Telomere Length as a Target for Therapy
Average telomere length in a tissue is some reflection of (a) stem cell activity and (b) pace of cell division. Telomeres, repeated DNA sequences at the ends of chromosomes, lose some of their length with each cell division, and cells self-destruct or become senescent when telomeres become too short. This limits the ability of somatic cells to replicate, reducing the odds that a given cell will mutate to become cancerous by imposing a limit on cell activity and cell life span, enforcing turnover of cells in tissues. Stem cells, in comparison, are a small, well protected, privileged set of cell populations that use telomera...
Source: Fight Aging! - February 26, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, February 26th 2024
In conclusion, mTORC1 signaling contributes to the ISC fate decision, enabling regional control of intestinal cell differentiation in response to nutrition.
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Reviewing the Development of Senotherapeutics to Treat Aging
https://www.fightaging.org/archives/2024/02/reviewing-the-development-of-senotherapeutics-to-treat-aging/
Senescent cells accumulate with age and contribute meaningfully to chronic inflammation and degenerative aging. Destroying these cells produces rapid and sizable reversal of age-related diseases in mice, demonstrating that the presence of senescence cells ...
Source: Fight Aging! - February 25, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Best books on cognitive ability and skills according to ChatSpot and ChatGPT
As a follow-up to the article Best books on brain health and cognitive fitness according to ChatSpot and ChatGPT we decided to find out what these popular AI chatbots say about books to understand and improve cognitive ability and skills.
Here you are:
(Links open corresponding Amazon book pages)
Best books on cognitive ability and skills, per ChatSpot:
Here are some highly recommended books on cognitive ability and skills:
1. “Thinking, Fast and Slow” by Daniel Kahneman: This book explores the two systems of thinking that drive our decision-making processes and provides insights into cognitive biases and how to improv...
Source: SharpBrains - February 21, 2024 Category: Neuroscience Authors: SharpBrains Tags: Books Education & Lifelong Learning Brain Teasers Brain-Plasticity ChatGPT ChatSpot cognitive biases cognitive-abilities cognitive-ability cognitive-skills decision-making-skills Source Type: blogs
The 7 Decade History of ChatGPT
By MIKE MAGEE
Over the past year, the general popularization of AI orArtificial Intelligence has captured the world’s imagination. Of course, academicians often emphasize historical context. But entrepreneurs tend to agree with Thomas Jefferson who said, “I like dreams of the future better than the history of the past.”
This particular dream however is all about language, its standing and significance in human society. Throughout history, language has been a species accelerant, a secret power that has allowed us to dominate and rise quickly (for better or worse) to the position of “masters of the un...
Source: The Health Care Blog - February 19, 2024 Category: Consumer Health News Authors: matthew holt Tags: Health Tech AI ChatGPT History of AI Mike Magee Source Type: blogs
The difficult balance between evidence-based healthcare … and person-centred self-management
For decades I’ve been an advocate for evidence-based healthcare because the alternative is ’eminence-based healthcare’ (for healthcare, read ‘medicine’ in the original!). Eminence-based healthcare is based on opinion and leverages power based on a hierarchy from within biomedicine (read this for more!). EBHC appealed because in clinical practice I heard the stories of people living with chronic pain who had experienced treatment after treatment of often invasive and typically unhelpful therapies, and EBHC offered a sifting mechanism to filter out the useless from the useful.
Where has EBHC...
Source: HealthSkills Weblog - February 18, 2024 Category: Anesthesiology Authors: BronnieLennoxThompson Tags: Chronic pain Clinical reasoning Coping strategies Pain conditions Professional topics Research Science in practice pain management Therapeutic approaches Source Type: blogs
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https://fb.watch/qeEcQRDcMn/Pardon typos and spelling errors-sent from iPhone***************************************** Kevin S. McGrew, PhD Educational& School Psychologist Director Institute for Applied Psychometrics (IAP)https://www.themindhub.com ****************************************** (Source: Intelligent Insights on Intelligence Theories and Tests (aka IQ's Corner))
Source: Intelligent Insights on Intelligence Theories and Tests (aka IQ's Corner) - February 16, 2024 Category: Neuroscience Source Type: blogs
The knowledge machine
That ' s the title of a book my Michael Strevens, which I recommend. (Liveright, New York, 2020)Strevens presents his own take on the philosophy of science accessibly and persuasively. If you ' ve even dabbled in this area you ' ve heard of the so-called demarcation problem -- how can we tell science from pseudoscience -- and the two best-known modern conceptions of science, Kuhn ' s construct of paradigms and paradigm shifts, and Popper ' s construct of falsfiability. Strevens doesn ' t think Kuhn or Popper are quite right. However I would say that without quite realizing it, he ' s pretty close to Popper -- he just...
Source: Stayin' Alive - February 15, 2024 Category: American Health Source Type: blogs
Best books on brain health and cognitive fitness according to ChatSpot and ChatGPT
Out of curiosity we queried a couple popular AI chatbots, ChatSpot and ChatGPT free versions, about the best books in a couple of key topics we discuss a lot in this blog. Here are the fascinating results, and some brief commentary at the end. (Links open corresponding Amazon book pages.)
Best books on brain health, per ChatSpot:
There are several great books on brain health that provide valuable insights and practical tips. Here are some highly recommended ones:
1. “The Brain That Changes Itself” by Norman Doidge: This book explores the concept of neuroplasticity and how the brain can rewire itself to overcome various...
Source: SharpBrains - February 14, 2024 Category: Neuroscience Authors: SharpBrains Tags: Books Education & Lifelong Learning brain-books Brain-Fitness brain-health-books ChatGPT ChatSpot cognitive-fitness cognitive-health-books neuroplasticity Source Type: blogs
Why are " Love Languages " so popular, when they're completely inaccurate?
I joined an online dating site a few months ago.1 Besides being asked about my sun, moon, and rising signs (?), I was puzzled by the following question.2My love language? I ' m supposed to choose only one answer? Gary Chapman has been apastor at Calvary Baptist Church in Winston-Salem, NC for 50 years. In 1992, he published a book based on his experience of advising heterosexual couples on the best ways to have a harmonious marriage. His notion of 5 Love Languages is based on conservative Christian gender roles, although subsequent editions are“less blatantly misogynistic.” Nonetheless, the popularity of his ideas...
Source: The Neurocritic - February 14, 2024 Category: Neuroscience Authors: The Neurocritic Source Type: blogs
What Does an Immunologist Do?
This post is part of a miniseries on the immune system. Be sure to check out the other posts in this series that you may have missed.
Immunology is the study of the immune system, including all the cells, tissues, and organs that work together to protect you from germs. A person who studies immunology is called an immunologist, and there are three types:
Researchers, who study the immune system in the laboratory to understand how it works or how it can go awry and find new treatments for immune system-related diseases
Doctors, who diagnose and care for patients with diseases related to the immune system, such as ...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - February 12, 2024 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Cells Injury and Illness Immunology Miniseries Infectious Diseases Medicines Microbes Research Roundup Source Type: blogs
Fight Aging! Newsletter, February 12th 2024
In conclusion, frailty is a dynamic process, and improved frailty and remaining robust are significantly associated with lower risk of all-cause mortality and cardiovascular death in older people.
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Greater Individual Wealth Correlates with Longer Life Expectancy
https://www.fightaging.org/archives/2024/02/greater-individual-wealth-correlates-with-longer-life-expectancy/
Individual wealth correlates with life expectancy, with an effect size that is in the same ballpark as those related to lifestyle choices involving exercise, diet, and consequences thereof. It remains unclear...
Source: Fight Aging! - February 11, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Systematic review finds more clinical harm than benefits in Alzheimer ’s “treatments” lecanemab, aducanumab, and donanemab
CONCLUSIONS: Although monoclonal antibodies targeting amyloid provide small benefits on cognitive and functional scales in patients with Alzheimer dementia, these improvements are far below the MCID for each outcome and are accompanied by clinically meaningful harms.
The Study in Context:
Should doctors prescribe lecanemab (Leqembi) to women? The answer, given available evidence, is probably No
First, do no harm? Six reasons to approach anti-amyloid drug Aduhelm cautiously, if at all
Report: 35% of worldwide dementia cases could be prevented by modifying these 9 modifiable risk factors
The post Systematic review fi...
Source: SharpBrains - February 9, 2024 Category: Neuroscience Authors: SharpBrains Tags: Brain/ Mental Health aducanumab Alzheimer's drug Alzheimers-treatment brain bleeds brain swelling cognition dementia donanemab FDA lecanemab Leqembi Medicare Mini-Mental State test minimal clinically important difference mono Source Type: blogs
Further Exploration of Drainage Pathways for Cerebrospinal Fluid
Considerable progress has been made in recent years in mapping the pathways by which cerebrospinal fluid drains from the brain into the body, many of which were only recently discovered. The present consensus is that the progressive loss of this drainage with advancing age is likely important in the development of neurodegenerative conditions, allowing molecular waste such as amyloid-β to build up in the brain. Researchers here discuss a new branch of the system of cerebrospinal fluid drainage that passes behind the nose. Like the related cribriform plate pathway, this makes it off interest in the development of Alzheimer...
Source: Fight Aging! - February 5, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
