National Institute for Health Research (NIHR) Clinical Trials This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Semaglutide and Cognition in Healthy Volunteers
Conditions: Cognitive Change Interventions: Drug: Semaglutide, 0.5 mg/mL; Other: Placebo, 0.9% NaCl 1.5mL Sponsors: University of Oxford; NIHR Oxford Health Biomedical Research Centre Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 12, 2024 Category: Research Source Type: clinical trials

Compassion Project: Developing an Empathy-Based Stress Intervention
Conditions: Reduction of Empathy-Based Stress in Healthcare Staff Interventions: Other: The Compassion Project: Intervention to Reduce Empathy-Based Stress in Staff Sponsors: University of Bath; National Institute for Health Research, United Kingdom; Oxford Health NHS Foundation Trust; Central and North West London NHS Foundation Trust Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 3, 2024 Category: Research Source Type: clinical trials

Timing to Restart Direct Oral Anticoagulants After Traumatic Intracranial Haemorrhage
Conditions: Traumatic Intracranial Haemorrhage Interventions: Drug: Direct-Acting Oral Anticoagulants (used as per local standard practice) Sponsors: Walton Centre NHS Foundation Trust; University of Liverpool; National Institute for Health Research, United Kingdom Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 21, 2024 Category: Research Source Type: clinical trials

IMAGINATOR 2.0: Co-design and Early Evaluation of a Novel Blended Digital Intervention Targeting Self-harm in Young People
Conditions: Self Injurious Behavior; Adolescent Behavior Problem; Child Behavior Problem; Mental Health Disorder Interventions: Other: Imaginator 2.0 Sponsors: Imperial College London; National Institute for Health Research, United Kingdom Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 15, 2024 Category: Research Source Type: clinical trials

Early Diagnosis of SSc in the General Rheumatology Clinic - Pilot
Conditions: Systemic Sclerosis; Raynaud Phenomenon Interventions: Device: Observation - Nailfold capillaroscopy Sponsors: University of Manchester; National Institute for Health Research, United Kingdom; Royal Bolton Hospital NHS Foundation Trust; Alder Hey Children ' s NHS Foundation Trust; University Hospitals of Morecambe Bay NHS Trust; Stockport NHS Foundation Trust; Medway NHS Foundation Trust; Northern Care Alliance NHS Foundation Trust; Royal Free Hospital NHS Foundation Trust Enrolling by invitation (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 4, 2024 Category: Research Source Type: clinical trials

Recording harms in randomised controlled trials of behaviour change interventions: a qualitative study of UK clinical trials units and NIHR trial investigators
ConclusionsRecording harms or adverse events in behaviour change intervention trials is complex and challenging; multi-disciplinary experts in trial design and implementation welcome forthcoming guidance on this topic. Issues include the high burden of recording irrelevant harms and use of definitions originally designed for drug trials. Proportionate recording of harms focused on events with a strong plausible link to the intervention and multi-disciplinary team input into decision making are essential. (Source: Trials)
Source: Trials - March 4, 2024 Category: Research Source Type: clinical trials

HONEY for the Treatment of POst-Tonsillectomy Pain
Conditions: Post Surgical Pain; Analgesia Interventions: Dietary Supplement: Manuka honey MGO 1000; Dietary Supplement: Sugar-based syrup, thickened with sodium alginate and flavoured with honey flavouring Sponsors: East and North Hertfordshire NHS Trust; Manuka Doctor UK Ltd; National Institute for Health Research, United Kingdom Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 23, 2024 Category: Research Source Type: clinical trials

DMD- Interactive Virtual Reality Study
Conditions: Duchenne Muscular Dystrophy Interventions: Device: IVR platform trial Sponsors: Sheffield Children ' s NHS Foundation Trust; National Institute for Health Research, United Kingdom; Sheffield Hallam University; UCL Great Ormond Street Institute of Child Health; Leeds General Infirmary Active, not recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 23, 2024 Category: Research Source Type: clinical trials

Good Statistical Practice —development of tailored Good Clinical Practice training for statisticians
ConclusionAll research staff should have training in GCP yet the training undertaken by most academic statisticians does not cover activities related to their role. The Good Statistical Practice (GCP for Statisticians) project has developed and extensively piloted new, role-specific, comprehensive, accessible GCP training tailored to statisticians working in clinical research, particularly the clinical trials arena. This role-specific training will encourage best practice, leading to transparent and reproducible statistical activity, as required by regulatory authorities and funders. (Source: Trials)
Source: Trials - February 10, 2024 Category: Research Source Type: clinical trials

Cardiac Rehabilitation Participation and South Asian Service Users
Conditions: Cardiac Rehabilitation; South Asian Service Users Interventions: Other: Qualitative exploration Sponsors: University of Leicester; Wellcome Trust; University Hospitals, Leicester; National Institute for Health Research, United Kingdom Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 2, 2024 Category: Research Source Type: clinical trials

The use of healthcare systems data for RCTs
ConclusionsHSD is being used in around two thirds of the studies but cannot yet be used to support PRO data collection within the cohort we examined. Comparison with an earlier cohort demonstrates an increase in the number of RCTs planning to use HSD. (Source: Trials)
Source: Trials - January 29, 2024 Category: Research Source Type: clinical trials

Associate Principal Investigators and the HEAL-COVID trial: good for trainees, good for trials
This study adds to the growing literature that the NIHR ’s API Scheme is effective in meeting its objectives in providing research training to clinicians, thus building a workforce of future clinical researchers. Moreover, data from the HEAL-COVID trial shows that sites with an API are associated with higher recruitment. Overall, registering a trial wi th the API Scheme not only trains future clinical researchers, but it is also likely to increase the number of patients recruited (amongst other benefits), increasing the efficiency of trials and improving access for patients. (Source: Trials)
Source: Trials - January 27, 2024 Category: Research Source Type: clinical trials

Improving the inclusion of an under-served group in trials: development and implementation of the INCLUDE Impaired Capacity to Consent Framework
ConclusionsThe INCLUDE Impaired Capacity to Consent Framework and implementation toolkit can support researchers to design more inclusive trials and other types of research studies. Further engagement, including with funders who are key to ensuring uptake, and evaluation is needed. (Source: Trials)
Source: Trials - January 25, 2024 Category: Research Source Type: clinical trials

The GRACE Multi-centre Randomised Controlled Trial
Conditions: Venous Thromboembolism; Surgery Interventions: Other: Graduated compression stockings; Other: No Graduated compression stockings Sponsors: Imperial College London; National Institute for Health Research, United Kingdom Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 12, 2023 Category: Research Source Type: clinical trials

GRACE: Evaluating Compression Stockings in Patients That Require Extended Duration Pharmacological Thromboprophylaxis
Conditions: Venous Thromboembolism; Surgery Interventions: Other: Graduated compression stockings; Other: No Graduated compression stockings Sponsors: Imperial College London; National Institute for Health Research, United Kingdom Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 12, 2023 Category: Research Source Type: clinical trials