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Outcome monitoring and risk stratification after cardiac procedure in neonates, infants, children and young adults born with congenital heart disease: protocol for a multicentre prospective cohort study (Children OMACp)
This study aims to develop a prospective cohort of patients undergoing cardiac procedures that will bring together routinely collected clinical data and biological samples from patients and their biological mothers, in order to investigate risk factors and predictors of postoperative-outcomes, as well as better understanding the effect of the surgical intervention on the early and long-term outcomes. Methods and analysis Children OMACp (OMACp, outcome monitoring after cardiac procedure in congenital heart disease) is a multicentre, prospective cohort study recruiting children with CHD undergoing a cardiac procedure. The s...
Source: BMJ Open - August 8, 2023 Category: General Medicine Authors: Baquedano, M., de Jesus, S. E., Rapetto, F., Murphy, G. J., Angelini, G., Benedetto, U., Caldas, P., Srivastava, P. K., Uzun, O., Luyt, K., Gonzalez Corcia, C., Taliotis, D., Stoica, S., Lawlor, D. A., Bamber, A. R., Perry, A., Skeffington, K. L., Omeje, Tags: Open access, Cardiovascular medicine Source Type: research

Innovative methods of recruitment through the NIHR Clinical Research Network (CRN) into large-scale pandemic trials in primary care: the PANORAMIC trial experience
CONCLUSION: Large-scale, at-pace recruitment supported by the English CRN and equivalent networks across the UK, is achievable in a pandemic situation, producing potentially game-changing results of national and international importance.PMID:37479296 | DOI:10.3399/bjgp23X733665 (Source: The British Journal of General Practice)
Source: The British Journal of General Practice - July 21, 2023 Category: Primary Care Authors: Emma Tonner Sarah Crawshaw Mark Dolman Emma Chambers James Williamson Nicholas Thomas Richard Hobbs Paul Little Christopher Butler Philip Evans Source Type: research

GP education posts for research
CONCLUSION: National recognition for education on research has been achieved and a career pathway for GPs to train in and then work in research has been established. This will help embed research expertise and interest within primary care. This should increase research delivery and hence a cycle of increased research funding for further similar posts.PMID:37479285 | DOI:10.3399/bjgp23X733557 (Source: The British Journal of General Practice)
Source: The British Journal of General Practice - July 21, 2023 Category: Primary Care Authors: Mark Rickenbach Martine Cross Patrick Moore Nick Francis Source Type: research

Prognostic models for surgical-site infection in gastrointestinal surgery: systematic review
CONCLUSION: The risk of surgical-site infection after gastrointestinal surgery is insufficiently described by existing risk-prediction tools, which are not suitable for routine use. Novel risk-stratification tools are required to target perioperative interventions and mitigate modifiable risk factors.PMID:37433918 | DOI:10.1093/bjs/znad187 (Source: The British Journal of Surgery)
Source: The British Journal of Surgery - July 11, 2023 Category: Surgery Authors: Kenneth A McLean Tanvi Goel Samuel Lawday Aya Riad Joana Simoes Stephen R Knight Dhruva Ghosh James C Glasbey Aneel Bhangu Ewen M Harrison NIHR Global Health Research Unit on Global Surgery Source Type: research

Prevalence of post-traumatic stress and tests of metacognition as a PTSD risk marker in patients with coronary heart disease and elevated HADS scores: analysis of data from the PATHWAY RCT's in UK cardiac rehabilitation
ConclusionPTSD symptoms appeared highly prevalent in the current CR sample. Metacognitive beliefs were individually associated with symptom severity with the strongest positive relationship observed for beliefs about uncontrollability and dangerousness of worry, followed by need to control thoughts. The results highlight the importance in assessing PTSD in CR patients and add support to implementing metacognitive therapy in CHD to target particular metacognition risk factors in anxiety, depression and PTSD. (Source: Frontiers in Psychiatry)
Source: Frontiers in Psychiatry - July 6, 2023 Category: Psychiatry Source Type: research

Developing an application for the UK Pre-Doctoral Clinical and Practitioner Academic Fellowship (PCAF): The collective experience of a community of physiotherapists.
For physiotherapists and other healthcare professionals, developing capability and expertise in research can be challenging. However, involvement in research is beneficial at organisational and individual levels, both for clinicians and patients. One way to embark on research is to apply for a personal fellowship such as the National Institute for Health and Care Research (NIHR) Pre-Doctoral Clinical Academic Fellowship (PCAF).While the NIHR has guidance on how to complete the application form, it can be difficult to implement this guidance and understand what a competitive application looks like. (Source: Physiotherapy)
Source: Physiotherapy - June 21, 2023 Category: Physiotherapy Authors: Pauline May, Kieran Mitham, Natasha Maher, Lisa Pitt, Gareth Whelan, Bruno Mazuquin, Maria Moffatt, James Selfe, Gillian Yeowell, Chris Littlewood Tags: Short communication Source Type: research

Centile reference chart for resting metabolic rate through the life course
Conclusion We have developed a reference centile chart for an index of resting metabolic rate in childhood and adults, and shown its clinical utility in assessing response to therapy of an endocrine disorder during a patient’s transition from childhood to adult. (Source: Archives of Disease in Childhood)
Source: Archives of Disease in Childhood - June 19, 2023 Category: Pediatrics Authors: Watson, L., Cole, T. J., Lyons, G., Georgiou, C., Worsley, J., Carr, K., Murgatroyd, P., Moran, C., Chatterjee, K., Venables, M. Tags: Open access Original research Source Type: research

KIR-HLA interactions extend human CD8+ T cell lifespan in vivo
CONCLUSIONS Together, these data reveal an unexpectedly large effect of iKIR genotype on T cell survival.FUNDING Wellcome Trust; Medical Research Council; EU Horizon 2020; EU FP7; Leukemia and Lymphoma Research; National Institute of Health Research (NIHR) Imperial Biomedical Research Centre; Imperial College Research Fellowship; National Institutes of Health; Jefferiss Trust. (Source: Journal of Clinical Investigation)
Source: Journal of Clinical Investigation - June 15, 2023 Category: Biomedical Science Authors: Yan Zhang, Ada W.C. Yan, Lies Boelen, Linda Hadcocks, Arafa Salam, Daniel Padrosa Gispert, Loiza Spanos, Laura Mora Bitria, Neda Nemat-Gorgani, James A. Traherne, Chrissy Roberts, Danai Koftori, Graham P. Taylor, Daniel Forton, Paul J. Norman, Steven G.E. Source Type: research