Comparison of the efficacy of intravenous labetalol versus oral nifedipine in patients with severe pregnancy-induced hypertension beyond 30 weeks of gestation
CONCLUSION: From this study, both drugs were found to be safe and effective in the reduction in BP. The use of nifedipine may be recommended in low-resource settings since it has an oral regimen and dosage is simple when compared to incremental intravenous dosing of labetalol.PMID:38361866 | PMC:PMC10866225 | DOI:10.4103/jfmpc.jfmpc_2427_22 (Source: Primary Care)
Source: Primary Care - February 16, 2024 Category: Primary Care Authors: Manika Agarwal Makakmayum Rukshana Ritisha Basu Wansalan K Shullai Santa A Singh Source Type: research

Comparison of the efficacy of intravenous labetalol versus oral nifedipine in patients with severe pregnancy-induced hypertension beyond 30 weeks of gestation
CONCLUSION: From this study, both drugs were found to be safe and effective in the reduction in BP. The use of nifedipine may be recommended in low-resource settings since it has an oral regimen and dosage is simple when compared to incremental intravenous dosing of labetalol.PMID:38361866 | PMC:PMC10866225 | DOI:10.4103/jfmpc.jfmpc_2427_22 (Source: Primary Care)
Source: Primary Care - February 16, 2024 Category: Primary Care Authors: Manika Agarwal Makakmayum Rukshana Ritisha Basu Wansalan K Shullai Santa A Singh Source Type: research

Efficient administration of a combination of nifedipine and sildenafil citrate versus only nifedipine on clinical outcomes in women with threatened preterm labor: a systematic review and meta-analysis
Preterm labor (PTL) is a common and serious pregnancy disorder that can cause long-term neurological issues in the infant. There are conflicting studies concerning whether sildenafil citrate (SC) reduces prete... (Source: BMC Pediatrics)
Source: BMC Pediatrics - February 10, 2024 Category: Pediatrics Authors: Elham Manouchehri, Somayeh Makvandi, Mahdieh Razi, Maryam Sahebari and Mona Larki Tags: Research Source Type: research

Ano1 regulates embryo transport by modulating intracellular calcium levels in oviduct smooth muscle
In this study, female mice with Ano1SMKO (smooth muscle-specific deletion of Ano1) had reduced fertility. Deficiency of Ano1 in mice resulted in impaired oviductal SRC function and reduced calcium signaling in individual smooth muscle cells in the oviduct. The Ano1 antagonist T16Ainh-A01 dose-dependently inhibited SRCs and [Ca2+]i in the oviducts of humans and mice. A similar inhibitory effect of SRCs and [Ca2+]i was observed after treatment with nifedipine. In our study, ANO1 acted primarily as an activator or amplifier in [Ca2+]i and contraction of tubal smooth muscle cells. We found that tubal SRC was markedly attenuate...
Source: Biochimica et Biophysica Acta - February 9, 2024 Category: Biochemistry Authors: Xiao-Man Liu Juan Li Defang Chen Hao Li Xiao-Yan Qin Yun-Xia Wang Yong-Zhong Gu Na Li Li-Guang Zhou Mei Feng Source Type: research

A Comparative Analysis of the Clinical Efficacy of Sacubitril Valsartan Sodium and Enalapril in Patients with Non-Valvular Ejection Fraction Reduction in Heart Failure
CONCLUSION: The main findings of the study showed that Sacubitril valsartan sodium showed better clinical efficacy than enalapril in patients with heart failure and non-valvular reduced ejection fraction. Specifically, the drug significantly improved patients' kidney function, reduced cardiovascular marker levels, and reduced the incidence of adverse cardiovascular events. These findings have important clinical implications for guiding treatment selection in patients with heart failure.PMID:38330576 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - February 8, 2024 Category: Complementary Medicine Authors: Qinqqing Zhang Jiao Wang Yingxiao Da Xin Li Lei Pan Source Type: research

A Comparative Analysis of the Clinical Efficacy of Sacubitril Valsartan Sodium and Enalapril in Patients with Non-Valvular Ejection Fraction Reduction in Heart Failure
CONCLUSION: The main findings of the study showed that Sacubitril valsartan sodium showed better clinical efficacy than enalapril in patients with heart failure and non-valvular reduced ejection fraction. Specifically, the drug significantly improved patients' kidney function, reduced cardiovascular marker levels, and reduced the incidence of adverse cardiovascular events. These findings have important clinical implications for guiding treatment selection in patients with heart failure.PMID:38330576 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - February 8, 2024 Category: Complementary Medicine Authors: Qinqqing Zhang Jiao Wang Yingxiao Da Xin Li Lei Pan Source Type: research

A Comparative Analysis of the Clinical Efficacy of Sacubitril Valsartan Sodium and Enalapril in Patients with Non-Valvular Ejection Fraction Reduction in Heart Failure
CONCLUSION: The main findings of the study showed that Sacubitril valsartan sodium showed better clinical efficacy than enalapril in patients with heart failure and non-valvular reduced ejection fraction. Specifically, the drug significantly improved patients' kidney function, reduced cardiovascular marker levels, and reduced the incidence of adverse cardiovascular events. These findings have important clinical implications for guiding treatment selection in patients with heart failure.PMID:38330576 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - February 8, 2024 Category: Complementary Medicine Authors: Qinqqing Zhang Jiao Wang Yingxiao Da Xin Li Lei Pan Source Type: research

A Comparative Analysis of the Clinical Efficacy of Sacubitril Valsartan Sodium and Enalapril in Patients with Non-Valvular Ejection Fraction Reduction in Heart Failure
CONCLUSION: The main findings of the study showed that Sacubitril valsartan sodium showed better clinical efficacy than enalapril in patients with heart failure and non-valvular reduced ejection fraction. Specifically, the drug significantly improved patients' kidney function, reduced cardiovascular marker levels, and reduced the incidence of adverse cardiovascular events. These findings have important clinical implications for guiding treatment selection in patients with heart failure.PMID:38330576 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - February 8, 2024 Category: Complementary Medicine Authors: Qinqqing Zhang Jiao Wang Yingxiao Da Xin Li Lei Pan Source Type: research

GSE254742 Sildenafil as a candidate drug for Alzheimer ’s disease: Real-world patient data observation and mechanistic observations from patient-induced pluripotent stem cell-derived neurons.
Contributors : Dhruv Gohel ; Amit K Gupta ; Feixiong ChengSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAlzheimer ’s disease (AD) is a chronic neurodegenerative disease needing effective therapeutics urgently. Sildenafil, one of the approved phosphodiesterase-5 inhibitors, has been implicated as having potential beneficial effect in AD. We showed that sildenafil usage is associated with reduced likelihood of AD across four new drug compactor cohorts, including bumetanide, furosemide, spironolactone, and nifedipine. For instance, sildenafil usage is associated with a 54% reduced ...
Source: GEO: Gene Expression Omnibus - February 5, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

Mechanistic Framework to Predict Maternal-Placental-Fetal Pharmacokinetics of Nifedipine Employing Physiologically Based Pharmacokinetic Modeling Approach
J Clin Pharmacol. 2024 Feb 2. doi: 10.1002/jcph.2404. Online ahead of print.ABSTRACTNifedipine is used for treating mild to severe hypertension and preventing preterm labor in pregnant women. Nevertheless, concerns about nifedipine fetal exposure and safety are always raised. The aim of this study was to develop and validate a maternal-placental-fetal nifedipine physiologically based pharmacokinetic (PBPK) model and apply the model to predict maternal, placental, and fetal exposure to nifedipine at different pregnancy stages. A nifedipine PBPK model was verified with nonpregnant data and extended to the pregnant population...
Source: The Journal of Clinical Pharmacology - February 2, 2024 Category: Drugs & Pharmacology Authors: Marya Ant ônya Werdan Romão Leonardo Pinto Ricardo Carvalho Cavalli Geraldo Duarte Nat ália Valadares de Moraes Khaled Abduljalil Fernanda de Lima Moreira Source Type: research

Investigation of the cytotoxicity, genotoxicity and antioxidant prospects of JM-20 on human blood cells: A multi-target compound with potential therapeutic applications
Blood Cells Mol Dis. 2024 Jan 19;106:102827. doi: 10.1016/j.bcmd.2024.102827. Online ahead of print.ABSTRACTJM-20 is a 1,5-benzodiazepine compound fused to a dihydropyridine fraction with different pharmacological properties. However, its potential toxic effects on blood cells have not yet been reported. Thus, the present study aimed to investigate, for the first time, the possible cytotoxicity of JM-20 through cell viability, cell cycle, morphology changes, reactive species (RS) to DCFH-DA, and lipid peroxidation in human leukocytes, its hemolytic effect on human erythrocytes, and its potential DNA genotoxicity using plas...
Source: Blood Cells, Molecules and Diseases - February 1, 2024 Category: Hematology Authors: Fernanda D'Avila da Silva Maria Eduarda de Andrade Galiciolli Ana Carolina Irioda Cl áudia Sirlene Oliveira Bruna Candia Piccoli Alessandro de Souza Prestes Bruna Cogo Borin Andre Passaglia Schuch Estael Ochoa-Rodr íguez Yanier Nu ñez-Figueredo Jo ão Source Type: research

Investigation of the cytotoxicity, genotoxicity and antioxidant prospects of JM-20 on human blood cells: A multi-target compound with potential therapeutic applications
Blood Cells Mol Dis. 2024 Jan 19;106:102827. doi: 10.1016/j.bcmd.2024.102827. Online ahead of print.ABSTRACTJM-20 is a 1,5-benzodiazepine compound fused to a dihydropyridine fraction with different pharmacological properties. However, its potential toxic effects on blood cells have not yet been reported. Thus, the present study aimed to investigate, for the first time, the possible cytotoxicity of JM-20 through cell viability, cell cycle, morphology changes, reactive species (RS) to DCFH-DA, and lipid peroxidation in human leukocytes, its hemolytic effect on human erythrocytes, and its potential DNA genotoxicity using plas...
Source: Blood Cells, Molecules and Diseases - February 1, 2024 Category: Hematology Authors: Fernanda D'Avila da Silva Maria Eduarda de Andrade Galiciolli Ana Carolina Irioda Cl áudia Sirlene Oliveira Bruna Candia Piccoli Alessandro de Souza Prestes Bruna Cogo Borin Andre Passaglia Schuch Estael Ochoa-Rodr íguez Yanier Nu ñez-Figueredo Jo ão Source Type: research

Investigation of the cytotoxicity, genotoxicity and antioxidant prospects of JM-20 on human blood cells: A multi-target compound with potential therapeutic applications
Blood Cells Mol Dis. 2024 Jan 19;106:102827. doi: 10.1016/j.bcmd.2024.102827. Online ahead of print.ABSTRACTJM-20 is a 1,5-benzodiazepine compound fused to a dihydropyridine fraction with different pharmacological properties. However, its potential toxic effects on blood cells have not yet been reported. Thus, the present study aimed to investigate, for the first time, the possible cytotoxicity of JM-20 through cell viability, cell cycle, morphology changes, reactive species (RS) to DCFH-DA, and lipid peroxidation in human leukocytes, its hemolytic effect on human erythrocytes, and its potential DNA genotoxicity using plas...
Source: Blood Cells, Molecules and Diseases - February 1, 2024 Category: Hematology Authors: Fernanda D'Avila da Silva Maria Eduarda de Andrade Galiciolli Ana Carolina Irioda Cl áudia Sirlene Oliveira Bruna Candia Piccoli Alessandro de Souza Prestes Bruna Cogo Borin Andre Passaglia Schuch Estael Ochoa-Rodr íguez Yanier Nu ñez-Figueredo Jo ão Source Type: research

Investigation of the cytotoxicity, genotoxicity and antioxidant prospects of JM-20 on human blood cells: A multi-target compound with potential therapeutic applications
Blood Cells Mol Dis. 2024 Jan 19;106:102827. doi: 10.1016/j.bcmd.2024.102827. Online ahead of print.ABSTRACTJM-20 is a 1,5-benzodiazepine compound fused to a dihydropyridine fraction with different pharmacological properties. However, its potential toxic effects on blood cells have not yet been reported. Thus, the present study aimed to investigate, for the first time, the possible cytotoxicity of JM-20 through cell viability, cell cycle, morphology changes, reactive species (RS) to DCFH-DA, and lipid peroxidation in human leukocytes, its hemolytic effect on human erythrocytes, and its potential DNA genotoxicity using plas...
Source: Blood Cells, Molecules and Diseases - February 1, 2024 Category: Hematology Authors: Fernanda D'Avila da Silva Maria Eduarda de Andrade Galiciolli Ana Carolina Irioda Cl áudia Sirlene Oliveira Bruna Candia Piccoli Alessandro de Souza Prestes Bruna Cogo Borin Andre Passaglia Schuch Estael Ochoa-Rodr íguez Yanier Nu ñez-Figueredo Jo ão Source Type: research

Gingival overgrowth approached using recent mechanical and laser technologies: A case report
Exp Ther Med. 2024 Jan 8;27(2):84. doi: 10.3892/etm.2024.12374. eCollection 2024 Feb.ABSTRACTGingival enlargement is a side effect of different drug classes, with calcium channel blockers being among the most often cited examples. Most often accompanied by a disruption in the oral biofilm, this form of gingival overgrowth, with histological signs of hyperplasia and hypertrophy, becomes a chronic inflammatory condition with the oral biofilm a primary cause. This periodontal disease is now classified as 'dental biofilm-induced gingivitis', and its preferred name is drug-influenced gingival expansion. The present study presen...
Source: Experimental and Therapeutic Medicine - January 26, 2024 Category: General Medicine Authors: Laurenta Lelia Mihai Ioanina Parlatescu Anca Calin Alexandru Burcea Source Type: research