Efficacy of Yisui granule on myelodysplastic syndromes in SKM-1 mouse xenograft model through suppressing Wnt/ β-catenin signaling pathway
CONCLUSIONS: Our findings demonstrated that YSG could be used alone or in combination with decitabine to improve outcomes in the MDS animal model, providing an alternative solution for treating MDS.PMID:38213242 | PMC:PMC10774724 | DOI:10.19852/j.cnki.jtcm.20231204.003 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - January 12, 2024 Category: Complementary Medicine Authors: W U Jieya Hou Li Zhang Xiaoyuan Elizabeth Gullen Gao Chong Wang Jing Source Type: research
Efficacy of Yisui granule on myelodysplastic syndromes in SKM-1 mouse xenograft model through suppressing Wnt/ β-catenin signaling pathway
CONCLUSIONS: Our findings demonstrated that YSG could be used alone or in combination with decitabine to improve outcomes in the MDS animal model, providing an alternative solution for treating MDS.PMID:38213242 | PMC:PMC10774724 | DOI:10.19852/j.cnki.jtcm.20231204.003 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - January 12, 2024 Category: Complementary Medicine Authors: W U Jieya Hou Li Zhang Xiaoyuan Elizabeth Gullen Gao Chong Wang Jing Source Type: research
Efficacy of Yisui granule on myelodysplastic syndromes in SKM-1 mouse xenograft model through suppressing Wnt/ β-catenin signaling pathway
CONCLUSIONS: Our findings demonstrated that YSG could be used alone or in combination with decitabine to improve outcomes in the MDS animal model, providing an alternative solution for treating MDS.PMID:38213242 | PMC:PMC10774724 | DOI:10.19852/j.cnki.jtcm.20231204.003 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - January 12, 2024 Category: Complementary Medicine Authors: W U Jieya Hou Li Zhang Xiaoyuan Elizabeth Gullen Gao Chong Wang Jing Source Type: research
Cancers, Vol. 16, Pages 332: The Role of Hepcidin in Myelodysplastic Syndromes (MDS): A Systematic Review of Observational Studies
tyczyński
Iron overload emerges as a serious complication in myelodysplastic syndromes (MDS), particularly associated with frequent transfusions during the course of the disease. The discovery and description of hepcidin’s mechanisms of action have contributed to a deeper understanding of iron metabolism. The existing literature reports a potential role of hepcidin in MDS, yet these data are fragmented and presented in an unstructured, somewhat chaotic manner. Hence, to address the existing data, we performed a systematic review of observational studies examining hepcidin levels in MDS. An extensive revi...
Source: Cancers - January 11, 2024 Category: Cancer & Oncology Authors: Artur S łomka Anna Pokrzywa Dominika Strza ła Maja Kubiaczyk Oliwia Wesolowska Kinga Denkiewicz Jan Styczy ński Tags: Systematic Review Source Type: research
Clinical impacts of severe thrombocytopenia in the first cycle of azacitidine monotherapy and cytogenetics in patients with myelodysplastic syndrome: The Kyoto Conditional Survival Scoring System
In conclusion, extreme PC transfusion dependency during the first cycle of AZA and very poor risk cytogenetics are important prognostic factors in AZA monotherapy for MDS.PMID:38192677 | PMC:PMC10773215 | DOI:10.3892/ol.2023.14193 (Source: Oncology Letters)
Source: Oncology Letters - January 9, 2024 Category: Cancer & Oncology Authors: Yu Inoue Haruya Okamoto Akihiro Miyashita Yuka Kawaji-Kanayama Shotaro Chinen Takahiro Fujino Taku Tsukamoto Yuji Shimura Shinsuke Mizutani Hiroto Kaneko Saeko Kuwahara-Ota Shin-Ichi Fuchida Daichi Nishiyama Koichi Hirakawa Hitoji Uchiyama Nobuhiko Uoshim Source Type: research
The role of ASXL1 mutations and ASXL1 CircRNAs in cancer
CONCLUSION: ASXL1 and ASXL1circRNA have dual functions in combination with different proteins, being involved in both transcriptional activation and repression in a context-dependent manner. Moreover, studies indicate these genes play an important role in epithelial-mesenchymal transition (EMT) and metastasis. Ongoing research is aimed at determining this gene family's function in biological events.PMID:38193494 | DOI:10.1080/1354750X.2024.2304187 (Source: Biomarkers)
Source: Biomarkers - January 9, 2024 Category: Research Authors: Narges Jafarbeik-Iravani Sara Kolahdozan Rezvan Esmaeili Source Type: research
Outcomes and effect of somatic mutations after erythropoiesis stimulating agents in patients with lower-risk myelodysplastic syndromes
CONCLUSION: This large study confirms the beneficial effect of ESAs and the adverse effect of somatic mutations in patients with LR-MDS.PMID:38186638 | PMC:PMC10768603 | DOI:10.1177/20406207231218157 (Source: Adv Data)
Source: Adv Data - January 8, 2024 Category: Epidemiology Authors: Juan Carlos Caballero Julio D ávila Mar ía López-Pavía Esperanza Such Teresa Bernal Fernando Ramos Marisa Calabuig Jes ús María Hernández Sánchez Helena Pomares Mercedes S ánchez Barba Mar ía Abáigar Bernardo Gonz ález Brayan Merch án Reyes S Source Type: research
Outcomes and effect of somatic mutations after erythropoiesis stimulating agents in patients with lower-risk myelodysplastic syndromes
CONCLUSION: This large study confirms the beneficial effect of ESAs and the adverse effect of somatic mutations in patients with LR-MDS.PMID:38186638 | PMC:PMC10768603 | DOI:10.1177/20406207231218157 (Source: Adv Data)
Source: Adv Data - January 8, 2024 Category: Epidemiology Authors: Juan Carlos Caballero Julio D ávila Mar ía López-Pavía Esperanza Such Teresa Bernal Fernando Ramos Marisa Calabuig Jes ús María Hernández Sánchez Helena Pomares Mercedes S ánchez Barba Mar ía Abáigar Bernardo Gonz ález Brayan Merch án Reyes S Source Type: research
The role of genetic factors in pediatric myelodysplastic syndromes with different outcomes
Pediatric myelodysplastic syndromes (MDS) are rare disorders with an unrevealed pathogenesis. Our aim is to explore the role of genetic factors in the pathogenesis of MDS in children with different outcomes an... (Source: BMC Pediatrics)
Source: BMC Pediatrics - January 8, 2024 Category: Pediatrics Authors: Ying Li, Li Cheng, Yun Peng, Lin Wang, Wenzhi Zhang, Yuhong Yin, Jing Zhang and Xiaoyan Wu Tags: Research Source Type: research
Vaccines: a promising therapy for myelodysplastic syndrome
Myelodysplastic neoplasms (MDS) define clonal hematopoietic malignancies characterized by heterogeneous mutational and clinical spectra typically seen in the elderly. Curative treatment entails allogeneic hema... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - January 8, 2024 Category: Hematology Authors: Kriti Gera, Anjali Chauhan, Paul Castillo, Maryam Rahman, Akash Mathavan, Akshay Mathavan, Elizabeth Oganda-Rivas, Leighton Elliott, John R. Wingard and Elias J. Sayour Tags: Review Source Type: research
Vemurafenib induces senescence in acute myeloid leukemia and myelodysplastic syndrome by activating the HIPPO signaling pathway: implications for potential targeted therapy
The outcome of Acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) remain dismal despite the development of treatment. Targeted therapy is gaining more and more attention in improving prognosis. (Source: Biology Direct)
Source: Biology Direct - January 4, 2024 Category: Biology Authors: Qiao Zhou, Jiamin Zhang, Jingsong Zhang, Simin Liang, Duo Cai, Han Xiao, Yu Zhu, Wenqiong Xiang, Fernando Rodrigues-Lima, Jianxiang Chi, Fabien Guidez and Li Wang Tags: Research Source Type: research
The der(1;7)(q10;p10) defining a distinct profile from −7/del(7q) in myelodysplastic syndromes: A systematic review and meta‐analysis
ConclusionThe findings revealed distinct clinical, cytogenetic, and molecular characteristics distinguishing der(1;7) from −7/del(7q), indicating der(1;7) defines a unique subtype within MDS with monosomy 7q. These findings support classifying der(1;7) as a separate MDS entity in future. (Source: Cancer Medicine)
Source: Cancer Medicine - January 2, 2024 Category: Cancer & Oncology Authors: Wei Lang,
Yingwan Luo,
Lu Wang,
Yudi Zhang,
Chao Hu,
Huanping Wang,
Hongyan Tong Tags: RESEARCH ARTICLE Source Type: research
Long-term complications after allogeneic hematopoietic stem cell transplantation for pediatric patients with acute leukemia or myelodysplastic syndrome given either a Treosulfan- or a Busulfan-based conditioning regimen: results of an AIEOP (Associazione Italiana Ematologia Oncologia Pediatrica) retrospective study.
Allogeneic hematopoietic stem cell transplantation (alloHSCT) represents the therapeutic option able to offer the highest rate of a successful cure for most children and young adults (AYA) with very high-risk and relapsed acute leukemia or myelodysplasia1. Although the prognosis has largely improved over the decades2,3, survivors after HSCT during childhood or adolescence still have an increased risk of developing long-term toxicities that can interfere with their general health4 and have a detrimental impact on their quality of life5. (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - January 2, 2024 Category: Hematology Authors: Francesco Saglio, Daria Pagliara, Marco Zecca, Adriana Balduzzi, Alessandro Cattoni, Arcangelo Prete, Francesco Paolo Tambaro, Maura Faraci, Elisabetta Calore, Franco Locatelli, Franca Fagioli, On Bhealf of AIEOP BMT Group Source Type: research
Long-Term Complications after Allogeneic Hematopoietic Stem Cell Transplantation with Treosulfan- or Busulfan-Based Conditioning in Pediatric Patients with Acute Leukemia or Myelodysplastic Syndrome: Results of an Associazione Italiana Ematologia Oncologia Pediatrica Retrospective Study
Patients undergoing hematopoietic stem cell transplantation (HSCT) for hematologic malignancies during childhood have an increased risk of developing long-term sequelae that are in part attributable to the conditioning regimen. The present study aimed to assess the occurrence of long-term toxicities in a population of children who underwent HSCT for hematologic malignancies using either treosulfan or busulfan in the conditioning regimen. The cumulative incidences of growth impairment, altered gonadal function, altered thyroid function, cataracts, secondary malignant neoplasia, and altered pulmonary function were evaluated ...
Source: Biology of Blood and Marrow Transplantation - January 2, 2024 Category: Hematology Authors: Francesco Saglio, Daria Pagliara, Marco Zecca, Adriana Balduzzi, Alessandro Cattoni, Arcangelo Prete, Francesco Paolo Tambaro, Maura Faraci, Elisabetta Calore, Franco Locatelli, Franca Fagioli, AIEOP BMT Group Tags: Full Length Article Source Type: research
Epigenetic therapy: Research progress of decitabine in the treatment of solid tumors
This article reviews the application mechanism and current status of decitabine in the treatment of solid tumors.PMID:38163523 | DOI:10.1016/j.bbcan.2023.189066 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - January 1, 2024 Category: Biochemistry Authors: Chenlin Ye Nan Jiang Jing Zheng Shumeng Zhang Jingchen Zhang Jianya Zhou Source Type: research
