Impact of Combined Nifedipine and Aspirin Therapy on Hemodynamics in Patients with Early Eclampsia
CONCLUSIONS: The nifedipine and aspirin combination effectively treats pregnancy hypertension, enhancing both coagulation and hemorheology for improved maternal and fetal health outcomes.PMID:38518161 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - March 22, 2024 Category: Complementary Medicine Authors: Jinyu Fan Yujiao Yang Xiumei Wang Source Type: research
Impact of Combined Nifedipine and Aspirin Therapy on Hemodynamics in Patients with Early Eclampsia
CONCLUSIONS: The nifedipine and aspirin combination effectively treats pregnancy hypertension, enhancing both coagulation and hemorheology for improved maternal and fetal health outcomes.PMID:38518161 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - March 22, 2024 Category: Complementary Medicine Authors: Jinyu Fan Yujiao Yang Xiumei Wang Source Type: research
Vasorelaxant and hypotensive effects of an ethanolic extract of Nymphaea pubescens and its main compound quercetin 3-methyl ether 3 ′-O-β-xylopyranoside
Conclusion and discussion: Our study demonstrated a vasorelaxant effect of the WL extract and its main compound quercetin 3-methyl ether 3′-O-β-xylopyranoside, relying on the potentiation of the NO-cGMP pathway and calcium inhibitory effects. These vasorelaxant effects were associated with a potent hypotensive effect, providing pharmacological evidence for the traditional use of this plant. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 21, 2024 Category: Drugs & Pharmacology Source Type: research
Spasmolytic Effect of Flopropione Does Not Involve Catechol-O- methyltransferase (COMT) Inhibition
Biol Pharm Bull. 2024;47(3):660-668. doi: 10.1248/bpb.b23-00808.ABSTRACTFlopropione (Flo) has been used for gallstone and urolithiasis as a spasmolytic agent almost exclusively in Japan. According to the package insert, its main mechanism is catechol-O-methyltransferase (COMT) inhibition and anti-serotonergic effect. This is obviously contrary to pharmacological common sense, but it is described that way in pharmacology textbooks and occurs in questions in the National Examination for Pharmacists in Japan. As this is a serious problem in education, we re-examined the action of Flo. The guinea pig ureter was hardly contract...
Source: Biological and Pharmaceutical Bulletin - March 20, 2024 Category: Drugs & Pharmacology Authors: Yoko Amagase Mari Hoshiyama Shiho Hasegawa Miwa Kanbara Yumiko Mizukawa Tetsuro Urushidani Source Type: research
Spasmolytic Effect of Flopropione Does Not Involve Catechol-O- methyltransferase (COMT) Inhibition
Biol Pharm Bull. 2024;47(3):660-668. doi: 10.1248/bpb.b23-00808.ABSTRACTFlopropione (Flo) has been used for gallstone and urolithiasis as a spasmolytic agent almost exclusively in Japan. According to the package insert, its main mechanism is catechol-O-methyltransferase (COMT) inhibition and anti-serotonergic effect. This is obviously contrary to pharmacological common sense, but it is described that way in pharmacology textbooks and occurs in questions in the National Examination for Pharmacists in Japan. As this is a serious problem in education, we re-examined the action of Flo. The guinea pig ureter was hardly contract...
Source: Biological and Pharmaceutical Bulletin - March 20, 2024 Category: Drugs & Pharmacology Authors: Yoko Amagase Mari Hoshiyama Shiho Hasegawa Miwa Kanbara Yumiko Mizukawa Tetsuro Urushidani Source Type: research
Spasmolytic Effect of Flopropione Does Not Involve Catechol-O- methyltransferase (COMT) Inhibition
Biol Pharm Bull. 2024;47(3):660-668. doi: 10.1248/bpb.b23-00808.ABSTRACTFlopropione (Flo) has been used for gallstone and urolithiasis as a spasmolytic agent almost exclusively in Japan. According to the package insert, its main mechanism is catechol-O-methyltransferase (COMT) inhibition and anti-serotonergic effect. This is obviously contrary to pharmacological common sense, but it is described that way in pharmacology textbooks and occurs in questions in the National Examination for Pharmacists in Japan. As this is a serious problem in education, we re-examined the action of Flo. The guinea pig ureter was hardly contract...
Source: Biological and Pharmaceutical Bulletin - March 20, 2024 Category: Drugs & Pharmacology Authors: Yoko Amagase Mari Hoshiyama Shiho Hasegawa Miwa Kanbara Yumiko Mizukawa Tetsuro Urushidani Source Type: research
In vitro inhibition of uterine contractions using electrospun nanofibers loaded with nifedipine and ML7
CONCLUSIONS: The results indicate that human uterine contractions can be inhibited using calcium channel blocker (nifedipine) and myosin light chain kinase inhibitor (ML7) loaded nanofibers in uterine tissue strips. These results strongly suggested the potential for the development of locally effective and safe controlled drug release systems to prevent premature birth.PMID:38497872 | DOI:10.26355/eurrev_202403_35603 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - March 18, 2024 Category: Drugs & Pharmacology Authors: Y Karasu M Demeli Ertu ş D Önal B Top çu H Ero ğlu B Pehlivano ğlu Source Type: research
In vitro inhibition of uterine contractions using electrospun nanofibers loaded with nifedipine and ML7
CONCLUSIONS: The results indicate that human uterine contractions can be inhibited using calcium channel blocker (nifedipine) and myosin light chain kinase inhibitor (ML7) loaded nanofibers in uterine tissue strips. These results strongly suggested the potential for the development of locally effective and safe controlled drug release systems to prevent premature birth.PMID:38497872 | DOI:10.26355/eurrev_202403_35603 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - March 18, 2024 Category: Drugs & Pharmacology Authors: Y Karasu M Demeli Ertu ş D Önal B Top çu H Ero ğlu B Pehlivano ğlu Source Type: research
In vitro inhibition of uterine contractions using electrospun nanofibers loaded with nifedipine and ML7
CONCLUSIONS: The results indicate that human uterine contractions can be inhibited using calcium channel blocker (nifedipine) and myosin light chain kinase inhibitor (ML7) loaded nanofibers in uterine tissue strips. These results strongly suggested the potential for the development of locally effective and safe controlled drug release systems to prevent premature birth.PMID:38497872 | DOI:10.26355/eurrev_202403_35603 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - March 18, 2024 Category: Drugs & Pharmacology Authors: Y Karasu M Demeli Ertu ş D Önal B Top çu H Ero ğlu B Pehlivano ğlu Source Type: research
In vitro inhibition of uterine contractions using electrospun nanofibers loaded with nifedipine and ML7
CONCLUSIONS: The results indicate that human uterine contractions can be inhibited using calcium channel blocker (nifedipine) and myosin light chain kinase inhibitor (ML7) loaded nanofibers in uterine tissue strips. These results strongly suggested the potential for the development of locally effective and safe controlled drug release systems to prevent premature birth.PMID:38497872 | DOI:10.26355/eurrev_202403_35603 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - March 18, 2024 Category: Drugs & Pharmacology Authors: Y Karasu M Demeli Ertu ş D Önal B Top çu H Ero ğlu B Pehlivano ğlu Source Type: research
In vitro inhibition of uterine contractions using electrospun nanofibers loaded with nifedipine and ML7
CONCLUSIONS: The results indicate that human uterine contractions can be inhibited using calcium channel blocker (nifedipine) and myosin light chain kinase inhibitor (ML7) loaded nanofibers in uterine tissue strips. These results strongly suggested the potential for the development of locally effective and safe controlled drug release systems to prevent premature birth.PMID:38497872 | DOI:10.26355/eurrev_202403_35603 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - March 18, 2024 Category: Drugs & Pharmacology Authors: Y Karasu M Demeli Ertu ş D Önal B Top çu H Ero ğlu B Pehlivano ğlu Source Type: research
In vitro inhibition of uterine contractions using electrospun nanofibers loaded with nifedipine and ML7
CONCLUSIONS: The results indicate that human uterine contractions can be inhibited using calcium channel blocker (nifedipine) and myosin light chain kinase inhibitor (ML7) loaded nanofibers in uterine tissue strips. These results strongly suggested the potential for the development of locally effective and safe controlled drug release systems to prevent premature birth.PMID:38497872 | DOI:10.26355/eurrev_202403_35603 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - March 18, 2024 Category: Drugs & Pharmacology Authors: Y Karasu M Demeli Ertu ş D Önal B Top çu H Ero ğlu B Pehlivano ğlu Source Type: research
