ATP and Pain
P2XRs Play a Key RoleIn dorsal root ganglion (DRG) neurons, ATP is an important neurotransmitter in nociceptive signaling through P2 receptors (P2Rs) such as P2X2/3R, and adenosine is also involved in anti-nociceptive signaling through adenosine A1R.ENNPs interact with P2XRs to metabolize ATP to AMP in DRGs. Kentaro Nishida, Yuka Nomura, Kanako Kawamori, Akihiro Ohishi, Kazuki Nagasawa.ATP metabolizing enzymes ENPP1, 2 and 3 are localized in sensory neurons of rat dorsal root ganglion. European Journal of Histochemistry 2018; 62:2877.Images: Rat DRG stained withNeuromics P2X2Rand ENPP1.Modulating ATP Processing in DRG...
Source: Neuromics - April 19, 2018 Category: Neuroscience Source Type: news
Long Term Culturing of Cells
Non-Perfusion ModelResearchers, for some studies, are demanding the ability to maintain vibrant cultures for long periods of time.Perfusion models afford this, but are expensive, sensitive and require specialized expertise. Given this, I believed it a good time to represent a protocol that can be used for ourprimary neurons and can be extrapolated to many of our other primary and stem cells.Here's the complete protocol.Rose Ludescher, Manager of Customer Satisfaction, is an expert in helping our customers successfully culturing cells. So if you need help with any of your cell-based assays do not hesitate to contact her. Ju...
Source: Neuromics - April 14, 2018 Category: Neuroscience Tags: Cell based assays Cell Cultures cell culturing protocol Neurons Source Type: news
National Eye Institute's 3-D ROC Challenge
Are you Ready?Neuromics is a proudSponsor of this challenge. It enables us to further leverage our potent, proven and published3-D Cell-Based Assay Solutions into drug discovery for eye-related diseases.Our solution set includes 21-CFR Complianthuman primary and stem cells and research ready custom and off the shelf 3-D Models. We also provide defined media and supplements.Neuromics 3-D Blood-Brain Barrier ModelIn addition to models, we offer: ECMS•Engineered hydrogels optimized for cell types•Coming soon: Bio-Inks for 3-D Printing-Engineered for Cells•NanofibersNeuromics ’ HUVECS in an engin...
Source: Neuromics - April 7, 2018 Category: Neuroscience Tags: 3-D Assays. 3-D imaging 3-D Cell based Assays 3-D ROC Challenge Collagen Hydrogels National Eye Insititute Source Type: news
Unmasking Root Causes of Stress/Anxiety
i-Fect Knocks Down Suspected Stress/Anxiety ReceptorThe molecular pathogenesis underlying anxiety disorders is still unclear. Here, the authors demonstrate that myristoylated alanine-rich C-kinase substrate like 1 (MARCKSL1) overexpression in mice increases spine formation in the amygdala and induces stress hormone upregulation and anxiety-like behaviors. Suppression of MARCKSL1 in the amygdala ameliorates both the increase in stress hormones and the elevated anxiety-like behaviors. Our results indicate that MARCKSL1 expression in the amygdala plays an important role in anxiety-like behaviors.This was proved, in part, by t...
Source: Neuromics - March 29, 2018 Category: Neuroscience Tags: Anxiety gene expression analysis i-Fect MARCKSL1 Source Type: news
Give it a Try
You will be SatisfiedOurFBS is growing in popularity over the past year. In follow up with users, we learned that our low price catalyzed their trying, but its potency resulted in high levels of satisfaction.Here are some recent reviews:I enjoyed working with the people at Neuromics. The sale person was very friendly and willing to take extra time to solve our problems. Organization: Mayo User: Wenqian Hu - Oct 15, 2017 - Rating: 5.0 Great Service. Got the products in a very prompt manner! Kemin AgriFoods North AmericaVM - Jul 27, 2017 - Rating: 4.0 Fast and easy supplier to work with! Organization: Fresenius Kab...
Source: Neuromics - March 23, 2018 Category: Neuroscience Tags: FBS Fetal Bovine Serum Source Type: news
Great Growth Factors
Potent and ProvenOurgrowth factors continue to be referenced in leadingpublications. They are excellent for amping up your stem-cell expansion and differentiation media-Tom Kamperman, Sieger Henke, Claas Willem Visser, Marcel Karperien, Jeroen Leijten. (2017).Centering Single Cells in Microgels via Delayed Crosslinking Supports Long-Term 3D Culture by Preventing Cell Escape. Small, doi: 10.1002/smll.201603711.We will continue to post updates. (Source: Neuromics)
Source: Neuromics - March 15, 2018 Category: Neuroscience Tags: BDNF Brain-Derived Neurotrophic Factor FGF Basic FGF2 Fibroblast Growth Factor 2 GDNF Protein Source Type: news
HUVECS in 3-D Action
In this study, the authors developed a 3D functional human microvascular network in a microfluidic device. The established model enables NeuromicsGFP-labeled human umbilical vein endothelial cells to form vessel-like microtissues and have physiological functions which are closer to cells in human blood vessels. The perfusable microvasculature allows the delivery of nutrients, and oxygen, as well as flow-induced mechanical stimuli into the luminal space of the endothelium. The microflow effectively mimic the blood flow in human vessels.Thisin-vivo like model is then used for toxicity assays-Yan Li, Qing-Meng Pi, Peng-Cheng ...
Source: Neuromics - March 2, 2018 Category: Neuroscience Tags: 3-D Cell based Assays 3-D Cell Culturing endothelial cells huvecs Microfluidics Tox assays Source Type: news
Primary Human Astrocytes vs Derived Astrocytes Cell Lines
Potent, Pure and Easy to CultureWe are often asked how ourhuman primary astrocytes stack up versus engineered astrocyte cell lines. Astrocyte cultures, whether primary or engineered, need to mimic how they workin-vivo.This publication is a comprehensive study of the capabilities of our primary astrocytes versus engineered cells. Anders Lundin, Louise Delsing, Maryam Clausen, Piero Ricchiuto, Jos é Sanchez, Alan Sabirsh, Mei Ding, Jane Synnergren, Henrik Zetterberg, Gabriella Brolén, Ryan Hicks, Anna Herland, and Anna Falk. (2018).Human iPS-Derived Astroglia from a Stable Neural Precursor State Show Impro...
Source: Neuromics - February 22, 2018 Category: Neuroscience Tags: astrocyte cultures Astrocyte Markers human Astrocytes iPSCs Source Type: news
i-Fect Delivers Again and Again
This study revealed that LDHA, which is a known damage marker, promotes CNS-specific angiogenesis. LDHA-mediated angiogenesis depends on vimentin on the surface of vascular endothelial cells. The work described here proposes a novel mechanism by which neurodegeneration drives angiogenesis in the CNS.A mixture of ouri-FectTM and LDHA siRNA, in this study, were directly injected into mice cortexes: Hsiaoyun Lin, Rieko Muramatsu, Noriko Maedera, Hiroto Tsunematsu, Machika Hamaguchi, Yoshihisa Koyama, Mariko Kuroda, Kenji Ono, Makoto Sawada, Toshihide Yamashita.Extracellular Lactate Dehydrogenase A Release ...
Source: Neuromics - February 19, 2018 Category: Neuroscience Tags: angiogenesis Delivering siRNA to the CNS Lactate Hydrogenase A LDHA Neurodegenerative Disease siRNA delivery in-vivo Source Type: news
iPSC Derived Human Neural Progenitors
Potent, Pure and Easy to CultureWe are pleased to announce the addition of HumanNeural Progenitors to ourPrimary and Stem Cell offering.Human Neural Progenitors at 95% ConfluencyCell potency, for us, includes the how well our cells can be differentiated into terminal types. For these progenitors, we have protocols for differentiating into neurons, astrocytes, and oligodendrocytes.Neural Progenitors differentiated into Neurons and Stained with Tuj-1We also have Neural Progenitors from Alcohol and Opioid-Addicted Donors. (Source: Neuromics)
Source: Neuromics - February 15, 2018 Category: Neuroscience Tags: astrocyte cultures Astrocytes Culturing Human Neurons Protocol Human Neural Progenitors Neuroprogenitors Oligodendrocytes Source Type: news
Culturing Cells in Defined 3-D Structures
In this study, the authors present in-air microfluidics (IAMF), a new chip-free platform technology that enables in-flight (that is, on-the-fly) formation of droplets, fibers, and particles and their one-step deposition into 3D constructs with a modular internal architecture.Figure: Concept of IAMF and guide to the article. (A) Chip-based microfluidics enables in-line control over droplets and particles, making it a versatile platform technology. A chip design where droplets (blue) are transported by a coflow (pink) is shown. (B) IAMF maintains the in-line control of chip-based microfluidics but relies on jet ejection and ...
Source: Neuromics - February 7, 2018 Category: Neuroscience Tags: 3-D Bioprinting 3-D Cell based Assays Bio-inks Fibroblast Growth Factor Basic Human Mesenchymal Stem Cells ISOKine FGF Source Type: news
From Healthy and Diseased DonorsWe continue to addhuman primary and derived cells important to your research.We now haveHuman Hepatocytes. They come from healthy and drug-addicted donors.Like all our cells, these are potent, pure and easy to culture.iPSC Derived HeptocytesHuman HepatocytesHC4230 Cell Assays1,000,000 Cells$795.00Human HepatocytesHC4230 Cell Assays500,000 Cells$595.00Human Hepatocytes - Alcohol AddictedHC4230AA Cell Assays1,000,000 Cells$895.00Human Hepatocytes - Alcohol AddictedHC4230AA Cell Assays500,000 Cells$695.00Human Hepatocytes - Opioid AddictedHC4230OP&nbs...
Source: Neuromics - February 4, 2018 Category: Neuroscience Tags: Human Heptaocytes iPSCs Source Type: news
By Cancer Researchers OurApoptosis Kits have proven rock solid in the hands of cancer researchers.Here's data from a study of the impact of Vestibular schwannoma (VS) on hearing loss.Images: Spiral Ganglion Cells labeled with our polycaspase kit stain to identify apoptotic cells. (Source: Neuromics)
Source: Neuromics - January 31, 2018 Category: Neuroscience Tags: Apoptosis Assays Apoptosis Detection Polcaspase Kits Spiral Ganglion Cells Vestibular Schwannoma Source Type: news
Culturing Neurons on Conductive Biomaterials
In this study, researchers successfully culture ourcortical neurons onNonfunctionalized graphene nanosheets (NGN): Shiyun Meng, Rong Peng. Growth and Follow-Up of Primary Cortical Neuron Cells on Nonfunctionalized Graphene Nanosheet Film. Article first published online: January 18, 2018. https://doi.org/10.5301/jabfm.5000263.Figure: Spray-coating a nonfunctionalized graphene nanosheet (NGN) on a glass slide. To fix the NGN onto the glass slide, polyurethane (PU) was firstly spin-coated onto glass slides as a polymer matrix, then NGN particles were spray-coated on by airbrush.Figure: Nuclei formed in 7 and 14 days of cell c...
Source: Neuromics - January 23, 2018 Category: Neuroscience Tags: conductive biomaterials e-18 Primary Rat Neurons graphene Source Type: news
Cells from Diseased Donors
Focus on Neuro Diseases We now have the capability to provide cells of the central and peripheral nervous system from donors with Neuro diseases. These include cells from donors with ALS, AD, PD, and Brain Cancer Donors, to name a few.We have provided cells to virtually all the large Pharmas and many small and mid-size Bio-techs. We have worked with Novartis to gain 21-CFR compliance for cells that they are using for their eye diseases drug discovery programs.I am at your “beck and call” should you have interested in exploring specific capabilities further. You can e-mail or call me at 612-801-1007 (Source: Neuromics)
Source: Neuromics - January 15, 2018 Category: Neuroscience Tags: 3-D Cell based Assays ALS Alzheimer ' s Disease Amyotrophic Lateral Sclerosis glioblastomas Parkinson Source Type: news
Microvascular Endothelial Cells
Tested, Characterized and Research ReadyOurMicrovascular Endothelial Cells continue to work and work in the hands of our customers.Check out these pubs:1. Odunayo O. Mugisho, Colin R. Green, Jie Zhang, Nicolette Binz, Monica L. Acosta, Elizabeth Rakoczy and Ilva D. Rupentha. (2017).Immunohistochemical Characterization of Connexin43 Expression in a Mouse Model of Diabetic Retinopathy and in Human Donor Retinas. Int. J. Mol. Sci. doi: 10.3390/ijms18122567 2. Michael Anthony Ruiz, Biao Feng, and Subrata Chakrabarti. (2015).Polycomb Repressive Complex 2 Regulates MiR-200b in Retinal Endothelial Cells: Potential Relev...
Source: Neuromics - January 9, 2018 Category: Neuroscience Tags: Diabetic retinopathy endothelial cells human microvascular endotothelial cells Human Retinal Microvascular Endothelial Cells Source Type: news
Medical Grade Soluble Collagen
This study developed a macroporous scaffold that is fabricated by weaving highly aligned collagen threads. The scaffold can deliver high density cell condensates while providing mechanical stiffness comparable to that of cartilage. The scaffold also mimicked the arcade-like orientation of collagen fibers in cartilage. A highly robust chondrogenesis was observed in this mesenchymal cell pellet delivery system. Baseline mechanical robustness of this scaffold system will enable delivery of cell pellets as early as three days. (Source: Neuromics)
Source: Neuromics - January 3, 2018 Category: Neuroscience Tags: 3-D Cell based Assays 3-D collagen scaffolds cartilage human chondrocytes Human Mesenchymal Stem Cells Source Type: news
Cell to Cell Signaling and Depression
This study also features the use of our excellentGFAP markersAbstract: Extracellular ATP is a widespread cell-to-cell signaling molecule in the brain, where it functions as a neuromodulator by activating glia and neurons. Although ATP exerts multiple effects on synaptic plasticity and neuro-glia interactions, as well as in mood disorders, the source and regulation of ATP release remain to be elaborated. Here, we define Calhm2 as an ATP-releasing channel protein based on in vitro and in vivo models. Conventional knockout and conditional astrocyte knockout of Calhm2 both lead to significantly reduced ATP concentrations, loss...
Source: Neuromics - December 21, 2017 Category: Neuroscience Tags: ATP release Depression Glia Glia Markers Neurons Source Type: news
Big Thank You!
Big YearWe exceeded our goals for 2017. By a lot. Both in sales and new products.I would like to personally thank our customers, collaborators, and friends for making this happen. You made it happen.I wish Joy to you in 2018!I wish you exciting, new discoveries, and adventures.Pete Shuster, CEO and Owner, Neuromics. (Source: Neuromics)
Source: Neuromics - December 13, 2017 Category: Neuroscience Tags: Neuromics Source Type: news
Coming Soon Hepatocytes and CSCS
Differentiated from iPSCs Neuromics is partnering withJaveen Biosciences to bring you Cancer Stem Cells and Hepatocytes derived from donor Induced Pluripotent Stem Cells.Rodney Nash, Javeen CEO, and his team are working to fill a major gap in cell-based drug discoveries. The lack of cells from specific diseased or ethnic populations. This limits the ability to predict how well a drug candidate will work with a diverse population of patients.Dr. Rodney Nash, CEO, Javeen BiosciencesOver time, we envision Javeen Biosciences as having the ability to engineer cells from donors that match tightly with the needs of drug hunters.W...
Source: Neuromics - December 8, 2017 Category: Neuroscience Tags: Cancer Stem Cells Drug Discovery Hepatocytes Source Type: news
Need Cells? Contest is Now Live
It's Easy! Creatively insert your favoritehuman cell culture(s) anywhere into a picture of your lab for $25 Amazon Gift Card. To enter, email the picture to email@example.com with a description of the image that includes your name, the lab name and the type of cells being cultured.First 100 entries are eligible for the gift card.Grand prize is $500 Visa Gift Card. Only entries that include the culture of Neuromics cells will be eligible for the grand prize.Official Contest Rules: Only one entry per lab. The first 100 entries are eligible. Cells cultured do not have to be Neuromics cells to be elig...
Source: Neuromics - November 29, 2017 Category: Neuroscience Tags: 3-D Cell based Assays Human Stem Cells needcells primary human cells Source Type: news
Need Cells? Contest
We're live; Be CreativeWe are offering a $25 Amazon Gift Card to scientists who creatively places images their favorite cell cultures anywhere in a picture of their lab AND if the picture has images ofour human cells, you could win a $500 VISA card.Here's a link to learn more about our Need Cells Contest.Please email your picture firstname.lastname@example.org and we will email you a $25 Amazon Gift Card. (Source: Neuromics)
Source: Neuromics - November 21, 2017 Category: Neuroscience Tags: Cell Cultures needcells primary human cells Source Type: news
Coming Soon-Need Cells? Contest
Creativity RewardedWe are revving up another contest as ourNeuromics Brain Adventure was successful and wow, were people creative.We are expert at finding humanprimary and stem cells so cell cultures are central to the contest. Rules are simple. Affix an image of your favorite cell culture anywhere in your lab and we will email you a $25 Amazon gift card.The contest will run for 3 months and the most creative entry will receive a $500 Visa Gift Card.Simply e-mail your entry to email@example.com and we will email back the gift card. Multiple entries encouraged. (Source: Neuromics)
Source: Neuromics - November 16, 2017 Category: Neuroscience Tags: astrocyte cultures Astrocyte-Glial-Neuron Co-cultures. endothelial cells needcells Source Type: news
More FBS Data!
Cells+Media Supplemented with our FBS!We continue to be pleased with the cell culture images our customers are sharing with us-https://www.neuromics.com/fbs-dataNeurons are notoriously hard to culture. Here're images of Mouse Neurons cultured in media supplemented with our FBS.Images: Mouse cortical neurons in culture, using Neuromics heat-inactivated FBS (in plating media for two days). Data courtesy of Dr. Saif at Barrow Neurological Institute.We continue to offer $50 Amazon Gift Card in return for data you share using any of our solutions. Just email the data to Rose Ludescher, Manager of Customer Satisfaction,rose@neur...
Source: Neuromics - November 6, 2017 Category: Neuroscience Tags: Cell based assays FBS Fetal Bovine Serum Neurons Source Type: news
3-D Retina Organoid Challenge
Proud SponsorThe National Eye Institute has its sights set on stimulating researchers to move rapidly toward treatments for retinal diseases. We need your scientific expertise: compete in a Challenge to develop a physiologically-competent3-D retina organoid model.Check us out on theirSponsor's Page. (Source: Neuromics)
Source: Neuromics - October 23, 2017 Category: Neuroscience Tags: 3-D Retinal Organoids Human Retinal Microvascular Endothelial Cells NEI Source Type: news
More Neuromics' FBS Related Data
Cells Cultured in Media Supplemented with our FBSCustomers continue submitting data. Here's the latest:Primary mouse vascular smooth muscle cells stained with smooth muscle alpha-actin in DMEM with Neuromics10% FBS. Image courtesy of Deng-Fu Guo, University of Iowa.HEK Cells Grown in Neuromics FBS. Image courtesy of Kavita Shah, Purdue University.We will continue be posting new FBS related data here. (Source: Neuromics)
Source: Neuromics - October 12, 2017 Category: Neuroscience Tags: FBS Fetal Bovine Serum HEK Cells Smooth Muscle Cells Source Type: news
Neuromics' FGF-2 for Expanding Human Cells
FGF-2 and Fibrochondrocytes FGF-2 of FGF-basic is an important a growth factor for manycell-based assays. Neuromics'has rock solidFGFs for supplementing media used to grow cells. Check outpublications referencing use of FGF-2.Here's the latest publication: Yan Liang, Enaam Idrees, Stephen H. J. Andrews, Kirollos Labib, Alexander Szojka, Melanie Kunze, Andrea D. Burbank, Aillette Mulet-Sierra, Nadr M. Jomha& Adetola B. Adesida.Plasticity of Human Meniscus Fibrochondrocytes: A Study on Effects of Mitotic Divisions and Oxygen Tension. Scientific Reports 7, Article number: 12148 (2017) doi:10.1038/s41598-017-12096-x. ...
Source: Neuromics - September 30, 2017 Category: Neuroscience Tags: FGF Basic FGF Basic Recombinant Protein FGF2 Fibroblast Growth Factor 2 Fibroblast Growth Factor Basic fibroblasts ISOKine ISOKineFGF Source Type: news
i-Fect Delivers Plasmids!
Important for Gene Expression Studies.I have posted many examples of how our customers usei-FectTM and otherTransfection Solutions for Gene Manipulation Studies. There are also manypublications.Here we feature how i-Fect was used to delivery plasmids to the CNS: Sara Elramah, Mar ía José López-González, Matthieu Bastide, Florence Dixmérias, Olivier Roca-Lapirot, Anne-Cécile Wielanek-Bachelet, Anne Vital, Thierry Leste-Lasserre, Alexandre Brochard, Marc Landry& Alexandre Favereaux.Spinal miRNA-124 regulates synaptopodin and nociception in an animal model of bone ...
Source: Neuromics - September 21, 2017 Category: Neuroscience Tags: Bone Cancer Pain cancer biology iFect Plasmids Transfection Reagents Source Type: news
Dynamics of Stem Cell Differentiation
Differentiation MarkersNeuromics hasexcellent markers for determining stem cell differentiation.This new publication references use of ourOTX2 marker: Sumin Jang, Sandeep Choubey, Leon Furchtgott, Ling-Nan Zou, Adele Doyle, Vilas Menon, Ethan B Loew, Anne-Rachel Krostag, Refugio A Martinez, Linda Madisen, Boaz P Levi, Sharad Ramanathan.Dynamics of embryonic stem cell differentiation inferred from single-cell transcriptomics show a series of transitions through discrete cell states. eLife 2017;6:e20487. DOI: http://dx.doi.org/10.7554/eLife.20487Figures: Single-Cell Gene Expression Profiling of mESCs during early germ layer ...
Source: Neuromics - September 16, 2017 Category: Neuroscience Tags: OTX-2 antibody Otx2 Antibody Stem Cell Differentiation Stem Cell Differentiation Protocol Stem cell markers Source Type: news
New Pub References 3 MarkersWe are recognized for our large catalog ofneuronal markers. Our strength, in this area, includes markers designed for pain researchers.They are widely used and frequently published. This new publication references use of ourGuinea Pig Substance P,Guinea Pig PGP9.5 andChicken NF200 of NF-Heavy. andla, Jagadeesha, Lomada, Santosh Kumara, Jianninga; Kuner, Rohinia, Bali, Kiran Kumar.miR-34c-5p functions as pronociceptive microRNA in cancer pain by targeting Cav2.3 containing calcium channels. Pain: September 2017 - Volume 158 - Issue 9 - p 1765 –1779 doi: 10.1097/j.pain.0000000000000971....
Source: Neuromics - September 1, 2017 Category: Neuroscience Tags: Neurofilament Antibody Neurofilament-H Antibody Neuronal Markers PGP9.5 Antibody Protein Gene Product 9.5 Substance P Antibody Source Type: news
FBS Works Great for Cell Lines
More Customer DataWe are pleased with the continuing stream of positive feedback on our potentFBS. This includes its supplementing media for cell lines.Here is an image courtesy of Kavita Shah of Purdue University.Image: HEK Cells cultured in Media Supplemented with Neuromics'FBSWe offer the best price anywhere. We will beat all competitive pricing. If you are interested, contact Rose Ludescher, Manager of Customer Satisfaction. email: firstname.lastname@example.org. (Source: Neuromics)
Source: Neuromics - August 31, 2017 Category: Neuroscience Tags: FBS Fetal Bovine Serum HEK Cells Source Type: news
Data Trifecta-Cells, Media + FBS
Optimizing your Cell-Based AssaysResearchers need solid proof that the solutions the use will work in their assays. Given the time and effort it takes to culture human primary cells, it is important that the media and supplements used are optimized.We engineer our cell media and supplements to work with our primary and stem cells. Its potency is tested every day in our cell cultures.As further proof, we ask customers to share their data with us. We reward them by emailing a 50 USD Amazon gift card. I would like to recognize Emily Rodela from TGEN for sharing the Trifecta ofNeuromics'CAFS grown inMSC-Gro Media suppleme...
Source: Neuromics - August 21, 2017 Category: Neuroscience Tags: CAFs Cancer Associated Fibroblasts FBS Fetal Bovine Serum MSCgro Pancreatic CAF-Stellate Cells Source Type: news
Neuromics' ISOKine bFGF in 3-D Cultures
Works Well in Perfusion ModelsOurISOKineTM FGF is produced in the endosperm tissue of barley grain (Hordeum vulgare), that exhibits up to 50 times less protease activity than E.coli or mammalian cells. Barley seed is void of any human or animal viral contaminants that could jeopardize your cell culture.It is a proven solution for all cell cultures and starts at the low price of 65 USD/10 ug.Here's a reference of its use in 3-D Cultures: Tom Kamperman, Sieger Henke, Claas Willem Visser, Marcel Karperien, Jeroen Leijten.Centering Single Cells in Microgels via Delayed Crosslinking Supports Long-Term 3D Culture by Pr...
Source: Neuromics - August 14, 2017 Category: Neuroscience Tags: FGF Basic FGF Basic Recombinant Protein Fibroblast Growth Factor 2 Fibroblast Growth Factor Basic ISOKineFGF Stem cell cultures Source Type: news
Cancer Associated Fibroblasts in Action
Publication ReferenceWe introduced ourCancer Associated Fibroblasts to researchers several years ago. The demand was strong from day one and continues to grow.We are pleased to announce the first reference in a Cancer Research Publication: Zenobia D'Costa, Keaton Jones, Abul Azad, Ruud van Stiphout, Su Y Lim, Ana L Gomes, Paul Kinchesh, Sean C Smart, W. Gillies McKenna, Francesca M Buffa, Owen J. Sansom, Ruth J. Muschel, Eric O'Neill and Emmanouil Fokas.Gemcitabine-induced TIMP1 attenuates therapy response and promotes tumor growth and liver metastasis in pancreatic cancer. Published OnlineFirst August 1, 2017 doi: 10.1158...
Source: Neuromics - August 9, 2017 Category: Neuroscience Tags: CAFs Cancer Associated Fibroblasts pancreas cancer Pancreatic CAF-Stellate Cells pancreatic cancer Pancreatic tumor cells Source Type: news
Pain and Inflammation Markers
Our TRPV1 Markers RockAs sales of ourCell Based Assay Solutions continue to explode. We don't want you to forget that our roots firmly remain in products forInflammation and Pain Researchers.To verify this, you only need to check out the many publications referencing use of ourTRPV1 Markers.Image: Immunoreactivity for CXCL12 was detected in the macrophages (F4/80) (Source: Neuromics)
Source: Neuromics - August 5, 2017 Category: Neuroscience Tags: Neuropathic Pain TRPV1 antibodies TRPV1 antibody Vanilloid Receptor Antibodies Vanilloid Receptor Antibody Source Type: news
Immune Response Research Solutions
Cytokine Markers and MoreImmune and inflammatory response are elevated in most diseases. We have strong solutions for detecting these responses. These includecytokine markers andpanels.Here's a new pub referencing use of one of ourInterleukin Markers. ArdoSabir and AndiSumidarti.Interleukin-6 expression on inflammed rat dental pulp tissue after capped withTrigona sp. propolis. Saudi Journal of Biological Sciences Volume 24, Issue 5, July 2017, Pages 1034-1037. doi.org/10.1016/j.sjbs.2016.12.019 ...Four rats were sacrificed at 6 h, 2 days, 4 days and 7 days respectively. The teeth and surrounding bone were resected, fixed i...
Source: Neuromics - July 31, 2017 Category: Neuroscience Tags: Cytokine Antibody Arrays Cytokine signaling IL-6 antibody ILs Interleukin-6 antibody Interleukins Source Type: news
Quality, High Titer Neuronal Markers
You Need Them; We got Them We are recognized for both the number and quality ofNeuronal Markers. Check out our manytestimonials from satisfied customers.Here's a sampling of recentpublications.Elisabet Garcia-Pino, Nikodemus Gessele and Ursula Koch.Enhanced Excitatory Connectivity and Disturbed Sound Processing in the Auditory Brainstem of Fragile X Mice. Journal of Neuroscience 3 July 2017, 2310-16; doi.org/10.1523/JNEUROSCI.2310-16.2017. ...chicken α-MAP2 (Neuromics; dilution 1:1000)...Anna Lisa G ündner Claas Aiko Meyera, Stefan Aigner, Klaus Christensen, Christoph Patsch, Ravi Jagasia, Karlheinz Baumann, Mar...
Source: Neuromics - July 24, 2017 Category: Neuroscience Tags: embryonic stem cells MAP Markers MAP2 antibody neural markers Neurofilament Antibody Neurofilament Markers Neuronal Markers Source Type: news
Electrical Preconditioning of Stem Cells
Cool Science The ability to manipulate hNPCs via a conductive scaffold creates a new approach to optimize stem cell-based therapy and determine which factors (such as VEGF-A) are essential for stroke recovery: Paul M. Georgea, Tonya M. Blissb, Thuy Huab, Alex Leed, Byeongtaek Oh, Alexa Levinson, Swapnil Mehta, Guohua Sun, Gary K. Steinberg.Electrical preconditioning of stem cells with a conductive polymer scaffold enhances stroke recovery. doi.org/10.1016/j.biomaterials.2017.07.020...anti βIII-tubulin (1:500, Neuromics, Edina, MN)...Image: Neural progenitors were labeled with anti-ratNestinpolyclonal antibody (Cat#:GT...
Source: Neuromics - July 17, 2017 Category: Neuroscience Tags: Human Neural Progenitors nestin antibody Stem cell markers Tuj 1 (Neuron-specific class III beta-tubulin) antibody Tuj-1 antibody Source Type: news
New Human RPES and BMSCS
NeedHuman Cells? Just Ask!This is our cornerstone and we keep building on it. You asked for them. We are pleased to announce we now haveHuman Bone Marrow-Derived Stem Cells (BMSCs) andRetinal Pigment Epithelial Cells (RPES).RPES in Culture.BMSCS in Culture.We will continue to post new cell offerings here. (Source: Neuromics)
Source: Neuromics - July 11, 2017 Category: Neuroscience Tags: BMSCs Bone marrow derived stem cells Human Mesenchymal Stem Cells Retinal Pigment Epithelial Cells RPES Source Type: news
3D Printing the Way to Artificial Muscles
Muscles Contract Under the Control Motor Neurons The methods used to develop the artificial muscles included use of ourGDNF Protein to maintain motor neurons in the 3-D Culture-Caroline Cvetkovic, Max H. Rich, Ritu Raman, Hyunjoon Kong , Rashid Bashir.A 3D-printed platform for modular neuromuscular motor units. Microsystems; Nanoengineering 3, Article number: 17015 (2017) doi:10.1038/micronano.2017.15Skeletal muscle cells and motor neurons were combined into a fabricated 3D co-culture system. C2C12 myoblasts were differentiated into multinucleated myotubes (a) and combined with extracellular matrix (ECM) proteins to c...
Source: Neuromics - July 6, 2017 Category: Neuroscience Tags: 3-D Cell based Assays 3-D Cell Culturing 3-D Printing GDNF Protein motor neurons Source Type: news
Renal Nerves and Blood Pressure
Role of Calcitonin gene-related peptide (CGRP) CGRP is a potent vasodilator so it is not surprising ourCGRP Antibody was used in this study. Cust ódio AH, de Lima MC, Vaccari B, Boer PA, Gontijo JAR (2017)Renal sodium handling and blood pressure changes in gestational protein-restricted offspring: Role of renal nerves and ganglia neurokinin expression. PLoS ONE 12(6): e0179499. https://doi.org/10.1371/journal.pone.0179499Figure. Comparative expression of SP and CGRP in the renal pelvis of 16-week-old rats. The pictures show a normal distribution of these neurokinins in NP (A and D). In LP offspring, no difference wa...
Source: Neuromics - July 5, 2017 Category: Neuroscience Tags: Blood Pressure CGRP antibody sodium channels Source Type: news
Petaka Cell Culturing System in Action
In this study, for hypoxia induction, Petaka G3 low oxygen transfer flasks (Neuromics) were used to culture melanoma cell lines or primary melanocytes for 48 –96 h at 37°C until>80% confluent: Rachel L. G. Maus, James W. Jakub, Wendy K. Nevala, Trace A. Christensen, Klara Noble-Orcutt, Zohar Sachs, Tina J. Hieken, and Svetomir N. Markovic.Human Melanoma-Derived Extracellular Vesicles Regulate Dendritic Cell Maturation. Front Immunol. 2017; 8: 358. Published online 2017Mar 29. doi: 10.3389/fimmu.2017.00358.Hypoxia increases extracellular vesicles (EVs) production in metastatic melanoma cell line SKMEL28 not pri...
Source: Neuromics - June 27, 2017 Category: Neuroscience Tags: Hypoxia Induction Melanocytes Melanoma Melanoma Cell Lines Petaka Cell Culturing Systems Petaka G3 LOT Source Type: news
Gap Junctions (GJs) and Glaucoma
This study references use of ourGFAP Antibody,Gap junctions (GJs), intercellular channels composed of subunit connexins, can play a major role in secondary cell death by forming conduits through which toxic molecules from dying cells pass to and injure coupled neighbors. Secondary cells like glia and astrocytes are involved in this process though the precise mechanisms have yet to be defined: Abram Akopian, Sandeep Kumar, Hariharasubramanian Ramakrishnan, Kaushambi Roy, Suresh Viswanathan, and Stewart A. Bloomfield.Targeting neuronal gap junctions in mouse retina offers neuroprotection in glaucoma. J Clin Invest. doi:10.11...
Source: Neuromics - June 21, 2017 Category: Neuroscience Tags: Astrocyte Marker Gap Junctions GFAP Antibody Glaucoma Glial Fibrillary Acidic Protein Antibody Glial Markers Neuronal Markers Source Type: news
Modeling HIV Latency
Generation of Infected NeuronsResearchers have developed a Neuronal Cell Line for the study of HSV-1 infection in humans. This line was developed by terminally differentiating human embryonic stem cells to neurons.Ourmouse monoclonal nestin antibodywas used as a marker for the neural progenitor phase of this differentiation.Aldo Pourchet, Aram S. Modrek, Dimitris G. Placantonakis, Ian Mohr and Angus C. Wilson. Modeling HSV-1 Latency in Human Embryonic Stem Cell-Derived Neurons. Pathogens 2017, 6(2), 24; doi:10.3390/pathogens6020024.Image: In vitro derivation of human neural stem cells by differentiation of the Hes5::G...
Source: Neuromics - June 13, 2017 Category: Neuroscience Tags: Culturing Human Neurons Protocol HIV Human Neural Progenitors nestin antibody neural progenitor markers Neuronal Differentation Source Type: news
How They Find Us and What they Buy Trust is hard to maintain and easily lost. It is important to us that our customers can find us and the products required to meet their research needs.In order to nurture trust, we follow up with each and every customer to make sure they are happy with their Neuromics'experience. We include the opportunity for them to formally rate this experience @ https://birdeye.com/neuromics-186498936.We plan on rolling out a new website. Our goal is to make it even easier for customers to find us and present content in a way that aligns with customers'needs. This includes making sure c...
Source: Neuromics - June 7, 2017 Category: Neuroscience Tags: 3D Cell Based Assays. Antibodies biomarkers primary human cells primary human endothelial cells Primary Human Neurons Source Type: news
Your Help NeededWe will be rolling out a new Neuromics'Website in August 2017. Our goal is to make it easy for you to find us and the solutions that meet your needs. Your input will help us achieve this. We have ashort survey. (Source: Neuromics)
Source: Neuromics - June 6, 2017 Category: Neuroscience Source Type: news
Rose Hip and Heart Disease
This study features the use of ourABCA1 Antibody. The ATP-binding cassette transporter (ABC) Protein called ABCA1 has a major impact on cellular and whole body cholesterol metabolism and is likely to play an important role in protecting against cardiovascular disease.The authors conclude that rose hip is a suitable dietary supplement for preventing atherosclerotic plaques formation by modulating systemic blood pressure and the expression of RCT and inflammatory genes.Michele Cavalera, Ulrika Axling, Catarina Rippe, Karl Sw ärd, and Cecilia Holm. Dietary rose hip exerts anti-atherosclerotic effects and increases nitric...
Source: Neuromics - May 30, 2017 Category: Neuroscience Tags: ABCA1 atherosclerosis Blood Pressure cholestrol metabolism heart Source Type: news
Parkinson's Disease and the Striatum
This study came to my attention the researchers used ourEnkaphalin Antibody as a marker for the Dopaminergic Neurons. Image: Mouse striatum stained with D2 cell marker Enkephalin (RA14124) in green and with neuronal marker NeuN in red courtesy of Dr Heike Rebholz of City College of New York (Source: Neuromics)
Source: Neuromics - May 24, 2017 Category: Neuroscience Tags: Dopamine Midbrain Dopamanergic Neurons Parkinson ' s Disease ppENK antibody Striatal Neurons Striatum Cultures Source Type: news
TRPV1 Channels and Neuropathic Pain
Neuromics'TRPV1 Stain Neurons and Microglia for Study TRPV1 is mainly functional in the microglia. Its activation, beyond controlling microglia reaction per se, modulated microglia-neuron communication, by promoting release of extracellular vesicles (EVs) from microglia. Indeed, EVs are important mediators of intercellular communication between microglia and brain cells: Maria Cristina Marrone, Annunziato Morabito, Michela Giustizieri, Valerio Chiurchi ù, Alessandro Leuti, Marzia Mattioli, Sara Marinelli, Loredana Riganti, Marta Lombardi, Emanuele Murana, Antonio Totaro, Daniele Piomelli, Davide Ragozzino, Sergio Od...
Source: Neuromics - May 19, 2017 Category: Neuroscience Tags: Microglia Neuropathic Pain Transient Receptor Potential Vanilloid 1 Receptor Antibodies TRPV1 antibody TRPV1-N Antibody Vanilloid Receptor Antibody Source Type: news
Designed for Your Success.The roots of ourTRPV1 Antibodies run deep. They have been key to our ongoing success. We have been providing them to Researchers since the inception of Neuromics (12 years ago).We measure our success one Researcher at a time. Positive feedback includes references in manypublications. There are indeed " Tested; Characterized and Research Ready "Here's a pub hot off the presses: No émi Bohonyi, Krisztina Pohóczky, Bálint Szalontai, Anikó Perkecz, Krisztina Kovács, Béla Kajtár, Lajos Orbán, Tamás Varga, Sarolta Sz...
Source: Neuromics - May 15, 2017 Category: Neuroscience Tags: Transient Receptor Potential Vanilloid 1 Receptor Antibodies TRPV1 TRPV1 antibodies TRPV1 antibody TRPV1s VR1-C antibody VR1-N Antibody Source Type: news