Brain Freeze!
Our Friend are Taking Neuromics Brain on Interesting #brainadventureIt is getting harder to select the winners. You can submit your entry now and earn a chance to win our monthly $100 monthly and $500 grand prize. To enter see: http://www.neuromics.com/brain-adventure-contest.We can all relate to this. (Source: Neuromics)
Source: Neuromics - October 20, 2015 Category: Neuroscience Tags: #BrainAdventure Source Type: news
hNP1 Neural Progenitors and Neuronal Regeneration after Injury
In this study, researchers used our hNP1TM Neural Progenitors to demonstrate that axonal PPARγ is involved in neuronal injury responses required for axonal regeneration: Juan Pablo Lezana, Shachar Y. Dagan, Ari Robinson, Ron S. Goldstein, Mike Fainzilber, Francisca C. Bronfman, and Miguel Bronfman. Axonal pparγ promotes neuronal regeneration after injury. DOI: 10.1002/dneu.22353... Culture and regeneration analysis of human axons. NP1 human neural precursors were purchased from Neuromics (Minnesota, USA) and passaged up to 8 times before generation of neurons. Cells were used up until passage 10 after defrosting the purc...
Source: Neuromics - October 13, 2015 Category: Neuroscience Tags: hNP1 Neural Progenitors Neurite outgrowth Neuronal Differentation Neuronal Regeneration PPARgamma Source Type: news
#brainadventure Update
2 Win $100 Monthly Prices!Our customers are creative. They find interesting #brainadventures for our Neuromics' Brains. Competitive hing for winning our $100 monthly and $500 grand prizes: more entries raise your odds of winning.Here're some of the submissions:Learn how you can win @ http://www.neuromics.com/brain-adventure-contest.Good luick to all. (Source: Neuromics)
Source: Neuromics - October 1, 2015 Category: Neuroscience Tags: #BrainAdventure Source Type: news
Retinal Microvascular Endothelial Cells & Diabetic Retinopathy
In this study, the authors show that human retinal microvascular endothelial cells exposed to high levels of glucose regulate miR-200b repression through histone methylation and that inhibition of PRC2 increases miR-200b while reducing VEGF: Michael Anthony Ruiz, Biao Feng, and Subrata Chakrabarti. Polycomb Repressive Complex 2 Regulates MiR-200b in Retinal Endothelial Cells: Potential Relevance in Diabetic Retinopathy. PLoS One. 2015; 10(4): e0123987. Published online 2015 Apr 17. doi: 10.1371/journal.pone.0123987...To investigate PRC2 and miR-200b regulation in the context of diabetic retinopathy, the major cell type use...
Source: Neuromics - September 26, 2015 Category: Neuroscience Tags: Glucose HRMECS Human Endothelial Cells Human Retinal Microvascular Cells VEGF Source Type: news
Mouse and Human Motor Neurons
Designed for Neuro-muscular Diseases ResearchClients have been using our easy to culture and research proven GFP Labeled Mouse Motor Neurons for Neuro-muscular disease research. This includes the inclusion of the cells in several ALS drug discovery programs being conducted by large Pharma.Image: GFP+ mMN Mouse Motor Neurons at 2 days post thaw 20X.I am pleased to announce the addition of Human Motor Neurons to our Primary Human, Mouse and Rat Neurons, Astrocytes and Neuron-Astroglial co-culture solutions.Image: Human alpha-Motor NeuronsQuestions? Do not hesitate to contact me directly, Pete Shuster, CEO and Owne...
Source: Neuromics - September 17, 2015 Category: Neuroscience Tags: ALS Amyotrophic Lateral Sclerosis GFP labeled mouse motor neurons Human Motor Neurons MS Multiple Sclerosis Source Type: news
hNP1 Neural Progenitors and HTS Tox Assays
This article demonstrates the sensitivity of Neuromics' hNP1TM Neural Progenitors to chemically induced apoptosis: Ingrid Druwea, Theresa M. Freudenrich, Kathleen Wallace, Timothy J. Shafer, William R. Mundy. Sensitivity of neuroprogenitor cells to chemical-induced apoptosis using a multiplexed assay suitable for high-throughput screening. doi:10.1016/j.tox.2015.03.011. Summary: The results demonstrate that, (1) all three commercially available models generated a robust source of proliferating neuroprogenitor cells, and that the assay was sensitive and reproducible when used in a multi-well plate format; (2) there were dif...
Source: Neuromics - September 11, 2015 Category: Neuroscience Tags: Apoptosis Cytotoxicity Assays Highthroughput Screening Highthroughput Toxicity Screening hNP1 Neural Progenitors Neurotoxicity Tox assays Source Type: news
Connective-Tissue Growth Factor (CTGF/CCN2) Induces Astrogenesis
SOX-2 Proves a Marker For AstrogenesisThis proved surprising to the authors of a recent publication referencing use of our Monoclonal SOX-2 Antibody. We have added our SOX-2 abs to our Glial-Astrocyte Markers. See: Fabio A. Mendes , Juliana M. Coelho Aguiar , Suzana A. Kahn, Alice H. Reis, Luiz Gustavo Dubois, Luciana Ferreira Romão, Lais S. S. Ferreira, Hervé Chneiweiss, Vivaldo Moura Neto, José G. Abreu. Connective-Tissue Growth Factor (CTGF/CCN2) Induces Astrogenesis and Fibronectin Expression of Embryonic Neural Cells In Vitro. Published: August 4, 2015DOI: 10.1371/journal.pone.0133689...monoclonal anti-Sox2 (...
Source: Neuromics - September 3, 2015 Category: Neuroscience Tags: astrocyte cultures Astrocyte Marker Astrocyte marker antibody Atrogenesis Glial Markers sox2 antibody Source Type: news
Small Molecules/Peptides for Pain Researchers
Agonists, Antagonists, Inhibitors and LigandsThe roots of Neuromics is providing solutions for the study of nociceptive and neuropathic pain. Our tools are widely used and frequently published. We are pleased to bring you these small molecules designed to help you better understand the roots of pain and potential therapies. Figure: Infarct volume after 3 days of reperfusion in the ipsilateral cortex and CP complex in male rats treated with vehicle saline (n=15) or 1 mg/kg per hour BRL 52537 (n=15) started at onset of reperfusion and continued for 22 hours (male-vehicle n=15; male-BRL n=15; mean±SEM). P<.0.05. Related ...
Source: Neuromics - August 28, 2015 Category: Neuroscience Tags: agonists antagonists chronic pain Inflammatory pain inhibitors ligands Neuropathy Nociception Nociceptive Pain Peptides Small Molecules Source Type: news
Take Your Neuromics' Brain on an Adventure
Grand Prize is 500 USD!Have fun. We can't wait to see your ideas.#brainadventure (Source: Neuromics)
Source: Neuromics - August 26, 2015 Category: Neuroscience Tags: #BrainAdventure Source Type: news
Have Brain; Will Travel
Join the Adventure and You Could Win 500 USD Contest begins September 2015. Monthly winners receive 100 USD. Contest will run for 6 months. Grand prize is 500 USD.Join Neuromics on our#BrainAdventure to see all the interesting and unique locations the brain ventures. Starting this September, with all orders, you will receive a Neuromics brain keychain. Take a creative picture or short video of the Neuromics Brain Keychain and tweet it @Neuromics, post it on Neuromics Facebook or LinkedIn Page and be entered in our contest. In the meantime, if you want to join the contest, e-mail rose@neuromics.com and she wi...
Source: Neuromics - August 14, 2015 Category: Neuroscience Tags: #BrainAdventure Neuromics Source Type: news
Medical Marijuana Research
What we are learning.I have reported here Medical Marijuana research and its therapeutic value for treating pain. The specifics posts feature publications that reference use of our Pain and Inflammation Research Markers. These include: J. Desroches, J.-F. Bouchard, L. Gendron, P. Beaulieu. Involvement of cannabinoid receptors in peripheral and spinal morphine analgesia ☆ Neuroscience, Volume 261, 7 March 2014, Pages 23–42.http://dx.doi.org/10.1016/j.neuroscience.2013.12.030.Iryna A. Khasabova,Sergey Khasabov, Justin Paz, Catherine Harding-Rose, Donald A. Simone, and Virginia S. Seybold. Cannabinoid Type-1 Receptor Redu...
Source: Neuromics - August 12, 2015 Category: Neuroscience Tags: 5HT Antibodies 5HT2AR Antibody Cognition Medical Marijuana Memory Pain Source Type: news
New Human Brain Microvascular Cells
HBMECS for BBB ResearchersI am pleased by the growing positive response to our Human Endothelial Cells offerings. Our Human Brain Microvascular Endothelial Cells have, far and away, been the most popular. We want to make it easier for you to "buy and try" We are offering them for only 699 USD/500,000 Cells through Aug. 31st, 2015. Note: customers have passaged these cells up to 15 X.Image: Human Brain Microvascular Endothelial Cells in Culture.Questions? Please contact me: pshuster@neuromics.com or 612-801-1007. (Source: Neuromics)
Source: Neuromics - August 8, 2015 Category: Neuroscience Tags: BBB Blood Brain Barrier Endothelial Cell Proliferation HBMECs human brain microvascular cells Source Type: news
Gene Expression-Have it Your Way
From Delivery to Stable ExpressionNeuromics has a successful track record of helping our clients delivery siRNA, miRNA, Plasmids and other oligos in vitro and in vivo with our Transfection Kits...But my vision with our cell based assay solutions has always been to provide engineered cells and plasmids modified to study your genes of interest. I am pleased to announce we are working with Smart Cell /B-MoGen Technologies to make this happen. We now can provide:Gene Transfer and Expression Products Leveraging the Sleeping Beauty Technology: Images: B-MoGen Transposon exhibiting stable expression of five fluorescent genes.&nbs...
Source: Neuromics - August 3, 2015 Category: Neuroscience Tags: gene expression analysis Gene Silencing gene transfer lentiviruses sleeping beauty Transfection Reagents transposons Source Type: news
Neuropeptides and Stress
Neuropeptides Antagonists, Stress and Alcohol SeekingSelect Neuropeptides can help moderate stress and related Alcohol seeking behaviors. The authors of this study reference use of our ppENK and proDYN Neuropeptides: J.R. Schank,B.S. Nelson,R. Damadzic,J.D. Tapocik,M. Yao,C.E. King,K.E. Rowe,K. Cheng,K.C. Rice,M. Heili. Neurokinin-1 receptor antagonism attenuates neuronal activity triggered by stress-induced reinstatement of alcohol seeking. doi:10.1016/j.neuropharm.2015.07.009.Image: Mouse striatum stained with D2 cell marker Enkephalin (RA14124) in green and with neuronal marker NeuN in red courtesy of Dr Heike Rebholz o...
Source: Neuromics - July 21, 2015 Category: Neuroscience Tags: Alcohol Nociceptive Pain Pain Research ppENK antibody pro-Dynorhin Antibody stress Source Type: news
Apoptosis and Neurodegeneration
Towards the Development of Disease Specific AssaysNeurodegenerative diseases are becoming increasingly prevalent, especially in the Western societies, with larger percentage of members living to an older age. They have to be seen not only as a health problem, but since they are care-intensive, they also carry a significant economic burden. Apoptotic pathways are induced in many of these diseases and are key culprits in disease progression. Figure: Schematic representation of apoptotic pathways. Apoptosis triggered by internal (intrinsic) or external (extrinsic) stress signals that is activated by binding of ligands (e.g. ...
Source: Neuromics - July 13, 2015 Category: Neuroscience Tags: ALS Alzheimer ' s Disease Apoptosis Assays Astrocyte-Glial-Neuron Co-cultures FLICA in vitro Apoptosis Detection Kits Multiple Sclerosis neuron cultures neuronal cultures Parkinson Source Type: news
