Fight Aging! Newsletter, November 20th 2023
In this study, we attempted to further explain the role, exact mechanism and target of ICA in treating AD from the ferroptosis perspective. We found that ICA could improve the neurobehavioral, memory, and motor abilities of AD mice. It could lower the ferroptosis level and enhance the resistance to oxidative stress. After inhibition of MDM2, ICA could no longer improve the cognitive ability of AD mice, nor could it further inhibit ferroptosis. Network pharmacological analysis revealed that MDM2 might be the target of ICA action.
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Particulate Air Pollution and Its Effects on the Mechan...
Source: Fight Aging! - November 19, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Study identifies protective brain structure that delays the onset of frontotemporal dementia symptoms over 2 years
This article was originally published on The Conversation.
To Learn More:
Deep learning model built on neuroimaging data identifies “Brain Age Gaps” as markers of Alzheimer’s disease (AD)
Study: Building cognitive reserve helps delay memory and thinking decline regardless of genetic or childhood markers
The post Study identifies protective brain structure that delays the onset of frontotemporal dementia symptoms over 2 years appeared first on SharpBrains. (Source: SharpBrains)
Source: SharpBrains - November 17, 2023 Category: Neuroscience Authors: The Conversation Tags: Brain/ Mental Health brain fold brain-reserve brain-structure Bruce Willis cognitive advantage cognitive-ability cognitive-reserve dementia frontal-lobes frontotemporal dementia paracingulate sulcus Source Type: blogs
The Brain Microbiome Theory of Alzheimer's Disease
The amyloid cascade hypothesis of Alzheimer's disease suggests that the disease arises from misfolding and aggregation of amyloid-β, which grows to disrupts brain metabolism to produce inflammation and tau aggregation in later stages of the condition. While the amyloid cascade hypothesis remains the dominant view of the causes of Alzheimer's disease, there are other views. For example, that persistent infection leads directly to a runaway feedback loop of chronic inflammation and tau aggregation. In this view, amyloid-β aggregation is a side-effect, given that amyloid-β appears to be an anti-microbial peptide, a part of...
Source: Fight Aging! - November 17, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Curiosity-Driven Science: Q & A With Saad Bhamla
What do worm blobs and insect pee have to do with human health? We talked to Saad Bhamla, Ph.D., assistant professor of chemical and biomolecular engineering at Georgia Institute of Technology (Georgia Tech) in Atlanta, to find out.
Q: What did your path to becoming a scientist look like?
Credit: Rob Felt, Georgia Tech.
A: I grew up in Dubai and did my undergraduate work in India, which is where I was first introduced to science. The science faculty members seemed to be having so much fun and would say things like “for the love of science,” but I couldn’t figure out what joy they were getting until I got a ta...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - November 15, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Tools and Techniques Cool Tools/Techniques Profiles Research Organisms Source Type: blogs
Quiz: Do You Know Pharmacology Facts?
This is the final post in our miniseries on pharmacology. Check out the others: “What Is Pharmacology?“, “What Happens to Medicine In Your Body?“, and “How Do Medicines Work?“
Credit: NIGMS.
Pharmacologists research how the body acts on medicines (e.g., absorption, excretion) and how medicines act in the body, as well as how these effects vary from person to person. NIGMS-funded pharmacology researchers are:
Conducting research to design medicines with fewer side effects
Exploring how genes cause people to respond differently to medicines
Developing new methods and molecul...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - November 13, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Chemistry, Biochemistry and Pharmacology Common questions Medicines Miniseries Quiz Source Type: blogs
Fight Aging! Newsletter, November 13th 2023
This study investigated the correlation among muscle strength, working memory (WM), and cortical hemodynamics during the N-back task of memory performance, and further explored whether cortical hemodynamics during N-back task mediated the relationship between muscle strength and WM performance. We observed that muscle strength (particularly grip strength) predicted WM of older adults in this cross-sectional study, which validated our hypothesis and expanded on previous research findings. Studies demonstrated that grip strength predicted executive function decline in patients with mild cognitive impairment. Other cross-sect...
Source: Fight Aging! - November 12, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Brain imaging AI start-up Neurophet raises $15M to better direct Alzheimer ’s treatments, lower ARIA side-effects
Korean AI startups Allganize, Neurophet raise over $35 mn (The Korea Economic Daily):
Founded in 2016, the company plans to next year roll out its new AI analysis program that can detect side effects of Alzheimer’s disease treatments with a microhemorrhage diagnosis.
The Korean AI startup is famous for its flagship AI analysis technologies, Neurophet AQUA, which is a brain MRI analysis technology, and Neurophet SCALE PET, an AI-based positron emission tomography (PET) image analysis program.
It plans to go public in Korea next year, said Neurophet CEO Bin Joon-gil, adding that it is currently working with its underwriter...
Source: SharpBrains - November 9, 2023 Category: Neuroscience Authors: SharpBrains Tags: Brain/ Mental Health Technology & Innovation Alzheimer’s disease treatments Alzheimers-disease anti-amyloid antibody treatments brain image analysis donanemab lecanemab microhemorrhage diagnosis Neurophet positron emission tomography Source Type: blogs
Robotic Ankle Helps with Postural Control in Amputees
Researchers at North Carolina State University have developed a robotic prosthetic ankle that can provide stability for lower limb amputees. The ankle uses electromyographic sensors placed on the sites of muscles in the residual limb that then convey the intentions of the wearer with regard to movement. So far, the system has been shown to assist with postural control, which in this context refers to the many complex and unconscious movements that the muscles in our legs make to maintain balance and keep us upright, even when we are largely standing still. Previously, lower limb amputees have sometimes struggled to maintai...
Source: Medgadget - November 7, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Rehab NCSU Source Type: blogs
Fight Aging! Newsletter, November 6th 2023
This study aimed to gather valuable insights from pharmaceutical experts and healthcare practitioners regarding the potential and challenges of translating senolytic drugs for treatment of vascular aging-related disorders. This study employed a qualitative approach by conducting in-depth interviews with healthcare practitioners and pharmaceutical experts. Participants were selected through purposeful sampling. Thematic analysis was used to identify themes from the interview transcripts. A total of six individuals were interviewed, with three being pharmaceutical experts and the remaining three healthcare practitioners.
...
Source: Fight Aging! - November 5, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The One Teaching Strategy That Will Fix Your Anatomy & Physiology Course | TAPP 143
In episode 143 ofThe A&P Professor podcast for anatomy and physiology faculty, host Kevin Patton uncovers the super-secret, single,ultimate teaching strategy you need to keep your course tuned up andeffective. He also revisits the " out there "transducer model of the brain and suggests a connection with a recent discovery supportingquantum wave activity in brain cell microtubules. Yes, quantum waves in the microtubules. Kevin also clarifies and expands on those wacky" extra " courses he described in Episodes 140 and 141.00:00 | Introduction00:51 | Clarifying Kevin ' s Wacky Supplemental Courses15:50 | Quantum Acti...
Source: The A and P Professor - November 2, 2023 Category: Physiology Authors: Kevin Patton Source Type: blogs
Glial Cell Mitochondrial Stress Can Indirectly Signal to the Whole Organism
Glia of various sorts are supporting cells in the brain, assisting the function of neurons. Dysfunction and stress in glial cells is nonetheless important. A growing body of evidence suggests that cellular senescence in astrocytes and microglia contribute to age-related neurodegenerative conditions, for example. Further, stress of various forms in these cells may be provoking both inflammation and altered signaling throughout the brain and body. Overly active, pro-inflammatory astrocytes and microglia are implicated in neurodegeneration, even when these cells are not senescent. It isn't clear as to how much of this is a re...
Source: Fight Aging! - October 30, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
On neuroplasticity, cognition, aging, medication, Alzheimer ’s, board games, brain teasers, and more
Welcome to a new edition of SharpBrains e‑newsletter, featuring fascinating research findings on neuroplasticity, cognition, aging, medication, Alzheimer’s, board games, and more, plus some brain teasers to get you in great shape for Halloween.
#1. Study: Playing board games like Chess, Mahjong, Go, helps slow cognitive decline as we age (but with clear differences in neurobiology and improved function)
So … let’s play all three!
#2. The Mindful Body argues against mindlessly accepting age-related decline in cognition and health as inevitable
“Perhaps Langer’s most provocative advice is reserved for doctors and...
Source: SharpBrains - October 26, 2023 Category: Neuroscience Authors: SharpBrains Tags: Brain/ Mental Health Education & Lifelong Learning SharpBrains Monthly eNewsletter Aduhelm aging Alzheimer’s board games cognition digital therapeutics DTx Leqembi medication neuroplasticity Source Type: blogs
Study: Playing board games like Chess, Mahjong, Go, helps slow cognitive decline as we age (but with clear differences in neurobiology and function)
Conclusions: Traditional board games may slow global cognitive decline and improve the quality of life in elderly subjects. Different games have varying impacts on specific cognitive domains, possibly mediated by functional and biological factors.
The Study in Context:
Study: For better memory and thinking skills at age 70 (and beyond), play cards and board games from age 11
How learning changes your brain
Solving the Brain Fitness Puzzle Is the Key to Self-Empowered Aging
The post Study: Playing board games like Chess, Mahjong, Go, helps slow cognitive decline as we age (but with clear differences in neurobio...
Source: SharpBrains - October 25, 2023 Category: Neuroscience Authors: SharpBrains Tags: Brain/ Mental Health Education & Lifelong Learning aging Alzheimer’s Disease BDNF chess cognition cognitive decline Cognitive-impairment dementia Go Mahjong neurobiology primary prevention recreational games secondary preve Source Type: blogs
The Ultimate Guide to Superfoods: Nourishing the Brain Beyond Basics
Conclusion
As we stand at the crossroads of ancient tradition and groundbreaking technologies, it's evident that our past still holds the key to our future. And in researching longevity and the desire for an active and healthy life, nutrition emerges as our ally.
We broke down the benefits of the 5 most overlooked superfoods and how to introduce them into our diet seamlessly, as well as the juxtaposition between age-old wisdom and cutting-edge science by showcasing humanity's continuous journey towards holistic well-being.
Incorporating them into our diets is more than just a trend; it's a testament to...
Source: PickTheBrain | Motivation and Self Improvement - October 25, 2023 Category: Consumer Health News Authors: Nahla Davies Tags: featured health and fitness productivity tips self-improvement superfoods Source Type: blogs
Understanding RNA-Modifying Enzymes: Q & A With Jeffrey Mugridge
Credit: Courtesy of Jeffrey Mugridge.
“One of the best aspects of research is the excitement of discovery, being the first person in the world to know a small detail about the system you’re studying,” says Jeffrey Mugridge, Ph.D., an assistant professor of chemistry and biochemistry at the University of Delaware in Newark. We talked with Dr. Mugridge about how a pet store job sparked his early interest in science, why he decided to change his career trajectory after graduate school, and what he believes is key to being a successful researcher.
Q: How did you first become interested in science?
A: ...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - October 25, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Chemistry, Biochemistry and Pharmacology Profiles RNA Source Type: blogs
