Cancers, Vol. 16, Pages 332: The Role of Hepcidin in Myelodysplastic Syndromes (MDS): A Systematic Review of Observational Studies

Cancers, Vol. 16, Pages 332: The Role of Hepcidin in Myelodysplastic Syndromes (MDS): A Systematic Review of Observational Studies Cancers doi: 10.3390/cancers16020332 Authors: Artur Słomka Anna Pokrzywa Dominika Strzała Maja Kubiaczyk Oliwia Wesolowska Kinga Denkiewicz Jan Styczyński Iron overload emerges as a serious complication in myelodysplastic syndromes (MDS), particularly associated with frequent transfusions during the course of the disease. The discovery and description of hepcidin’s mechanisms of action have contributed to a deeper understanding of iron metabolism. The existing literature reports a potential role of hepcidin in MDS, yet these data are fragmented and presented in an unstructured, somewhat chaotic manner. Hence, to address the existing data, we performed a systematic review of observational studies examining hepcidin levels in MDS. An extensive review of three bibliographic databases (Pubmed, Web of Science, and Scopus) enabled us to identify 12 observational studies. These studies focused primarily on adult patients with low-risk MDS who underwent transfusions and chelation therapy. An in-depth analysis of these manuscripts led to four main conclusions: (1) although high serum hepcidin levels are associated with MDS, most studies generally have not found a significant difference in these levels between patients and healthy individuals; (2) serum hepcidin levels are specific to MDS type; (3) serum hepcidin levels ...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Systematic Review Source Type: research