Comprehensive morphologic characterization of bone marrow biopsy findings in a large cohort of patients with VEXAS syndrome: A single-institution longitudinal study of 111 bone marrow samples from 52 patients
CONCLUSIONS: Our data reveal potential novel diagnostic features, such as a high incidence of monocytopenia and distinct patterns of atypical megakaryopoiesis, that appear different from dysmegakaryopoiesis typically associated with MDS. In our experience, those findings are suggestive of VEXAS, in the appropriate clinical context.PMID:38413044 | DOI:10.1093/ajcp/aqad186 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 27, 2024 Category: Pathology Authors: Horatiu Olteanu Mrinal Patnaik Matthew J Koster Jennifer L Herrick Dong Chen Rong He David Viswanatha Kenneth J Warrington Ronald S Go Abhishek A Mangaonkar Taxiarchis Kourelis Alexander Hines Sarah E Gibson Jess F Peterson Kaaren K Reichard Source Type: research
Comprehensive morphologic characterization of bone marrow biopsy findings in a large cohort of patients with VEXAS syndrome: A single-institution longitudinal study of 111 bone marrow samples from 52 patients
CONCLUSIONS: Our data reveal potential novel diagnostic features, such as a high incidence of monocytopenia and distinct patterns of atypical megakaryopoiesis, that appear different from dysmegakaryopoiesis typically associated with MDS. In our experience, those findings are suggestive of VEXAS, in the appropriate clinical context.PMID:38413044 | DOI:10.1093/ajcp/aqad186 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 27, 2024 Category: Pathology Authors: Horatiu Olteanu Mrinal Patnaik Matthew J Koster Jennifer L Herrick Dong Chen Rong He David Viswanatha Kenneth J Warrington Ronald S Go Abhishek A Mangaonkar Taxiarchis Kourelis Alexander Hines Sarah E Gibson Jess F Peterson Kaaren K Reichard Source Type: research
Comprehensive morphologic characterization of bone marrow biopsy findings in a large cohort of patients with VEXAS syndrome: A single-institution longitudinal study of 111 bone marrow samples from 52 patients
CONCLUSIONS: Our data reveal potential novel diagnostic features, such as a high incidence of monocytopenia and distinct patterns of atypical megakaryopoiesis, that appear different from dysmegakaryopoiesis typically associated with MDS. In our experience, those findings are suggestive of VEXAS, in the appropriate clinical context.PMID:38413044 | DOI:10.1093/ajcp/aqad186 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 27, 2024 Category: Pathology Authors: Horatiu Olteanu Mrinal Patnaik Matthew J Koster Jennifer L Herrick Dong Chen Rong He David Viswanatha Kenneth J Warrington Ronald S Go Abhishek A Mangaonkar Taxiarchis Kourelis Alexander Hines Sarah E Gibson Jess F Peterson Kaaren K Reichard Source Type: research
Comprehensive morphologic characterization of bone marrow biopsy findings in a large cohort of patients with VEXAS syndrome: A single-institution longitudinal study of 111 bone marrow samples from 52 patients
CONCLUSIONS: Our data reveal potential novel diagnostic features, such as a high incidence of monocytopenia and distinct patterns of atypical megakaryopoiesis, that appear different from dysmegakaryopoiesis typically associated with MDS. In our experience, those findings are suggestive of VEXAS, in the appropriate clinical context.PMID:38413044 | DOI:10.1093/ajcp/aqad186 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 27, 2024 Category: Pathology Authors: Horatiu Olteanu Mrinal Patnaik Matthew J Koster Jennifer L Herrick Dong Chen Rong He David Viswanatha Kenneth J Warrington Ronald S Go Abhishek A Mangaonkar Taxiarchis Kourelis Alexander Hines Sarah E Gibson Jess F Peterson Kaaren K Reichard Source Type: research
Azacitidine Post-transplant Maintenance Improves Disease Progression in High-Risk Acute Myeloid Leukemia and Myelodysplastic Syndrome
CONCLUSION: AZA maintenance was associated with a lower progression rate in patients with high-risk FLT3-negative AML or MDS, and AZA maintenance should be considered for post-alloHCT maintenance in this subset.PMID:38403505 | DOI:10.1016/j.clml.2024.01.012 (Source: Clinical Lymphoma and Myeloma)
Source: Clinical Lymphoma and Myeloma - February 25, 2024 Category: Cancer & Oncology Authors: Oren Pasvolsky Rima M Saliba Uday R Popat Amin Alousi Rohtesh Mehta Jason Yeh Gheath Al-Atrash Masood Adeel Jeremy Ramdial David Marin Gabriela Rondon Partow Kebriaei Richard Champlin Naval Daver Courtney Dinardo Nicholas J Short Elizabeth J Shpall Bet ü Source Type: research
Azacitidine Post-transplant Maintenance Improves Disease Progression in High-Risk Acute Myeloid Leukemia and Myelodysplastic Syndrome
CONCLUSION: AZA maintenance was associated with a lower progression rate in patients with high-risk FLT3-negative AML or MDS, and AZA maintenance should be considered for post-alloHCT maintenance in this subset.PMID:38403505 | DOI:10.1016/j.clml.2024.01.012 (Source: Clinical Lymphoma and Myeloma)
Source: Clinical Lymphoma and Myeloma - February 25, 2024 Category: Cancer & Oncology Authors: Oren Pasvolsky Rima M Saliba Uday R Popat Amin Alousi Rohtesh Mehta Jason Yeh Gheath Al-Atrash Masood Adeel Jeremy Ramdial David Marin Gabriela Rondon Partow Kebriaei Richard Champlin Naval Daver Courtney Dinardo Nicholas J Short Elizabeth J Shpall Bet ü Source Type: research
Azacitidine Post-transplant Maintenance Improves Disease Progression in High-Risk Acute Myeloid Leukemia and Myelodysplastic Syndrome
CONCLUSION: AZA maintenance was associated with a lower progression rate in patients with high-risk FLT3-negative AML or MDS, and AZA maintenance should be considered for post-alloHCT maintenance in this subset.PMID:38403505 | DOI:10.1016/j.clml.2024.01.012 (Source: Clinical Lymphoma and Myeloma)
Source: Clinical Lymphoma and Myeloma - February 25, 2024 Category: Cancer & Oncology Authors: Oren Pasvolsky Rima M Saliba Uday R Popat Amin Alousi Rohtesh Mehta Jason Yeh Gheath Al-Atrash Masood Adeel Jeremy Ramdial David Marin Gabriela Rondon Partow Kebriaei Richard Champlin Naval Daver Courtney Dinardo Nicholas J Short Elizabeth J Shpall Bet ü Source Type: research
Azacitidine Post-transplant Maintenance Improves Disease Progression in High-Risk Acute Myeloid Leukemia and Myelodysplastic Syndrome
CONCLUSION: AZA maintenance was associated with a lower progression rate in patients with high-risk FLT3-negative AML or MDS, and AZA maintenance should be considered for post-alloHCT maintenance in this subset.PMID:38403505 | DOI:10.1016/j.clml.2024.01.012 (Source: Clinical Lymphoma and Myeloma)
Source: Clinical Lymphoma and Myeloma - February 25, 2024 Category: Cancer & Oncology Authors: Oren Pasvolsky Rima M Saliba Uday R Popat Amin Alousi Rohtesh Mehta Jason Yeh Gheath Al-Atrash Masood Adeel Jeremy Ramdial David Marin Gabriela Rondon Partow Kebriaei Richard Champlin Naval Daver Courtney Dinardo Nicholas J Short Elizabeth J Shpall Bet ü Source Type: research
Azacitidine Post-transplant Maintenance Improves Disease Progression in High-Risk Acute Myeloid Leukemia and Myelodysplastic Syndrome
CONCLUSION: AZA maintenance was associated with a lower progression rate in patients with high-risk FLT3-negative AML or MDS, and AZA maintenance should be considered for post-alloHCT maintenance in this subset.PMID:38403505 | DOI:10.1016/j.clml.2024.01.012 (Source: Clinical Lymphoma and Myeloma)
Source: Clinical Lymphoma and Myeloma - February 25, 2024 Category: Cancer & Oncology Authors: Oren Pasvolsky Rima M Saliba Uday R Popat Amin Alousi Rohtesh Mehta Jason Yeh Gheath Al-Atrash Masood Adeel Jeremy Ramdial David Marin Gabriela Rondon Partow Kebriaei Richard Champlin Naval Daver Courtney Dinardo Nicholas J Short Elizabeth J Shpall Bet ü Source Type: research
An unusual Wolf's isotopic response: myelodysplastic syndrome with acute myeloid leukemia developed on the herpes zoster lesions
An Bras Dermatol. 2024 Feb 22:S0365-0596(24)00012-6. doi: 10.1016/j.abd.2023.02.011. Online ahead of print.NO ABSTRACTPMID:38395631 | DOI:10.1016/j.abd.2023.02.011 (Source: Herpes)
Source: Herpes - February 23, 2024 Category: Infectious Diseases Authors: Yu Zhu Wei Wu Source Type: research
Role of chromosomal cohesion and separation in aneuploidy and tumorigenesis
Cell Mol Life Sci. 2024 Feb 22;81(1):100. doi: 10.1007/s00018-024-05122-5.ABSTRACTCell division is a crucial process, and one of its essential steps involves copying the genetic material, which is organized into structures called chromosomes. Before a cell can divide into two, it needs to ensure that each newly copied chromosome is paired tightly with its identical twin. This pairing is maintained by a protein complex known as cohesin, which is conserved in various organisms, from single-celled ones to humans. Cohesin essentially encircles the DNA, creating a ring-like structure to handcuff, to keep the newly synthesized s...
Source: Cellular and Molecular Life Sciences : CMLS - February 22, 2024 Category: Cytology Authors: Debananda Pati Source Type: research
Role of chromosomal cohesion and separation in aneuploidy and tumorigenesis
Cell Mol Life Sci. 2024 Feb 22;81(1):100. doi: 10.1007/s00018-024-05122-5.ABSTRACTCell division is a crucial process, and one of its essential steps involves copying the genetic material, which is organized into structures called chromosomes. Before a cell can divide into two, it needs to ensure that each newly copied chromosome is paired tightly with its identical twin. This pairing is maintained by a protein complex known as cohesin, which is conserved in various organisms, from single-celled ones to humans. Cohesin essentially encircles the DNA, creating a ring-like structure to handcuff, to keep the newly synthesized s...
Source: Cellular and Molecular Life Sciences : CMLS - February 22, 2024 Category: Cytology Authors: Debananda Pati Source Type: research
