National Institute for Health Research (NIHR) Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Lived experience-centred word clouds may improve research uncertainty gathering in priority setting partnerships
CONCLUSIONS: Word clouds may increase the perspective of underrepresented stakeholders in the research question gathering stage of priority setting partnerships. This may help steer the process towards research questions that are of highest priority for people with the condition.PMID:37087419 | DOI:10.1186/s12874-023-01897-6 (Source: Cell Research)
Source: Cell Research - April 22, 2023 Category: Cytology Authors: Oliver D Mowforth Lance Burn Danyal Z Khan Xiaoyu Yang Sybil R L Stacpoole Toto Gronlund Lindsay Tetreault Sukhvinder Kalsi-Ryan Michelle L Starkey Iwan Sadler Ellen Sarewitz Delphine Houlton Julia Carter Paige Howard Vafa Rahimi-Movaghar James D Guest Bi Source Type: research

Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study
Lancet Respir Med. 2023 Apr 14:S2213-2600(23)00124-8. doi: 10.1016/S2213-2600(23)00124-8. Online ahead of print.ABSTRACTBACKGROUND: Sleep disturbance is common following hospital admission both for COVID-19 and other causes. The clinical associations of this for recovery after hospital admission are poorly understood despite sleep disturbance contributing to morbidity in other scenarios. We aimed to investigate the prevalence and nature of sleep disturbance after discharge following hospital admission for COVID-19 and to assess whether this was associated with dyspnoea.METHODS: CircCOVID was a prospective multicentre cohor...
Source: Respiratory Care - April 18, 2023 Category: Respiratory Medicine Authors: Callum Jackson Iain D Stewart Tatiana Plekhanova Peter S Cunningham Andrew L Hazel Bashar Al-Sheklly Raminder Aul Charlotte E Bolton Trudie Chalder James D Chalmers Nazia Chaudhuri Annemarie B Docherty Gavin Donaldson Charlotte L Edwardson Omer Elneima Ne Source Type: research

Trends in the full blood count blood test and colorectal cancer detection: a longitudinal, case-control study of UK primary care patient data [version 2; peer review: 2 approved, 1 not approved]
CONCLUSIONS: Trends in FBC parameters are different between patients with and without colorectal cancer for up to four years prior to diagnosis. Such trends could help earlier identification.PMID:37056715 | PMC:PMC7614427 | DOI:10.3310/nihropenres.13266.2 (Source: Cancer Control)
Source: Cancer Control - April 14, 2023 Category: Cancer & Oncology Authors: Pradeep S Virdee Julietta Patnick Peter Watkinson Jacqueline Birks Tim A Holt Source Type: research

Using the AR-V7 biomarker to determine treatment in metastatic castrate resistant prostate cancer, a feasibility randomised control trial, conclusions from the VARIANT trial [version 2; peer review: 2 approved]
CONCLUSIONS: Whilst the trial did not complete to target, we have ascertained that men with advanced cancer are willing to take part in trials utilising biomarker guided treatment. A number of issues were identified that serve as important learning points in future clinical trials.PMID:37035713 | PMC:PMC7614403 | DOI:10.3310/nihropenres.13284.2 (Source: Cancer Control)
Source: Cancer Control - April 10, 2023 Category: Cancer & Oncology Authors: Paul Gravestock Emma Clark Miranda Morton Shirya Sharma Holly Fisher Jenn Walker Ruth Wood Helen Hancock Nichola Waugh Aislinn Cooper Rebecca Maier John Marshall Robert Chandler Amit Bahl Simon Crabb Suneil Jain Ian Pedley Rob Jones John Staffurth Rakesh Source Type: research

Adaptation of the Wound Healing Questionnaire universal-reporter outcome measure for use in global surgery trials (TALON-1 study): mixed-methods study and Rasch analysis
CONCLUSION: This study made recommendations for cross-cultural adaptation of the WHQ for use in global surgical research and practice, using co-produced mixed-methods data from three continents. Translations are now available for implementation into remote wound assessment pathways.PMID:37005373 | DOI:10.1093/bjs/znad058 (Source: The British Journal of Surgery)
Source: The British Journal of Surgery - April 3, 2023 Category: Surgery Authors: James Glasbey NIHR Global Health Research Unit on Global Surgery Source Type: research

NIHR Imaging Group. Who are we and what do we do?
(Source: Clinical Radiology)
Source: Clinical Radiology - March 31, 2023 Category: Radiology Authors: S.A. Taylor, A. Darekar, V. Goh, S. Neubauer, A. Rockall, J. Solomon, NIHR Imaging Group and NIHR Imaging Champions Tags: Editorial Source Type: research

Biomarker-guided intervention to prevent acute kidney injury after major surgery (BigpAK-2 trial): study protocol for an international, prospective, randomised controlled multicentre trial
Introduction Previous studies demonstrated that the implementation of the Kidney Disease Improving Global Outcomes (KDIGO) guideline-based bundle, consisting of different supportive measures in patients at high risk for acute kidney injury (AKI), might reduce rate and severity of AKI after surgery. However, the effects of the care bundle in broader population of patients undergoing surgery require confirmation. Methods and analysis The BigpAK-2 trial is an international, randomised, controlled, multicentre trial. The trial aims to enrol 1302 patients undergoing major surgery who are subsequently admitted to the intensive ...
Source: BMJ Open - March 27, 2023 Category: General Medicine Authors: von Groote, T., Meersch, M., Romagnoli, S., Ostermann, M., Ripolles-Melchor, J., Schneider, A. G., Vandenberghe, W., Monard, C., De Rosa, S., Cattin, L., Rahmel, T., Adamzik, M., Parise, D., Candela-Toha, A., Haaker, J. G., Göbel, U., Bernard, A., Tags: Open access, Intensive care Source Type: research

A systematic review of Clinical Practice Guidelines for persons with non-specific low back pain with and without radiculopathy: Identification of best evidence for rehabilitation to develop the WHO's Package of Interventions for Rehabilitation
CONCLUSION: We developed evidence-based recommendations from high-quality CPGs to inform the WHO PIR for people with LBP with and without radiculopathy. These recommendations emphasize the potential benefits of education, exercise, manual therapy and cognitive/behavioral interventions.PMID:36963709 | DOI:10.1016/j.apmr.2023.02.022 (Source: Health Physics)
Source: Health Physics - March 24, 2023 Category: Physics Authors: Fabio Zaina Pierre C ôté Carolina Cancelliere Francesca Di Felice Sabrina Donzelli Alexandra Rauch Leslie Verville Stefano Negrini Margareta Nordin Source Type: research

Methodology of economic evaluations in spine surgery: a systematic review and qualitative assessment
Conclusions The comparability of economic evaluations in spine surgery is extremely low due to different study designs, follow-up duration and outcome measurements such as utility, effectiveness and costs. This illustrates the need for uniformity in conducting and reporting economic evaluations in spine surgery. (Source: BMJ Open)
Source: BMJ Open - March 23, 2023 Category: General Medicine Authors: Droeghaag, R., Schuermans, V. N. E., Hermans, S. M. M., Smeets, A. Y. J. M., Caelers, I. J. M. H., Hiligsmann, M., Evers, S., van Hemert, W. L. W., van Santbrink, H. Tags: Open access, Health economics Source Type: research

A suspected physical abuse examination: The radiographer's perspective
Introduction: Jessica Eaton is a paediatric radiographer from London who specialises in Forensic Imaging. She currently holds a HEE/NIHR Pre-Doctoral Clinical and Practitioner Academic Fellowship (PCAF) award and is interested in pursuing a PhD investigating the Mental Health and Wellbeing of radiographers. This piece of work describes her experience undertaking Suspected Physical Abuse examinations in a specialised paediatric centre. (Source: Journal of Medical Imaging and Radiation Sciences)
Source: Journal of Medical Imaging and Radiation Sciences - March 22, 2023 Category: Radiology Authors: Jessica Eaton Tags: Medical Radiation Sciences Narrative Source Type: research

Salivary electrostimulation in the treatment of radiotherapy-induced xerostomia (LEONIDAS-2): a multicentre, randomised, double-masked sham-controlled phase 3 trial
CONCLUSION: LEONIDAS-2 did not meet the primary and secondary outcomes.FUNDING: NIHR Research for Patient Benefit Programme.PMID:36933846 | DOI:10.1016/j.ijrobp.2023.03.047 (Source: Health Physics)
Source: Health Physics - March 18, 2023 Category: Physics Authors: V Mercadante A Al Hamad J McCaul C Nutting K Harrington D Carnell T Guerrero Urbano N Kalavrezos J A Barber S R Porter S Fedele Source Type: research