Unified platforM for a Better integRal Evaluation of MyeLodyspLastic Syndromes in SpAin-Strategy for Unraveling Personalized genoMic Medicine in Public heAlth System (UMBRELLA-SUMMA)
Conditions: Myelodysplastic Syndromes Sponsors: Instituto de Investigaci ón Biomédica de Salamanca; Carlos III Health Institute Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 23, 2024 Category: Research Source Type: clinical trials

A Study of GLB-001 in Patients With Myeloid Malignancies
Conditions: Polycythemia Vera; Essential Thrombocythemia; Myelofibrosis; Myelodysplastic Syndromes; Acute Myeloid Leukemia; Myeloid Malignancy Interventions: Drug: GLB-001 Sponsors: Hangzhou GluBio Pharmaceutical Co., Ltd. Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 22, 2024 Category: Research Source Type: clinical trials

A Study to Investigate APL-4098 Alone and/or in Combination With Azacitidine in R/R AML and High-Risk MDS
Conditions: Acute Myeloid Leukemia Refractory; Myelodysplastic Syndrome Acute Myeloid Leukemia; Myelodysplastic Syndrome With Excess Blasts; Acute Myeloid Leukemia, in Relapse Interventions: Drug: APL-4098; Drug: Azacitidine and APL-4098 Sponsors: Apollo Therapeutics Ltd Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 18, 2024 Category: Research Source Type: clinical trials

Iadademstat in Combination With Azacitidine and Venetoclax in Treating Newly Diagnosed Acute Myeloid Leukemia
Conditions: Acute Myeloid Leukemia; Myelodysplastic Syndrome/Acute Myeloid Leukemia Interventions: Drug: Azacitidine; Procedure: Biospecimen Collection; Procedure: Bone Marrow Biopsy; Procedure: Echocardiography; Drug: Iadademstat; Procedure: Multigated Acquisition Scan; Other: Questionnaire Administration; Drug: Venetoclax Sponsors: OHSU Knight Cancer Institute; Oregon Health and Science University; Oryzon Genomics S.A. Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 10, 2024 Category: Research Source Type: clinical trials

Intestinal Microbiota Transplant Prior to Allogeneic Stem Cell Transplant (MAST) Trial
Conditions: Acute Lymphoblastic Leukaemia; Acute Leukemia of Ambiguous Lineage; Chronic Myeloid Leukemia; Chronic Myelomonocytic Leukemia; Myelodysplastic Syndrome; Acute Myeloid Leukemia Interventions: Drug: EBX-102; Drug: Placebo Sponsors: Imperial College London Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 9, 2024 Category: Research Source Type: clinical trials

Adding Venetoclax to the High-dose Chemotherapy Regimen Prior to Mismatche Allogeneic Stem Cell Transplant
Conditions: Acute Myeloid Leukemia; Myelodysplastic Syndromes Interventions: Drug: Venetoclax; Drug: Decitabine; Drug: Fludarabine; Drug: Busulfan; Radiation: Total Body Irradiation Sponsors: Northside Hospital, Inc. Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 29, 2024 Category: Research Source Type: clinical trials

A Prospective, Multicenter, and Exploratory Study of CMGV in the Treatment of Recurrent Adult AML and MDS-EB-2/Elder AML
Conditions: Recurrent Adult Acute Myeloid Leukemia; Myelodysplastic Syndrome; Adult Acute Myeloid Leukemia Interventions: Drug: CMGV Sponsors: Ruijin Hospital; Huadong Hospital; Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine; Huashan Hospital; Army Medical Center of PLA; Sun Yat-sen University; RenJi Hospital; Shanghai Jiading District Central Hospital; The Second Affiliated Hospital of Dalian Medical University; First Hospital of China Medical University; Dalian Municipal Central Hospital; Shanghai Zhongshan Hospital; Shanghai Pudong Hospital; Shanghai Public Health Clinical Center; Xuhui Cent...
Source: ClinicalTrials.gov - March 26, 2024 Category: Research Source Type: clinical trials

Trial of 2 Step ATG for Acute GVHD Prevention Post Myeloablative Allogeneic Stem Cell Transplant
Conditions: GVHD,Acute; Acute Leukemia; Myelodysplastic Syndromes; Myeloproliferative Disorders Interventions: Drug: ATG Combined with Tacrolimus and Mini Methotrexate Sponsors: University of Alabama at Birmingham Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 18, 2024 Category: Research Source Type: clinical trials

Keros Therapeutics Announces U.S. FDA Fast Track Designation for KER-050 in Lower-Risk Myelodysplastic Syndromes
LEXINGTON, Mass., March 14, 2024 (GLOBE NEWSWIRE) -- Keros Therapeutics, Inc. (“Keros”) (Nasdaq: KROS), a clinical-stage biopharmaceutical company focused on developing and commercializing novel therapeutics to treat a wide range of... (Source: Drugs.com - Clinical Trials)
Source: Drugs.com - Clinical Trials - March 14, 2024 Category: Pharmaceuticals Source Type: clinical trials

Pacritinib, a Kinase Inhibitor of CSF1R, IRAK1, JAK2, and FLT3, in Adults and Pediatric Participants 12 Years of Age or Older With Myelodysplastic Syndromes or Myelodysplastic/Myeloproliferative Neoplasms
Conditions: Myelodysplastic Syndromes Interventions: Drug: pacritinib Sponsors: National Cancer Institute (NCI) Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 11, 2024 Category: Research Source Type: clinical trials

A Study of Efficacy and Safety of AND017 in Patients With Myelodysplastic Syndrome
Conditions: Myelodysplastic Syndromes Anemia Interventions: Drug: AND017 Sponsors: Kind Pharmaceuticals LLC Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 11, 2024 Category: Research Source Type: clinical trials

PTCy and ATG for MSD and MUD Transplants
Conditions: Acute Myeloid Leukemia; Acute Lymphoblastic Leukemia; Myelodysplastic Syndromes; Hodgkin Lymphoma; Non-hodgkin Lymphoma Interventions: Drug: ATG 5.0; Drug: Cyclophosphamide injection; Drug: ATG 2.5 ±1.5 Sponsors: Instituto Nacional de Cancer, Brazil Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 7, 2024 Category: Research Source Type: clinical trials

Study of REM-422 in Patients With AML or Higher Risk MDS
Conditions: Myelodysplastic Syndromes; Higher Risk Myelodysplastic Syndromes; Acute Myeloid Leukemia; Acute Myeloid Leukemia Refractory Interventions: Drug: REM-422 Sponsors: Remix Therapeutics Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 7, 2024 Category: Research Source Type: clinical trials

Real-World Practice Patterns and Outcomes of Lower-Risk Myelodysplastic Syndrome Patients in Japan
Conditions: Lower-risk Myelodysplastic Syndromes Interventions: Procedure: Red blood cell transfusion; Procedure: Red blood cell transfusion Sponsors: Bristol-Myers Squibb Active, not recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 7, 2024 Category: Research Source Type: clinical trials

A Study of Single and Multiple Dose Administration of LP-001 in Healthy Subjects
Conditions: Myelodysplastic Syndrome (MDS) Interventions: Biological: LP-001 Dose 1 (Single); Biological: LP-001 Dose 2 (Single); Biological: LP-001 Dose 3 (Single); Biological: LP-001 Dose 4 (Single); Biological: LP-001 Dose 5 (Single); Biological: LP-001 Dose 6 (Single); Biological: Placebo (Single); Biological: LP-001 Dose 7 (Multiple); Biological: LP-001 Dose 8 (Multiple); Biological: Placebo (Multiple) Sponsors: Longbio Pharma Active, not recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 5, 2024 Category: Research Source Type: clinical trials