Cuminum cyminum Ameliorates Urotoxic Effects of Cyclophosphamide by Modulating Antioxidant, Inflammatory Cytokines, and Urinary Bladder Overactivity: In vivo and In Silioc investigations
This study aimed to investigate the effect of aqueous ethanol extract of Cuminum cyminum (AEECC) on oxidative stress, inflammation and overactivity of the urinary bladder induced by cyclophosphamide (CYP). The enhanced nociception behavior, bladder weight, vascular permeability, edema, hemorrhage, nitric oxide, IL-6 and TNF-α levels by CYP administration were significantly reduced by AEECC (250 and 500 mg/kg). A significant increase in serum antioxidant systems such as CAT and GPx was also observed in AEECC-treated rats. The AEECC (3 mg/ml) significantly reduced urinary bladder tone in the strips pre-contracted with carba...
Source: Chemistry and Biodiversity - October 16, 2023 Category: Biochemistry Authors: Mohammed Bourhia Irfan Anjum Daanyaal Ali Mueen Ahmad Chaudhry Farhan Siddique Mehvish Bibi Abdel-Rhman Z Gaafar Touriya Zair Farid Khallouki Source Type: research

Cuminum cyminum Ameliorates Urotoxic Effects of Cyclophosphamide by Modulating Antioxidant, Inflammatory Cytokines, and Urinary Bladder Overactivity: In vivo and In Silioc investigations
This study aimed to investigate the effect of aqueous ethanol extract of Cuminum cyminum (AEECC) on oxidative stress, inflammation and overactivity of the urinary bladder induced by cyclophosphamide (CYP). The enhanced nociception behavior, bladder weight, vascular permeability, edema, hemorrhage, nitric oxide, IL-6 and TNF-α levels by CYP administration were significantly reduced by AEECC (250 and 500 mg/kg). A significant increase in serum antioxidant systems such as CAT and GPx was also observed in AEECC-treated rats. The AEECC (3 mg/ml) significantly reduced urinary bladder tone in the strips pre-contracted with carba...
Source: Chemistry and Biodiversity - October 16, 2023 Category: Biochemistry Authors: Mohammed Bourhia Irfan Anjum Daanyaal Ali Mueen Ahmad Chaudhry Farhan Siddique Mehvish Bibi Abdel-Rhman Z Gaafar Touriya Zair Farid Khallouki Source Type: research

Efficacy analysis of minimally invasive surgery for Raynaud's syndrome
CONCLUSION: Our retrospective analysis on RS patients indicates that microsurgical techniques are safe and effective in the short term. As surgical practices lean towards minimally invasive methods, our data supports this shift. However, extensive, prospective studies are essential for conclusive insights.PMID:37838733 | DOI:10.1186/s12893-023-02225-x (Source: Hand Surgery)
Source: Hand Surgery - October 14, 2023 Category: Surgery Authors: Fengwei Yu Yongtao Liu Chengnian Zhang Botao Pang Daijie Zhang Wei Zhao Xuecheng Li Weiqiang Yang Source Type: research

A Super-elderly Case of Suspected New-onset Vasospastic Angina Complicated by Myocardial Bridge
Intern Med. 2023 Oct 6. doi: 10.2169/internalmedicine.2413-23. Online ahead of print.ABSTRACTA 90-year-old man experienced chest oppressive sensation at 12:30 AM for the first time. Electrocardiography showed a newly developed inversion of the terminal T-wave in the V2-5 leads. A left coronary angiogram showed no significant atherosclerotic stenosis. A myocardial bridge was found in the mid-left anterior descending artery (LAD). Myocardial scintigraphy with 123I beta-methyl 15-para-iodophenyl 3(R,S)-methylpentadecanoic acid revealed a reduced uptake in the apical and septal areas. Based on these findings, we suspected new-...
Source: Internal Medicine - October 9, 2023 Category: Internal Medicine Authors: Satoshi Kurisu Hitoshi Fujiwara Source Type: research

L-type calcium ion channel-mediated activation of autophagy in vascular smooth muscle cells via thonningianin A (TA) alleviates vascular calcification in type 2 diabetes mellitus
Eur J Pharmacol. 2023 Oct 6:176084. doi: 10.1016/j.ejphar.2023.176084. Online ahead of print.ABSTRACTVascular calcification (VC) is associated with increased morbidity and mortality, especially among people with type 2 diabetes mellitus (T2DM). The pathogenesis of vascular calcification is incompletely understood, and until now, there have been no effective therapeutics for vascular calcification. The L-type calcium ion channel in the cell membrane is vital for Ca2+ influx. The effect of L-type calcium ion channels on autophagy remains to be elucidated. Here, the natural compound thonningianin A (TA) was found to ameliorat...
Source: European Journal of Pharmacology - October 8, 2023 Category: Drugs & Pharmacology Authors: Jialing Shen Cheng Zhang Yong Liu Ming Zhao Qianqian Wang Pengyun Li Runyu Liu Vincent Kam Wai Wong Chunxiang Zhang Xiaolei Sun Source Type: research

L-type calcium ion channel-mediated activation of autophagy in vascular smooth muscle cells via thonningianin A (TA) alleviates vascular calcification in type 2 diabetes mellitus
Eur J Pharmacol. 2023 Oct 6:176084. doi: 10.1016/j.ejphar.2023.176084. Online ahead of print.ABSTRACTVascular calcification (VC) is associated with increased morbidity and mortality, especially among people with type 2 diabetes mellitus (T2DM). The pathogenesis of vascular calcification is incompletely understood, and until now, there have been no effective therapeutics for vascular calcification. The L-type calcium ion channel in the cell membrane is vital for Ca2+ influx. The effect of L-type calcium ion channels on autophagy remains to be elucidated. Here, the natural compound thonningianin A (TA) was found to ameliorat...
Source: European Journal of Pharmacology - October 8, 2023 Category: Drugs & Pharmacology Authors: Jialing Shen Cheng Zhang Yong Liu Ming Zhao Qianqian Wang Pengyun Li Runyu Liu Vincent Kam Wai Wong Chunxiang Zhang Xiaolei Sun Source Type: research

L-type calcium ion channel-mediated activation of autophagy in vascular smooth muscle cells via thonningianin A (TA) alleviates vascular calcification in type 2 diabetes mellitus
Eur J Pharmacol. 2023 Oct 6:176084. doi: 10.1016/j.ejphar.2023.176084. Online ahead of print.ABSTRACTVascular calcification (VC) is associated with increased morbidity and mortality, especially among people with type 2 diabetes mellitus (T2DM). The pathogenesis of vascular calcification is incompletely understood, and until now, there have been no effective therapeutics for vascular calcification. The L-type calcium ion channel in the cell membrane is vital for Ca2+ influx. The effect of L-type calcium ion channels on autophagy remains to be elucidated. Here, the natural compound thonningianin A (TA) was found to ameliorat...
Source: European Journal of Pharmacology - October 8, 2023 Category: Drugs & Pharmacology Authors: Jialing Shen Cheng Zhang Yong Liu Ming Zhao Qianqian Wang Pengyun Li Runyu Liu Vincent Kam Wai Wong Chunxiang Zhang Xiaolei Sun Source Type: research