Research priorities for future pulmonary hypertension research: a James Lind Alliance priority setting partnership
Conclusions: We identified the top 10 researchable questions for future PH research, which may inform PH researchers and funding agencies where to focus resources. (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Weatherald, J., Iqbal, H., Mielniczuk, L., Syed, A. R., Howard, J., Dempsey, N., Rader, T., Swiston, J., Provencher, S. Tags: 13.01 - Pulmonary hypertension Source Type: research

Deep learning of regulatory regions discovers enhancer variants implicated in PAH
Pulmonary arterial hypertension (PAH) is a rare and fatal lung disease. To date, in only a third of patients, the cause can be attributed to rare genetic variation in the protein-coding space. The sequencing of 15,000 whole genomes by the NIHR BioResource – Rare Diseases (NBR), including ~1,200 PAH samples, provides an unprecedented opportunity to estimate the contribution of regulatory genome variation to the development of PAH.This work aims to determine whether sequence-based predictions of epigenetic features can be used to narrow down the possible regions of interest and allow aggregation of variants into functi...
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Tilly, T., Auckland, K., Nibhani, R., Martin, J., Nihr Bioresource - Rare Diseases, N., National Cohort Study Of Idiopathic And Heritable Pah, N., Morrell, N. W., Lio', P., Gräf, S. Tags: 13.01 - Pulmonary hypertension Source Type: research

Observation of traumatic haemo-pneumothorax
Conclusions: There is observational data that asymptomatic traumatic pneumothoraces can be observed. There is no completed randomised trial in haemothorax but emerging observational data such as ours that they can also be osberved. Our data is limited as it is retrospective and significant trauma and large haemothoraces are diverted to the regional trauma centre. A RCT is planned.2Reference1. https://www.mdpi.com/2077-0383/10/24/58062. https://fundingawards.nihr.ac.uk/award/NIHR132889 (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Aujayeb, A. Tags: 01.01 - Clinical problems - no related to asthma or COPD Source Type: research

Prevalence of atrial fibrillation in Northern Sri Lanka: a study protocol for a cross-sectional household survey
This study was approved by the Ethics Review Committee of Faculty of Medicine at University of Jaffna. Written informed consent will be obtained from all participants. Findings will be disseminated through publication in a peer-reviewed journal and presentations at conferences. The findings will enable early treatment for new AF diagnoses and inform interventions to improve community-based management of AF in LMICs. (Source: BMJ Open)
Source: BMJ Open - November 23, 2022 Category: General Medicine Authors: Kanesamoorthy, S., Sheron, V. A., Uruthirakumar, P., Kodippily, C., Kumarendran, B., Gooden, T. E., Thomas, G. N., Nirantharakumar, K., Lip, G. Y. H., Guruparan, M., Haniffa, R., Surenthirakumaran, R., Beane, A., Subaschandran, K., on behalf of the NIHR G Tags: Open access, Diagnostics Source Type: research

A longitudinal observational study of home-based conversations for detecting early dementia: protocol for the CUBOId TV task
Introduction Limitations in effective dementia therapies mean that early diagnosis and monitoring are critical for disease management, but current clinical tools are impractical and/or unreliable, and disregard short-term symptom variability. Behavioural biomarkers of cognitive decline, such as speech, sleep and activity patterns, can manifest prodromal pathological changes. They can be continuously measured at home with smart sensing technologies, and permit leveraging of interpersonal interactions for optimising diagnostic and prognostic performance. Here we describe the ContinUous behavioural Biomarkers Of cognitive Imp...
Source: BMJ Open - November 23, 2022 Category: General Medicine Authors: Kumpik, D. P., Santos-Rodriguez, R., Selwood, J., Coulthard, E., Twomey, N., Craddock, I., Ben-Shlomo, Y. Tags: Open access, Neurology Source Type: research

Economic evaluations of fall prevention exercise programs: a systematic review
Conclusions Most economic evaluations investigated fall prevention exercise programmes for older adults living in the community. There is moderate certainty evidence that fall prevention exercise programmes are likely to be cost-effective. The evidence for older adults living in care facilities is more limited but promising. PROSPERO registration number PROSPERO 2020 CRD42020178023. (Source: British Journal of Sports Medicine)
Source: British Journal of Sports Medicine - November 17, 2022 Category: Sports Medicine Authors: Pinheiro, M. B., Sherrington, C., Howard, K., Caldwell, P., Tiedemann, A., Wang, B., S Oliveira, J., Santos, A., Bull, F. C., Willumsen, J. F., Michaleff, Z. A., Ferguson, S., Mayo, E., Fairhall, N. J., Bauman, A. E., Norris, S. Tags: Open access, BJSM Reviews with MCQs, BJSM Source Type: research

A Multi-centre, Single Arm, Non-randomized, Prospective European Trial to Evaluate the Safety and Efficacy of the HistoSonics System in the Treatment of Primary and Metastatic Liver Cancers (#HOPE4LIVER)
AbstractPurposeImage-guided thermal ablation are established treatment options for non-surgical patients with primary and metastatic liver cancers. However, there are limitations with nonuniformity of cancer tissue destruction, heat sink effect and the risk of thermal ablative injury. The current non-thermal ablative techniques have high risk of local recurrence and are not widely adopted. Histotripsy is a treatment technology that destroys targeted tissue under ultrasound visualization via mechanical destruction through the precise application of acoustic cavitation and can offer the potential of non-invasive, non-thermal...
Source: CardioVascular and Interventional Radiology - November 15, 2022 Category: Radiology Source Type: research

Rituximab versus intravenous cyclophosphamide in patients with connective tissue disease-associated interstitial lung disease in the UK (RECITAL): a double-blind, double-dummy, randomised, controlled, phase 2b trial
This study aimed to assess whether rituximab is superior to cyclophosphamide as a treatment for severe or progressive CTD associated ILD.METHODS: We conducted a randomised, double-blind, double-dummy, phase 2b trial to assess the superiority of rituximab compared with cyclophosphamide. Patients aged 18-80 years with severe or progressive ILD related to scleroderma, idiopathic inflammatory myositis, or mixed CTD, recruited across 11 specialist ILD or rheumatology centres in the UK, were randomly assigned (1:1) to receive rituximab (1000 mg at weeks 0 and 2 intravenously) or cyclophosphamide (600 mg/m2 body surface area ever...
Source: Respiratory Care - November 14, 2022 Category: Respiratory Medicine Authors: Toby M Maher Veronica A Tudor Peter Saunders Michael A Gibbons Sophie V Fletcher Christopher P Denton Rachel K Hoyles Helen Parfrey Elisabetta A Renzoni Maria Kokosi Athol U Wells Deborah Ashby Matyas Szigeti Philip L Molyneaux RECITAL Investigators Source Type: research

Rituximab versus intravenous cyclophosphamide in patients with connective tissue disease-associated interstitial lung disease in the UK (RECITAL): a double-blind, double-dummy, randomised, controlled, phase 2b trial
This study aimed to assess whether rituximab is superior to cyclophosphamide as a treatment for severe or progressive CTD associated ILD.METHODS: We conducted a randomised, double-blind, double-dummy, phase 2b trial to assess the superiority of rituximab compared with cyclophosphamide. Patients aged 18-80 years with severe or progressive ILD related to scleroderma, idiopathic inflammatory myositis, or mixed CTD, recruited across 11 specialist ILD or rheumatology centres in the UK, were randomly assigned (1:1) to receive rituximab (1000 mg at weeks 0 and 2 intravenously) or cyclophosphamide (600 mg/m2 body surface area ever...
Source: Respiratory Care - November 14, 2022 Category: Respiratory Medicine Authors: Toby M Maher Veronica A Tudor Peter Saunders Michael A Gibbons Sophie V Fletcher Christopher P Denton Rachel K Hoyles Helen Parfrey Elisabetta A Renzoni Maria Kokosi Athol U Wells Deborah Ashby Matyas Szigeti Philip L Molyneaux RECITAL Investigators Source Type: research

A Systematic Review of Operative Team Familiarity on Metrics of Efficiency, Patient Outcomes, Cost, and Team Satisfaction
Conclusions: Improving OR team familiarity is associated with superior operative efficiency and may be associated with other favorable measures. Further inferences are limited by literature heterogeneity, yet could be a novel focus for improving OR performance. (Source: Annals of Surgery)
Source: Annals of Surgery - November 14, 2022 Category: Surgery Tags: Meta-Analysis Source Type: research

Induction of labour for predicted macrosomia: study protocol for the 'Big Baby randomised controlled trial
Introduction Large-for-gestational age (LGA) fetuses have an increased risk of shoulder dystocia. This can lead to adverse neonatal outcomes and death. Early induction of labour in women with a fetus suspected to be macrosomic may mitigate the risk of shoulder dystocia. The Big Baby Trial aims to find if induction of labour at 38+0–38+4 weeks’ gestation, in pregnancies with suspected LGA fetuses, reduces the incidence of shoulder dystocia. Methods and analysis The Big Baby Trial is a multicentre, prospective, individually randomised controlled trial of induction of labour at 38+0 to 38+4 weeks’ gestation...
Source: BMJ Open - November 11, 2022 Category: General Medicine Authors: Ewington, L. J., Gardosi, J., Lall, R., Underwood, M., Fisher, J. D., Wood, S., Griffin, R., Harris, K., Bick, D., Booth, K., Brown, J., Butler, E., Fowler, K., Williams, M., Deshpande, S., Gornall, A., Dewdney, J., Hillyer, K., Gates, S., Jones, C., Mist Tags: Open access Obstetrics and gynaecology Source Type: research

Reirradiation Options for Previously Irradiated Prostate cancer (RO-PIP): Feasibility study investigating toxicity outcomes following reirradiation with stereotactic body radiotherapy (SBRT) versus high-dose-rate brachytherapy (HDR-BT)
This study has been approved by the Yorkshire and The Humber-Bradford Leeds Research Ethics Committee (Reference: 21/YH/0305, IRAS: 297060, January 2022). The results will be presented in national and international conferences, published in peer-reviewed journals and will be communicated to relevant stakeholders. A plain English report will be shared with the study participants, patients' organisations and media.TRIAL REGISTRATION NUMBER: ISRCTN 12238218 (Amy Ackroyd NIHR CPMS Team).PMID:36351720 | DOI:10.1136/bmjopen-2022-068580 (Source: Cancer Control)
Source: Cancer Control - November 9, 2022 Category: Cancer & Oncology Authors: Jim Zhong Sarah Brown Maria Serra Pam Shuttleworth Peter Bownes Christopher Thompson Rachel Reed Kimberley Reeves Michael Dubec Damien McHugh Cynthia Eccles Robert Chuter Yat Man Tsang N Jane Taylor Catharine West David Buckley Andrew Scarsbrook Ananya Ch Source Type: research

Cost-effectiveness of single-inhaler triple therapy for patients with severe COPD: A systematic literature review
This study conducted a systematic literature review to evaluate the cost-effectiveness of using a single combination inhaler regimen for patients with severe COPD. This review also investigated the health impact on patients in different settings.AREAS COVERED: A systematic literature search was conducted in PubMed (MEDLINE), EMBASE, Web of Science, Scopus, Cochrane Library, EBSCO Host (including CINAHL and EconLit), Health Technology Assessment Database, National Institute for Health Research Economic Evaluation Database, Cost-Effectiveness Analysis Registry and Google Scholar.EXPERT OPINION: Based on the primary findings ...
Source: Expert Review of Respiratory Medicine - November 9, 2022 Category: Respiratory Medicine Authors: Rezwanul Hasan Rana Khorshed Alam Syed Afroz Keramat Jeff Gow Source Type: research

Reirradiation Options for Previously Irradiated Prostate cancer (RO-PIP): Feasibility study investigating toxicity outcomes following reirradiation with stereotactic body radiotherapy (SBRT) versus high-dose-rate brachytherapy (HDR-BT)
This study has been approved by the Yorkshire and The Humber—Bradford Leeds Research Ethics Committee (Reference: 21/YH/0305, IRAS: 297060, January 2022). The results will be presented in national and international conferences, published in peer-reviewed journals and will be communicated to relevant stakeholders. A plain English report will be shared with the study participants, patients’ organisations and media. Trial registration number ISRCTN 12238218 (Amy Ackroyd NIHR CPMS Team). (Source: BMJ Open)
Source: BMJ Open - November 8, 2022 Category: General Medicine Authors: Zhong, J., Brown, S., Serra, M., Shuttleworth, P., Bownes, P., Thompson, C., Reed, R., Reeves, K., Dubec, M., McHugh, D., Eccles, C., Chuter, R., Tsang, Y. M., Taylor, N. J., West, C., Buckley, D., Scarsbrook, A., Choudhury, A., Hoskin, P., Henry, A. Tags: Open access, Oncology Source Type: research