Fight Aging! Newsletter, July 10th 2023
In conclusion, the examination of the GBA can aid in understanding the etiology and development of NDs, which may benefit the improvement of clinical treatments for these disorders and ND interventions. This review indicates existing knowledge about the involvement of microbiota present in the gut in NDs and potential treatment options. The Aging of the Enteric Nervous System https://www.fightaging.org/archives/2023/07/the-aging-of-the-enteric-nervous-system/ The enteric nervous system is the nervous system of the intestines, and likely an important part of the relationship between the gut microbiome ...
Source: Fight Aging! - July 9, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Psychedelic Science 2023 – Full Conference Review
In June I attended the Psychedelic Science 2023 conference at the Colorado Convention Center in Denver. We were told this was the largest psychedelic-related gathering in the history of the planet, attracting about 12,000 attendees and 500 speakers. In this post I’ll share about my experiences and insights from the conference. Here’s a pic from inside the Bellco Theater where the main keynotes were held. The Colorado Convention Center is sizable, and sessions were spread across many different rooms. Even though I didn’t do extra exercise on this trip, I was typically hitting about 1000 calories ...
Source: Steve Pavlina's Personal Development Blog - July 7, 2023 Category: Psychiatry & Psychology Authors: Steve Pavlina Tags: Creating Reality Health Lifestyle Source Type: blogs

Major evidence review supports an “exercise prescription” for most adults to boost mental health and well-being
Conclusion and relevance: Physical activity is highly beneficial for improving symptoms of depression, anxiety and distress across a wide range of adult populations, including the general population, people with diagnosed mental health disorders and people with chronic disease. Physical activity should be a mainstay approach in the management of depression, anxiety and psychological distress. The Study in Context: Can you grow your hippocampus? Yes. Here’s how, and why it matters Three ways to protect your mental health during –and after– COVID-19 Solving the Brain Fitness Puzzle Is the Key to Self-Empowered Aging ...
Source: SharpBrains - July 6, 2023 Category: Neuroscience Authors: Greater Good Science Center Tags: Brain/ Mental Health Education & Lifelong Learning Peak Performance anxiety depression exercise exercise prescription gym improve mental health lift weights medication mental-health-treatment physical-health therapy yoga class Source Type: blogs

Science Snippet: Antioxidants Explained
Many types of fruits, vegetables, and legumes are rich in antioxidants. Credit: iStock. While at the grocery store, you’ve likely noticed foods with labels saying they contain antioxidants, but what does that mean? In short, antioxidants are substances that may prevent or delay some types of cell damage. Many foods, including fruits and vegetables, naturally produce antioxidants like vitamins C and E, beta-carotene, and selenium. Our bodies also naturally produce antioxidant molecules such as alpha-lipoic acid, glutathione, and coenzyme Q10. Antioxidants are united by their ability to donate electrons, whi...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - July 5, 2023 Category: Research Authors: Chrissa Chverchko Tags: Chemistry, Biochemistry and Pharmacology Science Snippet Source Type: blogs

Fight Aging! Newsletter, July 3rd 2023
In this study, cultured adipose-derived stem cells (ASCs) were derived from subcutaneous white adipose tissue isolated from mice fed a normal diet. We performed senescence-associated-β-galactosidase (SA-β-gal) staining, real-time PCR, and Western blot to evaluate the levels related to cellular senescence markers. The mRNA expression levels of senescence markers were significantly increased in the later passages of ASCs. We show that light activation reduced the expression of senescent genes, and SA-β-Gal in all cells at passages. Moreover, the light-activated ASCs-derived exosomes decrease the expression of senes...
Source: Fight Aging! - July 2, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Biodegradable Ultrasound Implant Helps Chemo Reach Brain
Researchers at the University of Connecticut have developed an ultrasound implant that can assist in opening the blood brain barrier to allow chemotherapy to enter and treat brain cancer. However, unlike cumbersome ultrasound systems, this technology can be implanted directly into the brain, and does not require a follow-up surgery to remove the device later as it degrades away to nothing in the brain over time. The implant contains crystals of the amino acid glycine, which has been shown to be strongly piezoelectric, meaning that it vibrates when an electrical current is passed through it. The researchers combined this wi...
Source: Medgadget - June 28, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Medicine Neurosurgery Oncology UConn Source Type: blogs

Should doctors prescribe Leqembi (lecanemab) to women with early Alzheimer ’s Disease? The evidence-based answer is probably No
Welcome to a new edition of SharpBrains e‑newsletter, featuring this time a range of interventions for brain/ cognitive/ mental health plus a few brain teasers to test our perception and cognitive skills. #1. Should doctors prescribe lecanemab (Leqembi) to women? The answer, given available evidence, is probably No Huge (and mostly overlooked) red flag regarding newly approved “anti-Alzheimer’s” drugs: “To put it bluntly, if lecanemab doesn’t work in women it would be unethical to supply it to women. Recall this costly immunotherapy comes with substantive risks, including high incidence of ARIA and even death....
Source: SharpBrains - June 28, 2023 Category: Neuroscience Authors: SharpBrains Tags: Brain/ Mental Health SharpBrains Monthly eNewsletter Technology & Innovation ADHD-symptoms Alzheimers-disease Anti-Alzheimer’s Drugs anti-amyloid drugs ARIA Brain Teasers brain teasers for adults cognitive-behavioral-therapy cognit Source Type: blogs

Thinking New Thoughts about the Human Brain | TAPP 139
In Episode 139, we explore anew discovery in nerve signaling in the brain called adendritic action potential (dCaAP), we look at a whackyproposed model of brain function, and we share some ideas about how we can help our students understand thecore concepts ofchemical signaling andsignal transduction in different contexts. Put on your thinking caps and jump into this fresh episode now.00:00 | Introduction00:50 | Dendritic Action Potentials12:16 | Transducer Model of the Brain21:43 | Chemical Signals& Signal Transduction35:09 | Staying Connected ★ If you cannot see or activate the audio player, go to:theAPprofess...
Source: The A and P Professor - June 28, 2023 Category: Physiology Authors: Kevin Patton Source Type: blogs

Generational intelligence tests score changes in Spain: Are we asking the right question? - ScienceDirect
 Generational intelligence tests score changes in Spain: Are we asking the right question? - ScienceDirect  https://www.sciencedirect.com/science/article/abs/pii/S0160289623000533Generational intelligence test score gains have been documented worldwide in the twentieth century. However, recent evidence suggests these increased scores are coming to an end in some world regions. Here we compare two cohorts of university freshmen. The first cohort (n = 311) was assessed in 1991, whereas the second cohort (n = 349) was assessed thirty years later (2022). These cohorts completed the same intelligen...
Source: Intelligent Insights on Intelligence Theories and Tests (aka IQ's Corner) - June 27, 2023 Category: Neuroscience Source Type: blogs

If Probiotics in their Present Form Were a Truly Effective Intervention, We Would Already Know
There is an increasing focus in the research community on the role of the gut microbiome in aging. This is in large part driven by the ability to accurately, cost-effectively measure the composition of the gut microbiome from a stool sample, using 16S rRNA sequencing. The 16S rRNA gene is differs between bacterial species, without being subject to a high rate of mutation and change. Using low-cost modern techniques, researchers can thus read out the relative numbers of different species in the gut microbiome, a service now available to the public at large as well. This allows researchers to see exactly how the balance of p...
Source: Fight Aging! - June 26, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Fight Aging! Newsletter, June 26th 2023
This study explored the association between different cooking fuel types and the risk of cancer and all-cause mortality among seniors constructing Cox regression models. Data were obtained by linking waves of 6, 7, and 8 of the Chinese Longitudinal Healthy Longevity Survey, which included a total of 7,269 participants who were 65 years old and over. Cooking fuels were categorized as either biomass, fossil, or clean fuels. And the effects of switching cooking fuels on death risk were also investigated using Cox regression models. The results indicate that, compared with the users of clean fuels, individuals using bio...
Source: Fight Aging! - June 25, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Optimism for the Future of Amyloid- β Clearance
In today's popular science article, the SENS Research Foundation offers a more rosy picture of the near future of amyloid-β clearance than is the usual fare these days. Amyloids are misfolded or otherwise altered proteins that can aggregate to form solid deposits that disrupt cellular biochemistry. In principle they should all be removed. Their existence is a form of harmful change that takes place with age, and the connections to cell dysfunction are quite clear. The failure of amyloid-β clearance to produce meaningful benefits in Alzheimer's patients has led to some disillusionment, however. Alzheimer's may be a...
Source: Fight Aging! - June 21, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Growing controversy over role of FDA and Medicare in promoting anti-amyloid drugs given limited benefit, high cost, severe side-effects
The War Over Whether Medicare Should Pay For The New Anti-Alzheimer’s Drugs (Forbers): The powerful Alzheimer’s Disease lobby is fighting a multi-billion-dollar battle on two fronts. It is quietly trying to limit restrictions the Food and Drug Administration puts on the use of new drugs aimed at slowing the progression of the brain disease. And it is publicly pressing Medicare to pay for the widespread use of the monoclonal antibodies FDA already has conditionally approved as well as others in the pipeline. While the FDA approves drugs for use, it doesn’t decide who pays for them. And, for now, the Centers for Medica...
Source: SharpBrains - June 21, 2023 Category: Neuroscience Authors: SharpBrains Tags: Brain/ Mental Health Alzheimer's experts Alzheimer’s Disease Anti-Alzheimer’s Drugs Biogen brain swelling Eisai europe FDA lecanemab Medicare Source Type: blogs

Fight Aging! Newsletter, June 19th 2023
In conclusion, among Swedish middle-aged subjects, nearly two-thirds showed complete fatty degeneration of thymus on CT. Age-Related Dysfunction of Water Homeostasis https://www.fightaging.org/archives/2023/06/age-related-dysfunction-of-water-homeostasis/ Dehydration can be an issue in older people. As in every complex system in the body, the mechanisms by which hydration is regulated become dysfunctional with advancing age. Researchers here look at the brain region responsible for regulating some of the response to dehydration, cataloging altered gene expression in search of the more important mechan...
Source: Fight Aging! - June 18, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs