Autophagy Assay Kits
Detects Autophagy in Living CellsAutophagy is a conserved lysosomal recycling process by which cells break down their own components such as proteins, lipids, and carbohydrates. The process plays an important role in maintaining homeostasis and destroying intracellular pathogens. In addition, autophagy can be upregulated in times of starvation or stress to provide additional nutrients for the cell. Dysregulation of autophagy has implications for cancer, infection, and degenerative diseases.Autophagy is a three-stage process. First, cytoplasmic components targeted for degradation are sequestered, resulting in the formation ...
Source: Neuromics - June 26, 2018 Category: Neuroscience Tags: Apoptosis Detection Apoptosis Visualization autophagy autophagy detection Cytotoxicity Assays necrosis Source Type: news
Markers for Tyrosine Hydroxylase-TH
Proven and PublishedTyrosine hydroxylase TH is a necessary enzyme to create neurotransmitters and protect the body against oxidative stress.Dysregulation of this enzyme results in manic-depression and schizophrenia. Parkinson ' s disease is also considered a TH deficiency as low dopamine levels are a consistent neurochemical abnormality.Markers to TH are important for studying its role in neurotransmission and how it is altered in disorders and diseases.We have many options and this enables you to choose the best markers for your research. All are proven andpublished.TH staining of mouse salivary gland tissue. https:/...
Source: Neuromics - June 14, 2018 Category: Neuroscience Tags: neuroscience TH antibody Tyrosine Hydroxlase antibody Source Type: news
Put our Antibodies to Work for You!
Tested and Characterized for Results You Can TrustWhen you select a vendor forantibodies, there is a measure of trust. We know you are asking, " will it work in the applications as advertised " .Since the inception of Neuromics, our guiding principle is providing well-characterized solutions for results you can trust and understand. In order to provide as much comfort in the purchase of our solutions, we encourage access topublications,data, andtestimonials.Here ' re some recent testimonials:Good antibody! Product Name: Tuj 1, Chicken – (Cat# CH23005) Good for neuronal staining. Bright and specific.Liang Shi - May 03, 20...
Source: Neuromics - June 6, 2018 Category: Neuroscience Tags: Antibodies Antibody TRPV1 antibodies TRPV1 antibody Source Type: news
New Fibrillarin Antibody
Potent Nucleoli MarkerGiven the importance ofNucleus and Related Markers to all branches of cell/molecular biology, we are dedicated to having the best.We have just added a newFibrillarin Antibody.Images: Immunofluorescent analysis of (A) C6 rat glioma cells and (B) Human embryonic kidney cells stained with mouse mAb to fibrillarin, MO22169, dilution 1:1,000 in red, in both cases costained with chicken pAb to vimentin, CPCA-Vim, dilution 1:10,000 in green. The blue is DAPI staining of nuclear DNA.Nop1p/Fibrillarin was originally identified as a nucleolar protein of bakers yeast, Saccharomyces cerevisiae (accession P15646)....
Source: Neuromics - June 4, 2018 Category: Neuroscience Tags: Fibrillarin Antibody Nuclear Staining Nucleoli Source Type: news
New 3-D Eye Model
Morein-vivo like ModelWe see our world in 3-D. Diseases of the eye compromise this ability.Neuromics ' is pleased to announce that we have a3-D model aimed at accelerating drug discovery for these diseases. Sight is a terrible thing to lose and the faster new drugs can be discovered, fewer people will have to suffer the loss of sight.Our 3D Human Retinal Microvascular Angiogenesis model is constructed using GFP ‐Tagged human Retinal Microvascular Endothelial cells. They are co-cultured with RFP-Tagged human supporting cells. GFP positive human retinal capillary-like tubule formation can be monitored in real time under fl...
Source: Neuromics - May 30, 2018 Category: Neuroscience Tags: 3-D Cell based Assays 3-D Cell Culturing 3-D Retinal Organoids Diabetic retinopathy Human Retinal Microvascular Endothelial Cells Source Type: news
Antibodies Against Neuropeptides
Another Nod From Nature Scientific ReportsPublications referencing use of our antibodies continue to build. We are recognized for having potentNeuropeptide Antibodies.This most recent publication references ourGuinea Pig Substance-P Antibody: Khaled Abdallah, Francis Nadeau, Francis Bergeron, Sylvie Blouin, V éronique Blais, Kelly M. Bradbury, Christine L. Lavoie, Jean-Luc Parent;, Louis Gendron. (2018). Adeno-associated virus 2/9 delivery of Cre recombinase in mouse primary afferents. Scientific Reports volume 8, Article number: 7321 (2018) doi:10.1038/s41598-018-25626-yFigure: Distribution of the Cre-GFP in the neu...
Source: Neuromics - May 20, 2018 Category: Neuroscience Tags: Neuropeptide Antibodies Neuropeptides Substance P Antibodies Substance P Antibody Source Type: news
Researchers Love our FBS
Potent Serum at a Great Price!We are pleased by the 5-star ratings on ourFetal Bovine Serum(FBS). Check them out.Outstanding service. Fetal bovine serum was of highest quality, easy to order and packaging and shipping were best possible.Rosemary Dziak - May 08, 2018 - Rating: 5.0This is first time to buy FBS from them. Rose is very nice person. they make you easy and comfortable to purchase.jie wei - Feb 16, 2018 - Rating: 5.0I enjoyed working with the people at Neuromics. The sale person was very friend and willing to take extra time to solve our problems. Product Name: FBS - (Cat#FBS001) https://www.neuromics.com/FBS001 ...
Source: Neuromics - May 10, 2018 Category: Neuroscience Tags: 3-D Cell based Assays Cell Based Assays. FBS Fetal Bovine Serum Source Type: news
Fibroblast Compression and Tumor Cells Migration
Role of Compression in MetastasisOurHuman Pancreatic Fibroblasts play a key role in this study.Pancreatic fibroblasts are continuously gaining ground as an important component of tumor microenvironment that dynamically interact with cancer cells to promote tumor progression. In addition, these tumor-infiltrated fibroblasts can acquire an activated phenotype and produce excessive amounts of extracellu lar matrix creating a highly dense stroma, a situation known as desmoplasia. Maria Kalli, Panagiotis Papageorgis, Vasiliki Gkretsi, Triantafyllos Stylianopoulos. (2018).Solid Stress Facilitates Fibroblasts Activation to Pro...
Source: Neuromics - May 1, 2018 Category: Neuroscience Tags: Cancer Associated Fibroblasts Desmoplasia Human Pancreatic Fibroblasts metastasis Source Type: news
Pure and Potent Human Primary Retinal Pigment Endothelial Cells (HRPES)
Culture ReadyNeuromics is a recognized leader in providing researchers 21-CFR CompliantPrimary Human Cells.Here we feature our newRetinal Pigment Epithelial Cell (HRPES). These hard to find cells are reasonably priced and culture ready,HRPES in CultureCells are provided at passage 3. HRPEs growth medium (contains 10% serum and growth supplements, Alpha-33) is recommended for cell culture and these cells have a minimum average population doubling capacity of 8 when cultured following the detailedprotocol. (Source: Neuromics)
Source: Neuromics - April 26, 2018 Category: Neuroscience Tags: cell culturing protocol culturing human retinal pigment epithelial cells Source Type: news
ATP and Pain
P2XRs Play a Key RoleIn dorsal root ganglion (DRG) neurons, ATP is an important neurotransmitter in nociceptive signaling through P2 receptors (P2Rs) such as P2X2/3R, and adenosine is also involved in anti-nociceptive signaling through adenosine A1R.ENNPs interact with P2XRs to metabolize ATP to AMP in DRGs. Kentaro Nishida, Yuka Nomura, Kanako Kawamori, Akihiro Ohishi, Kazuki Nagasawa.ATP metabolizing enzymes ENPP1, 2 and 3 are localized in sensory neurons of rat dorsal root ganglion. European Journal of Histochemistry 2018; 62:2877.Images: Rat DRG stained withNeuromics P2X2Rand ENPP1.Modulating ATP Processing in DRG...
Source: Neuromics - April 19, 2018 Category: Neuroscience Source Type: news
Long Term Culturing of Cells
Non-Perfusion ModelResearchers, for some studies, are demanding the ability to maintain vibrant cultures for long periods of time.Perfusion models afford this, but are expensive, sensitive and require specialized expertise. Given this, I believed it a good time to represent a protocol that can be used for ourprimary neurons and can be extrapolated to many of our other primary and stem cells.Here ' s the complete protocol.Rose Ludescher, Manager of Customer Satisfaction, is an expert in helping our customers successfully culturing cells. So if you need help with any of your cell-based assays do not hesitate to contact her. ...
Source: Neuromics - April 14, 2018 Category: Neuroscience Tags: Cell based assays Cell Cultures cell culturing protocol Neurons Source Type: news
National Eye Institute's 3-D ROC Challenge
Are you Ready?Neuromics is a proudSponsor of this challenge. It enables us to further leverage our potent, proven and published3-D Cell-Based Assay Solutions into drug discovery for eye-related diseases.Our solution set includes 21-CFR Complianthuman primary and stem cells and research ready custom and off the shelf 3-D Models. We also provide defined media and supplements.Neuromics 3-D Blood-Brain Barrier ModelIn addition to models, we offer: ECMS•Engineered hydrogels optimized for cell types•Coming soon: Bio-Inks for 3-D Printing-Engineered for Cells•NanofibersNeuromics ’ HUVECS in an engineered ECMFor ...
Source: Neuromics - April 7, 2018 Category: Neuroscience Tags: 3-D Assays. 3-D imaging 3-D Cell based Assays 3-D ROC Challenge Collagen Hydrogels National Eye Insititute Source Type: news
Unmasking Root Causes of Stress/Anxiety
i-Fect Knocks Down Suspected Stress/Anxiety ReceptorThe molecular pathogenesis underlying anxiety disorders is still unclear. Here, the authors demonstrate that myristoylated alanine-rich C-kinase substrate like 1 (MARCKSL1) overexpression in mice increases spine formation in the amygdala and induces stress hormone upregulation and anxiety-like behaviors. Suppression of MARCKSL1 in the amygdala ameliorates both the increase in stress hormones and the elevated anxiety-like behaviors. Our results indicate that MARCKSL1 expression in the amygdala plays an important role in anxiety-like behaviors.This was proved, in part, by t...
Source: Neuromics - March 29, 2018 Category: Neuroscience Tags: Anxiety gene expression analysis i-Fect MARCKSL1 Source Type: news
Give it a Try
You will be SatisfiedOurFBS is growing in popularity over the past year. In follow up with users, we learned that our low price catalyzed their trying, but its potency resulted in high levels of satisfaction.Here are some recent reviews:I enjoyed working with the people at Neuromics. The sale person was very friendly and willing to take extra time to solve our problems. Organization: Mayo User: Wenqian Hu - Oct 15, 2017 - Rating: 5.0 Great Service. Got the products in a very prompt manner! Kemin AgriFoods North AmericaVM - Jul 27, 2017 - Rating: 4.0 Fast and easy supplier to work with! Organization: Fresenius Kab...
Source: Neuromics - March 23, 2018 Category: Neuroscience Tags: FBS Fetal Bovine Serum Source Type: news
Great Growth Factors
Potent and ProvenOurgrowth factors continue to be referenced in leadingpublications. They are excellent for amping up your stem-cell expansion and differentiation media-Tom Kamperman, Sieger Henke, Claas Willem Visser, Marcel Karperien, Jeroen Leijten. (2017).Centering Single Cells in Microgels via Delayed Crosslinking Supports Long-Term 3D Culture by Preventing Cell Escape. Small, doi: 10.1002/smll.201603711.We will continue to post updates. (Source: Neuromics)
Source: Neuromics - March 15, 2018 Category: Neuroscience Tags: BDNF Brain-Derived Neurotrophic Factor FGF Basic FGF2 Fibroblast Growth Factor 2 GDNF Protein Source Type: news
