National Institute for Health Research (NIHR) Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Characterization of diet-dependent temporal changes in circulating short-chain fatty acid concentrations: A randomized crossover dietary trial
CONCLUSIONS: The GC-MS method allowed robust mapping of diurnal patterns in SCFA concentrations, which were affected by diet, and highlighted the importance of standardizing the timing of SCFA measurements in dietary studies. This trial was registered on the NIHR UK clinical trial gateway and with ISRCTN as ISRCTN43087333.PMID:36137188 | DOI:10.1093/ajcn/nqab211 (Source: The American Journal of Clinical Nutrition)
Source: The American Journal of Clinical Nutrition - September 22, 2022 Category: Nutrition Authors: Jerusa Brignardello Sofia Fountana Joram Matthias Posma Edward S Chambers Jeremy K Nicholson Julien Wist Gary Frost Isabel Garcia-Perez Elaine Holmes Source Type: research

Characterization of diet-dependent temporal changes in circulating short-chain fatty acid concentrations: A randomized crossover dietary trial
CONCLUSIONS: The GC-MS method allowed robust mapping of diurnal patterns in SCFA concentrations, which were affected by diet, and highlighted the importance of standardizing the timing of SCFA measurements in dietary studies. This trial was registered on the NIHR UK clinical trial gateway and with ISRCTN as ISRCTN43087333.PMID:36137188 | DOI:10.1093/ajcn/nqab211 (Source: Am J Clin Nutr)
Source: Am J Clin Nutr - September 22, 2022 Category: Nutrition Authors: Jerusa Brignardello Sofia Fountana Joram Matthias Posma Edward S Chambers Jeremy K Nicholson Julien Wist Gary Frost Isabel Garcia-Perez Elaine Holmes Source Type: research

Effects of an e-health intervention 'iSupport for reducing distress of dementia carers: protocol for a randomised controlled trial and feasibility study
Introduction In the UK, National Health Service (NHS) guidelines recommend that informal carers of people living with dementia should be offered training to help them develop care skills and manage their own physical and mental health. The WHO recommends access to affordable, proven, well-designed, online technologies for education, skills training and support for dementia carers. In response to these recommendations, this multisite randomised controlled trial (RCT) is the first study in the UK to evaluate the clinical and cost-effectiveness of an online support programme developed by the WHO called ‘iSupport for dem...
Source: BMJ Open - September 21, 2022 Category: General Medicine Authors: Windle, G., Flynn, G., Hoare, Z., Masterson-Algar, P., Egan, K., Edwards, R. T., Jones, C., Spector, A., Algar-Skaife, K., Hughes, G., Brocklehurst, P., Goulden, N., Skelhorn, D., Stott, J. Tags: Open access, Mental health Source Type: research

Effectiveness of early spectacle intervention on visual outcomes in babies at risk of cerebral visual impairment: a parallel group, open-label, randomised clinical feasibility trial protocol
This study aims to establish the feasibility and acceptability of conducting a randomised controlled trial to test the effectiveness of early near vision correction with spectacles in infancy, for babies, at risk of visual dysfunction. Methods and analysis This is a parallel group, open-label, randomised controlled (feasibility) study to assess visual outcomes in children with perinatal brain injury when prescribed near vision spectacles compared with the current standard care—waiting until a problem is detected. The study hypothesis is that accommodation, and possibly other aspects of vision, may be improved by int...
Source: BMJ Open - September 21, 2022 Category: General Medicine Authors: Bullaj, R., Dyet, L., Mitra, S., Bunce, C., Clarke, C. S., Saunders, K., Dale, N., Horwood, A., Williams, C., St Clair Tracy, H., Marlow, N., Bowman, R. Tags: Open access, Neurology Source Type: research

Correction: Understanding stage of innovation of invasive procedures and devices: protocol for a systematic review and thematic analysis
This study was supported by the Medical Research Council [MR/S001751/1] and NIHR Biomedical Research Centre at University Hospitals Bristol and Weston NHS Foundation Trust and the University of Bristol. (Source: BMJ Open)
Source: BMJ Open - August 26, 2022 Category: General Medicine Tags: Open access Correction Source Type: research

Respiratory research in the UK: investing for the next 10 years
In July 2021, the UK Office of Life Sciences (OLS)1 published a Life Sciences Vision for the UK highlighting key areas for action. The report specifically flagged reducing morbidity and mortality from respiratory disease as one of the seven healthcare mission priorities. In addition, the report emphasised more generally the need to support underpinning infrastructure to enable better use of health data and genomic data and increasing the efficiency of clinical research delivery to improve healthcare. The importance of a flourishing respiratory disease research community in the UK has also been bought into sharp focus by th...
Source: Thorax - August 17, 2022 Category: Respiratory Medicine Authors: Hall, I., Walker, S., Holgate, S. T. Tags: Open access, Thorax Controversies and challenges in respiratory medicine Source Type: research

What are the barriers to the diagnosis and management of chronic respiratory disease in sub-Saharan Africa? A qualitative study with healthcare workers, national and regional policy stakeholders in five countries
Conclusion Health systems in the five countries are ill-equipped to respond to CRD, an issue that has been brought into sharp focus as countries plan for post-COVID-19 lung diseases. CRD are underdiagnosed, under-reported and underfunded, leading to a vicious cycle of invisibility and neglect. Appropriate diagnosis and management require health systems strengthening, particularly at the primary healthcare level. (Source: BMJ Open)
Source: BMJ Open - July 29, 2022 Category: General Medicine Authors: Mulupi, S., Ayakaka, I., Tolhurst, R., Kozak, N., Shayo, E. H., Abdalla, E., Osman, R., Egere, U., Mpagama, S. G., Chinouya, M., Chikaphupha, K. R., ElSony, A., Meme, H., Oronje, R., Ntinginya, N. E., Obasi, A., Taegtmeyer, M., On behalf of the NIHR Inter Tags: Open access, Health services research Source Type: research

Patient and Public Involvement and Engagement (PPIE): first steps in the process of the engagement in research projects in Brazil
Braz J Med Biol Res. 2022 Jul 25;55:e12369. doi: 10.1590/1414-431X2022e12369. eCollection 2022.ABSTRACTPatient and Public Involvement and Engagement (PPIE) - sometimes called Community Engagement and Involvement (CEI) - comes as a big challenge but one that can be very helpful for health care professionals and stakeholders in planning better health policies for attending to the main needs of the community. PPIE involves three pillars: public involvement, public engagement, and participation. Public involvement occurs when members of the general population are actively involved in developing the research question, designing...
Source: Brazilian Journal of Medical and Biological Research - July 27, 2022 Category: Research Authors: I M Bensenor A C Goulart G N Thomas G Y H Lip NIHR Global Health Research Group on Atrial Fibrillation Management Source Type: research

Patient and Public Involvement and Engagement (PPIE): first steps in the process of the engagement in research projects in Brazil
Braz J Med Biol Res. 2022 Jul 25;55:e12369. doi: 10.1590/1414-431X2022e12369. eCollection 2022.ABSTRACTPatient and Public Involvement and Engagement (PPIE) - sometimes called Community Engagement and Involvement (CEI) - comes as a big challenge but one that can be very helpful for health care professionals and stakeholders in planning better health policies for attending to the main needs of the community. PPIE involves three pillars: public involvement, public engagement, and participation. Public involvement occurs when members of the general population are actively involved in developing the research question, designing...
Source: Braz J Med Biol Res - July 27, 2022 Category: Research Authors: I M Bensenor A C Goulart G N Thomas G Y H Lip NIHR Global Health Research Group on Atrial Fibrillation Management Source Type: research