Got Autofluorescence?
Problem Solved!Autofluorescence muddies data and can lead to incorrect solutions. Using ourFluoMateTM ,you can trust your results. Check it out today.FluoMute ™ ready-to-use reagent to reduce autofluorescence in cells and tissue. Just incubate fixed cells of tissue sections with FluoMute™ for 30-60 min at room temperature, rinse with PBS and continue with immunofluorescence ICC or/and IHC protocols. Treatment with FluoMute™ does not affect cell morp hology and the integrity of tissue antigens to be detected with primary antibodies. FluoMute™ is compatible with paraffin-embedded and frozen tissue sec...
Source: Neuromics - April 25, 2017 Category: Neuroscience Tags: autofluorescence FluoMute IHC Immunofluorescence Immunohistochemistry Source Type: news
Hypoxia Induced Angiogenesis and Tumor Microenvironment
Neuromic ' s HUVECS Used in Study The tumor microenvironment is essential for promoting tumor physiology, structure, function, and growth. It is important that emerging therapies eradicate both tumors and related microenvironment. This important study focuses on the formation of these microenvironments:ERICA K. SCHNETTLER. THE FUNCTIONAL ROLE OF MIR-210 IN HYPOXIA-INDUCED ANGIOGENESIS. A DISSERTATION SUBMITTED TO THE FACULTY OF THE UNIVERSITY OF MINNESOTA. FEBRUARY 2017...Primary Human umbilical vein endothelial cells (HUVEC)were purchased from Lonza (Basel, Switzerland) and Neuromics (Edina, MN)...Figure: miR-210 sensitiz...
Source: Neuromics - April 19, 2017 Category: Neuroscience Tags: angiogenesis endothelial cells human umbilical cord endothelial cells Tumor tumor cells tumor initiation tumor microenvironment Source Type: news
mGluRs Protect OPCs
Valuable for Remyelination of Damaged Neurons We add a new publication to our mGluR Markers Category:Arthur M. Butt, Ilaria Vanzulli, Maria Papanikolaou, Irene Chacon De La Rocha, Virginia E. Hawkins. Metabotropic Glutamate Receptors Protect Oligodendrocytes from Acute Ischemia in the Mouse Optic Nerve. Neurochem Res (2017).doi:10.1007/s11064-017-2220-1. Its focus is the protective characteristics of mGluRs.Images: Expression ofmGluR in optic nerve oligodendrocytes. a RT-qPCR of mGluR subtypes in the postnatal (P8 –12) and young adult (P30–35) optic nerve, compared to cortex at the same ages (inset); data are expressed...
Source: Neuromics - April 13, 2017 Category: Neuroscience Tags: Metabotropic glutamate receptor; mGluR5 Oligodendrocyte Precursor Cells OPCs Optic Nerve Source Type: news
Need the Beat?
Check out our Cardiomyocytes!We are pleased to announce the addition ofrat and mouse myocytes to our extensive catalog ofprimary and stem cells.Questions? Do not hesitate to contact me directly atpshuster@neuromics.com or 612-801-1007. Thank you. Pete Shuster, CEO and Owner (Source: Neuromics)
Source: Neuromics - April 6, 2017 Category: Neuroscience Tags: cardiomyocytes Source Type: news
Immuno-fluorescence in 3-D
Potent Markers! We are seeing more3-D Cell Based Assays being used for Neuroscience Research. It is important researchers have theNeuron-Astroglial-Progenitor Markers required for staining in 3-D. This helps researchers determine the cell types present in their assays.I have posted here published results. I would like to share the latest: Yiting Liu, Katherine S. Given,Danielle E. Harlow, Adeline M. Matschulat, Wendy B. Macklin, Jeffrey L. Bennett and Gregory P. Owens. Myelin-specific multiple sclerosis antibodies cause complement-dependent oligodendrocyte loss and demyelination. Acta Neuropathologica Communications Neuros...
Source: Neuromics - March 31, 2017 Category: Neuroscience Tags: ' neuronal markers 3-D Cell based Assays 3-D Cell Culturing Cerebellar Organoids Neurofilament Markers Neurofilament-H Antibody Source Type: news
Targeted Delivery of Our UCB Derived hMSCs
Liver-targeting Delivery via Intravenous Injection of Cells Check out how ourUCB Human Mesenchymal Stem Cells are engineered for delivery to the liver:Hahn, Sei Kwang (Pohang-si, KR), Kim, Yun Seop (Seoul, KR), Kong, Won Ho (Pohang-si, KR),Kim, Hyemin (Daegu, KR). HYALURONIC ACID DERIVATIVES AND COMPOSITION FOR CELL-SURFACE ENGINEERING USING THE SAME. United States Patent Application 20170067012.Images: Neuromics ' hMSCS in culturePreparation method of a hyaluronic acid derivative capable of modifying the surface of cells and also having biocompatibility, biodegradability, and liver-targeting deliver property, and use of t...
Source: Neuromics - March 26, 2017 Category: Neuroscience Tags: adult stem cells Human Mesenchymal Stem Cells Targeted Delivery of Stem Cells UCB Derived hMSCs Umblical Cells Source Type: news
High Titer Cathepsin Antibodies
Used in Thyroid Gland ResearchWe strive to provide quality tools to studyproteases and apoptosis. Here is a publication featuring 2 of ourCathepsin Antibodies: Jonas Weber, Joseph McInnes, Cise Kizilirmak, Maren Rehders, Maria Qatato, Eva K. Wirth, Ulrich Schweizer, Francois Verrey, Heike Heuer, Klaudia Brix.Interdependence of thyroglobulin processing and thyroid hormone export in the mouse thyroid gland. European Journal of Cell Biology. Available online 6 March 2017. doi.org/10.1016/j.ejcb.2017.02.002... goat anti-cathepsin B (GT15047; 1 in 1000, Neuromics through Acris, Herford, Germany),goat anti-cathepsin L (GT15049; ...
Source: Neuromics - March 18, 2017 Category: Neuroscience Tags: caspase cathepsin cathepsin antibodies cathepsin-B cathepsin-L Proteases thyroid Source Type: news
Certified and Potent FBS
We Use It for ourPrimary, Human Cell Culture MediaWe have a low introductoryFetal Bovine Serum price for this week only (3/13-3/19)=$299/500 ml.BUY NOWHRMECs were initiated by elutriation from dissociated normal human retinal tissue. Passage 3 cells are ship in proliferating culture with a confluency of greater than 90 %.ENDO-Growth medium containing5% serum and growth supplements are recommended for culture. Cells have an average additional population doubling levels>16 when cultured. (Source: Neuromics)
Source: Neuromics - March 13, 2017 Category: Neuroscience Tags: Cell Cultures endothelial cells FBS Fetal Bovine Serum Human Retinal Microvascular Cells Human Retinal Microvascular Endothelial Cells Source Type: news
Adult Primary Neurons
Build Yourself a Stock. We now haveadult primary neurons that can be passaged up to 5 times! You can now build a stock of 20-30 million cells.Human primary neurons are isolated from brain cortical tissue. We highly recommend culturing in our human neuron growth media (cat#HNM001).Check out our manyPrimary Neuron and Astrocyte options.ECS DerivedhN2 Human Primary Neurons grown in culture for 4 days and stained with ourchicken polyclonal to Neurofilament light or low molecular weight chain NF-L, a marker of neurons. Many of the differentiating cells show strong cytoplasmic and clearly fibrillar staining for NF-L. B...
Source: Neuromics - March 6, 2017 Category: Neuroscience Tags: ' neuronal markers Astrocyte Markers Glia Markers primary human cells Primary Human Neurons Source Type: news
Staining Tissue From Space Mice
OurSynaptic Marker is Used to Compare Earth vs Space SamplesExposure to the microgravity conditions of spaceflight alleviates the load normally imposed by the Earth ’s gravitational field upon the inner ear utricular epithelia. Previous ultrastructural investigations showed that spaceflight induced an increase in synapse density within hair cells of the rat utricle. However, the utricle exhibits broad physiologic heterogeneity across different epithelial regi ons, and it is unknown whether capabilities for synaptic plasticity generalize to hair cells across its topography. To achieve systematic and broader sampling of th...
Source: Neuromics - March 1, 2017 Category: Neuroscience Tags: Shank 1a antibody Spaceflight Synaptic Loss Synaptic Markers Synaptic Plasticity Source Type: news
Holistic Medicine for the Brain
Mind Expansion? There is a slowly growing body of support for certain hallucinogenic serotonin-like molecules supporting cognitive gains, antidepressant effects and changes in brain areas related to attention, self-referential thought, and internal mentation. These molecules are present inVirola Ayahuascaand used in traditional native South American medicine.Here researchers found thatin silico systems biology analyses support 5- MeO-DMT ’s anti-inflammatory effects and reveal a modulation of proteins associated with the formation of dendritic spines, including proteins involved in cellular protrusion formation, mic...
Source: Neuromics - February 20, 2017 Category: Neuroscience Tags: 5-methoxy-N 5HT Antibodies 5HT2AR Antibody Depression Human Neural Progenitors N-dimethyltryptamine Serotonin Source Type: news
Human Melanoma Cancer Associated Fibroblasts
More Hard to Find Human CellsWe are recognized for providing potent, pure and easy to cultureCAFs and Immortalized Tumor Cells. We are pleased to announce the addition ofMelanoma CAFS. Our introductory price is only 899 USD/1,000,000 Cells. They have been successfully passaged 10X..Image: Human Melanoma Cells in CultureNeed CAFs or Tumor Cells? Just email me atpshuster@neuromics.com. (Source: Neuromics)
Source: Neuromics - February 13, 2017 Category: Neuroscience Tags: CAFs Cancer Associated Fibroblasts Melanoma Skin Cancer Source Type: news
Desperately Seeking Data
In this study, researchers showed that oscillating nanomagnetic gene transfection could be used to successfully transfect SH ‐SY5Y cells as well asour primary hippocampal and cortical neurons on different days in vitro. This novel technique was used to effectively deliver genetic material into various cell types, resulting in high transfection efficiency and viability. Mahendran Subramanian, Aimee ‐Jayne Tyler, Eva Maria Luther, Elena Di Daniel, Jenson Lim and Jon Dobson. Oscillating Magnet Array−Based Nanomagnetic Gene Transfection: A Valuable Tool for Molecular Neurobiology Studies. Nanomaterials 2017, 7, 28; doi:1...
Source: Neuromics - January 31, 2017 Category: Neuroscience Tags: e-18 Primary Rat Cortical Neurons E18 Primary Hippocampal Neurons GFP Reporter GFP Transfection magnetic assisted transfection Source Type: news
mCherry and GFP
Excellent Markers These markers are stoutfluorescent tracers for transfection and transgenic experiments. Here is data showing ourmCherry Mouse Monoclonal Antibody Staining transfected HeLa Cells.Image: Mouse mononclonal mCherry antibody used to stain transfected Hela Cells (see:Catherine M Duclos, Audrey Champagne, Julie C Carrier, Caroline Saucier, Christine L Lavoie& Jean-Bernard Denault. Caspase-mediated proteolysis of the sorting nexin 2 disrupts retromer assembly and potentiates Met/hepatocyte growth factor receptor signaling. Cell Death Discovery 3, Article number: 16100 (2017) doi:10.1038/cddiscovery.2016.100)....
Source: Neuromics - January 28, 2017 Category: Neuroscience Tags: GFP Antibody GFP Reporter Green Fluorescent Protein Antibody mCherry Antibody Transfection Markers Source Type: news
Leptin and Remyelination
Leptin Promotes Proliferation of OPCs Demyelination occurs in many diseases of the Central Nervous System (CNS) including Multiple Sclerosis and Parkinson ' s Disease. Here researchers show that Leptin plays a role in the proliferation of Oligodendrocyte Precursor Cells (OPCs): These cells are critical for keeping the myelin sheath on Neurons of the CNS healthy and happy. Ken Matoba, Rieko Muramatsu& Toshihide Yamashita. Leptin sustains spontaneous remyelination in the adult central nervous system. Scientific Reports 7, Article number: 40397 (2017) doi:10.1038/srep40397.OurLepRB Antibody is used in this study to s...
Source: Neuromics - January 21, 2017 Category: Neuroscience Tags: LepRb antibody Leptin Multiple Sclerosis Oligodendrocyte Precursor Cells OPCs Parkinson ' s Disease Source Type: news
