The Power of ISOkine Stem Cell Growth Factors
What Endotoxin, Animal and Serum Free Means to YouISOkine™ growth factors are produced in barley, bypassing the use of bacterial or animal cell systems.Why Does this Matter? Proteins produced in bacterial systems contain trace Endotoxins (toxins produced by the bacterial hosts). Studies show that these Endotoxins can compromise health of your stem cell based assays. Animal and human cell expression systems pose risk to your assays, because they may harbor pathogens.They are Low Cost and Work in the Hands of our Customers: "The ISOKine mouse LIF is an excellent product! I enjoyed dealing with Neuromics. My interactio...
Source: Neuromics - March 17, 2015 Category: Neuroscience Tags: FGF Basic Fibroblast Growth Factor Basic Flt3-Ligand Growth Factor ISOKine Leukemia inhibitory factor LIF Stem Cell growth Factor stem cell growth factors Source Type: news
Curcumin and Aging Health
Cellular Uptake Matters-Not All Curcumin Based Supplements Are Created EqualThere have been many academic publications on the miracles of Curcumin for Aging Health. Here's a description of its therapeutic properties: The desirable preventive or putative therapeutic properties of curcumin have also been considered to be associated with its antioxidant and anti-inflammatory properties. Because free-radical-mediated peroxidation of membrane lipids and oxidative damage of DNA and proteins are believed to be associated with a variety of chronic pathological complications such as cancer, atherosclerosis, and neurodegenerative di...
Source: Neuromics - March 13, 2015 Category: Neuroscience Tags: Aging Health Curcumin immune system boosters Inflammation Stem Cells Tumeric Acid Tumerin Source Type: news
The Roots of Anxiety Induced Pain
Conclusion: pain-induced anxiety is mediated by CRF neurotransmission in the LC through ERK1/2 signaling cascade.Figure: a) Schematic representation of the anatomical pathways implicated. Briefly, the contralateral LC indirectly receives inputs from the inflamed paw (red dashed line; ascending pathways) and, subsequently, the information is sent to corticolimbic areas. Additionally, the LC sends direct projections to the spinal cord (blue straight line; descending pathways). b) Body weight of the control and MA rats. c) Body rectal temperature of control and MA rats. d) Mechanical hyperalgesia represented by a significant ...
Source: Neuromics - March 4, 2015 Category: Neuroscience Tags: corticotrophin-releasing factor receptor 1 CRP Immunhistochemistry pain induced anxiety. phospho-ERK1/2 antibody Western Blotting Source Type: news
Neurite Outgrowth Assays-96 Well Plates
Fast, Effective and Data Rich!Our Customers' are reporting great results using our hN2 Primary Human Neurons. We are seeing a natural evolution for high content to high throughput screening. This is because our human neuron culturing kits are proving pure and potent (sample pubs).Here's some customer data using hN2™ Human Neurons High Throughput Screening (HTS) Kit:Image: Neurite Outgrowth Assay in 96 Well Plate using hN2 Neurons-Blue – Nuclear staining; Green – Neurite and cell body staining.Want to learn more? Contact me directly at pshuster@neuromics.com or 612-801-1007. Thank you. Pete Shuster, CEO and ...
Source: Neuromics - February 27, 2015 Category: Neuroscience Tags: Highthroughput Screening Highthroughput Toxicity Screening hN2 Kits hN2 Neurons Cell Cultures Neurite outgrowth primary human cells Primary Human Neurons Source Type: news
Neuromics-ArunA Biomedical Partnership
The objective of the meeting was to finalize plans for our Strategic Selling Partnership. This partnership enables us to open up more cell based assay solutions to current and future Customers involved in neuro-diseases/disorders research and drug discovery.The Aruna Team...And the news gets better. By combining our expertise and experience, we are now well positioned to to:Shape new solutions and services that would more tightly aligned with your unique requirementsCommunicate how other labs within your organization are using our solutions and look for ways to leverage this.Track buying volume so we can give favorabl...
Source: Neuromics - February 25, 2015 Category: Neuroscience Tags: Aruna Biomedical astrocyte cultures Astrocyte-Glial-Neuron Co-cultures. eSC Derived human neural progenitors GFP labeled mouse motor neurons human glia Primary Human Neurons Source Type: news
i-Fect Delivers siRNA in vitro and in vivo
In this study data suggest the protective effects of EPO on NUV injuries are highly associated with the increase of p-Cx43, which improves GJIC to reduce neurotoxic substances: Ziyi Zhoua, Xiaobai Weib, Jun Xiang, Junpeng Gao, Lixin Wang, Jinsong You, Yefeng Cai , Dingfang Caid. Protection of erythropoietin against ischemic neurovascular unit injuries through the effects of connexin43. Biochemical and Biophysical Research Communications. doi:10.1016/j.bbrc.2015.02...The strands were incubated at 90°C for 5 min and then at 37°C for 1 h. SiRNA was prepared immediately before administration by mixing the RNA solution (1 μg...
Source: Neuromics - February 21, 2015 Category: Neuroscience Tags: Cerebral Ischemia Connexin 43 Delivering siRNA to the CNS EPO HDAC2 i-Fect Stroke Source Type: news
Proven and Published Sandwich ELISA Kits
Growing Catalog of ELISA KitsWe are partnering with RayBiotech to manufacture our ELISA Kits. They have proven valuable additions to our Cell Based Assay solutions.Neuromics has been built on a foundation of quality. RayBiotech's commitment to quality includes compliance to GLP/GMP FDA and ISO9000 regulations.ELISA Kits Sample DataFigure: Induction of proinflammatory cytokines is attenuated in CX3CL1−/− mice expressing sFKN. TNFα and IL-1β concentrations were measured using standard ELISA techniques for VM lysates. a, TNFα concentrations were upregulated following MPTP administration (three-way ANOVA; F(1,...
Source: Neuromics - February 11, 2015 Category: Neuroscience Tags: ELISA IL-1beta Interleukins Sandwich ELISA Kits TNF-alpha Source Type: news
Your Feedback Matters
Our Solutions Must WorkWe take our ability to serve you very seriously. We use bird-eye to make sure each and every one of our customers are pleased with results. If you are not happy, we do everything we can to fix your issue. This includes replacement and refunds:Should you ever have questions or issues, I am at your "beck and call". Do not hesitate to contact me directly. Pete Shuster, CEO and Owner, Neuromics, 612-801-1007 or pshuster@neuromics.com. Thank you! (Source: Neuromics)
Source: Neuromics - February 7, 2015 Category: Neuroscience Tags: adult stem cells Antibodies Birdeye.com neural progenitors Neuromics Neurons primary human cells proteins Transfection Reagents Source Type: news
Neural Progenitors and Cool Science
Titania Nanotubes and Neural Prostheses I an always on the hunt for the use of our Neural Progenitor Markers in cool and important human health applications. Here our Nestin Antibody is use to access the growth and maintenance of C17.2 neural stem cell line cultured in these nanotubes: Jonathan A. Sorkin, Stephen Hughes, Paulo Soares, Ketul C. Popat. Titania nanotube arrays as interfaces for neural prostheses. Materials Science and Engineering: C Volume 49, 1 April 2015, Pages 735–745. doi:10.1016/j.msec.2015.01.077Image: Nestin staining of human week-11 fetal neural progenitor cells. Cells were stained using g...
Source: Neuromics - January 31, 2015 Category: Neuroscience Tags: Astrocytes nestin antibody Neural Progenitor Cells neural progenitor markers neural progenitors Neural prostheses Neurons Titania nanotube arrays; C17.2 neural stem cell line Source Type: news
Sensitive, Specific and Cost Effective Protein Expression Analysis
Reaching for Cell Based Assay Solutions ExcellenceWe have been receiving positive feedback from clients using our Quantibody® and RayBio® C-Series Membrane-Based Antibody Arrays. Our manufacturing partner, Raybiotech, is ISO 9000 certified insuring all arrays are made to exacting specification. The cost for measuring a single cytokine runs as low as 16 USD/Cytokine! We use these arrays to test the blood serum of clients with autoimmune diseases to determine levels of cytokine and growth factor expression vs healthy controls. We also use them to determine proteins secreted by our USB Derived hMSCs cultured in o...
Source: Neuromics - January 30, 2015 Category: Neuroscience Tags: autoimmune disease Autoimmunity C-Series Antibody Arrays Cytokine Antibody Arrays Growth factors hMSCs Media neuroinflammatory cytokines Neurotrophins Quantibody Arrays Source Type: news
Human Growth Factor+Neurotrophin+Cytokine Array-Test 40 Markers in on Assay
Sensitive, Specific and Cost EffectiveNeuro-immuno and degenerative diseases and disorders commonly show dysregulation of Growth Factors and Cytokines. Using our Quantibody Neuroscience Arrays, we have measured the blood serum of clients with Neuro-inflammatory/immune response diseases/disorders including Autism Spectrum Disorder (ASD). Most showed lowered levels of Growth Factors/Neurotrophins and elevated levels of Inflammatory Response Cytokines.In order to expand the number of biomarkers measured, we are pleased to announce the addition of our New Growth Factor+Neurotrophin+Cytokine Array. This will enable us to furthe...
Source: Neuromics - January 28, 2015 Category: Neuroscience Tags: angiogenesis Angiogenic Growth Factors BDNF GDNF expression IGF Neurodegenerative Disease Neurotrophin NT-3 NT-4 TGF-beta VEGF Source Type: news
Solutions for Studying Neuro-degeneration
Data Rich and Frequently PublishedThe Neuromics' brand is built, in part, by our proven ability to provide solutions for the study of neuro-degeneration. These include:Neuronal-Glial MarkersPrimary Neurons and AstrocytesApoptosis Research ReagentsTransfection ReagentsA recent example shows the use of one of MAP-2 markers to study hearing decline with age: Radtke-schuller S, Seeler S and Grothe B(2015) Restricted loss of olivocochlear but not vestibular efferent neurons in the senescent gerbil (Meriones unguiculatus). Front. Aging Neurosci. 7:4. doi:10.3389/fnagi.2015.00004.Figure: Lipofuscin granules in MSO neur...
Source: Neuromics - January 19, 2015 Category: Neuroscience Tags: AD ALS Alzheimer ' s Disease Amyotrophic Lateral Sclerosis Astrocytes Glia Glial Markers MS. Neuron Markers Multiple Sclerosis Neurodegenerative Disease Neurons Parkinson Source Type: news
Cancer Associated Fibroblasts (CAFs)-Flow Cytometry and Immunostaining Results
If they Walk and Talk Like CAFs, They Are!We are experiencing growing demand for are CAFs. They are closely associated with primary tumor cells and participate in the neoplastic process. There is reciprocal communication between CAFs and tumor cells through paracrine effects of secreted growth factors, cytokines & chemokines from both fibroblasts, tumor cells and other tumor-associated cells.Potential users are asking how well the cells are characterized. The purpose of this posting is to share key gene expression data: CELL LINES CD105 CD90 CD44 CD326 CD133 FAP ...
Source: Neuromics - January 12, 2015 Category: Neuroscience Tags: Adenocarcinoma CAFs Cancer Associated Fibroblasts colorectal CAFs Colorectal Cancer Pancreatic Fibrioblasts Pancreatic Stellates Source Type: news
Racing into 2015
Thank you for a Great 2014!Wow. I would like to thank our customers, collaborators and friends for helping us achieve unprecedented success in 2014.We plan on racing hard into 2015. I would like to highlight are focus areas for the New Year. Stem Cell Activating Solutions-We have been pilot tetsing solutions foir balanced immunity and stem cell vitality. Our clients have been mostly peopole with autoimmune related issues. After 6 months of therapy, the improvement in symptoms and test results, for many, has been stunning (see below).We have developed migration and other assays to test these solutions in vitro usi...
Source: Neuromics - January 5, 2015 Category: Neuroscience Tags: CAFs Cancer Associated Fibroblasts Cell Based Assays. human Mesenchymal Stem Cell Based Assays HVECs immune response ImmunoLinkTherapies neuron cultures Source Type: news
immunoLink Therapies and Treating ASD Children
6-Months of Therapy and Testing ResultsI have previously posted our testing and treatment regime for ASD Children. For some of the children, we are seeing marked improvement after 6 months of our treatment regime using solution aimed at balance immunity and stem cell vitality.We find that for the children we treat all have varying dysregulated levels of immune/inflammatory response, oxidative stress and growth factor/neurotrophin biomarkers. We customize treatment plans based on pre-treatment testing results. We then re-test after 6 months to see the level of moderation in these biomarkers/factors. The re-tests are u...
Source: Neuromics - December 24, 2014 Category: Neuroscience Tags: ASD ASD therapies Autism Autism Bio-markers Autism Therapies Autistic immunoLink ImmunoLinkTherapies Source Type: news
