: a scoping review
CONCLUSIONS: There is significant variability in social prescribing approaches internationally. Social prescribing programs can be summarised as including six planning stages and six program processes. We provide guidance for decision-makers regarding what to consider when designing social prescribing programs.PMID:37316920 | PMC:PMC10268538 | DOI:10.1186/s12913-023-09650-x (Source: Rural Remote Health)
Source: Rural Remote Health - June 14, 2023 Category: Rural Health Authors: Candice Oster Claire Skelton Richard Leibbrandt Sonia Hines Billie Bonevski Source Type: research

Factors that influence the administration of tranexamic acid (TXA) to trauma patients in prehospital settings: a systematic review
Conclusions This review highlights an absence of high-quality research. Preliminary evidence suggests a host of system and individual-level factors that may be important in determining whether TXA is administered to trauma patients in the prehospital setting. Funding and registration This review was supported by Research Capability Funding from the South Western Ambulance Service NHS Foundation Trust and the National Institute for Health Research Applied Research Collaboration South West Peninsula. PROSPERO registration number CRD42020162943. (Source: BMJ Open)
Source: BMJ Open - May 31, 2023 Category: General Medicine Authors: Nicholson, H., Scotney, N., Briscoe, S., Kirby, K., Bedson, A., Goodwin, L., Robinson, M., Taylor, H., Thompson Coon, J., Voss, S., Benger, J. R. Tags: Open access, Emergency medicine Source Type: research

COVID-19 vaccination decisions among Gypsy, Roma, and Traveller communities: A qualitative study moving beyond "vaccine hesitancy"
Vaccine. 2023 May 1:S0264-410X(23)00515-7. doi: 10.1016/j.vaccine.2023.04.080. Online ahead of print.ABSTRACTBACKGROUND: Many people refuse vaccination and it is important to understand why. Here we explore the experiences of individuals from Gypsy, Roma, and Traveller groups in England to understand how and why they decided to take up or to avoid COVID-19 vaccinations.METHODS: We used a participatory, qualitative design, including wide consultations, in-depth interviews with 45 individuals from Gypsy, Roma, and Traveller, communities (32 female, 13 male), dialogue sessions, and observations, in five locations across Engla...
Source: Vaccine - May 18, 2023 Category: Allergy & Immunology Authors: Charlotte K ühlbrandt Catherine R McGowan Rachel Stuart Pippa Grenfell Sam Miles Alicia Renedo Cicely Marston Source Type: research

The global impact of tobacco control policies on smokeless tobacco use: a systematic review
Lancet Glob Health. 2023 Jun;11(6):e953-e968. doi: 10.1016/S2214-109X(23)00205-X.ABSTRACTBACKGROUND: Smokeless tobacco, used by more than 300 million people globally, results in substantial morbidity and mortality. For smokeless tobacco control, many countries have adopted policies beyond the WHO Framework Convention on Tobacco Control, which has been instrumental in reducing smoking prevalence. The impact of these policies (within and outside the Framework Convention on Tobacco Control) on smokeless tobacco use remains unclear. We aimed to systematically review policies that are relevant to smokeless tobacco and its conte...
Source: Cancer Control - May 18, 2023 Category: Cancer & Oncology Authors: Aastha Chugh Monika Arora Neha Jain Aishwarya Vidyasagaran Anne Readshaw Aziz Sheikh Jappe Eckhardt Kamran Siddiqi Mansi Chopra Masuma Pervin Mishu Mona Kanaan Muhammad Aziz Rahman Ravi Mehrotra Rumana Huque Sarah Forberger Suranji Dahanayake Zohaib Khan Source Type: research

Surgical implementation gap: an interrupted time series analysis with interviews examining the impact of surgical trials on surgical practice in England
Conclusion While practice does not always change in the direction indicated by clinical trials, our results suggest that individuals, official committees and professional societies do assimilate trial evidence. Decision-makers seem to respond to the totality of evidence such that there are often plausible reasons for not adopting the evidence of any one trial in isolation. (Source: BMJ Quality and Safety)
Source: BMJ Quality and Safety - May 18, 2023 Category: General Medicine Authors: Schmidtke, K. A., Evison, F., Grove, A., Kudrna, L., Tucker, O., Metcalfe, A., Bradbury, A. W., Bhangu, A., Lilford, R. Tags: Open access, Editor's choice Original research Source Type: research

NHS staff awareness, attitudes and actions towards the change in organ donation law in England —results of the #options survey 2020
ConclusionsNHS staff in England were well informed about the change in organ donation legislation and levels of support were high. NHS staff were six times more likely than the public to have a conversation with their family about their organ donation choices. The size and ethnic diversity of the NHS workforce offers an opportunity to enable and support NHS staff to be advocates for organ donation and raise awareness of the change in legislation amongst their communities. (Source: Archives of Public Health)
Source: Archives of Public Health - May 10, 2023 Category: International Medicine & Public Health Source Type: research

Predictors of self-harm and emergency department attendance for self-harm in deprived communities
Int J Inj Contr Saf Promot. 2023 Apr 26:1-7. doi: 10.1080/17457300.2023.2204474. Online ahead of print.ABSTRACTEmergency departments (EDs) are often the first point of contact for individuals following self-harm. The majority of previous research relies on hospital-based data, yet only a minority of individuals who self-harm in the community present to healthcare services. The study design is cross-sectional survey design. Data from the National Institute for Health Research Applied Research Collaboration North West Coast (NIHR ARC NWC) Household Health Survey, a community-based public health survey in North West England, ...
Source: International Journal of Injury Control and Safety Promotion - May 1, 2023 Category: Accident Prevention Authors: Molly McCarthy Pooja Saini Rajan Nathan Jason McIntyre Source Type: research