Mechanistic Framework to Predict Maternal-Placental-Fetal Pharmacokinetics of Nifedipine Employing Physiologically Based Pharmacokinetic Modeling Approach
J Clin Pharmacol. 2024 Feb 2. doi: 10.1002/jcph.2404. Online ahead of print.ABSTRACTNifedipine is used for treating mild to severe hypertension and preventing preterm labor in pregnant women. Nevertheless, concerns about nifedipine fetal exposure and safety are always raised. The aim of this study was to develop and validate a maternal-placental-fetal nifedipine physiologically based pharmacokinetic (PBPK) model and apply the model to predict maternal, placental, and fetal exposure to nifedipine at different pregnancy stages. A nifedipine PBPK model was verified with nonpregnant data and extended to the pregnant population...
Source: The Journal of Clinical Pharmacology - February 2, 2024 Category: Drugs & Pharmacology Authors: Marya Ant ônya Werdan Romão Leonardo Pinto Ricardo Carvalho Cavalli Geraldo Duarte Nat ália Valadares de Moraes Khaled Abduljalil Fernanda de Lima Moreira Source Type: research

Investigation of the cytotoxicity, genotoxicity and antioxidant prospects of JM-20 on human blood cells: A multi-target compound with potential therapeutic applications
Blood Cells Mol Dis. 2024 Jan 19;106:102827. doi: 10.1016/j.bcmd.2024.102827. Online ahead of print.ABSTRACTJM-20 is a 1,5-benzodiazepine compound fused to a dihydropyridine fraction with different pharmacological properties. However, its potential toxic effects on blood cells have not yet been reported. Thus, the present study aimed to investigate, for the first time, the possible cytotoxicity of JM-20 through cell viability, cell cycle, morphology changes, reactive species (RS) to DCFH-DA, and lipid peroxidation in human leukocytes, its hemolytic effect on human erythrocytes, and its potential DNA genotoxicity using plas...
Source: Blood Cells, Molecules and Diseases - February 1, 2024 Category: Hematology Authors: Fernanda D'Avila da Silva Maria Eduarda de Andrade Galiciolli Ana Carolina Irioda Cl áudia Sirlene Oliveira Bruna Candia Piccoli Alessandro de Souza Prestes Bruna Cogo Borin Andre Passaglia Schuch Estael Ochoa-Rodr íguez Yanier Nu ñez-Figueredo Jo ão Source Type: research

Investigation of the cytotoxicity, genotoxicity and antioxidant prospects of JM-20 on human blood cells: A multi-target compound with potential therapeutic applications
Blood Cells Mol Dis. 2024 Jan 19;106:102827. doi: 10.1016/j.bcmd.2024.102827. Online ahead of print.ABSTRACTJM-20 is a 1,5-benzodiazepine compound fused to a dihydropyridine fraction with different pharmacological properties. However, its potential toxic effects on blood cells have not yet been reported. Thus, the present study aimed to investigate, for the first time, the possible cytotoxicity of JM-20 through cell viability, cell cycle, morphology changes, reactive species (RS) to DCFH-DA, and lipid peroxidation in human leukocytes, its hemolytic effect on human erythrocytes, and its potential DNA genotoxicity using plas...
Source: Blood Cells, Molecules and Diseases - February 1, 2024 Category: Hematology Authors: Fernanda D'Avila da Silva Maria Eduarda de Andrade Galiciolli Ana Carolina Irioda Cl áudia Sirlene Oliveira Bruna Candia Piccoli Alessandro de Souza Prestes Bruna Cogo Borin Andre Passaglia Schuch Estael Ochoa-Rodr íguez Yanier Nu ñez-Figueredo Jo ão Source Type: research

Investigation of the cytotoxicity, genotoxicity and antioxidant prospects of JM-20 on human blood cells: A multi-target compound with potential therapeutic applications
Blood Cells Mol Dis. 2024 Jan 19;106:102827. doi: 10.1016/j.bcmd.2024.102827. Online ahead of print.ABSTRACTJM-20 is a 1,5-benzodiazepine compound fused to a dihydropyridine fraction with different pharmacological properties. However, its potential toxic effects on blood cells have not yet been reported. Thus, the present study aimed to investigate, for the first time, the possible cytotoxicity of JM-20 through cell viability, cell cycle, morphology changes, reactive species (RS) to DCFH-DA, and lipid peroxidation in human leukocytes, its hemolytic effect on human erythrocytes, and its potential DNA genotoxicity using plas...
Source: Blood Cells, Molecules and Diseases - February 1, 2024 Category: Hematology Authors: Fernanda D'Avila da Silva Maria Eduarda de Andrade Galiciolli Ana Carolina Irioda Cl áudia Sirlene Oliveira Bruna Candia Piccoli Alessandro de Souza Prestes Bruna Cogo Borin Andre Passaglia Schuch Estael Ochoa-Rodr íguez Yanier Nu ñez-Figueredo Jo ão Source Type: research

Investigation of the cytotoxicity, genotoxicity and antioxidant prospects of JM-20 on human blood cells: A multi-target compound with potential therapeutic applications
Blood Cells Mol Dis. 2024 Jan 19;106:102827. doi: 10.1016/j.bcmd.2024.102827. Online ahead of print.ABSTRACTJM-20 is a 1,5-benzodiazepine compound fused to a dihydropyridine fraction with different pharmacological properties. However, its potential toxic effects on blood cells have not yet been reported. Thus, the present study aimed to investigate, for the first time, the possible cytotoxicity of JM-20 through cell viability, cell cycle, morphology changes, reactive species (RS) to DCFH-DA, and lipid peroxidation in human leukocytes, its hemolytic effect on human erythrocytes, and its potential DNA genotoxicity using plas...
Source: Blood Cells, Molecules and Diseases - February 1, 2024 Category: Hematology Authors: Fernanda D'Avila da Silva Maria Eduarda de Andrade Galiciolli Ana Carolina Irioda Cl áudia Sirlene Oliveira Bruna Candia Piccoli Alessandro de Souza Prestes Bruna Cogo Borin Andre Passaglia Schuch Estael Ochoa-Rodr íguez Yanier Nu ñez-Figueredo Jo ão Source Type: research

Investigation of the cytotoxicity, genotoxicity and antioxidant prospects of JM-20 on human blood cells: A multi-target compound with potential therapeutic applications
Blood Cells Mol Dis. 2024 Jan 19;106:102827. doi: 10.1016/j.bcmd.2024.102827. Online ahead of print.ABSTRACTJM-20 is a 1,5-benzodiazepine compound fused to a dihydropyridine fraction with different pharmacological properties. However, its potential toxic effects on blood cells have not yet been reported. Thus, the present study aimed to investigate, for the first time, the possible cytotoxicity of JM-20 through cell viability, cell cycle, morphology changes, reactive species (RS) to DCFH-DA, and lipid peroxidation in human leukocytes, its hemolytic effect on human erythrocytes, and its potential DNA genotoxicity using plas...
Source: Blood Cells, Molecules and Diseases - February 1, 2024 Category: Hematology Authors: Fernanda D'Avila da Silva Maria Eduarda de Andrade Galiciolli Ana Carolina Irioda Cl áudia Sirlene Oliveira Bruna Candia Piccoli Alessandro de Souza Prestes Bruna Cogo Borin Andre Passaglia Schuch Estael Ochoa-Rodr íguez Yanier Nu ñez-Figueredo Jo ão Source Type: research

Investigation of the cytotoxicity, genotoxicity and antioxidant prospects of JM-20 on human blood cells: A multi-target compound with potential therapeutic applications
Blood Cells Mol Dis. 2024 Jan 19;106:102827. doi: 10.1016/j.bcmd.2024.102827. Online ahead of print.ABSTRACTJM-20 is a 1,5-benzodiazepine compound fused to a dihydropyridine fraction with different pharmacological properties. However, its potential toxic effects on blood cells have not yet been reported. Thus, the present study aimed to investigate, for the first time, the possible cytotoxicity of JM-20 through cell viability, cell cycle, morphology changes, reactive species (RS) to DCFH-DA, and lipid peroxidation in human leukocytes, its hemolytic effect on human erythrocytes, and its potential DNA genotoxicity using plas...
Source: Blood Cells, Molecules and Diseases - February 1, 2024 Category: Hematology Authors: Fernanda D'Avila da Silva Maria Eduarda de Andrade Galiciolli Ana Carolina Irioda Cl áudia Sirlene Oliveira Bruna Candia Piccoli Alessandro de Souza Prestes Bruna Cogo Borin Andre Passaglia Schuch Estael Ochoa-Rodr íguez Yanier Nu ñez-Figueredo Jo ão Source Type: research

Investigation of the cytotoxicity, genotoxicity and antioxidant prospects of JM-20 on human blood cells: A multi-target compound with potential therapeutic applications
Blood Cells Mol Dis. 2024 Jan 19;106:102827. doi: 10.1016/j.bcmd.2024.102827. Online ahead of print.ABSTRACTJM-20 is a 1,5-benzodiazepine compound fused to a dihydropyridine fraction with different pharmacological properties. However, its potential toxic effects on blood cells have not yet been reported. Thus, the present study aimed to investigate, for the first time, the possible cytotoxicity of JM-20 through cell viability, cell cycle, morphology changes, reactive species (RS) to DCFH-DA, and lipid peroxidation in human leukocytes, its hemolytic effect on human erythrocytes, and its potential DNA genotoxicity using plas...
Source: Blood Cells, Molecules and Diseases - February 1, 2024 Category: Hematology Authors: Fernanda D'Avila da Silva Maria Eduarda de Andrade Galiciolli Ana Carolina Irioda Cl áudia Sirlene Oliveira Bruna Candia Piccoli Alessandro de Souza Prestes Bruna Cogo Borin Andre Passaglia Schuch Estael Ochoa-Rodr íguez Yanier Nu ñez-Figueredo Jo ão Source Type: research

Gingival overgrowth approached using recent mechanical and laser technologies: A case report
Exp Ther Med. 2024 Jan 8;27(2):84. doi: 10.3892/etm.2024.12374. eCollection 2024 Feb.ABSTRACTGingival enlargement is a side effect of different drug classes, with calcium channel blockers being among the most often cited examples. Most often accompanied by a disruption in the oral biofilm, this form of gingival overgrowth, with histological signs of hyperplasia and hypertrophy, becomes a chronic inflammatory condition with the oral biofilm a primary cause. This periodontal disease is now classified as 'dental biofilm-induced gingivitis', and its preferred name is drug-influenced gingival expansion. The present study presen...
Source: Experimental and Therapeutic Medicine - January 26, 2024 Category: General Medicine Authors: Laurenta Lelia Mihai Ioanina Parlatescu Anca Calin Alexandru Burcea Source Type: research

High-throughput drug screen identifies calcium and calmodulin inhibitors that reduce JCPyV infection
Antiviral Res. 2024 Feb;222:105817. doi: 10.1016/j.antiviral.2024.105817. Epub 2024 Jan 19.ABSTRACTJC polyomavirus (JCPyV) is a nonenveloped, double-stranded DNA virus that infects the majority of the population. Immunocompetent individuals harbor infection in their kidneys, while severe immunosuppression can result in JCPyV spread to the brain, causing the neurodegenerative disease progressive multifocal leukoencephalopathy (PML). Due to a lack of approved therapies to treat JCPyV and PML, the disease results in rapid deterioration, and is often fatal. In order to identify potential antiviral treatments for JCPyV, a high-...
Source: Antiviral Research - January 21, 2024 Category: Virology Authors: Avery C S Bond Mason A Crocker Michael P Wilczek Jeanne K DuShane Amanda L Sandberg Lucas J Bennett Nicholas R Leclerc Melissa S Maginnis Source Type: research

Pregnancy-associated changes in urinary uromodulin excretion in chronic hypertension
CONCLUSIONS: In summary, we demonstrate pregnancy-associated differences in urinary uromodulin: creatinine ratio and uromodulin excretion rate between chronic hypertensive and normotensive pregnancies. Further research is needed to fully understand uromodulin physiology in human pregnancy and establish uromodulin's potential as a biomarker for renal adaptation and renal function in pregnancy.PMID:38236469 | DOI:10.1007/s40620-023-01830-6 (Source: Journal of Nephrology)
Source: Journal of Nephrology - January 18, 2024 Category: Urology & Nephrology Authors: Sheon Mary Fran Conti-Ramsden Philipp Boder Humaira Parveen Dellaneira Setjiadi Jessica Fleminger Anna Brockbank Delyth Graham Kate Bramham Lucy Charlotte Chappell Christian Delles Source Type: research

Biological Activity of a Coumarin Derivative on Heart Failure Using an Ischemia/Reperfusion Injury Model
Drug Res (Stuttg) DOI: 10.1055/a-2228-4258Heart failure is a health problem worldwide. There are some drugs for it, including digoxin, spironolactone, captopril, and valsartan, but some of these drugs can produce secondary effects, such as arrhythmia, cough, hyperkalemia, hyponatremia and hypotension. The aim of this research was to evaluate the biological activity of coumarin (2H-chromen-2-one) and its derivatives (3BrAcet-C, 3–4Br-Ph-C, 4-CN-7D-C, 4-Me-7-Ph-C and 6Br-3-D-C) against ischemia/reperfusion injury as a therapeutic alternative for heart fa...
Source: Drug Research - January 17, 2024 Category: Drugs & Pharmacology Authors: Figueroa-Valverde, Lauro Rosas-Nexticapa, Marcela Alvarez-Ramirez, Magdalena Melgarejo-Guti érrez, Montserrat Mateu-Armand, Virginia Garcimarrero-Espino, Alejandra Tags: Original Article Source Type: research

Utility of nifedipine use for Doppler ultrasound early after liver transplantation to predict short-term complications and long-term outcomes
ConclusionShort-term complication rates and long-term outcomes for patients with liver transplant who responded to nifedipine administration on Doppler US are similar to those who did not require nifedipine administration. A lack of response to nifedipine was associated with a higher re-operation rate. (Source: Abdominal Imaging)
Source: Abdominal Imaging - January 14, 2024 Category: Radiology Source Type: research

Unagi: Deep Generative Model for Deciphering Cellular Dynamics and In-Silico Drug Discovery in Complex Diseases
Res Sq. 2023 Dec 18:rs.3.rs-3676579. doi: 10.21203/rs.3.rs-3676579/v1. Preprint.ABSTRACTHuman diseases are characterized by intricate cellular dynamics. Single-cell sequencing provides critical insights, yet a persistent gap remains in computational tools for detailed disease progression analysis and targeted in-silico drug interventions. We introduce UNAGI, a deep generative neural network tailored to analyze time-series single-cell transcriptomic data. This innovative tool captures the complex cellular dynamics underlying disease progression, enhancing drug perturbation modeling and discovery. When applied to a dataset f...
Source: Cell Research - January 10, 2024 Category: Cytology Authors: Jun Ding Yumin Zheng Jonas Schupp Taylor Adams Geremy Clair Aurelien Justet Farida Ahangari Xiting Yan Paul Hansen Marianne Carlon Emanuela Cortesi Marie Vermant Robin Vos Laurens De Sadeleer Ivan Rosas Ricardo Pineda John Sembrat Melanie K önigshoff Joh Source Type: research

A Highly Chemically Robust 3D Interpenetrated MOF Heterogeneous Catalyst for the Synthesis of Hantzsch 1,4 ‐Dihydropyridines and Drug Molecules
This report inaugurates the usage of a MOF material as a catalyst for the synthesis of drug molecules. (Source: Small)
Source: Small - January 9, 2024 Category: Nanotechnology Authors: Rupam Sahoo, Bikram Pramanik, Supriya Mondal, Madhab C. Das Tags: Research Article Source Type: research