HUVECS in 3-D Action
In this study, the authors developed a 3D functional human microvascular network in a microfluidic device. The established model enables NeuromicsGFP-labeled human umbilical vein endothelial cells to form vessel-like microtissues and have physiological functions which are closer to cells in human blood vessels. The perfusable microvasculature allows the delivery of nutrients, and oxygen, as well as flow-induced mechanical stimuli into the luminal space of the endothelium. The microflow effectively mimic the blood flow in human vessels.Thisin-vivo like model is then used for toxicity assays-Yan Li, Qing-Meng Pi, Peng-Cheng ...
Source: Neuromics - March 2, 2018 Category: Neuroscience Tags: 3-D Cell based Assays 3-D Cell Culturing endothelial cells huvecs Microfluidics Tox assays Source Type: news
Primary Human Astrocytes vs Derived Astrocytes Cell Lines
Potent, Pure and Easy to CultureWe are often asked how ourhuman primary astrocytes stack up versus engineered astrocyte cell lines. Astrocyte cultures, whether primary or engineered, need to mimic how they workin-vivo.This publication is a comprehensive study of the capabilities of our primary astrocytes versus engineered cells. Anders Lundin, Louise Delsing, Maryam Clausen, Piero Ricchiuto, Jos é Sanchez, Alan Sabirsh, Mei Ding, Jane Synnergren, Henrik Zetterberg, Gabriella Brolén, Ryan Hicks, Anna Herland, and Anna Falk. (2018).Human iPS-Derived Astroglia from a Stable Neural Precursor State Show Improved Function...
Source: Neuromics - February 22, 2018 Category: Neuroscience Tags: astrocyte cultures Astrocyte Markers human Astrocytes iPSCs Source Type: news
i-Fect Delivers Again and Again
This study revealed that LDHA, which is a known damage marker, promotes CNS-specific angiogenesis. LDHA-mediated angiogenesis depends on vimentin on the surface of vascular endothelial cells. The work described here proposes a novel mechanism by which neurodegeneration drives angiogenesis in the CNS.A mixture of ouri-FectTM and LDHA siRNA, in this study, were directly injected into mice cortexes: Hsiaoyun Lin, Rieko Muramatsu, Noriko Maedera, Hiroto Tsunematsu, Machika Hamaguchi, Yoshihisa Koyama, Mariko Kuroda, Kenji Ono, Makoto Sawada, Toshihide Yamashita.Extracellular Lactate Dehydrogenase A Release ...
Source: Neuromics - February 19, 2018 Category: Neuroscience Tags: angiogenesis Delivering siRNA to the CNS Lactate Hydrogenase A LDHA Neurodegenerative Disease siRNA delivery in-vivo Source Type: news
iPSC Derived Human Neural Progenitors
Potent, Pure and Easy to CultureWe are pleased to announce the addition of HumanNeural Progenitors to ourPrimary and Stem Cell offering.Human Neural Progenitors at 95% ConfluencyCell potency, for us, includes the how well our cells can be differentiated into terminal types. For these progenitors, we have protocols for differentiating into neurons, astrocytes, and oligodendrocytes.Neural Progenitors differentiated into Neurons and Stained with Tuj-1We also have Neural Progenitors from Alcohol and Opioid-Addicted Donors. (Source: Neuromics)
Source: Neuromics - February 15, 2018 Category: Neuroscience Tags: astrocyte cultures Astrocytes Culturing Human Neurons Protocol Human Neural Progenitors Neuroprogenitors Oligodendrocytes Source Type: news
Culturing Cells in Defined 3-D Structures
In this study, the authors present in-air microfluidics (IAMF), a new chip-free platform technology that enables in-flight (that is, on-the-fly) formation of droplets, fibers, and particles and their one-step deposition into 3D constructs with a modular internal architecture.Figure: Concept of IAMF and guide to the article. (A) Chip-based microfluidics enables in-line control over droplets and particles, making it a versatile platform technology. A chip design where droplets (blue) are transported by a coflow (pink) is shown. (B) IAMF maintains the in-line control of chip-based microfluidics but relies on jet ejection and ...
Source: Neuromics - February 7, 2018 Category: Neuroscience Tags: 3-D Bioprinting 3-D Cell based Assays Bio-inks Fibroblast Growth Factor Basic Human Mesenchymal Stem Cells ISOKine FGF Source Type: news
Human Hepatocytes
From Healthy and Diseased DonorsWe continue to addhuman primary and derived cells important to your research.We now haveHuman Hepatocytes. They come from healthy and drug-addicted donors.Like all our cells, these are potent, pure and easy to culture.iPSC Derived HeptocytesHuman HepatocytesHC4230 Cell Assays1,000,000 Cells$795.00Human HepatocytesHC4230 Cell Assays500,000 Cells$595.00Human Hepatocytes - Alcohol AddictedHC4230AA Cell Assays1,000,000 Cells$895.00Human Hepatocytes - Alcohol AddictedHC4230AA Cell Assays500,000 Cells$695.00Human Hepatocytes - Opioid AddictedHC4230OP&nbs...
Source: Neuromics - February 4, 2018 Category: Neuroscience Tags: Human Heptaocytes iPSCs Source Type: news
Studying Apoptosis
By Cancer Researchers OurApoptosis Kits have proven rock solid in the hands of cancer researchers.Here ' s data from a study of the impact of Vestibular schwannoma (VS) on hearing loss.Images: Spiral Ganglion Cells labeled with our polycaspase kit stain to identify apoptotic cells. (Source: Neuromics)
Source: Neuromics - January 31, 2018 Category: Neuroscience Tags: Apoptosis Assays Apoptosis Detection Polcaspase Kits Spiral Ganglion Cells Vestibular Schwannoma Source Type: news
Culturing Neurons on Conductive Biomaterials
In this study, researchers successfully culture ourcortical neurons onNonfunctionalized graphene nanosheets (NGN): Shiyun Meng, Rong Peng. Growth and Follow-Up of Primary Cortical Neuron Cells on Nonfunctionalized Graphene Nanosheet Film. Article first published online: January 18, 2018. https://doi.org/10.5301/jabfm.5000263.Figure: Spray-coating a nonfunctionalized graphene nanosheet (NGN) on a glass slide. To fix the NGN onto the glass slide, polyurethane (PU) was firstly spin-coated onto glass slides as a polymer matrix, then NGN particles were spray-coated on by airbrush.Figure: Nuclei formed in 7 and 14 days of cell c...
Source: Neuromics - January 23, 2018 Category: Neuroscience Tags: conductive biomaterials e-18 Primary Rat Neurons graphene Source Type: news
Cells from Diseased Donors
Focus on Neuro Diseases We now have the capability to provide cells of the central and peripheral nervous system from donors with Neuro diseases. These include cells from donors with ALS, AD, PD, and Brain Cancer Donors, to name a few.We have provided cells to virtually all the large Pharmas and many small and mid-size Bio-techs. We have worked with Novartis to gain 21-CFR compliance for cells that they are using for their eye diseases drug discovery programs.I am at your “beck and call” should you have interested in exploring specific capabilities further. You can e-mail or call me at 612-801-1007 (Source: Neuromics)
Source: Neuromics - January 15, 2018 Category: Neuroscience Tags: 3-D Cell based Assays ALS Alzheimer ' s Disease Amyotrophic Lateral Sclerosis glioblastomas Parkinson Source Type: news
Microvascular Endothelial Cells
Tested, Characterized and Research ReadyOurMicrovascular Endothelial Cells continue to work and work in the hands of our customers.Check out these pubs:1. Odunayo O. Mugisho, Colin R. Green, Jie Zhang, Nicolette Binz, Monica L. Acosta, Elizabeth Rakoczy and Ilva D. Rupentha. (2017).Immunohistochemical Characterization of Connexin43 Expression in a Mouse Model of Diabetic Retinopathy and in Human Donor Retinas. Int. J. Mol. Sci. doi: 10.3390/ijms18122567 2. Michael Anthony Ruiz, Biao Feng, and Subrata Chakrabarti. (2015).Polycomb Repressive Complex 2 Regulates MiR-200b in Retinal Endothelial Cells: Potential Relev...
Source: Neuromics - January 9, 2018 Category: Neuroscience Tags: Diabetic retinopathy endothelial cells human microvascular endotothelial cells Human Retinal Microvascular Endothelial Cells Source Type: news
Medical Grade Soluble Collagen
This study developed a macroporous scaffold that is fabricated by weaving highly aligned collagen threads. The scaffold can deliver high density cell condensates while providing mechanical stiffness comparable to that of cartilage. The scaffold also mimicked the arcade-like orientation of collagen fibers in cartilage. A highly robust chondrogenesis was observed in this mesenchymal cell pellet delivery system. Baseline mechanical robustness of this scaffold system will enable delivery of cell pellets as early as three days. (Source: Neuromics)
Source: Neuromics - January 3, 2018 Category: Neuroscience Tags: 3-D Cell based Assays 3-D collagen scaffolds cartilage human chondrocytes Human Mesenchymal Stem Cells Source Type: news
Cell to Cell Signaling and Depression
This study also features the use of our excellentGFAP markersAbstract: Extracellular ATP is a widespread cell-to-cell signaling molecule in the brain, where it functions as a neuromodulator by activating glia and neurons. Although ATP exerts multiple effects on synaptic plasticity and neuro-glia interactions, as well as in mood disorders, the source and regulation of ATP release remain to be elaborated. Here, we define Calhm2 as an ATP-releasing channel protein based on in vitro and in vivo models. Conventional knockout and conditional astrocyte knockout of Calhm2 both lead to significantly reduced ATP concentrations, loss...
Source: Neuromics - December 21, 2017 Category: Neuroscience Tags: ATP release Depression Glia Glia Markers Neurons Source Type: news
Big Thank You!
Big YearWe exceeded our goals for 2017. By a lot. Both in sales and new products.I would like to personally thank our customers, collaborators, and friends for making this happen. You made it happen.I wish Joy to you in 2018!I wish you exciting, new discoveries, and adventures.Pete Shuster, CEO and Owner, Neuromics. (Source: Neuromics)
Source: Neuromics - December 13, 2017 Category: Neuroscience Tags: Neuromics Source Type: news
Coming Soon Hepatocytes and CSCS
Differentiated from iPSCs Neuromics is partnering withJaveen Biosciences to bring you Cancer Stem Cells and Hepatocytes derived from donor Induced Pluripotent Stem Cells.Rodney Nash, Javeen CEO, and his team are working to fill a major gap in cell-based drug discoveries. The lack of cells from specific diseased or ethnic populations. This limits the ability to predict how well a drug candidate will work with a diverse population of patients.Dr. Rodney Nash, CEO, Javeen BiosciencesOver time, we envision Javeen Biosciences as having the ability to engineer cells from donors that match tightly with the needs of drug hunters.W...
Source: Neuromics - December 8, 2017 Category: Neuroscience Tags: Cancer Stem Cells Drug Discovery Hepatocytes Source Type: news
Need Cells? Contest is Now Live
It ' s Easy! Creatively insert your favoritehuman cell culture(s) anywhere into a picture of your lab for $25 Amazon Gift Card. To enter, email the picture to rose@neuromics.com with a description of the image that includes your name, the lab name and the type of cells being cultured.First 100 entries are eligible for the gift card.Grand prize is $500 Visa Gift Card. Only entries that include the culture of Neuromics cells will be eligible for the grand prize.Official Contest Rules: Only one entry per lab. The first 100 entries are eligible. Cells cultured do not have to be Neuromics cells to be el...
Source: Neuromics - November 29, 2017 Category: Neuroscience Tags: 3-D Cell based Assays Human Stem Cells needcells primary human cells Source Type: news
