Unlocking the growth potential: harnessing the power of synbiotics to enhance cultivation of Pleurotus spp.
AbstractThe oyster mushroom (Pleurotus spp.) is one of the most widely cultivated mushroom species globally. The present study investigated the effect of synbiotics on the growth and quality ofPleurotus ostreatus andPleurotus pulmonarius. Different synbiotics formulations were applied by spraying mushroom samples daily and measuring their growth parameters, yield, biological efficiency, proximate composition, mineral content, total phenolic content (TPC), and diphenyl-1-picryl-hydrazyl (DPPH) radical scavenging activity. Results demonstrated that the most significant yield of oyster mushrooms was harvested from synbiotics ...
Source: Journal of Zhejiang University. Science. B. - April 1, 2024 Category: Universities & Medical Training Source Type: research
Polysaccharides from an edible mushroom, Hericium erinaceus, alleviate ulcerative colitis in mice by inhibiting the NLRP3 inflammasomes and reestablish intestinal homeostasis
This study aimed to assess the effects of polysaccharides extracted from Hericium erinaceus fruiting bodies (HEFPs) on the inflammatory response to oxidative stress in a mouse model of ulcerative colitis (UC) induced by ingestion of dextran sodium sulfate. The results indicated reduced oxidative damage in the HEFPs groups, as evidenced by significantly decreased malondialdehyde levels and significantly increased levels of the antioxidant enzymes superoxide dismutase and catalase in colon homogenates, compared with those in the Model Control (MC) group. Additionally, compared with the levels in the MC group, the levels of t...
Source: International Journal of Biological Macromolecules - March 31, 2024 Category: Biochemistry Authors: Hao Li Jiaxin Feng Chang Liu Shuting Hou Junlong Meng Jing-Yu Liu Sun Zilong Ming-Chang Chang Source Type: research
Polysaccharides from an edible mushroom, Hericium erinaceus, alleviate ulcerative colitis in mice by inhibiting the NLRP3 inflammasomes and reestablish intestinal homeostasis
This study aimed to assess the effects of polysaccharides extracted from Hericium erinaceus fruiting bodies (HEFPs) on the inflammatory response to oxidative stress in a mouse model of ulcerative colitis (UC) induced by ingestion of dextran sodium sulfate. The results indicated reduced oxidative damage in the HEFPs groups, as evidenced by significantly decreased malondialdehyde levels and significantly increased levels of the antioxidant enzymes superoxide dismutase and catalase in colon homogenates, compared with those in the Model Control (MC) group. Additionally, compared with the levels in the MC group, the levels of t...
Source: International Journal of Biological Macromolecules - March 31, 2024 Category: Biochemistry Authors: Hao Li Jiaxin Feng Chang Liu Shuting Hou Junlong Meng Jing-Yu Liu Sun Zilong Ming-Chang Chang Source Type: research
Transforming toxins into treatments: the revolutionary role of α-amanitin in cancer therapy
Arch Toxicol. 2024 Mar 30. doi: 10.1007/s00204-024-03727-0. Online ahead of print.ABSTRACTAmanita phalloides is the primary species responsible for fatal mushroom poisoning, as its main toxin, α-amanitin, irreversibly and potently inhibits eukaryotic RNA polymerase II (RNAP II), leading to cell death. There is no specific antidote for α-amanitin, which hinders its clinical application. However, with the advancement of precision medicine in oncology, including the development of antibody-drug conjugates (ADCs), the potential value of various toxic small molecules has been explored. These ADCs ingeniously combine the targe...
Source: Archives of Toxicology - March 30, 2024 Category: Toxicology Authors: Deyuan Ning Jinfang Xue Xiran Lou Ruifei Shao Yu Liu Guobing Chen Source Type: research
The exp2 gene, which encodes a protein with two zinc finger domains, regulates cap expansion and autolysis in Coprinopsis cinerea
Microbiol Res. 2024 Mar 19;283:127695. doi: 10.1016/j.micres.2024.127695. Online ahead of print.ABSTRACTCap expansion in agaricoid mushroom species is an important event for sexual reproduction because meiosis occurs in basidia under the cap, and basidiospores can be released by opening the cap. However, molecular mechanisms underlying cap expansion in basidiomycetes remain poorly understood. We aimed to elucidate the molecular mechanisms of cap expansion in basidiomycetes by analyzing the unique cap-expansionless UV mutant #13 (exp2-1) in Coprinopsis cinerea. Linkage analysis and consequent genome sequence analysis reveal...
Source: Cell Research - March 30, 2024 Category: Cytology Authors: Yuichi Sakamoto Shiho Sato Hiroshi Yoshida Machiko Takahashi Keishi Osakabe Hajime Muraguchi Source Type: research
Transforming toxins into treatments: the revolutionary role of α-amanitin in cancer therapy
Arch Toxicol. 2024 Mar 30. doi: 10.1007/s00204-024-03727-0. Online ahead of print.ABSTRACTAmanita phalloides is the primary species responsible for fatal mushroom poisoning, as its main toxin, α-amanitin, irreversibly and potently inhibits eukaryotic RNA polymerase II (RNAP II), leading to cell death. There is no specific antidote for α-amanitin, which hinders its clinical application. However, with the advancement of precision medicine in oncology, including the development of antibody-drug conjugates (ADCs), the potential value of various toxic small molecules has been explored. These ADCs ingeniously combine the targe...
Source: Archives of Toxicology - March 30, 2024 Category: Toxicology Authors: Deyuan Ning Jinfang Xue Xiran Lou Ruifei Shao Yu Liu Guobing Chen Source Type: research
Transforming toxins into treatments: the revolutionary role of α-amanitin in cancer therapy
Arch Toxicol. 2024 Mar 30. doi: 10.1007/s00204-024-03727-0. Online ahead of print.ABSTRACTAmanita phalloides is the primary species responsible for fatal mushroom poisoning, as its main toxin, α-amanitin, irreversibly and potently inhibits eukaryotic RNA polymerase II (RNAP II), leading to cell death. There is no specific antidote for α-amanitin, which hinders its clinical application. However, with the advancement of precision medicine in oncology, including the development of antibody-drug conjugates (ADCs), the potential value of various toxic small molecules has been explored. These ADCs ingeniously combine the targe...
Source: Archives of Toxicology - March 30, 2024 Category: Toxicology Authors: Deyuan Ning Jinfang Xue Xiran Lou Ruifei Shao Yu Liu Guobing Chen Source Type: research
Transgenic line for characterizing GABA-receptor expression to study the neural basis of olfaction in the yellow-fever mosquito
The mosquito Aedes aegypti is an important vector of diseases including dengue, Zika, chikungunya, and yellow fever. Olfaction is a critical modality for mosquitoes enabling them to locate hosts, sources of nectar, and sites for oviposition. GABA is an essential neurotransmitter in olfactory processing in the insect brain, including the primary olfactory center, the antennal lobe. Previous work with Ae. aegypti has suggested that antennal lobe inhibition via GABA may be involved in the processing of odors. However, little is known about GABA receptor expression in the mosquito brain, or how they may be involved in odor att...
Source: Frontiers in Physiology - March 28, 2024 Category: Physiology Source Type: research
Kidney toxicity and transcriptome analyses of male ICR mice acutely exposed to the mushroom toxin α-amanitin
Food Chem Toxicol. 2024 Mar 24:114622. doi: 10.1016/j.fct.2024.114622. Online ahead of print.ABSTRACTAmatoxins are responsible for most fatal mushroom poisoning cases, as it causes both hepatotoxicity and nephrotoxicity. However, studies on amatoxin nephrotoxicity are limited. Here, we investigated nephrotoxicity over 4 days and nephrotoxicity/hepatotoxicity over 14 days in mice. The organ weight ratio, serological indices, and tissue histology results indicated that a nephrotoxicity mouse model was established with two stages: (1) no apparent effects within 24 h; and (2) the appearance of adverse effects, with gradual wor...
Source: Food and Chemical Toxicology - March 26, 2024 Category: Food Science Authors: Zhijun Wu Haijiao Li Wenjin Zhao Min Zheng Juan Cheng Zhengjie Cao Chengye Sun Source Type: research
Kidney toxicity and transcriptome analyses of male ICR mice acutely exposed to the mushroom toxin α-amanitin
Food Chem Toxicol. 2024 Mar 24:114622. doi: 10.1016/j.fct.2024.114622. Online ahead of print.ABSTRACTAmatoxins are responsible for most fatal mushroom poisoning cases, as it causes both hepatotoxicity and nephrotoxicity. However, studies on amatoxin nephrotoxicity are limited. Here, we investigated nephrotoxicity over 4 days and nephrotoxicity/hepatotoxicity over 14 days in mice. The organ weight ratio, serological indices, and tissue histology results indicated that a nephrotoxicity mouse model was established with two stages: (1) no apparent effects within 24 h; and (2) the appearance of adverse effects, with gradual wor...
Source: Food and Chemical Toxicology - March 26, 2024 Category: Food Science Authors: Zhijun Wu Haijiao Li Wenjin Zhao Min Zheng Juan Cheng Zhengjie Cao Chengye Sun Source Type: research
Plant Soup Formulations Show Cholinesterase Inhibition Potential in the Prevention of Alzheimer's Disease
CONCLUSION: The outcomes of our study should serve as a catalyst for further exploration of this important research domain. Our current research focuses on deeper insights into the potential of comprehensive meal options. Furthermore, the synergy/antagonism/non-interaction between respective soup ingredients as well as elements of individual soups' chemical composition is a very interesting topic currently under our intensive scientific investigation.PMID:38523524 | DOI:10.2174/0115672050306101240321050146 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - March 25, 2024 Category: Neurology Authors: Dorota Gajowniczek-A łasa Dominik Szwajgier Ewa Baranowska-W ójcik Source Type: research
Analysis of molecular structure and topological properties of chitosan isolated from crab shell and mushroom
Int J Biol Macromol. 2024 Mar 21:131047. doi: 10.1016/j.ijbiomac.2024.131047. Online ahead of print.ABSTRACTThis investigation aimed to scrutinize the chemical and structural analogies between chitosan extracted from crab exoskeleton (High Molecular Weight Chitosan, HMWC) and chitosan obtained from mushrooms (Mushroom-derived Chitosan, MRC), and to assess their biological functionalities. The resulting hydrolysates from the hydrolysis of HMWC by chitosanase were categorized as chitosan oligosaccharides (csCOS), while those from MRC were denoted as mrCOS. The molecular weights (MW) of csCOS and mrCOS were determined using M...
Source: International Journal of Biological Macromolecules - March 23, 2024 Category: Biochemistry Authors: Eung Take Lee Jio Song Ji Hyun Lee Bon Guen Goo Jae Kweon Park Source Type: research
Food and human health applications of edible mushroom by-products
N Biotechnol. 2024 Mar 21:S1871-6784(24)00010-4. doi: 10.1016/j.nbt.2024.03.003. Online ahead of print.ABSTRACTMushroom waste can account for up to 50% of the total mushroom mass. Spent mushroom substrate, misshapen mushrooms, and mushroom stems are examples of mushroom byproducts. In ancient cultures, fungi were prized for their medicinal properties. Aqueous extracts containing high levels of β-glucans as functional components capable of providing prebiotic polysaccharides and improved texture to foods have been widely used and new methods have been tested to improve extraction yields. Similarly, the addition of insolubl...
Source: New Biotechnology - March 23, 2024 Category: Biotechnology Authors: Pablo Navarro-Simarro Lourdes G ómez-Gómez Oussama Ahrazem Ángela Rubio-Moraga Source Type: research
Analysis of molecular structure and topological properties of chitosan isolated from crab shell and mushroom
Int J Biol Macromol. 2024 Mar 21:131047. doi: 10.1016/j.ijbiomac.2024.131047. Online ahead of print.ABSTRACTThis investigation aimed to scrutinize the chemical and structural analogies between chitosan extracted from crab exoskeleton (High Molecular Weight Chitosan, HMWC) and chitosan obtained from mushrooms (Mushroom-derived Chitosan, MRC), and to assess their biological functionalities. The resulting hydrolysates from the hydrolysis of HMWC by chitosanase were categorized as chitosan oligosaccharides (csCOS), while those from MRC were denoted as mrCOS. The molecular weights (MW) of csCOS and mrCOS were determined using M...
Source: International Journal of Biological Macromolecules - March 23, 2024 Category: Biochemistry Authors: Eung Take Lee Jio Song Ji Hyun Lee Bon Guen Goo Jae Kweon Park Source Type: research
Food and human health applications of edible mushroom by-products
N Biotechnol. 2024 Mar 21:S1871-6784(24)00010-4. doi: 10.1016/j.nbt.2024.03.003. Online ahead of print.ABSTRACTMushroom waste can account for up to 50% of the total mushroom mass. Spent mushroom substrate, misshapen mushrooms, and mushroom stems are examples of mushroom byproducts. In ancient cultures, fungi were prized for their medicinal properties. Aqueous extracts containing high levels of β-glucans as functional components capable of providing prebiotic polysaccharides and improved texture to foods have been widely used and new methods have been tested to improve extraction yields. Similarly, the addition of insolubl...
Source: New Biotechnology - March 23, 2024 Category: Biotechnology Authors: Pablo Navarro-Simarro Lourdes G ómez-Gómez Oussama Ahrazem Ángela Rubio-Moraga Source Type: research
