Prognostic impact of < em > SF3B1 < /em > mutation and multilineage dysplasia in myelodysplastic syndromes with ring sideroblasts: a Mayo Clinic study of 170 informative cases
Haematologica. 2024 Mar 7. doi: 10.3324/haematol.2023.284719. Online ahead of print.ABSTRACTThe revised 4th edition of the World Health Organization (WHO4R) classification lists myelodysplastic syndromes with ring sideroblasts (MDS-RS) as a separate entity with single lineage (MDS-RS-SLD) or multilineage (MDS-RS-MLD) dysplasia. The more recent International Consensus Classification (ICC) distinguishes between MDS with SF3B1 mutation (MDS-SF3B1) and MDS-RS without SF3B1 mutation; the latter is instead included under the category of MDS not otherwise specified. The current study includes 170 Mayo Clinic patients with WHO4R-d...
Source: Haematologica - March 7, 2024 Category: Hematology Authors: Faiqa Farrukh Maymona Abdelmagid Abhishek Mangaonkar Mrinal Patnaik Aref Al-Kali Michelle A Elliott Kebede H Begna Christopher C Hook William J Hogan Animesh Pardanani Mark R Litzow Rhett P Ketterling Naseema Gangat Daniel A Arber Attilio Orazi Rong He Ka Source Type: research
Prognostic impact of < em > SF3B1 < /em > mutation and multilineage dysplasia in myelodysplastic syndromes with ring sideroblasts: a Mayo Clinic study of 170 informative cases
Haematologica. 2024 Mar 7. doi: 10.3324/haematol.2023.284719. Online ahead of print.ABSTRACTThe revised 4th edition of the World Health Organization (WHO4R) classification lists myelodysplastic syndromes with ring sideroblasts (MDS-RS) as a separate entity with single lineage (MDS-RS-SLD) or multilineage (MDS-RS-MLD) dysplasia. The more recent International Consensus Classification (ICC) distinguishes between MDS with SF3B1 mutation (MDS-SF3B1) and MDS-RS without SF3B1 mutation; the latter is instead included under the category of MDS not otherwise specified. The current study includes 170 Mayo Clinic patients with WHO4R-d...
Source: Haematologica - March 7, 2024 Category: Hematology Authors: Faiqa Farrukh Maymona Abdelmagid Abhishek Mangaonkar Mrinal Patnaik Aref Al-Kali Michelle A Elliott Kebede H Begna Christopher C Hook William J Hogan Animesh Pardanani Mark R Litzow Rhett P Ketterling Naseema Gangat Daniel A Arber Attilio Orazi Rong He Ka Source Type: research
Prognostic impact of < em > SF3B1 < /em > mutation and multilineage dysplasia in myelodysplastic syndromes with ring sideroblasts: a Mayo Clinic study of 170 informative cases
Haematologica. 2024 Mar 7. doi: 10.3324/haematol.2023.284719. Online ahead of print.ABSTRACTThe revised 4th edition of the World Health Organization (WHO4R) classification lists myelodysplastic syndromes with ring sideroblasts (MDS-RS) as a separate entity with single lineage (MDS-RS-SLD) or multilineage (MDS-RS-MLD) dysplasia. The more recent International Consensus Classification (ICC) distinguishes between MDS with SF3B1 mutation (MDS-SF3B1) and MDS-RS without SF3B1 mutation; the latter is instead included under the category of MDS not otherwise specified. The current study includes 170 Mayo Clinic patients with WHO4R-d...
Source: Haematologica - March 7, 2024 Category: Hematology Authors: Faiqa Farrukh Maymona Abdelmagid Abhishek Mangaonkar Mrinal Patnaik Aref Al-Kali Michelle A Elliott Kebede H Begna Christopher C Hook William J Hogan Animesh Pardanani Mark R Litzow Rhett P Ketterling Naseema Gangat Daniel A Arber Attilio Orazi Rong He Ka Source Type: research
Comprehensive study of chromosomal CNVs and genomic variations predicting overall survival in Myelodysplastic syndromes
CONCLUSION: CGH + SNP array changed the cytogenetic and IPSS-R risk group in 18% and 13% of patients respectively with an improved prediction of prognosis. This study emphasizes the cytogenetic heterogeneity of MDS and highlights that abnormality with chromosome 2 may have a diagnostic and prognostic impact.PMID:38442690 | DOI:10.1159/000536446 (Source: Oncology)
Source: Oncology - March 5, 2024 Category: Cancer & Oncology Authors: Nehakumari Maurya Chandrakala Shanmukhaiah Somprakash Dhangar Manisha Madkaikar Babu Rao Vundinti Source Type: research
Comprehensive study of chromosomal CNVs and genomic variations predicting overall survival in Myelodysplastic syndromes
CONCLUSION: CGH + SNP array changed the cytogenetic and IPSS-R risk group in 18% and 13% of patients respectively with an improved prediction of prognosis. This study emphasizes the cytogenetic heterogeneity of MDS and highlights that abnormality with chromosome 2 may have a diagnostic and prognostic impact.PMID:38442690 | DOI:10.1159/000536446 (Source: Oncology)
Source: Oncology - March 5, 2024 Category: Cancer & Oncology Authors: Nehakumari Maurya Chandrakala Shanmukhaiah Somprakash Dhangar Manisha Madkaikar Babu Rao Vundinti Source Type: research
Comprehensive study of chromosomal CNVs and genomic variations predicting overall survival in Myelodysplastic syndromes
CONCLUSION: CGH + SNP array changed the cytogenetic and IPSS-R risk group in 18% and 13% of patients respectively with an improved prediction of prognosis. This study emphasizes the cytogenetic heterogeneity of MDS and highlights that abnormality with chromosome 2 may have a diagnostic and prognostic impact.PMID:38442690 | DOI:10.1159/000536446 (Source: Oncology)
Source: Oncology - March 5, 2024 Category: Cancer & Oncology Authors: Nehakumari Maurya Chandrakala Shanmukhaiah Somprakash Dhangar Manisha Madkaikar Babu Rao Vundinti Source Type: research
Comprehensive study of chromosomal CNVs and genomic variations predicting overall survival in Myelodysplastic syndromes
CONCLUSION: CGH + SNP array changed the cytogenetic and IPSS-R risk group in 18% and 13% of patients respectively with an improved prediction of prognosis. This study emphasizes the cytogenetic heterogeneity of MDS and highlights that abnormality with chromosome 2 may have a diagnostic and prognostic impact.PMID:38442690 | DOI:10.1159/000536446 (Source: Oncology)
Source: Oncology - March 5, 2024 Category: Cancer & Oncology Authors: Nehakumari Maurya Chandrakala Shanmukhaiah Somprakash Dhangar Manisha Madkaikar Babu Rao Vundinti Source Type: research
Comprehensive study of chromosomal CNVs and genomic variations predicting overall survival in Myelodysplastic syndromes
CONCLUSION: CGH + SNP array changed the cytogenetic and IPSS-R risk group in 18% and 13% of patients respectively with an improved prediction of prognosis. This study emphasizes the cytogenetic heterogeneity of MDS and highlights that abnormality with chromosome 2 may have a diagnostic and prognostic impact.PMID:38442690 | DOI:10.1159/000536446 (Source: Oncology)
Source: Oncology - March 5, 2024 Category: Cancer & Oncology Authors: Nehakumari Maurya Chandrakala Shanmukhaiah Somprakash Dhangar Manisha Madkaikar Babu Rao Vundinti Source Type: research
Comprehensive study of chromosomal CNVs and genomic variations predicting overall survival in Myelodysplastic syndromes
CONCLUSION: CGH + SNP array changed the cytogenetic and IPSS-R risk group in 18% and 13% of patients respectively with an improved prediction of prognosis. This study emphasizes the cytogenetic heterogeneity of MDS and highlights that abnormality with chromosome 2 may have a diagnostic and prognostic impact.PMID:38442690 | DOI:10.1159/000536446 (Source: Oncology)
Source: Oncology - March 5, 2024 Category: Cancer & Oncology Authors: Nehakumari Maurya Chandrakala Shanmukhaiah Somprakash Dhangar Manisha Madkaikar Babu Rao Vundinti Source Type: research
A Pre-Leukemic DNA Methylation Signature in Healthy Individuals at Higher Risk for Developing Myeloid Malignancy
CONCLUSIONS: The epigenetic changes may be acquired independently and prior to somatic mutations that relevant for AML/MDS development. The association between methylation changes and the risk of pre-AML/MDS in these individuals was considerably stronger than somatic mutations, suggesting that methylation changes could be used as biomarkers for pre- AML/MDS screening.PMID:38437679 | DOI:10.1158/1078-0432.CCR-22-3804 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - March 4, 2024 Category: Cancer & Oncology Authors: Zhentang Lao Ling-Wen Ding Qiao-Yang Sun Li Jia Benedict Yan Alvin Yu-Jin Ng Sharah Mae Capinpin Renwei Wang Li Ying Wee Joo Chng H Phillip Koeffler Woon-Puay Koh Jian-Min Yuan Henry Yang Yeow Tee Goh Nicholas Grigoropoulos Source Type: research
A Pre-Leukemic DNA Methylation Signature in Healthy Individuals at Higher Risk for Developing Myeloid Malignancy
CONCLUSIONS: The epigenetic changes may be acquired independently and prior to somatic mutations that relevant for AML/MDS development. The association between methylation changes and the risk of pre-AML/MDS in these individuals was considerably stronger than somatic mutations, suggesting that methylation changes could be used as biomarkers for pre- AML/MDS screening.PMID:38437679 | DOI:10.1158/1078-0432.CCR-22-3804 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - March 4, 2024 Category: Cancer & Oncology Authors: Zhentang Lao Ling-Wen Ding Qiao-Yang Sun Li Jia Benedict Yan Alvin Yu-Jin Ng Sharah Mae Capinpin Renwei Wang Li Ying Wee Joo Chng H Phillip Koeffler Woon-Puay Koh Jian-Min Yuan Henry Yang Yeow Tee Goh Nicholas Grigoropoulos Source Type: research
Myelodysplastic syndrome with IgG4 ‑related disease: A case report
Oncol Lett. 2024 Feb 20;27(4):166. doi: 10.3892/ol.2024.14299. eCollection 2024 Apr.ABSTRACTAt present, to the best of our knowledge, there are only a few case reports of IgG4-related disease (IgG4-RD) involving myelodysplastic syndrome (MDS), yet the incidence of MDS and IgG4-RD is increasing in middle-aged and elderly people. The present study presents a case of MDS combined with IgG4-RD admitted to Zhejiang Provincial Hospital of Chinese Medicine in September 2022. The (66-year-old; male) patient was admitted to the hospital due to hematopenia with an elevated IgG4 index. The diagnosis of MDS combined with IgG4-RD was c...
Source: Oncology Letters - March 1, 2024 Category: Cancer & Oncology Authors: Lina Wang Xi Pang Zirui Hong Baodong Ye Zhiping Hu Chunli Zhang Shuyan Liu Source Type: research
< em > UBTF < /em > tandem duplications in pediatric myelodysplastic syndrome and acute myeloid leukemia: implications for clinical screening and diagnosis
Haematologica. 2024 Feb 29. doi: 10.3324/haematol.2023.284683. Online ahead of print.ABSTRACTRecent genomic studies in adult and pediatric acute myeloid leukemia (AML) demonstrated recurrent in-frame tandem duplications (TD) in exon 13 of upstream binding transcription factor (UBTF). These alterations, which account for ~4.3% of AMLs in childhood and about 3% in adult AMLs under 60, are subtype-defining and associated with poor outcomes. Here, we provide a comprehensive investigation into the clinicopathological features of UBTF-TD myeloid neoplasms in childhood, including 89 unique pediatric AML and 6 myelodysplastic synd...
Source: Haematologica - March 1, 2024 Category: Hematology Authors: Juan M Barajas Masayuki Umeda Lisett Contreras Mahsa Khanlari Tamara Westover Michael P Walsh Emily Xiong Chenchen Yang Brittney Otero Marc Arribas-Layton Sherif Abdelhamed Guangchun Song Xiaotu Ma Melvin E Thomas Rd Jing Ma Jeffery M Klco Source Type: research
Myelodysplastic syndrome with IgG4 ‑related disease: A case report
Oncol Lett. 2024 Feb 20;27(4):166. doi: 10.3892/ol.2024.14299. eCollection 2024 Apr.ABSTRACTAt present, to the best of our knowledge, there are only a few case reports of IgG4-related disease (IgG4-RD) involving myelodysplastic syndrome (MDS), yet the incidence of MDS and IgG4-RD is increasing in middle-aged and elderly people. The present study presents a case of MDS combined with IgG4-RD admitted to Zhejiang Provincial Hospital of Chinese Medicine in September 2022. The (66-year-old; male) patient was admitted to the hospital due to hematopenia with an elevated IgG4 index. The diagnosis of MDS combined with IgG4-RD was c...
Source: Oncology Letters - March 1, 2024 Category: Cancer & Oncology Authors: Lina Wang Xi Pang Zirui Hong Baodong Ye Zhiping Hu Chunli Zhang Shuyan Liu Source Type: research
< em > UBTF < /em > tandem duplications in pediatric myelodysplastic syndrome and acute myeloid leukemia: implications for clinical screening and diagnosis
Haematologica. 2024 Feb 29. doi: 10.3324/haematol.2023.284683. Online ahead of print.ABSTRACTRecent genomic studies in adult and pediatric acute myeloid leukemia (AML) demonstrated recurrent in-frame tandem duplications (TD) in exon 13 of upstream binding transcription factor (UBTF). These alterations, which account for ~4.3% of AMLs in childhood and about 3% in adult AMLs under 60, are subtype-defining and associated with poor outcomes. Here, we provide a comprehensive investigation into the clinicopathological features of UBTF-TD myeloid neoplasms in childhood, including 89 unique pediatric AML and 6 myelodysplastic synd...
Source: Haematologica - March 1, 2024 Category: Hematology Authors: Juan M Barajas Masayuki Umeda Lisett Contreras Mahsa Khanlari Tamara Westover Michael P Walsh Emily Xiong Chenchen Yang Brittney Otero Marc Arribas-Layton Sherif Abdelhamed Guangchun Song Xiaotu Ma Melvin E Thomas Rd Jing Ma Jeffery M Klco Source Type: research
