High-throughput drug screen identifies calcium and calmodulin inhibitors that reduce JCPyV infection
Antiviral Res. 2024 Feb;222:105817. doi: 10.1016/j.antiviral.2024.105817. Epub 2024 Jan 19.ABSTRACTJC polyomavirus (JCPyV) is a nonenveloped, double-stranded DNA virus that infects the majority of the population. Immunocompetent individuals harbor infection in their kidneys, while severe immunosuppression can result in JCPyV spread to the brain, causing the neurodegenerative disease progressive multifocal leukoencephalopathy (PML). Due to a lack of approved therapies to treat JCPyV and PML, the disease results in rapid deterioration, and is often fatal. In order to identify potential antiviral treatments for JCPyV, a high-...
Source: Antiviral Research - January 21, 2024 Category: Virology Authors: Avery C S Bond Mason A Crocker Michael P Wilczek Jeanne K DuShane Amanda L Sandberg Lucas J Bennett Nicholas R Leclerc Melissa S Maginnis Source Type: research

Pregnancy-associated changes in urinary uromodulin excretion in chronic hypertension
CONCLUSIONS: In summary, we demonstrate pregnancy-associated differences in urinary uromodulin: creatinine ratio and uromodulin excretion rate between chronic hypertensive and normotensive pregnancies. Further research is needed to fully understand uromodulin physiology in human pregnancy and establish uromodulin's potential as a biomarker for renal adaptation and renal function in pregnancy.PMID:38236469 | DOI:10.1007/s40620-023-01830-6 (Source: Journal of Nephrology)
Source: Journal of Nephrology - January 18, 2024 Category: Urology & Nephrology Authors: Sheon Mary Fran Conti-Ramsden Philipp Boder Humaira Parveen Dellaneira Setjiadi Jessica Fleminger Anna Brockbank Delyth Graham Kate Bramham Lucy Charlotte Chappell Christian Delles Source Type: research

Biological Activity of a Coumarin Derivative on Heart Failure Using an Ischemia/Reperfusion Injury Model
Drug Res (Stuttg) DOI: 10.1055/a-2228-4258Heart failure is a health problem worldwide. There are some drugs for it, including digoxin, spironolactone, captopril, and valsartan, but some of these drugs can produce secondary effects, such as arrhythmia, cough, hyperkalemia, hyponatremia and hypotension. The aim of this research was to evaluate the biological activity of coumarin (2H-chromen-2-one) and its derivatives (3BrAcet-C, 3–4Br-Ph-C, 4-CN-7D-C, 4-Me-7-Ph-C and 6Br-3-D-C) against ischemia/reperfusion injury as a therapeutic alternative for heart fa...
Source: Drug Research - January 17, 2024 Category: Drugs & Pharmacology Authors: Figueroa-Valverde, Lauro Rosas-Nexticapa, Marcela Alvarez-Ramirez, Magdalena Melgarejo-Guti érrez, Montserrat Mateu-Armand, Virginia Garcimarrero-Espino, Alejandra Tags: Original Article Source Type: research

Utility of nifedipine use for Doppler ultrasound early after liver transplantation to predict short-term complications and long-term outcomes
ConclusionShort-term complication rates and long-term outcomes for patients with liver transplant who responded to nifedipine administration on Doppler US are similar to those who did not require nifedipine administration. A lack of response to nifedipine was associated with a higher re-operation rate. (Source: Abdominal Imaging)
Source: Abdominal Imaging - January 14, 2024 Category: Radiology Source Type: research

Unagi: Deep Generative Model for Deciphering Cellular Dynamics and In-Silico Drug Discovery in Complex Diseases
Res Sq. 2023 Dec 18:rs.3.rs-3676579. doi: 10.21203/rs.3.rs-3676579/v1. Preprint.ABSTRACTHuman diseases are characterized by intricate cellular dynamics. Single-cell sequencing provides critical insights, yet a persistent gap remains in computational tools for detailed disease progression analysis and targeted in-silico drug interventions. We introduce UNAGI, a deep generative neural network tailored to analyze time-series single-cell transcriptomic data. This innovative tool captures the complex cellular dynamics underlying disease progression, enhancing drug perturbation modeling and discovery. When applied to a dataset f...
Source: Cell Research - January 10, 2024 Category: Cytology Authors: Jun Ding Yumin Zheng Jonas Schupp Taylor Adams Geremy Clair Aurelien Justet Farida Ahangari Xiting Yan Paul Hansen Marianne Carlon Emanuela Cortesi Marie Vermant Robin Vos Laurens De Sadeleer Ivan Rosas Ricardo Pineda John Sembrat Melanie K önigshoff Joh Source Type: research

A Highly Chemically Robust 3D Interpenetrated MOF Heterogeneous Catalyst for the Synthesis of Hantzsch 1,4 ‐Dihydropyridines and Drug Molecules
This report inaugurates the usage of a MOF material as a catalyst for the synthesis of drug molecules. (Source: Small)
Source: Small - January 9, 2024 Category: Nanotechnology Authors: Rupam Sahoo, Bikram Pramanik, Supriya Mondal, Madhab C. Das Tags: Research Article Source Type: research

1118 Postpartum Antihypertensive Choice and Readmission Outcomes
Postpartum women with hypertensive disorders are routinely discharged on Labetalol, Nifedipine, and Lasix; however, the impact of antihypertensive selection on readmission is not well understood. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - January 1, 2024 Category: OBGYN Authors: Anne Reed-Weston, Lauren Roby, Dianne Holleran, Matthew Hoffman Source Type: research

948 Postpartum health-care utilization and blood pressure control by antihypertensive agent in hypertensive disorders of pregnancy
To evaluate rates of postpartum hospital readmission and emergency room (ER) utilization for individuals with a hypertensive disorder of pregnancy (HDP) after discharge on labetalol versus nifedipine XL. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - January 1, 2024 Category: OBGYN Authors: Carrie Bennett, Lara S. Lemon, Kripa Venkatakrishnan, Hannah Wichmann, Sanjana Ghosh, Hyagriv Simhan, Alisse Hauspurg Source Type: research

288 Amlodipine versus nifedipine ER for the management of postpartum hypertension: a noninferiority randomized controlled trial
Hypertensive disorders of pregnancy (HDP) are a leading cause of maternal morbidity, yet data comparing postpartum hypertension (PPHTN) medications are limited. We sought to compare the effectiveness of 2 dihydropyridine calcium channel blockers: amlodipine, which is often used as first-line monotherapy for non-obstetric hypertension, and nifedipine ER, which is frequently used for PPHTN. We hypothesized that amlodipine is non-inferior to nifedipine ER for PPHTN control, as defined by time from delivery until discharge (PPLOS). (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - January 1, 2024 Category: OBGYN Authors: Katelyn Pratt, Ross Lordo, Stella Self, Laura Carlson Source Type: research

Giant negative T waves in an elder with generalized pain and weakness
A 72-year-old man with a history of hypertension and chronic kidney disease presented to our emergency department complaining of numbness in his arms and legs, diarrhea, generalized pain, and weakness for 10 days, which gradually worsened and made moving difficult. His medications included trichloromethiazide, azosemide, doxazosin, nifedipine, carvedilol, and cilostazol. Additionally, prednisone had been used to treat cholesterol embolisms in the toes. Approximately 1 month prior, osteoporosis due to chronic kidney disease and steroid use was suspected, and denosumab therapy and calcium replacement ware initiated. (Source:...
Source: The American Journal of Medicine - December 30, 2023 Category: General Medicine Authors: Yoshikazu Hirose, Nobuhiro Sato, Yasuo Hirose Tags: ECG image of the month Source Type: research

Giant Negative T Waves in an Elderly Patient with Generalized Pain and Weakness
A 72-year-old male with a history of hypertension and chronic kidney disease presented to our emergency department complaining of numbness in his arms and legs, diarrhea, generalized pain, and weakness for 10 days, which gradually worsened and made moving difficult. His medications included trichloromethiazide, azosemide, doxazosin, nifedipine, carvedilol, and cilostazol. Additionally, prednisone had been used to treat cholesterol embolisms in the toes. Approximately 1 month prior, osteoporosis due to chronic kidney disease and steroid use was suspected, and denosumab therapy and calcium replacement were initiated. (Source...
Source: The American Journal of Medicine - December 30, 2023 Category: General Medicine Authors: Yoshikazu Hirose, Nobuhiro Sato, Yasuo Hirose Tags: ECG image of the month Source Type: research

Anti-diarrheal effect of piperine possibly through the interaction with inflammation inducing enzymes: In vivo and in silico studies
In conclusion, piperine showed a potent anti-diarrheal effect in castor oil-induced diarrheal chicks by suppressing the inflammation and calcium ion influx induced by castor oil.PMID:38158111 | DOI:10.1016/j.ejphar.2023.176289 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - December 29, 2023 Category: Drugs & Pharmacology Authors: Meher Afroz Md Shimul Bhuia Md Anisur Rahman Rubel Hasan Tawhida Islam Md Rakibul Islam Raihan Chowdhury Md Ali Khan Davi Antas E Silva Henrique Douglas Melo Coutinho Muhammad Torequl Islam Source Type: research

N-phenyl and N-benzyl substituted succinimides: Preclinical evaluation for their antihypertensive effect and underlying mechanism
This study demonstrated the antihypertensive, anti-inflammatory, antioxidant, and vasodilate effects of the test compounds. In addition, the results supported the phenomenon of calcium channel blockades responsible for vasodilation.PMID:38142849 | DOI:10.1016/j.ejphar.2023.176195 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - December 24, 2023 Category: Drugs & Pharmacology Authors: Muhammad Imran Qayyum Sami Ullah Umer Rashid Abdul Sadiq Mater H Mahnashi Saif Ullah Khan Khalil Muhammad Masoom Akhtar Source Type: research

Neuro-Restorative Effect of Nimodipine and Calcitriol in 1-Methyl 4-Phenyl 1,2,3,6 Tetrahydropyridine-Induced Zebrafish Parkinson's Disease Model
CONCLUSION: The present study identified the neuro-restorative effects of nimodipine and calcitriol in an MPTP-induced zebrafish model of Parkinson's disease. They restored dopaminergic neurons which were damaged due to the effects of MPTP and normalized the locomotor activity. LTCCs have potential pathological roles in neurodevelopmental and neurodegenerative disorders. Zebrafish are highly amenable to high-throughput drug screening and might, therefore, be a useful tool to work towards the identification of disease-modifying treatment for PD. Further studies including zebrafish genetic models to elucidate the mechanism o...
Source: Journal of Korean Neurosurgical Society - December 22, 2023 Category: Neurosurgery Authors: Myung Ji Kim Su Hee Cho Yongbo Seo Sang-Dae Kim Hae-Chul Park Bum-Joon Kim Source Type: research