The Quality of Epigenetic Clocks Continues to Improve
There is at present a diverse exploration of clocks that assess biological age, these clocks constructed as weighted combinations of data picked from the epigenome, transcriptome, or proteome, all of which change in characteristic ways with age. Many different clocks are at various stages of development and refinement. The goal is the production of a robust, low-cost, rapid way to assess the efficacy of potential rejuvenation therapies: if one can use a blood test ten days before and ten days after a treatment, that would be a great deal easier than having to wait and see over the course of a life span.
Unfortunate...
Source: Fight Aging! - December 16, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
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Luna G, Alping P, Burman J et al. Infection risks among patients with multiple sclerosis treated with fingolimod, natalizumab, rituximabm and injectable therapies. JAMA Neurology2020; 77:184-91.var gaJsHost = (( " https: " == document.location.protocol) ? " https://ssl. " : " http://www. " ); document.write(unescape( " %3Cscript src= ' " + gaJsHost + " google-analytics.com/ga.js ' type= ' text/javascript ' %3E%3C/script%3E " ));var pageTracker = _gat._getTracker( " UA-3639768-12 " ); pageTracker._initData(); pageTracker._trackPageview();Swedish study examines risk of infections severe enough to caus...
Source: neurologyminutiae - November 22, 2020 Category: Neurology Source Type: blogs
Fight Aging! Newsletter, November 23rd 2020
In conclusion, the study indicates that HBOT may induce significant senolytic effects that include significantly increasing telomere length and clearance of senescent cells in the aging populations.
Data on the Prevalence of Liver Fibrosis in Middle Age
https://www.fightaging.org/archives/2020/11/data-on-the-prevalence-of-liver-fibrosis-in-middle-age/
Fibrosis is a consequence of age-related disarray in tissue maintenance processes, leading to the deposition of scar-like collagen that disrupts tissue structure and function. It is an ultimately fatal issue for which there are only poor treatment options ...
Source: Fight Aging! - November 22, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Tau Protein and Blood-Brain Barrier Dysfunction in Aging
Aggregation of phosphorylated tau protein into neurofibrillary tangles (and consequent toxicity leading to widespread cell death) is characteristic of late stage Alzheimer's disease, while dysfunction of the blood-brain barrier is a feature of aging thought to begin much earlier in the progression of the condition. The blood-brain barrier is a specialized set of cells lining the blood vessels of the central nervous system, allowing only certain molecules and cells to pass. When this barrier starts to leak, unwanted materials make their way into the brain, generating chronic inflammation and consequent issues in brain tissu...
Source: Fight Aging! - November 18, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, November 16th 2020
This study conclusively demonstrates the long-speculated relationship between aging, gene regulation, and somatic damage. The results open up new avenues of research with practical implications. If the same level of coordination reduction between genes is indeed a leading cause for aging phenomena, there may be a need to change course in current efforts to develop aging treatments.
Using Oligodendrocyte Extracellular Vesicles to Induce Tolerance to Myelin as a Treatment for Multiple Sclerosis
https://www.fightaging.org/archives/2020/11/using-oligodendrocyte-extracellular-vesicles-to-induce-tolerance-to-myelin-...
Source: Fight Aging! - November 15, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Using Oligodendrocyte Extracellular Vesicles to Induce Tolerance to Myelin as a Treatment for Multiple Sclerosis
In multiple sclerosis, the immune system becomes intolerant towards myelin, the sheathing around nerves that is essential to nervous system function. One class of approach to treating autoimmune diseases of this nature is to produce immune tolerance by delivering more of the problem molecule into the body. The challenge in multiple sclerosis is that it is unclear as to which of the many possible protein sequences is the problem in any given patient, and indeed to build a comprehensive list of such sequences in the first place. Researchers here report on the discovery that the oligodendrocyte cells responsible for building ...
Source: Fight Aging! - November 11, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Illness-related fatigue: More than just feeling tired
A common refrain during the COVID-19 pandemic is, “I’m so tired.” After months of adjusted living and anxiety, people are understandably weary. Parents who haven’t had a break from their kids are worn out. Those trying to juggle working from home with homeschooling are stretched thin. Between concerns about health, finances, and isolation, everyone is feeling some level of additional stress during this unusual time, and that’s tiring. We all could use a good, long nap — or better yet, a vacation.
But while a break would be nice, most people — except those who are actually sick with COVID-19 or other illnesses...
Source: Harvard Health Blog - October 21, 2020 Category: Consumer Health News Authors: Jennifer Crystal, MFA Tags: Autoimmune diseases Fatigue Source Type: blogs
New Technologies Drive Cost Growth Over Time
By KEN TERRY
(This is the eighth and final installment in a series of excerpts from Terry’s new book, Physician-Led Healthcare Reform: a New Approach to Medicare for All, published by the American Association for Physician Leadership.)
Medical technologies include drugs, devices, tests, and procedures. Considered as a whole, these technologies are the key driver of growth in health costs, according to Georgetown University professor Gregg Bloche and his associates.
Bloche, et al., view insurance coverage as the chief enabler of these technological innovations. In a 2017 Health Affairs Blog post, they said, ...
Source: The Health Care Blog - October 5, 2020 Category: Consumer Health News Authors: Christina Liu Tags: Health Policy Ken Terry Source Type: blogs
Five Problems with Democrats ’ “Preexisting Conditions” Strategy
Michael F. CannonDemocrats think preexisting conditions will once again carry them to electoral victory. Despite their own liabilities and callousness on the issue, they ’re probably right.In 2018, Democrats accused Republicans of wanting to deny health care to the sick. Exhibit A, they said, was the GOP ’s attempt to repeal ObamaCare’s popular preexisting‐conditions provisions. The accusation worked. Democratsflipped a net 41 House seats to take control of the chamber. Conventional wisdom considers the outcome to be proof that ObamaCare is (finally) popular with voters.In 2020, Democrats are deploying the sam...
Source: Cato-at-liberty - September 29, 2020 Category: American Health Authors: Michael F. Cannon Source Type: blogs
CBD for chronic pain: The science doesn ’t match the marketing
If you ask health care providers about the most challenging condition to treat, chronic pain is mentioned frequently. By its nature, chronic pain is a complex and multidimensional experience. Pain perception is affected by our unique biology, our mood, our social environment, and past experiences. If you or a loved one is suffering from chronic pain, you already know the heavy burden.
People are looking for novel, nonaddictive ways to treat pain
Given the ongoing challenges of chronic pain management coupled with the consequences of the opioid epidemic, pain management practitioners and their patients are searching for eff...
Source: Harvard Health Blog - September 23, 2020 Category: Consumer Health News Authors: Shafik Boyaji, MD Tags: Back Pain Marijuana Pain Management Source Type: blogs
Learning to live well with a persistent illness
When we get an acute illness like the flu or a cold, we feel sick for a week or two and then get back to our usual lives. This is how illness is “supposed” to go. But what happens when illness doesn’t fit this bill? What do patients with chronic conditions like diabetes or multiple sclerosis, or with persistent symptoms of Lyme disease or long-haul COVID-19, do when they can’t go back to their normal lives? Having suffered from the latter two — tick-borne illnesses that have plagued me for two decades, and a case of COVID-19 that took four months to shake — I’ve learned a few lessons about living with persist...
Source: Harvard Health Blog - September 14, 2020 Category: Consumer Health News Authors: Jennifer Crystal, MFA Tags: Fatigue Source Type: blogs
Fight Aging! Newsletter, September 7th 2020
In conclusion, using a large cohort with rich health and DNA methylation data, we provide the first comparison of six major epigenetic measures of biological ageing with respect to their associations with leading causes of mortality and disease burden. DNAm GrimAge outperformed the other measures in its associations with disease data and associated clinical traits. This may suggest that predicting mortality, rather than age or homeostatic characteristics, may be more informative for common disease prediction. Thus, proteomic-based methods (as utilised by DNAm GrimAge) using large, physiologically diverse protein sets for p...
Source: Fight Aging! - September 6, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Theophylline Produces Accelerated Remyelination in the Central Nervous System of Mice
The myelin sheathing around axons is necessary for the proper function of nervous system tissue. Demyelinating conditions such as multiple sclerosis, an autoimmune disease in which the immune system attacks myelin, well illustrate the severe consequences that result from a sizable loss of myelin. Unfortunately, the integrity of myelin sheathing declines with age for everyone, most likely the result of disruption and damage in the oligodendrocyte cell population responsible for maintaining these structures. Evidence suggests that this contributes to cognitive decline and other issues. Thus it is worth keeping an eye on prog...
Source: Fight Aging! - September 1, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Psychology Around the Net: August 29, 2020
Before we get on with this week’s Psychology Around the Net, I need to let you know that this will be the last one.
Healthline has purchased Psych Central and content production stops August 31, 2020. Dr. John Grohol, Psych Central’s founder and our fearless leader, recently shared his reflections and gratitude.
Additionally, many of our talented and knowledgeable contributers have shared goodbye posts, and invitations to follow their new blogs.
Now, let’s see what’s new in the world of mental health this week!
The Psychology Behind Why Some College Students Break COVID-19 Rules: According to deve...
Source: World of Psychology - August 29, 2020 Category: Psychiatry & Psychology Authors: Alicia Sparks Tags: Psychology Around the Net Burnout College Students coronavirus COVID-19 Fatigue Happiness Life Satisfaction Mood pandemic Source Type: blogs
Fight Aging! Newsletter, August 3rd 2020
In this study, we examined the effects of oxytocin on the Aβ-induced impairment of synaptic plasticity in mice.
To investigate the effect of oxytocin on synaptic plasticity, we prepared acute hippocampal slices for extracellular recording and assessed long-term potentiation (LTP) with perfusion of the Aβ active fragment (Aβ25-35) in the absence and presence of oxytocin. We found that oxytocin reversed the impairment of LTP induced by Aβ25-35 perfusion in the mouse hippocampus. These effects were blocked by pretreatment with the selective oxytocin receptor antagonist L-368,899. Furthermore, the treatment with the...
Source: Fight Aging! - August 2, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
