The Mushroom Albatrellus confluens: A Minireview on Phytochemistry, Biosynthesis, Synthesis and Pharmacological Activities
CONCLUSION: The continuation of chromatographic separation and biomedical research is expected. Modern biological assays for explaining the pharmacological values of A. confluens constituents are warranted. Toxicological and pharmacokinetic assessments are urgently needed.PMID:38284736 | DOI:10.2174/0115680266291757240124093756 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - January 29, 2024 Category: Chemistry Authors: Ninh The Son Chu Anh Van Source Type: research
Genes, Vol. 15, Pages 183: The Impact of Psilocybin on High Glucose/Lipid-Induced Changes in INS-1 Cell Viability and Dedifferentiation
This study investigates the potential impacts of psilocybin on β-cell viability, dedifferentiation, and function using an in vitro system. The INS-1 832/13 Rat Insulinoma cell line underwent psilocybin pretreatment, followed by exposure to high glucose-high lipid (HG-HL) conditions for specific time periods. After being harvested from treated cells, total transcript and cellular protein were utilized for further investigation. Our findings implied that psilocybin administration effectively mitigates HG-HL-stimulated β-cell loss, potentially mediated through the modulation of apoptotic biomarkers, ...
Source: Genes - January 29, 2024 Category: Genetics & Stem Cells Authors: Esmaeel Ghasemi Gojani Bo Wang Dong-Ping Li Olga Kovalchuk Igor Kovalchuk Tags: Article Source Type: research
Nakazawaea tricholomae f.a., sp. nov., a Novel Ascomycetous Yeast Species Isolated from Two Mushroom Species in China
Curr Microbiol. 2024 Jan 28;81(3):78. doi: 10.1007/s00284-023-03600-w.ABSTRACTTwo yeast strains designated as 20-27-1 and 20-28 were isolated from the fruiting bodies of Tricholoma gambosum and Marasmius maximus, respectively, which were collected in Wudaogou, Weichang county, Chengde area, Hebei Province, China. The multi-locus analysis of the sequences of the rDNA ITS, D1/D2 LSU, and SSU regions, together with partial sequences of two protein-coding genes RPB1 and TEF1 indicates that the two strains are closely related to Nakazawaea ernobii and Nakazawaea holstii, showing the similarity values of 99.3-98.7%, 97.2-97.1%, ...
Source: Current Microbiology - January 28, 2024 Category: Microbiology Authors: Min Liu You-Liang Jiang Yu-Xuan Zhang Qi-Ming Wang Source Type: research
Inhibition of melanoma cell proliferation by strobilurins isolated from mushrooms and their synthetic analogues
Biosci Biotechnol Biochem. 2024 Jan 25:zbae006. doi: 10.1093/bbb/zbae006. Online ahead of print.ABSTRACTStrobilurins A and X, isolated from Mucidula venosolamellata cluture extracts, demonstrated potent inhibition of human melanoma G-361 cell proliferation. Strobilurin X exhibited milder inhibitory effects on human fibroblast cells (NB1RGB) compared to strobilurin A. Additional strobilurin-related compounds were isolated from the other mushroom species. Oudemansins A and B displayed weaker activities on G-361 cells than strobilurins A and B, respectively, emphasizing the importance of a conjugated double-bond structure. Am...
Source: Bioscience, Biotechnology, and Biochemistry - January 25, 2024 Category: Biochemistry Authors: Tomoya Tanaka Kenji Takahashi Yuki Inoue Naoki Endo Emiko Shimoda Kotomi Ueno Tsuyoshi Ichiyanagi Toshio Ohta Atsushi Ishihara Source Type: research
Effects of Flammulina velutipes mushroom residues on growth performance, apparent digestibility, serum biochemical indicators, rumen fermentation and microbial of Guizhou black goat
In conclusion, the results of the current study indicated that 30% FVMR in the FTMR diet improves rumen fermentation and rumen microbial composition in Guizhou black male goats, which improves growth performance, apparent digestibility, and immunity. (Source: Frontiers in Microbiology)
Source: Frontiers in Microbiology - January 24, 2024 Category: Microbiology Source Type: research
Design and synthesis of 4-amino-2',4'-dihydroxyindanone derivatives as potent inhibitors of tyrosinase and melanin biosynthesis in human melanoma cells
Eur J Med Chem. 2024 Feb 15;266:116165. doi: 10.1016/j.ejmech.2024.116165. Epub 2024 Jan 19.ABSTRACTMelanogenesis inhibition constitutes a privileged therapeutic solution to treat skin hyperpigmentation, a major dermatological concern associated with the overproduction of melanin by human tyrosinase (hsTYR). Despite the existence of many well-known TYR (tyrosinase) inhibitors commercialized in skin formulations, their hsTYR-inhibition efficacy remains poor since most of them were investigated over mushroom tyrosinase (abTYR), a model with low homology relative to hsTYR. Considering the need for new potent hsTYR inhibitors,...
Source: European Journal of Medicinal Chemistry - January 23, 2024 Category: Chemistry Authors: Leticia M Lazinski Morane Beaumet Brayan Roulier R émy Gay Guy Royal Marc Maresca Romain Haudecoeur Source Type: research
Optimization of chemical conditions for metabolites production by Ganoderma lucidum using response surface methodology and investigation of antimicrobial as well as anticancer activities
Ganoderma lucidum (G. lucidum) is a medicinal mushroom that is known for its ability to produce compounds with physiological effects on human health. This research was undertaken to amplify the production of bioactive components of G. lucidum under optimal cultivation conditions, obtained in a submerged state and utilized in solid state fermentation, with the purpose of enhancing antimicrobial and anticancer activities. The results indicated that titanium dioxide (TiO2 NPs), magnesium oxide nanoparticles (MgO2 NPs), and B6, along with glucose syrup and CLS syrups, were the most effective for producing GA, while wheat starc...
Source: Frontiers in Microbiology - January 22, 2024 Category: Microbiology Source Type: research
Trip-killers: a concerning practice associated with psychedelic drug use
Psychedelic drugs such as lysergic acid diethylamide (LSD) and psilocybin (‘magic mushrooms’) induce hallucinations and distort thought-processes. The intensity of a psychedelic ‘trip’ can cause distress, agitation, and even psychosis. A recent report showed that at least 8.4% of drug-related presentations to European emergency departments involve psychedelics.1 This proportion may increase as the clinical use of these agents expands.2 There are multiple ways to control a ‘bad trip’ and avoid hospitalisation. One is to take psychedelics under the supervision of a ‘trip-sitter&rsquo...
Source: Emergency Medicine Journal - January 22, 2024 Category: Emergency Medicine Authors: Yates, G., Melon, E. Tags: Press releases Research letter Source Type: research
Bibliometric, taxonomic, and medicinal perspectives of Ganoderma neo-japonicum Imazeki: A mini review
. (Source: Mycology)
Source: Mycology - January 21, 2024 Category: Biology Authors: Meng Fei LauChia Wei PhanVikineswary SabaratnamUmah Rani Kuppusamya Department of Biomedical Sciences, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysiab Mushroom Research Centre, Universiti Malaya, Kuala Lumpur, Malaysiac Department of Pharm Source Type: research
In vitro and in vivo anti-pigmentation effects of 2-mercaptobenzimidazoles as nanomolar tyrosinase inhibitors on mammalian cells and zebrafish embryos: Preparation of pigment-free zebrafish embryos
Eur J Med Chem. 2024 Feb 15;266:116136. doi: 10.1016/j.ejmech.2024.116136. Epub 2024 Jan 9.ABSTRACTRecently, 10 2-mercaptobenzo[d]imidazole (2-MBI) compounds (1-10) were synthesized. Although all 2-MBI compounds are tyrosinase inhibitors that inhibit mushroom tyrosinase at extremely low concentrations (IC50 values: 20-740 nM) and effectively inhibit the browning of apples, to our knowledge, no studies have determined whether 2-MBI compounds inhibit mammalian tyrosinase. Mammalian tyrosinase is different from mushroom tyrosinase in its distribution within the cell and has structural characteristics that are different from m...
Source: European Journal of Medicinal Chemistry - January 20, 2024 Category: Chemistry Authors: Dahye Yoon Hee Jin Jung Jieun Lee Hye Jin Kim Hye Soo Park Yu Jung Park Min Kyung Kang Ga Young Kim Dongwan Kang Yujin Park Pusoon Chun Hae Young Chung Hyung Ryong Moon Source Type: research
Effects of grafted polymers on the lipid membrane fluidity
Biophys J. 2024 Jan 18:S0006-3495(24)00030-4. doi: 10.1016/j.bpj.2024.01.014. Online ahead of print.ABSTRACTSince the membrane fluidity controls the cellular functions, it is important to identify the factors that determine the cell membrane viscosity. Cell membranes are composed of not only lipids and proteins but also polysaccharide chain-anchored molecules, such as glycolipids. To reveal the effects of grafted polymers on the membrane fluidity, in this study, we measured the membrane viscosity of polymer-grafted giant unilamellar vesicles (GUVs), which were prepared by introducing the poly (ethylene glycol) (PEG)-anchor...
Source: Biophysical Journal - January 20, 2024 Category: Physics Authors: Yuka Sakuma Nana Kayamori Julia Tanaka Kenya Haga Masayuki Imai Toshihiro Kawakatsu Source Type: research
Mushroom intake and risk of incident disabling dementia: the Circulatory Risk in Communities Study (CIRCS)
Br J Nutr. 2024 Jan 19:1-7. doi: 10.1017/S000711452400014X. Online ahead of print.ABSTRACTIt is uncertain whether dietary intake of mushrooms rich in dietary fibre and several antioxidants is associated with a lower risk of dementia. We sought to examine prospectively the association between mushroom intake and the risk of disabling dementia. We performed a prospective study involving 3750 people aged 40 to 64 years residing in three communities who participated in an annual cardiovascular risk survey from 1985 to 1999. Cases of incident disabling dementia were surveyed from 1999 to 2020. We calculated the hazard ratios (H...
Source: The British Journal of Nutrition - January 19, 2024 Category: Nutrition Authors: Shoko Aoki Kazumasa Yamagishi Kotatsu Maruyama Ai Ikeda Masanori Nagao Hiroyuki Noda Mitsumasa Umesawa Mina Hayama-Terada Isao Muraki Chika Okada Mari Tanaka Rie Kishida Tomomi Kihara Midori Takada Yuji Shimizu Tetsuya Ohira Hironori Imano Tomoko Sankai T Source Type: research
Psilocybe cubensis extract potently prevents fear memory recall and freezing behavior in short- but not long-term in a rat model of posttraumatic stress disorder.
In conclusion, Psilocybe cubensis effects on PTSD-like behavior and locomotor activity seem to be remained in short-term, while Psilocybe cubensis effects on pain subthreshold and anxiety remained long-term. This is the first study evaluating the effect of Psilocybe cubensis on PTSD-like behavior in rats in three different time protocols (1, 3, and 21 days after fear conditioning). (PsycInfo Database Record (c) 2024 APA, all rights reserved) (Source: Behavioral Neuroscience)
Source: Behavioral Neuroscience - January 18, 2024 Category: Neuroscience Source Type: research
Drug induced autoimmune hepatitis: An unfortunate case of herbal toxicity from Skullcap supplement: A case report
CONCLUSION: This scenario highlights an uncommon instance of DILI caused by Skullcap supplements. It's crucial for hepatologists to recognize this connection due to the increasing prevalence of herbal supplements.PMID:38223420 | PMC:PMC10784811 | DOI:10.4254/wjh.v15.i12.1333 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - January 15, 2024 Category: Gastroenterology Authors: Nimish Thakral Venkata Rajesh Konjeti Fady William Salama Source Type: research
A comprehensive review of the application of ultrasonication in the production and processing of edible mushrooms: Drying, extraction of bioactive compounds, and post-harvest preservation
Ultrason Sonochem. 2024 Jan;102:106763. doi: 10.1016/j.ultsonch.2024.106763. Epub 2024 Jan 9.ABSTRACTEdible mushrooms are high in nutrients, low in calories, and contain bioactive substances; thus, they are a valuable food source. However, the high moisture content of edible mushrooms not only restricts their storage and transportation after harvesting, but also leads to a shorter processable cycle, production and processing limitations, and a high risk of deterioration. In recent years, ultrasonic technology has been widely applied to various food production operations, including product cleaning, post-harvest preservatio...
Source: Ultrasonics Sonochemistry - January 14, 2024 Category: Chemistry Authors: Mianli Sun Yongliang Zhuang Ying Gu Gaopeng Zhang Xuejing Fan Yangyue Ding Source Type: research
