Obesity-induced inflammation exacerbates clonal hematopoiesis
Characterized by the accumulation of somatic mutations in blood cell lineages, clonal hematopoiesis of indeterminate potential (CHIP) is frequent in aging and involves the expansion of mutated hematopoietic stem and progenitor cells (HSC/Ps) that leads to an increased risk of hematologic malignancy. However, the risk factors that contribute to CHIP-associated clonal hematopoiesis (CH) are poorly understood. Obesity induces a proinflammatory state and fatty bone marrow (FBM), which may influence CHIP-associated pathologies. We analyzed exome sequencing and clinical data for 47,466 individuals with validated CHIP in the UK B...
Source: Journal of Clinical Investigation - June 2, 2023 Category: Biomedical Science Authors: Santhosh Kumar Pasupuleti, Baskar Ramdas, Sarah S. Burns, Lakshmi Reddy Palam, Rahul Kanumuri, Ramesh Kumar, Taruni Reddy Pandhiri, Utpal P. Dave, Nanda Kumar Yellapu, Xinyu Zhou, Chi Zhang, George E. Sandusky, Zhi Yu, Michael C. Honigberg, Alexander G. B Source Type: research

Pharmacokinetics of Nifedipine ‐Sustained Release Tablets in Healthy Subjects After a Single Oral Administration: Bioequivalence Analysis and Food Effects
AbstractWe compared newly developed delayed-release oral tablets (test) of 30-mg nifedipine (NFP) with its marketed counterpart (30  mg; reference) in healthy adult Chinese volunteers to assess the former's bioequivalence. This was a randomized, open-label, four-period, crossover trial study including fasting and fed trials. The participants were randomly administered test or reference formulations (1:1 ratio) throughout each period, with a 7-day washout period. In the next session, they were administered the alternate products. Liquid chromatography–tandem mass spectrometry and WinNonlin software were used to evaluate...
Source: Clinical Pharmacology in Drug Development - May 28, 2023 Category: Drugs & Pharmacology Authors: You ‐Xuan Wu, Xue‐Feng Zhong, Xiao‐Min Li, Wan‐Li Liu, Yan‐Xin Zhang, Qiu‐Ying Shen, Su‐Mei Xu, Ping‐Sheng Xu Tags: Original Article Source Type: research

Fluoride induces neutrophil extracellular traps and aggravates brain inflammation by disrupting neutrophil calcium homeostasis and causing ferroptosis
Environ Pollut. 2023 May 18:121847. doi: 10.1016/j.envpol.2023.121847. Online ahead of print.ABSTRACTEndemic fluorosis (EF) has been listed as one of the serious public health problems in many countries. Long-term exposure to high fluoride can lead to severe neuropathological damage to the brain. Although long-term research has revealed the mechanism of some brain inflammation caused by excessive fluoride, the role of intercellular interactions, especially immune cells, in brain damage is still unclear. Fluoride can induce ferroptosis and inflammation in the brain in our study. A co-culture system of neutrophil extranets a...
Source: Environmental Pollution - May 20, 2023 Category: Environmental Health Authors: Dongxu Wang Kai Yin Yue Zhang Hongmin Lu Lulu Hou Hongjing Zhao Mingwei Xing Source Type: research

Fluoride induces neutrophil extracellular traps and aggravates brain inflammation by disrupting neutrophil calcium homeostasis and causing ferroptosis
Environ Pollut. 2023 May 18:121847. doi: 10.1016/j.envpol.2023.121847. Online ahead of print.ABSTRACTEndemic fluorosis (EF) has been listed as one of the serious public health problems in many countries. Long-term exposure to high fluoride can lead to severe neuropathological damage to the brain. Although long-term research has revealed the mechanism of some brain inflammation caused by excessive fluoride, the role of intercellular interactions, especially immune cells, in brain damage is still unclear. Fluoride can induce ferroptosis and inflammation in the brain in our study. A co-culture system of neutrophil extranets a...
Source: Environmental Pollution - May 20, 2023 Category: Environmental Health Authors: Dongxu Wang Kai Yin Yue Zhang Hongmin Lu Lulu Hou Hongjing Zhao Mingwei Xing Source Type: research