Persistent or new cytopenias predict relapse better than routine bone marrow aspirate evaluations after hematopoietic cell transplantation for acute leukemia or myelodysplastic syndrome in children and young adult patients
Allogeneic hematopoietic cell transplantation (alloHCT) offers a curative approach to children with high-risk leukemia, refractory leukemia, and myelodysplastic syndrome (MDS) with survival rates ranging from 50% to 70%.1,2. Relapse within the first two years after HCT is the most common cause of treatment failure.1,3,4 Among pediatric transplantation providers there is growing consensus regarding appropriate patient and donor selection, cytoreduction and source of stem cells.2 Although detection of bone marrow (BM) minimal residual disease (MRD) by multiparameter flow cytometry (MFC, MFC-MRD) or next generation sequencing...
Source: Biology of Blood and Marrow Transplantation - April 19, 2024 Category: Hematology Authors: Nancy A. Kernan, Elizabeth Klein, Audrey Mauguen, Joanne Torok-Castanza, Susan E. Prockop, Andromachi Scaradavou, Kevin Curran, Barbara Spitzer, Maria Cancio, Julie Ruggiero, Jennifer Allen, Andrew Harris, Joseph Oved, Richard J. O'Reilly, Jaap Jan Boelen Source Type: research
Treatment of Myelodysplastic Syndromes for Older Patients: Current State of Science, Challenges, and Opportunities
AbstractPurpose of ReviewMyelodysplastic syndromes/neoplasms (MDS) represent a diverse group of pathologically distinct diseases with varying prognoses and risks of leukemia progression. This review aims to discuss current treatment options for elderly patients with MDS, focusing on patients ineligible for intensive chemotherapy or allogenic hematopoietic stem cell transplantation (HSCT). The challenges associated with treatment in this population and emerging therapeutic prospects are also explored.Recent FindingsRecent advancements in molecular diagnostics have enhanced risk stratification by incorporating genetic mutati...
Source: Current Hematologic Malignancy Reports - April 18, 2024 Category: Hematology Source Type: research
Eosinophilia During Lenalidomide Therapy in Myelodysplastic Syndrome
Lenalidomide is an immunomodulatory therapy used to treat multiple hematologic malignancies. The incidence of eosinophilia and hypereosinophilia during lenalidomide therapy, and the requirement for high-dose steroids are not well-defined (Source: Clinical Lymphoma, Myeloma and Leukemia)
Source: Clinical Lymphoma, Myeloma and Leukemia - April 18, 2024 Category: Hematology Authors: Koji Sasaki, Hagop Kantarjian, Guillermo Montalban-Bravo, Danielle Hammond, Elias Jabbour, Rashmi Kanagal-Shamanna, Kelly Chien, Guillermo Garcia-Manero Tags: Original Study Source Type: research
Treatment of Myelodysplastic Syndromes for Older Patients: Current State of Science, Challenges, and Opportunities
AbstractPurpose of ReviewMyelodysplastic syndromes/neoplasms (MDS) represent a diverse group of pathologically distinct diseases with varying prognoses and risks of leukemia progression. This review aims to discuss current treatment options for elderly patients with MDS, focusing on patients ineligible for intensive chemotherapy or allogenic hematopoietic stem cell transplantation (HSCT). The challenges associated with treatment in this population and emerging therapeutic prospects are also explored.Recent FindingsRecent advancements in molecular diagnostics have enhanced risk stratification by incorporating genetic mutati...
Source: Current Hematologic Malignancy Reports - April 18, 2024 Category: Hematology Source Type: research
Ectopic expression of the transcription factor ONECUT3 drives a complex karyotype in myelodysplastic syndromes
This study revealed that ONECUT3 promoted chromosomal instability by transcriptional activation of INCENP and CDCA8, suggesting potential prognostic and therapeutic roles for targeting high-risk MDS patients with a CK. (Source: Journal of Clinical Investigation)
Source: Journal of Clinical Investigation - April 15, 2024 Category: Biomedical Science Authors: Yingwan Luo, Xiaomin Feng, Wei Lang, Weihong Xu, Wei Wang, Chen Mei, Li Ye, Shuanghong Zhu, Lu Wang, Xinping Zhou, Huimin Zeng, Liya Ma, Yanling Ren, Jie Jin, Rongzhen Xu, Gang Huang, Hongyan Tong Source Type: research
Molecular responses in decitabine- and decitabine/venetoclax-treated patients with acute myeloid leukemia and myelodysplastic syndromes
Haematologica. 2024 Apr 11. doi: 10.3324/haematol.2022.281396. Online ahead of print.ABSTRACTNot available.PMID:38618679 | DOI:10.3324/haematol.2022.281396 (Source: Haematologica)
Source: Haematologica - April 15, 2024 Category: Hematology Authors: Agata Gruszczynska Abhishek Maiti Christopher A Miller Sai Mukund Ramakrishnan Daniel C Link Geoffrey L Uy Allegra A Petti Kala Hayes Courtney D DiNardo Farhad Ravandi Timothy J Ley David H Spencer Feng Gao Marina Y Konopleva John S Welch Source Type: research
Molecular responses in decitabine- and decitabine/venetoclax-treated patients with acute myeloid leukemia and myelodysplastic syndromes
Haematologica. 2024 Apr 11. doi: 10.3324/haematol.2022.281396. Online ahead of print.ABSTRACTNot available.PMID:38618679 | DOI:10.3324/haematol.2022.281396 (Source: Haematologica)
Source: Haematologica - April 15, 2024 Category: Hematology Authors: Agata Gruszczynska Abhishek Maiti Christopher A Miller Sai Mukund Ramakrishnan Daniel C Link Geoffrey L Uy Allegra A Petti Kala Hayes Courtney D DiNardo Farhad Ravandi Timothy J Ley David H Spencer Feng Gao Marina Y Konopleva John S Welch Source Type: research
Molecular responses in decitabine- and decitabine/venetoclax-treated patients with acute myeloid leukemia and myelodysplastic syndromes
Haematologica. 2024 Apr 11. doi: 10.3324/haematol.2022.281396. Online ahead of print.ABSTRACTNot available.PMID:38618679 | DOI:10.3324/haematol.2022.281396 (Source: Haematologica)
Source: Haematologica - April 15, 2024 Category: Hematology Authors: Agata Gruszczynska Abhishek Maiti Christopher A Miller Sai Mukund Ramakrishnan Daniel C Link Geoffrey L Uy Allegra A Petti Kala Hayes Courtney D DiNardo Farhad Ravandi Timothy J Ley David H Spencer Feng Gao Marina Y Konopleva John S Welch Source Type: research
Role of reactive oxygen species in myelodysplastic syndromes
Cell Mol Biol Lett. 2024 Apr 14;29(1):53. doi: 10.1186/s11658-024-00570-0.ABSTRACTReactive oxygen species (ROS) serve as typical metabolic byproducts of aerobic life and play a pivotal role in redox reactions and signal transduction pathways. Contingent upon their concentration, ROS production not only initiates or stimulates tumorigenesis but also causes oxidative stress (OS) and triggers cellular apoptosis. Mounting literature supports the view that ROS are closely interwoven with the pathogenesis of a cluster of diseases, particularly those involving cell proliferation and differentiation, such as myelodysplastic syndro...
Source: Cellular and Molecular Biology Letters - April 14, 2024 Category: Biochemistry Authors: Qiangan Jing Chaoting Zhou Junyu Zhang Ping Zhang Yunyi Wu Junyu Zhou Xiangmin Tong Yanchun Li Jing Du Ying Wang Source Type: research
Role of reactive oxygen species in myelodysplastic syndromes
Cell Mol Biol Lett. 2024 Apr 14;29(1):53. doi: 10.1186/s11658-024-00570-0.ABSTRACTReactive oxygen species (ROS) serve as typical metabolic byproducts of aerobic life and play a pivotal role in redox reactions and signal transduction pathways. Contingent upon their concentration, ROS production not only initiates or stimulates tumorigenesis but also causes oxidative stress (OS) and triggers cellular apoptosis. Mounting literature supports the view that ROS are closely interwoven with the pathogenesis of a cluster of diseases, particularly those involving cell proliferation and differentiation, such as myelodysplastic syndro...
Source: Mol Biol Cell - April 14, 2024 Category: Molecular Biology Authors: Qiangan Jing Chaoting Zhou Junyu Zhang Ping Zhang Yunyi Wu Junyu Zhou Xiangmin Tong Yanchun Li Jing Du Ying Wang Source Type: research
Characteristic phenotypes of ADH5/ALDH2 deficiency during childhood
Eur J Med Genet. 2024 Apr 15;69:104939. doi: 10.1016/j.ejmg.2024.104939. Online ahead of print.ABSTRACTADH5/ALDH2 deficiency is a rare inherited syndrome characterized by short stature, microcephaly, delayed mental development, and hematopoietic dysfunction and has recently been proposed as a disease paradigm. Acute and severe presentations include aplastic anemia, myelodysplastic syndrome, or leukemia, requiring bone marrow transplantation during childhood. Conversely, non-hematological manifestations may exhibit a prolonged and nonspecific clinical trajectory, with growth failure and developmental delay, most of which ar...
Source: European Journal of Medical Genetics - April 13, 2024 Category: Genetics & Stem Cells Authors: Mio Matsumoto Momoko Oyake Tomoyo Itonaga Miwako Maeda Soichi Suenobu Daichi Sato Yoji Sasahara Hiroyuki Mishima Koh-Ichiro Yoshiura Kenji Ihara Source Type: research
Characteristic phenotypes of ADH5/ALDH2 deficiency during childhood
Eur J Med Genet. 2024 Apr 15;69:104939. doi: 10.1016/j.ejmg.2024.104939. Online ahead of print.ABSTRACTADH5/ALDH2 deficiency is a rare inherited syndrome characterized by short stature, microcephaly, delayed mental development, and hematopoietic dysfunction and has recently been proposed as a disease paradigm. Acute and severe presentations include aplastic anemia, myelodysplastic syndrome, or leukemia, requiring bone marrow transplantation during childhood. Conversely, non-hematological manifestations may exhibit a prolonged and nonspecific clinical trajectory, with growth failure and developmental delay, most of which ar...
Source: European Journal of Medical Genetics - April 13, 2024 Category: Genetics & Stem Cells Authors: Mio Matsumoto Momoko Oyake Tomoyo Itonaga Miwako Maeda Soichi Suenobu Daichi Sato Yoji Sasahara Hiroyuki Mishima Koh-Ichiro Yoshiura Kenji Ihara Source Type: research
Characteristic phenotypes of ADH5/ALDH2 deficiency during childhood
Eur J Med Genet. 2024 Apr 15;69:104939. doi: 10.1016/j.ejmg.2024.104939. Online ahead of print.ABSTRACTADH5/ALDH2 deficiency is a rare inherited syndrome characterized by short stature, microcephaly, delayed mental development, and hematopoietic dysfunction and has recently been proposed as a disease paradigm. Acute and severe presentations include aplastic anemia, myelodysplastic syndrome, or leukemia, requiring bone marrow transplantation during childhood. Conversely, non-hematological manifestations may exhibit a prolonged and nonspecific clinical trajectory, with growth failure and developmental delay, most of which ar...
Source: European Journal of Medical Genetics - April 13, 2024 Category: Genetics & Stem Cells Authors: Mio Matsumoto Momoko Oyake Tomoyo Itonaga Miwako Maeda Soichi Suenobu Daichi Sato Yoji Sasahara Hiroyuki Mishima Koh-Ichiro Yoshiura Kenji Ihara Source Type: research
Characteristic phenotypes of ADH5/ALDH2 deficiency during childhood
Eur J Med Genet. 2024 Apr 15;69:104939. doi: 10.1016/j.ejmg.2024.104939. Online ahead of print.ABSTRACTADH5/ALDH2 deficiency is a rare inherited syndrome characterized by short stature, microcephaly, delayed mental development, and hematopoietic dysfunction and has recently been proposed as a disease paradigm. Acute and severe presentations include aplastic anemia, myelodysplastic syndrome, or leukemia, requiring bone marrow transplantation during childhood. Conversely, non-hematological manifestations may exhibit a prolonged and nonspecific clinical trajectory, with growth failure and developmental delay, most of which ar...
Source: European Journal of Medical Genetics - April 13, 2024 Category: Genetics & Stem Cells Authors: Mio Matsumoto Momoko Oyake Tomoyo Itonaga Miwako Maeda Soichi Suenobu Daichi Sato Yoji Sasahara Hiroyuki Mishima Koh-Ichiro Yoshiura Kenji Ihara Source Type: research
Characteristic phenotypes of ADH5/ALDH2 deficiency during childhood
Eur J Med Genet. 2024 Apr 15;69:104939. doi: 10.1016/j.ejmg.2024.104939. Online ahead of print.ABSTRACTADH5/ALDH2 deficiency is a rare inherited syndrome characterized by short stature, microcephaly, delayed mental development, and hematopoietic dysfunction and has recently been proposed as a disease paradigm. Acute and severe presentations include aplastic anemia, myelodysplastic syndrome, or leukemia, requiring bone marrow transplantation during childhood. Conversely, non-hematological manifestations may exhibit a prolonged and nonspecific clinical trajectory, with growth failure and developmental delay, most of which ar...
Source: European Journal of Medical Genetics - April 13, 2024 Category: Genetics & Stem Cells Authors: Mio Matsumoto Momoko Oyake Tomoyo Itonaga Miwako Maeda Soichi Suenobu Daichi Sato Yoji Sasahara Hiroyuki Mishima Koh-Ichiro Yoshiura Kenji Ihara Source Type: research
