Should doctors prescribe Leqembi (lecanemab) to women with early Alzheimer ’s Disease? The evidence-based answer is probably No
Welcome to a new edition of SharpBrains e‑newsletter, featuring this time a range of interventions for brain/ cognitive/ mental health plus a few brain teasers to test our perception and cognitive skills.
#1. Should doctors prescribe lecanemab (Leqembi) to women? The answer, given available evidence, is probably No
Huge (and mostly overlooked) red flag regarding newly approved “anti-Alzheimer’s” drugs: “To put it bluntly, if lecanemab doesn’t work in women it would be unethical to supply it to women. Recall this costly immunotherapy comes with substantive risks, including high incidence of ARIA and even death....
Source: SharpBrains - June 28, 2023 Category: Neuroscience Authors: SharpBrains Tags: Brain/ Mental Health SharpBrains Monthly eNewsletter Technology & Innovation ADHD-symptoms Alzheimers-disease Anti-Alzheimer’s Drugs anti-amyloid drugs ARIA Brain Teasers brain teasers for adults cognitive-behavioral-therapy cognit Source Type: blogs
Thinking New Thoughts about the Human Brain | TAPP 139
In Episode 139, we explore anew discovery in nerve signaling in the brain called adendritic action potential (dCaAP), we look at a whackyproposed model of brain function, and we share some ideas about how we can help our students understand thecore concepts ofchemical signaling andsignal transduction in different contexts. Put on your thinking caps and jump into this fresh episode now.00:00 | Introduction00:50 | Dendritic Action Potentials12:16 | Transducer Model of the Brain21:43 | Chemical Signals& Signal Transduction35:09 | Staying Connected ★ If you cannot see or activate the audio player, go to:theAPprofess...
Source: The A and P Professor - June 28, 2023 Category: Physiology Authors: Kevin Patton Source Type: blogs
Generational intelligence tests score changes in Spain: Are we asking the right question? - ScienceDirect
Generational intelligence tests score changes in Spain: Are we asking the right question? - ScienceDirect https://www.sciencedirect.com/science/article/abs/pii/S0160289623000533Generational intelligence test score gains have been documented worldwide in the twentieth century. However, recent evidence suggests these increased scores are coming to an end in some world regions. Here we compare two cohorts of university freshmen. The first cohort (n = 311) was assessed in 1991, whereas the second cohort (n = 349) was assessed thirty years later (2022). These cohorts completed the same intelligen...
Source: Intelligent Insights on Intelligence Theories and Tests (aka IQ's Corner) - June 27, 2023 Category: Neuroscience Source Type: blogs
If Probiotics in their Present Form Were a Truly Effective Intervention, We Would Already Know
There is an increasing focus in the research community on the role of the gut microbiome in aging. This is in large part driven by the ability to accurately, cost-effectively measure the composition of the gut microbiome from a stool sample, using 16S rRNA sequencing. The 16S rRNA gene is differs between bacterial species, without being subject to a high rate of mutation and change. Using low-cost modern techniques, researchers can thus read out the relative numbers of different species in the gut microbiome, a service now available to the public at large as well. This allows researchers to see exactly how the balance of p...
Source: Fight Aging! - June 26, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, June 26th 2023
This study explored the association between different cooking fuel types and the risk of cancer and all-cause mortality among seniors constructing Cox regression models. Data were obtained by linking waves of 6, 7, and 8 of the Chinese Longitudinal Healthy Longevity Survey, which included a total of 7,269 participants who were 65 years old and over. Cooking fuels were categorized as either biomass, fossil, or clean fuels. And the effects of switching cooking fuels on death risk were also investigated using Cox regression models.
The results indicate that, compared with the users of clean fuels, individuals using bio...
Source: Fight Aging! - June 25, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Optimism for the Future of Amyloid- β Clearance
In today's popular science article, the SENS Research Foundation offers a more rosy picture of the near future of amyloid-β clearance than is the usual fare these days. Amyloids are misfolded or otherwise altered proteins that can aggregate to form solid deposits that disrupt cellular biochemistry. In principle they should all be removed. Their existence is a form of harmful change that takes place with age, and the connections to cell dysfunction are quite clear. The failure of amyloid-β clearance to produce meaningful benefits in Alzheimer's patients has led to some disillusionment, however.
Alzheimer's may be a...
Source: Fight Aging! - June 21, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Growing controversy over role of FDA and Medicare in promoting anti-amyloid drugs given limited benefit, high cost, severe side-effects
The War Over Whether Medicare Should Pay For The New Anti-Alzheimer’s Drugs (Forbers):
The powerful Alzheimer’s Disease lobby is fighting a multi-billion-dollar battle on two fronts. It is quietly trying to limit restrictions the Food and Drug Administration puts on the use of new drugs aimed at slowing the progression of the brain disease. And it is publicly pressing Medicare to pay for the widespread use of the monoclonal antibodies FDA already has conditionally approved as well as others in the pipeline.
While the FDA approves drugs for use, it doesn’t decide who pays for them. And, for now, the Centers for Medica...
Source: SharpBrains - June 21, 2023 Category: Neuroscience Authors: SharpBrains Tags: Brain/ Mental Health Alzheimer's experts Alzheimer’s Disease Anti-Alzheimer’s Drugs Biogen brain swelling Eisai europe FDA lecanemab Medicare Source Type: blogs
Fight Aging! Newsletter, June 19th 2023
In conclusion, among Swedish middle-aged subjects, nearly two-thirds showed complete fatty degeneration of thymus on CT.
Age-Related Dysfunction of Water Homeostasis
https://www.fightaging.org/archives/2023/06/age-related-dysfunction-of-water-homeostasis/
Dehydration can be an issue in older people. As in every complex system in the body, the mechanisms by which hydration is regulated become dysfunctional with advancing age. Researchers here look at the brain region responsible for regulating some of the response to dehydration, cataloging altered gene expression in search of the more important mechan...
Source: Fight Aging! - June 18, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Notes from the 2023 Age-Related Disease Therapeutics Summit
The former Longevity Therapeutics conference series was renamed to the Age-Related Disease Therapeutics Summit and held its fifth event recently in San Francisco. It was a smaller meeting than in past years, perhaps a result of the recent downturn in the global financial and investment environment. Few investors were present. Nonetheless, one can usually learn something interesting from the presenting biotech founders and executives. I took a few notes while I was there to present on progress at Repair Biotechnologies, and they follow in the order of the conference program.
Birget Schilling from the Buck Institute f...
Source: Fight Aging! - June 16, 2023 Category: Research Authors: Reason Tags: Longevity Industry Source Type: blogs
Young people are abandoning news websites – new research reveals scale of challenge to media
This is a major factor in why my three blogs are now largely dormant of new creative content from me, and instead, serve as quick FYI posts. Blogging was great for a while, but one must move with the times. Perhaps, someday, I ' ll try TikTok. Young people are abandoning news websites – new research reveals scale of challenge to media https://flip.it/rtzoEZ****************************************** Kevin S. McGrew, PhD Educational& School Psychologist Director Institute for Applied Psychometrics (IAP)https://www.themindhub.com ****************************************** (Source: Intel...
Source: Intelligent Insights on Intelligence Theories and Tests (aka IQ's Corner) - June 15, 2023 Category: Neuroscience Source Type: blogs
The National Health Service (NHS) in England to roll-out nine online cognitive-behavioural therapies (CBT) for adults with anxiety or depression
Online depression therapy given go-ahead in England (BBC News):
Nine online talking-therapy treatments for anxiety or depression have been given the green light to be used by the NHS in England.
… The new digital therapies are delivered via a website or an app and use cognitive-behavioural therapy (CBT).
They provide an alternative way of accessing support, which may be more convenient for some, the National Institute for Health and Care Excellence (NICE) says. They could also free up resources and help reduce the wait for care.…
Mark Chapman from NICE said: “One of our priorities is to get the best care to peop...
Source: SharpBrains - June 14, 2023 Category: Neuroscience Authors: SharpBrains Tags: Brain/ Mental Health Technology & Innovation anxiety-disorders Beating the Blues CBT methods cognitive behavioural therapy Deprexis iCT-PTSD iCT-SAD National Institute for Health and Care Excellence NHS NHS Talking Therapies online Source Type: blogs
Proceeding with Caution: The Impact of (Generative) AI on Healthcare and Life Sciences
Conclusion:
The benefits of AI in healthcare outweigh the negatives, but that does not mean organizations should jump in without careful consideration. Initiating the AI conversation and creating a concrete action plan are essential and reach out to the Dell team so we can help you navigate these challenging conversations.
Dell Technologies can help by working with healthcare, clinical, research, operational, and IT teams to create, and codify action plans that establish robust governance frameworks and ensure data integrity – ultimately protecting patient safety and privacy. Pandora’s box has been opened, and we c...
Source: EMR and HIPAA - June 13, 2023 Category: Information Technology Authors: Guest Author Tags: AI/Machine Learning Analytics/Big Data C-Suite Leadership Health IT Company Healthcare IT Hospital - Health System IT Infrastructure and Dev Ops Artificial Intelligence ChatGPT Data Protection Dell Technologies Dell Technologies Worl Source Type: blogs
“We Are Electric” by Sally Adee: Medgadget Interviews the Author
The human body has a deep connection with electricity. The transmission of electrical impulses is responsible for the movement of our limbs, the functioning of our organs, and the formation and recall of memories. The signatures of the various electrical signals emanating from our body can be telltale signs of our health, and a jolt of electricity can literally bring us back from the brink of death.
But while these things have long been known about the electricity constantly coursing through our bodies, what has more recently been discovered is the role that “bioelectricity” plays in the formation of our bod...
Source: Medgadget - June 12, 2023 Category: Medical Devices Authors: Scott Jung Tags: Education etc. Exclusive Source Type: blogs
Fight Aging! Newsletter, June 12th 2023
In this study, we investigated the effect of NXP032 on neurovascular stabilization through the changes of PECAM-1, PDGFR-β, ZO-1, laminin, and glial cells involved in maintaining the integrity of the blood-brain barrier (BBB) in aged mice. NXP032 was orally administered daily for 8 weeks. Compared to young mice and NXP032-treated mice, 20-month-old mice displayed cognitive impairments in Y-maze and passive avoidance tests. NXP032 treatment contributed to reducing the BBB damage by attenuating the fragmentation of microvessels and reducing PDGFR-β, ZO-1, and laminin expression, thereby mitigating astrocytes and microglia ...
Source: Fight Aging! - June 11, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Looking Back at the Growth and Maturation of the Field of Aging Research
A great deal has changed in these last few decades in the field of aging research. From the 60s onward to the 90s, aging research was increasingly characterized by a philosophy of "look but don't touch", an effort to distance academia from the growing anti-aging industry and its hype. It made itself a backwater science in which talk of intervention was aggressively discouraged by leaders in the field. Starting in the 90s, with studies showing significant life extension in lower animals following single gene mutations, it became impossible to ignore the potential to treat aging as a medical condition in humans.
Nonet...
Source: Fight Aging! - June 9, 2023 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
