Therapeutic improvements of nifedipine controlled-release tablets combined with sacubitril valsartan on patients with diabetic nephropathy complicated with hypertension
This study aimed to evaluate the efficacy of nifedipine controlled-release tablets combined with sacubitril valsartan in diabetic nephropathy (DN) patients with hypertension. One hundred and twelve DN patients with hypertension were enrolled. They were randomly divided into the control group (treated with nifedipine controlled-release tablets combined with valsartan) and the observation group (treated with nifedipine controlled-release tablets combined with sacubitril valsartan). Renal function, endothelial function and inflammatory response were examined. After three-months treatment, the levels of clinical indexes (glyco...
Source: International Immunopharmacology - August 7, 2023 Category: Allergy & Immunology Authors: Yinyu Wei Lele Hu Guoying Liu Source Type: research

Therapeutic improvements of nifedipine controlled-release tablets combined with sacubitril valsartan on patients with diabetic nephropathy complicated with hypertension
This study aimed to evaluate the efficacy of nifedipine controlled-release tablets combined with sacubitril valsartan in diabetic nephropathy (DN) patients with hypertension. One hundred and twelve DN patients with hypertension were enrolled. They were randomly divided into the control group (treated with nifedipine controlled-release tablets combined with valsartan) and the observation group (treated with nifedipine controlled-release tablets combined with sacubitril valsartan). Renal function, endothelial function and inflammatory response were examined. After three-months treatment, the levels of clinical indexes (glyco...
Source: International Immunopharmacology - August 7, 2023 Category: Allergy & Immunology Authors: Yinyu Wei Lele Hu Guoying Liu Source Type: research

Calcium handling coupled to the endothelin ET < sub > A < /sub > and ET < sub > B < /sub > receptor-mediated vasoconstriction in resistance arteries: Differential regulation by PI3K, PKC and RhoK
Eur J Pharmacol. 2023 Aug 2:175948. doi: 10.1016/j.ejphar.2023.175948. Online ahead of print.ABSTRACTAbnormal endothelin-1 (ET-1) activity is involved in the pathogenesis of vascular diseases such as essential and pulmonary arterial hypertension, coronary artery disease, and cerebrovascular disease, blockade of ET receptors having shown efficacy in clinical assays and experimental models of hypertension. Augmented Ca2+ influx and changes in Ca2+ sensitization associated with arterial vasoconstriction underlie increased systemic vascular resistance in hypertension. Since peripheral resistance arteries play a key role in blo...
Source: European Journal of Pharmacology - August 4, 2023 Category: Drugs & Pharmacology Authors: Alejandro Guti érrez Alfonso G ómez Del Val Cristina Contreras Lucia Olmos Ana S ánchez Dolores Prieto Source Type: research

Calcium handling coupled to the endothelin ET < sub > A < /sub > and ET < sub > B < /sub > receptor-mediated vasoconstriction in resistance arteries: Differential regulation by PI3K, PKC and RhoK
Eur J Pharmacol. 2023 Aug 2;956:175948. doi: 10.1016/j.ejphar.2023.175948. Online ahead of print.ABSTRACTAbnormal endothelin-1 (ET-1) activity is involved in the pathogenesis of vascular diseases such as essential and pulmonary arterial hypertension, coronary artery disease, and cerebrovascular disease, blockade of ET receptors having shown efficacy in clinical assays and experimental models of hypertension. Augmented Ca2+ influx and changes in Ca2+ sensitization associated with arterial vasoconstriction underlie increased systemic vascular resistance in hypertension. Since peripheral resistance arteries play a key role in...
Source: European Journal of Pharmacology - August 4, 2023 Category: Drugs & Pharmacology Authors: Alejandro Guti érrez Alfonso G ómez Del Val Cristina Contreras Lucia Olmos Ana S ánchez Dolores Prieto Source Type: research

Arrest of mouse preterm labor until term delivery by combination therapy with atosiban and mundulone, a natural product with tocolytic efficacy
In this study, we probed the tocolytic potential of these compounds using human myometrial samples and a mouse model of preterm birth. In a phenotypic assay, mundulone displayed greater efficacy, while MA showed greater potency and uterine-selectivity in the inhibition of intracellular-Ca2+. Cell viability assays revealed that MA was significantly less cytotoxic. Organ bath and vessel myography studies showed that only mundulone exerted inhibition of myometrial contractions and that neither compounds affected vasoreactivity of ductus arteriosus. A high-throughput combination screen identified that mundulone exhibits synerg...
Source: Cell Research - August 3, 2023 Category: Cytology Authors: Shajila Siricilla Christopher J Hansen Jackson H Rogers Debasmita De Carolyn L Simpson Alex G Waterson Gary A Sulikowski Stacey L Crockett Naoko Boatwright Jeff Reese Bibhash C Paria J Newton Jennifer L Herington Source Type: research

Hypocalcemic tetany associated with simultaneous administration of cimetidine and nifedipine: a case report
ConclusionsSevere hypocalcemic tetany can occur with concomitant administration of cimetidine and nifedipine. Immediate treatment with calcium gluconate quickly reverses this adverse event. Concomitant administration of these drugs should be done with caution or be avoided if possible. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - July 28, 2023 Category: General Medicine Source Type: research

Effect of Nifedipine Used in the Treatment of the Threat of Preterm Labor on Total Uterine Artery Blood Volume Flow Rate
CONCLUSIONS: Our study showed a statistically significant increase in total uterine artery blood volume flow rate 48 hours after oral nifedipine treatment.PMID:37487520 | DOI:10.1055/a-2109-5279 (Source: Zeitschrift fur Geburtshilfe und Neonatologie)
Source: Zeitschrift fur Geburtshilfe und Neonatologie - July 24, 2023 Category: Perinatology & Neonatology Authors: Hasan Ero ğlu Mert Turgal Orhan Alt ınboğa G ökhan Karakoç Kemal Sarsmaz Aykan Yucel Source Type: research

Effect of Nifedipine Used in the Treatment of the Threat of Preterm Labor on Total Uterine Artery Blood Volume Flow Rate
CONCLUSIONS: Our study showed a statistically significant increase in total uterine artery blood volume flow rate 48 hours after oral nifedipine treatment.PMID:37487520 | DOI:10.1055/a-2109-5279 (Source: Zeitschrift fur Geburtshilfe und Neonatologie)
Source: Zeitschrift fur Geburtshilfe und Neonatologie - July 24, 2023 Category: Perinatology & Neonatology Authors: Hasan Ero ğlu Mert Turgal Orhan Alt ınboğa G ökhan Karakoç Kemal Sarsmaz Aykan Yucel Source Type: research

Repurposing drugs to treat trichinellosis: in vitro analysis of the anthelmintic activity of nifedipine and Chrysanthemum coronarium extract
Albendazole is the most common benzimidazole derivative used for trichinellosis treatment but has many drawbacks. The quest for alternative compounds is, therefore, a target for researchers. This work aims to ... (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - July 17, 2023 Category: Complementary Medicine Authors: Mona Hasan El-Sayad, Eman Sayed El-Wakil, Zizi Hesham Moharam, Naglaa Fathi Abd El-Latif, Mosad A. Ghareeb and Heba Elhadad Tags: Research Source Type: research

Oral nifedipine may be a preferential option for treating acute severe hypertension during pregnancy: a meta-analysis
CONCLUSION: Oral nifedipine was associated with less RTATBP and NoD and otherwise did not differ from intravenous labetalol.PMID:37434338 | DOI:10.1080/10641955.2023.2209637 (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - July 12, 2023 Category: OBGYN Authors: Minghui Ou Futao Zhang Shichao Cui Shibo Zhao Yan Yu Source Type: research

Sleep Deprivation Disturbs Uterine Contractility and Structure in Pregnant Rats: Role of Matrix Metalloproteinase 9 and Transforming Growth Factor- β
Can J Physiol Pharmacol. 2023 Jul 11. doi: 10.1139/cjpp-2023-0120. Online ahead of print.ABSTRACTSleep deprivation (SD) during pregnancy can impact the delivery procedure, with prolongation of the labor duration. Matrix metalloproteinase-9 (MMP9) and transforming growth factor-β (TGF-β) are regulators of uterine remodeling. Their dysregulation is vital for abnormal placentation and uterine enlargement in complicated pregnancies. Therefore, this study aims to explore the outcome of SD throughout pregnancy on ex vivo uterine contractility, MMP9 and TGF-β, and uterine microscopic structure. A total of 24 pregnant rats were...
Source: Canadian Journal of Physiology and Pharmacology - July 11, 2023 Category: Drugs & Pharmacology Authors: Nanees Elmalkey Mohammed Aref Nehal Goda Marwa Hussien Walaa Samy Shimaa Hadhod Source Type: research

Sleep Deprivation Disturbs Uterine Contractility and Structure in Pregnant Rats: Role of Matrix Metalloproteinase 9 and Transforming Growth Factor- β
Can J Physiol Pharmacol. 2023 Jul 11. doi: 10.1139/cjpp-2023-0120. Online ahead of print.ABSTRACTSleep deprivation (SD) during pregnancy can impact the delivery procedure, with prolongation of the labor duration. Matrix metalloproteinase-9 (MMP9) and transforming growth factor-β (TGF-β) are regulators of uterine remodeling. Their dysregulation is vital for abnormal placentation and uterine enlargement in complicated pregnancies. Therefore, this study aims to explore the outcome of SD throughout pregnancy on ex vivo uterine contractility, MMP9 and TGF-β, and uterine microscopic structure. A total of 24 pregnant rats were...
Source: Canadian Journal of Physiology and Pharmacology - July 11, 2023 Category: Drugs & Pharmacology Authors: Nanees Elmalkey Mohammed Aref Nehal Goda Marwa Hussien Walaa Samy Shimaa Hadhod Source Type: research

Sleep Deprivation Disturbs Uterine Contractility and Structure in Pregnant Rats: Role of Matrix Metalloproteinase 9 and Transforming Growth Factor- β
Can J Physiol Pharmacol. 2023 Jul 11. doi: 10.1139/cjpp-2023-0120. Online ahead of print.ABSTRACTSleep deprivation (SD) during pregnancy can impact the delivery procedure, with prolongation of the labor duration. Matrix metalloproteinase-9 (MMP9) and transforming growth factor-β (TGF-β) are regulators of uterine remodeling. Their dysregulation is vital for abnormal placentation and uterine enlargement in complicated pregnancies. Therefore, this study aims to explore the outcome of SD throughout pregnancy on ex vivo uterine contractility, MMP9 and TGF-β, and uterine microscopic structure. A total of 24 pregnant rats were...
Source: Canadian Journal of Physiology and Pharmacology - July 11, 2023 Category: Drugs & Pharmacology Authors: Nanees Elmalkey Mohammed Aref Nehal Goda Marwa Hussien Walaa Samy Shimaa Hadhod Source Type: research

Sleep Deprivation Disturbs Uterine Contractility and Structure in Pregnant Rats: Role of Matrix Metalloproteinase 9 and Transforming Growth Factor- β
Can J Physiol Pharmacol. 2023 Jul 11. doi: 10.1139/cjpp-2023-0120. Online ahead of print.ABSTRACTSleep deprivation (SD) during pregnancy can impact the delivery procedure, with prolongation of the labor duration. Matrix metalloproteinase-9 (MMP9) and transforming growth factor-β (TGF-β) are regulators of uterine remodeling. Their dysregulation is vital for abnormal placentation and uterine enlargement in complicated pregnancies. Therefore, this study aims to explore the outcome of SD throughout pregnancy on ex vivo uterine contractility, MMP9 and TGF-β, and uterine microscopic structure. A total of 24 pregnant rats were...
Source: Canadian Journal of Physiology and Pharmacology - July 11, 2023 Category: Drugs & Pharmacology Authors: Nanees Elmalkey Mohammed Aref Nehal Goda Marwa Hussien Walaa Samy Shimaa Hadhod Source Type: research

Sleep Deprivation Disturbs Uterine Contractility and Structure in Pregnant Rats: Role of Matrix Metalloproteinase 9 and Transforming Growth Factor- β
Can J Physiol Pharmacol. 2023 Jul 11. doi: 10.1139/cjpp-2023-0120. Online ahead of print.ABSTRACTSleep deprivation (SD) during pregnancy can impact the delivery procedure, with prolongation of the labor duration. Matrix metalloproteinase-9 (MMP9) and transforming growth factor-β (TGF-β) are regulators of uterine remodeling. Their dysregulation is vital for abnormal placentation and uterine enlargement in complicated pregnancies. Therefore, this study aims to explore the outcome of SD throughout pregnancy on ex vivo uterine contractility, MMP9 and TGF-β, and uterine microscopic structure. A total of 24 pregnant rats were...
Source: Canadian Journal of Physiology and Pharmacology - July 11, 2023 Category: Drugs & Pharmacology Authors: Nanees Elmalkey Mohammed Aref Nehal Goda Marwa Hussien Walaa Samy Shimaa Hadhod Source Type: research