N-phenyl and N-benzyl substituted succinimides: Preclinical evaluation for their antihypertensive effect and underlying mechanism
This study demonstrated the antihypertensive, anti-inflammatory, antioxidant, and vasodilate effects of the test compounds. In addition, the results supported the phenomenon of calcium channel blockades responsible for vasodilation.PMID:38142849 | DOI:10.1016/j.ejphar.2023.176195 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - December 24, 2023 Category: Drugs & Pharmacology Authors: Muhammad Imran Qayyum Sami Ullah Umer Rashid Abdul Sadiq Mater H Mahnashi Saif Ullah Khan Khalil Muhammad Masoom Akhtar Source Type: research
Neuro-Restorative Effect of Nimodipine and Calcitriol in 1-Methyl 4-Phenyl 1,2,3,6 Tetrahydropyridine-Induced Zebrafish Parkinson's Disease Model
CONCLUSION: The present study identified the neuro-restorative effects of nimodipine and calcitriol in an MPTP-induced zebrafish model of Parkinson's disease. They restored dopaminergic neurons which were damaged due to the effects of MPTP and normalized the locomotor activity. LTCCs have potential pathological roles in neurodevelopmental and neurodegenerative disorders. Zebrafish are highly amenable to high-throughput drug screening and might, therefore, be a useful tool to work towards the identification of disease-modifying treatment for PD. Further studies including zebrafish genetic models to elucidate the mechanism o...
Source: Journal of Korean Neurosurgical Society - December 22, 2023 Category: Neurosurgery Authors: Myung Ji Kim Su Hee Cho Yongbo Seo Sang-Dae Kim Hae-Chul Park Bum-Joon Kim Source Type: research
Use of physiologically ‐based pharmacokinetic modeling to understand the effect of omeprazole administration on the pharmacokinetics of oral extended‐release nifedipine
This study used physiologically-based pharmacokinetic (PBPK ) modeling and simulations to investigate the underlying mechanism of these complex DDIs. A formulation exhibiting differences in in vitro dissolution across physiological pH range and another formulation where pH does not impact dissolution appreciably (e.g., an osmotic pump) were chosen to charac terize the potential impact of pH. The PBPK models incorporated two-stage in vitro release profiles via US Pharmacopeia 2 apparatus. PBPK simulations suggest that the elevated gastric pH following multiple-dose administration of omeprazole has a minimal effect on nife...
Source: CPT: Pharmacometrics and Systems Pharmacology - December 22, 2023 Category: Drugs & Pharmacology Authors: Ming ‐Liang Tan,
Zongming Gao,
Andrew Babiskin,
Myong‐Jin Kim,
Lanyan Fang,
Lei Zhang,
Liang Zhao Tags: ARTICLE Source Type: research
Retracted: Effects of Nifedipine and Labetalol Combined with Magnesium Sulfate on Blood Pressure Control, Blood Coagulation Function, and Maternal and Infant Outcome in Patients with Pregnancy-Induced Hypertension
Comput Math Methods Med. 2023 Dec 13;2023:9805202. doi: 10.1155/2023/9805202. eCollection 2023.ABSTRACT[This retracts the article DOI: 10.1155/2022/9317114.].PMID:38124976 | PMC:PMC10733025 | DOI:10.1155/2023/9805202 (Source: Computational and Mathematical Methods in Medicine)
Source: Computational and Mathematical Methods in Medicine - December 21, 2023 Category: Statistics Authors: Computational And Mathematical Methods In Medicine Source Type: research
