Long-Term Complications after Allogeneic Hematopoietic Stem Cell Transplantation with Treosulfan- or Busulfan-Based Conditioning in Pediatric Patients with Acute Leukemia or Myelodysplastic Syndrome: Results of an Associazione Italiana Ematologia Oncologia Pediatrica Retrospective Study
Patients undergoing hematopoietic stem cell transplantation (HSCT) for hematologic malignancies during childhood have an increased risk of developing long-term sequelae that are in part attributable to the conditioning regimen. The present study aimed to assess the occurrence of long-term toxicities in a population of children who underwent HSCT for hematologic malignancies using either treosulfan or busulfan in the conditioning regimen. The cumulative incidences of growth impairment, altered gonadal function, altered thyroid function, cataracts, secondary malignant neoplasia, and altered pulmonary function were evaluated ...
Source: Biology of Blood and Marrow Transplantation - January 2, 2024 Category: Hematology Authors: Francesco Saglio, Daria Pagliara, Marco Zecca, Adriana Balduzzi, Alessandro Cattoni, Arcangelo Prete, Francesco Paolo Tambaro, Maura Faraci, Elisabetta Calore, Franco Locatelli, Franca Fagioli, AIEOP BMT Group Tags: Full Length Article Source Type: research
Epigenetic therapy: Research progress of decitabine in the treatment of solid tumors
This article reviews the application mechanism and current status of decitabine in the treatment of solid tumors.PMID:38163523 | DOI:10.1016/j.bbcan.2023.189066 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - January 1, 2024 Category: Biochemistry Authors: Chenlin Ye Nan Jiang Jing Zheng Shumeng Zhang Jingchen Zhang Jianya Zhou Source Type: research
Epigenetic therapy: Research progress of decitabine in the treatment of solid tumors
This article reviews the application mechanism and current status of decitabine in the treatment of solid tumors.PMID:38163523 | DOI:10.1016/j.bbcan.2023.189066 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - January 1, 2024 Category: Biochemistry Authors: Chenlin Ye Nan Jiang Jing Zheng Shumeng Zhang Jingchen Zhang Jianya Zhou Source Type: research
Association between leukemic evolution and uncommon chromosomal alterations in pediatric myelodysplastic syndrome
Conclusion:The study of uncommon cytogenetic alterations in pMDS is important to improve the prognosis and guide early indication of HSCT.Keywords: Pediatric MDS; Leukemic evolution; rare chromosomal altwerations; HSCT, Children (Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - January 1, 2024 Category: Hematology Authors: Lovatel, VL., Silva, BF., Rodrigues, EF., Borges, MLRR, Tavares, RCB, Bueno, APS., Costa, ES, Salles, TJM., Teresa de Souza Fernandez Source Type: research
Haploidentical transplant with post-transplant cyclophosphamide for acute myeloid leukaemia and myelodysplastic syndromes patients: the role of previous lines of therapy.
Conclusions: Haploidentical haematopoietic stem-cell transplant is potentially curative in chemo-sensitive AML and MDS and offers a high rate of prolonged remission. Our cohort further confirms the role of consolidative haploidentical transplant in patients in complete remission and highlights that patients with heavily pre-treated disease may not benefit from this strategy. (Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - January 1, 2024 Category: Hematology Authors: Daniele Avenoso, Fabio Serpenti, Liron Barnea Slonim, Styliani Bouziana, Francesco Dazzi, Guy Hannah, Michelle Kenyon, Varun Mehra, Austin Kulasekararaj, Pramila Krishnamurthy, Mili Naresh Shah, Sharon Lionel, Antonio Pagliuca, Victoria Potter Source Type: research
Treatment Outcomes of Acute Myeloid Leukemia in Patients Living with Human Immunodeficiency Virus Receiving Antiretroviral Therapy: A Single-Center Experience
Acta Haematol. 2023;146(6):490-495. doi: 10.1159/000533346. Epub 2023 Aug 9.ABSTRACTPatients living with HIV are now living longer due to increased access to antiretroviral therapy (ART) and a decrease in acquired immunodeficiency syndrome-defining cancer (ADC). However, increasing age and previous chemotherapy exposure for ADC (e.g., anthracyclines and topoisomerase inhibitors) are factors that may increase the risk of developing therapy-related myelodysplastic syndrome and acute myeloid leukemia (AML) and highlight an unmet need. There are no established guidelines for the treatment of AML in patients with HIV and the li...
Source: Acta Haematologica - December 29, 2023 Category: Hematology Authors: Jose Tinajero Dat Ngo Alfredo Puing Paul Koller Source Type: research
Treatment Outcomes of Acute Myeloid Leukemia in Patients Living with Human Immunodeficiency Virus Receiving Antiretroviral Therapy: A Single-Center Experience
Acta Haematol. 2023;146(6):490-495. doi: 10.1159/000533346. Epub 2023 Aug 9.ABSTRACTPatients living with HIV are now living longer due to increased access to antiretroviral therapy (ART) and a decrease in acquired immunodeficiency syndrome-defining cancer (ADC). However, increasing age and previous chemotherapy exposure for ADC (e.g., anthracyclines and topoisomerase inhibitors) are factors that may increase the risk of developing therapy-related myelodysplastic syndrome and acute myeloid leukemia (AML) and highlight an unmet need. There are no established guidelines for the treatment of AML in patients with HIV and the li...
Source: Acta Haematologica - December 29, 2023 Category: Hematology Authors: Jose Tinajero Dat Ngo Alfredo Puing Paul Koller Source Type: research
Treatment Outcomes of Acute Myeloid Leukemia in Patients Living with Human Immunodeficiency Virus Receiving Antiretroviral Therapy: A Single-Center Experience
Acta Haematol. 2023;146(6):490-495. doi: 10.1159/000533346. Epub 2023 Aug 9.ABSTRACTPatients living with HIV are now living longer due to increased access to antiretroviral therapy (ART) and a decrease in acquired immunodeficiency syndrome-defining cancer (ADC). However, increasing age and previous chemotherapy exposure for ADC (e.g., anthracyclines and topoisomerase inhibitors) are factors that may increase the risk of developing therapy-related myelodysplastic syndrome and acute myeloid leukemia (AML) and highlight an unmet need. There are no established guidelines for the treatment of AML in patients with HIV and the li...
Source: Acta Haematologica - December 29, 2023 Category: Hematology Authors: Jose Tinajero Dat Ngo Alfredo Puing Paul Koller Source Type: research
Treatment Outcomes of Acute Myeloid Leukemia in Patients Living with Human Immunodeficiency Virus Receiving Antiretroviral Therapy: A Single-Center Experience
Acta Haematol. 2023;146(6):490-495. doi: 10.1159/000533346. Epub 2023 Aug 9.ABSTRACTPatients living with HIV are now living longer due to increased access to antiretroviral therapy (ART) and a decrease in acquired immunodeficiency syndrome-defining cancer (ADC). However, increasing age and previous chemotherapy exposure for ADC (e.g., anthracyclines and topoisomerase inhibitors) are factors that may increase the risk of developing therapy-related myelodysplastic syndrome and acute myeloid leukemia (AML) and highlight an unmet need. There are no established guidelines for the treatment of AML in patients with HIV and the li...
Source: Acta Haematologica - December 29, 2023 Category: Hematology Authors: Jose Tinajero Dat Ngo Alfredo Puing Paul Koller Source Type: research
Treatment Outcomes of Acute Myeloid Leukemia in Patients Living with Human Immunodeficiency Virus Receiving Antiretroviral Therapy: A Single-Center Experience
Acta Haematol. 2023;146(6):490-495. doi: 10.1159/000533346. Epub 2023 Aug 9.ABSTRACTPatients living with HIV are now living longer due to increased access to antiretroviral therapy (ART) and a decrease in acquired immunodeficiency syndrome-defining cancer (ADC). However, increasing age and previous chemotherapy exposure for ADC (e.g., anthracyclines and topoisomerase inhibitors) are factors that may increase the risk of developing therapy-related myelodysplastic syndrome and acute myeloid leukemia (AML) and highlight an unmet need. There are no established guidelines for the treatment of AML in patients with HIV and the li...
Source: Acta Haematologica - December 29, 2023 Category: Hematology Authors: Jose Tinajero Dat Ngo Alfredo Puing Paul Koller Source Type: research
Clinicopathological characteristics of myelodysplastic syndromes with del(5q) in Taiwan
CONCLUSION: The bone marrow morphology, clinical features, and prognosis of Taiwanese MDS patients with del(5q) were different from those associated with MDS with isolated del(5q) as defined in the current WHO classification. Researchers should compare different geographic regions and racial populations to determine whether geographic and racial differences exist with respect to MDS with del(5q).PMID:38155382 (Source: Malaysian Journal of Pathology)
Source: Malaysian Journal of Pathology - December 28, 2023 Category: Pathology Authors: C F Yang C Y Hsu L T Hsiao S W Chen S S Chuang Source Type: research
