National Institute for Health Research (NIHR) Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Codesigning a systemic discharge intervention for inpatient mental health settings (MINDS): a protocol for integrating realist evaluation and an engineering-based systems approach
Introduction Transition following discharge from mental health hospital is high risk in terms of relapse, readmission and suicide. Discharge planning supports transition and reduces risk. It is a complex activity involving interacting systemic elements. The codesigning a systemic discharge intervention for inpatient mental health settings (MINDS) study aims to improve the process for people being discharged, their carers/supporters and staff who work in mental health services, by understanding, co-designing and evaluating implementation of a systemic approach to discharge planning. Methods and analysis The MINDS study int...
Source: BMJ Open - September 13, 2023 Category: General Medicine Authors: Hackmann, C., Komashie, A., Handley, M., Murdoch, J., Wagner, A. P., Grünwald, L. M., Waller, S., Kaminskiy, E., Zeilig, H., Jones, J., Bray, J., Bagge, S., Simpson, A., Dalkin, S. M., Clarkson, J., Borghini, G., Kipouros, T., Rohricht, F., Taousi Tags: Open access, Mental health Source Type: research

Metformin for the prevention of diabetes among people with HIV and either impaired fasting glucose or impaired glucose tolerance (prediabetes) in Tanzania: a Phase II randomised placebo-controlled trial
Conclusions/interpretationBlood glucose decreased over time in both the metformin and placebo arms during the trial but did not differ significantly between the arms at 12 months of follow up. Metformin therapy was found to be safe for use in individuals with HIV and prediabetes. A larger trial with longer follow up is needed to establish if metformin can be safely used for the prevention of diabetes in people who have HIV.Trial registrationThe trial is registered on the International Standard Randomised Controlled Trial Number (ISRCTN) registry (www.isrctn.com/), registration number: ISCRTN76157257.FundingThis research wa...
Source: Diabetologia - September 3, 2023 Category: Endocrinology Source Type: research

Barriers to childhood asthma care in sub-Saharan Africa: a multicountry qualitative study with children and their caregivers
Conclusions In a continent with rapidly increasing levels of poorly controlled asthma, we identified multiple barriers to achieving good asthma control along the trajectory of care. Exploration of these barriers reveals several generalisable recommendations that should modify asthma care plans and potentially transform asthma care in Africa. Trial registration number 269211. (Source: BMJ Open)
Source: BMJ Open - September 1, 2023 Category: General Medicine Authors: Naidoo, K. L., Dladla, S., Mphahlele, R. E., Mosler, G., Muyemayema, S., Ssemata, A. S., Mkutumula, E., Adeyeye, O. O., Moyo, M., Goodman, O., Kuyinu, Y., Nantanda, R., Ticklay, I., Mujuru, H. A., Grigg, J., Masekela, R. Tags: Open access, Paediatrics Source Type: research

Key features of puberty onset and progression can help distinguish self-limited delayed puberty from congenital hypogonadotrophic hypogonadism
This study sought to elucidate phenotypic differences between the two diagnoses, in order to optimise patient management and pubertal development.MethodsThis was a study of a UK DP cohort managed 2015-2023, identified through the NIHR clinical research network. Patients were followed longitudinally until adulthood, with a definite diagnosis made: SLDP if they had spontaneously completed puberty by age 18 years; HH if they had not commenced (complete, cHH), or had commenced but not completed puberty (partial, pHH), by this stage. Phenotypic data pertaining to auxology, Tanner staging, biochemistry, bone age and hormonal tre...
Source: Frontiers in Endocrinology - August 28, 2023 Category: Endocrinology Source Type: research

Musculoskeletal pain in Parkinson's disease: Association with dopaminergic deficiency in the caudate nucleus
ConclusionsOur findings suggest an association between MSK pain in PwP and the severity of dopaminergic deficiency in the caudate nucleus.SignificanceIn People with Parkinson's, musculoskeletal pain does not arise simply as a direct sequel to motor symptoms —instead, it is linked to the severity of dopaminergic depletion in the caudate nucleus. (Source: European Journal of Pain)
Source: European Journal of Pain - August 17, 2023 Category: Anesthesiology Authors: Katarina Rukavina, Nicola Mulholland, Benjamin Corcoran, Magdalena Krbot Skoric, Juliet Staunton, Silvia Rota, Pavlos Zinzalias, Kit Wu, Anna Fieldwalker, Kirsty Bannister, Alexandra Rizos, K Ray Chaudhuri Tags: ORIGINAL ARTICLE Source Type: research

Identifying infection in chronic wounds in a community setting: A systematic review of diagnostic test accuracy studies
CONCLUSION: Only a small number of studies were included in this systematic review due to our strict inclusion criteria. We have not identified any methods for diagnosing infection in chronic wounds with either a sufficient quality of evidence to recommend their use in community settings at present. Further research is needed to develop and evaluate appropriate diagnostics for this purpose.IMPACT: This study highlights the paucity of research into wound diagnostics in a community setting and should prompt further research in this area. Accurate diagnostic tests have the potential to improve community-based wound care by op...
Source: Adv Data - August 14, 2023 Category: Epidemiology Authors: George Edwards Adam Carter Chloe Wallis Gail Hayward Abigail Moore Source Type: research

Dual bronchodilators in Bronchiectasis study (DIBS): protocol for a pragmatic, multicentre, placebo-controlled, three-arm, double-blinded, randomised controlled trial studying bronchodilators in preventing exacerbations of bronchiectasis
Introduction Bronchiectasis is a long-term lung condition, with dilated bronchi, chronic inflammation, chronic infection and acute exacerbations. Recurrent exacerbations are associated with poorer clinical outcomes such as increased severity of lung disease, further exacerbations, hospitalisations, reduced quality of life and increased risk of death. Despite an increasing prevalence of bronchiectasis, there is a critical lack of high-quality studies into the disease and no treatments specifically approved for its treatment. This trial aims to establish whether inhaled dual bronchodilators (long acting beta agonist (LABA) a...
Source: BMJ Open - August 10, 2023 Category: General Medicine Authors: Morton, M., Wilson, N., Homer, T. M., Simms, L., Steel, A., Maier, R., Wason, J., Ternent, L., Abouhajar, A., Allen, M., Joyce, R., Hildreth, V., Lakey, R., Cherlin, S., Walker, A., Devereux, G., Chalmers, J. D., Hill, A. T., Haworth, C., Hurst, J. R., De Tags: Open access, Respiratory medicine Source Type: research

Relevance of the COVID-19 rapid response system to public health policymaking in Islamic Republic of Iran
CONCLUSION: National institutions responding to health emergencies need to take responsibility for establishing and managing a robust rapid response systems that can provide valid and timely evidence to policymakers. Over time, their capacity should be monitored, evaluated and strengthened to adapt and respond appropriately to pandemics, outbreaks and epidemics.PMID:37553745 | DOI:10.26719/emhj.23.079 (Source: Eastern Mediterranean Health Journal)
Source: Eastern Mediterranean Health Journal - August 8, 2023 Category: Middle East Health Authors: Ali Akbari-Sari Elham Ahmadnezhad Zhaleh Abdi Sahand Riazi-Isfahani Sara Saffarpour Source Type: research