Detecting Unusual Score Patterns in the Context of Relevant Predictors-Joel Schneider on a neuropsych assessment issue
Anytime Dr. Joel Schneider drops an article that provides " smart " routines/software to help solve some of the persistent and complex problems in cognitive test interpretation, I make sure to pay attention. Progress is and can be made. Detecting Unusual Score Patterns in the Context of Relevant Predictors | SpringerLink https://link.springer.com/article/10.1007/s40817-022-00137-x Abstract Neuropsychological assessment requires integrating new information with what is already known about an examinee. In constructing a case conceptualization, it can be helpful to quantify how unusual a pattern of scores is ...
Source: Intelligent Insights on Intelligence Theories and Tests (aka IQ's Corner) - March 8, 2023 Category: Neuroscience Source Type: blogs
Inhibiting the NLRP1 Inflammasome Reduces the Senescence-Associated Secretory Phenotype
A sizable portion of the chronic inflammation of aging is produced by the growing presence of senescent cells in tissues throughout the body. Senescent cells secrete a mix of pro-growth, pro-inflammatory signals (the senescence-associated secretory phenotype, SASP), useful when present in the short-term in the context of wound healing and suppression of cancer risk resulting from cell damage. When sustained over the long-term, however, this signaling becomes highly disruptive to tissue structure and function. The inflammatory mechanisms inside senescent cells that produce pro-inflammatory components of the SASP include the...
Source: Fight Aging! - March 8, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
The 7 Habits of Highly Stress-Resilient Minds
Are you suffering from chronic stress? Many of us are—whether we’re stressed out by our jobs, complicated relationships, caregiving responsibilities, or the general state of the world.
That’s where Elissa Epel’s new book, The Stress Prescription, comes in. A health psychologist and director of the Aging, Metabolism, and Emotions Center at the University of California, San Francisco, Epel explains how stress affects our bodies and minds—including our health, happiness, and longevity—and how to manage it in the best way possible.
Too many of us are in a constant state of alertness, she argues, which makes us ill-...
Source: SharpBrains - March 7, 2023 Category: Neuroscience Authors: Greater Good Science Center Tags: Brain/ Mental Health Education & Lifelong Learning aging chronic-stress deep breathing Gratitude high-intensity interval training meditation mindfulness mindfulness-meditation physiological stress Stress Prescription Stress Respons Source Type: blogs
From MDPI: " It Runs in the Family: Testing for Longitudinal Family Flynn Effects "
https://www.mdpi.com/2177634:It Runs in the Family: Testing for Longitudinal Family Flynn EffectsThe Flynn effect refers to increases over time in measured (particularly fluid) intelligence of approximately 3 IQ points per decade. We define the Flynn effect at the family level, using longitudinal data and two new family-level cohort definitions. Multilevel growth curve analyses of the National Longitudinal Survey of Youth 1979 data showed that children in families with later-born mothers had higher average PIAT math scores, and lower average reading comprehension scores and growth, in young and middle childhood. Children i...
Source: Intelligent Insights on Intelligence Theories and Tests (aka IQ's Corner) - March 7, 2023 Category: Neuroscience Source Type: blogs
OI May Be The Next AI
In the past few months, artificial intelligence (AI) has suddenly seemed to come of age, with “generative AI” showing that AI was capable of being creative in ways that we thought was uniquely human. Whether it is writing, taking tests, creating art, inventing things, making convincing deepfake videos, or conducting searches on your behalf, AI is proving its potential. Even healthcare has figured out a surprising number of uses.
It’s fun to speculate about which AI — ChatGPT, Bard, DeepMind, Sydney, etc. – will prove “best,” but it turns out that “AI” as we’ve known it may become outdated...
Source: The Health Care Blog - March 7, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Health Tech Artificial intelligence health technology Kim Bellard Organoid Intelligence Source Type: blogs
Fight Aging! Newsletter, March 6th 2023
In this study, we develop a rFOXN1 fusion protein that contains the N-terminal of CCR9, FOXN1, and TAT. We show here that, when injected intravenously (i.v.) into aged mice, the rFOXN1 fusion protein can migrate into the thymus and enhance T cell generation in the thymus, resulting in increased number of peripheral T cells. Our results suggest that the rFOXN1 fusion protein has the potential to be used in preventing and treating T cell immunodeficiency in the older adult.
Increased miR-181a-5p Expression Improves Neural Stem Cell Activity, Learning, and Memory in Old Mice
https://www.fightaging.org/archives/20...
Source: Fight Aging! - March 5, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Looking for Flynn effects in a recent online U.S. adult sample: Examining shifts within the SAPA Project - ScienceDirect
Looking for Flynn effects in a recent online U.S. adult sample: Examining shifts within the SAPA Project - ScienceDirect https://www.sciencedirect.com/science/article/pii/S0160289623000156?via%3Dihub Compared to European countries, research is limited regarding if the Flynn effect, or its reversal, is a current phenomenon in the United States. Though recent research on the United States suggests that a Flynn effect could still be present, or partially present, among child and adolescent samples, few studies have explored differences of cognitive ability scores among US adults. Thirteen years of cross-sectional ...
Source: Intelligent Insights on Intelligence Theories and Tests (aka IQ's Corner) - March 3, 2023 Category: Neuroscience Source Type: blogs
CMS: anti-amyloid drug Leqembi (lecanemab) doesn ’t meet the “reasonable and necessary” standard required for wider Medicare coverage
CMS Sticks to Sharply Limited Coverage of New Alzheimer’s Drug, Leqembi (Managed Healthcare Executive):
For now, CMS (Note: Centers for Medicare & Medicaid Services) is sticking to the coverage decision it made for Aduhelm (aducanumab) and applying it Leqembi (lecanemab). The decision limits Medicare coverage of the two Alzheimer disease’s drugs to Medicare beneficiaries who have enrolled in clinical trials of the drugs
The decision, which was announced in a press release yesterday, was denounced in strong language by the Alzheimer’s Association.
“CMS’ role is to provide health care coverage” said Joanne Pi...
Source: SharpBrains - February 28, 2023 Category: Neuroscience Authors: SharpBrains Tags: Brain/ Mental Health aducanumab Aduhelm Alzheimer's drug Alzheimers-Association amyloid CMS dementia FDA lecanemab Leqembi Medicare monoclonal antibodies Source Type: blogs
Exercise is Medicine
It remains the case that all too little in medical science is demonstrated to be better than exercise for improved long-term health. Much of the early work on ways to slow aging, pioneered by the supplement industry, has proven to be less effective than structured exercise programs when finally evaluated in clinical trials. One conclusion is that the research and development communities must do better, aim higher. Another conclusion, the subject of this open access paper, is that perhaps the practicing medical community should become much more serious about exercise.
Lack of exercise is a health concern worldwide....
Source: Fight Aging! - February 28, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Starting Out on the Long Road to Tissue Engineering for the Brain
Can one replace parts of the brain? In principle, yes. It is a tissue, and tissue engineering is a field intent on regrowth and replacement of lost or damaged tissue. There are parts of the brain immediately vital to life, and parts that hold the memory that defines the self; if those are lost, that is irrecoverable. But much of the brain might be tissue engineered in the same way as muscle or liver might be replaced. Researchers are still in the early stages of the long road towards replacement tissues created to order, as illustrated by the scientific work noted here, but much of the brain will be a part of that field of...
Source: Fight Aging! - February 27, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, February 27th 2023
This study tested the hypothesis that ischemic vascular repair in aging by Ang-(1-7) involves attenuation of myelopoietic potential in the bone marrow and decreased mobilization of inflammatory cells.
Young or Old male mice of age 3-4 and 22-24 months, respectively, received Ang-(1-7) for four weeks. Myelopoiesis was evaluated in the bone marrow (BM) cells by carrying out the colony forming unit (CFU-GM) assay followed by flow cytometry of monocyte-macrophages. Expression of pro-myelopoietic factors and alarmins in the hematopoietic progenitor-enriched BM cells was evaluated. Hindlimb ischemia (HLI) was induced by ...
Source: Fight Aging! - February 26, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Propelling Rare Disease Research for More Than 50 Years
Vials of samples from the NIGMS HGCR. Credit: Coriell Institute for Medical Research.
The year 2022 marked 50 years since the creation of the NIGMS Human Genetic Cell Repository (HGCR) at the Coriell Institute for Medical Research in Camden, New Jersey. The NIGMS HGCR consists of cell lines and DNA samples with a focus on those from people with rare, heritable diseases. “Many rare diseases now have treatments because of the samples in the NIGMS HGCR,” says Nahid Turan, Ph.D., Coriell’s chief biobanking officer and co-principal investigator of the NIGMS HGCR. She gives the example of a rare disease advocacy group wh...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - February 22, 2023 Category: Research Authors: Chrissa Chverchko Tags: Cells Genes Injury and Illness Diseases Genomics Scientific Process Source Type: blogs
Reframing the clouded scientific spectacles of the Flynn effect: A view through two lenses - ScienceDirect
Reframing the clouded scientific spectacles of the Flynn effect: A view through two lenses - ScienceDirect https://www.sciencedirect.com/science/article/abs/pii/S0160289623000168?via%3Dihub Flynn argued that the Flynn effect was due to an increasing use of " scientific spectacles " among the general population (Flynn, 2010), yet the Flynn effect itself has been viewed through clouded scientific spectacles. Most research has focused on Flynn ' s main finding: IQ scores have increased over time. Flynn (1987) presumed the effect was a cohort (generational) effect, yet a variety of within- and between-person proces...
Source: Intelligent Insights on Intelligence Theories and Tests (aka IQ's Corner) - February 21, 2023 Category: Neuroscience Source Type: blogs
BrainHealth Week starts today! Plus: dancing, personalized mental health, brain stimulation and more
Welcome to a new edition of SharpBrains e‑newsletter, annoucing the kick-off of BrainHealth Week and featuring some stimulating resources and teasers.
#1. BrainHealth Week (February 20–24th) starts today:
Explore many fun events including a daily text challenge, a talk with the always great Dr. Tom Insel, and more!
#2. Without Brain Health, you do not have Health
Important article given that “It typically takes twenty to forty years or more for scientific discoveries to meaningfully benefit human life. We cannot wait that long.” — Wise words!
#3. Sin Salud Cerebral, Usted no tiene Salud –same article, in Spa...
Source: SharpBrains - February 20, 2023 Category: Neuroscience Authors: SharpBrains Tags: Brain/ Mental Health Education & Lifelong Learning Alto Neuroscience Alzheimer’s Disease brain stimulation Brain Teasers brain-teaser BrainHealth Week cerebral cognitive-skills dancing mental-fitness personalized salud salud Source Type: blogs
Fight Aging! Newsletter, February 20th 2023
In this study, researchers stimulate the ghrelin receptor using a suitable small molecule for much of the lifespan of mice, and observe the results. The overall extension of life span is a quarter of that produced by calorie restriction, and so we might draw some conclusions from that as to the relative importance of hunger in the benefits resulting from the practice of calorie restriction or fasting. Interestingly, the short term weight gains observed in mice given this ghrelin receptor agonist in the past don't appear in this long term study, in which the controls are the heaver animals. This is possibly because the rese...
Source: Fight Aging! - February 19, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
