Further Consideration of Subtypes of Alzheimer's Disease
There has been some thought given to whether Alzheimer's disease is a collection of fairly distinct subtypes, with different origins and different dominant processes of pathology. The evidence for subtypes of Alzheimer's disease is suggestive, as noted in this article. It remains to be seen as to what the research community will do with all of this data, but it is possible that some therapies are not as bad as originally thought, if analysis were restricted to only one subtype of Alzheimer's disease.
Proteins floating in the cerebrospinal fluid (CSF) might do more than diagnose Alzheimer's disease (AD) - they may ...
Source: Fight Aging! - December 18, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Study identifies protective brain structure that delays the onset of frontotemporal dementia symptoms over 2 years
This article was originally published on The Conversation.
To Learn More:
Deep learning model built on neuroimaging data identifies “Brain Age Gaps” as markers of Alzheimer’s disease (AD)
Study: Building cognitive reserve helps delay memory and thinking decline regardless of genetic or childhood markers
The post Study identifies protective brain structure that delays the onset of frontotemporal dementia symptoms over 2 years appeared first on SharpBrains. (Source: SharpBrains)
Source: SharpBrains - November 17, 2023 Category: Neuroscience Authors: The Conversation Tags: Brain/ Mental Health brain fold brain-reserve brain-structure Bruce Willis cognitive advantage cognitive-ability cognitive-reserve dementia frontal-lobes frontotemporal dementia paracingulate sulcus Source Type: blogs
Fight Aging! Newsletter, October 16th 2023
In conclusion, a number of studies have shown that CD4+ Treg cells are crucial in the maintenance of peripheral tolerance and have an important role in the control of atherosclerosis-related inflammation. Therefore, Treg cells are a promising target of major research efforts focused on immune-modulating therapies against atherosclerosis. Developing anti-atherosclerotic Treg-based therapies faces challenges. However, rapid progress in genetic, epigenetic, and molecular aspects of cellular immunology gives hope for a fast-track solution.
« Back to Top
Delivering Senolytic Nanoparticles to Atheroscle...
Source: Fight Aging! - October 15, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Towards More Selective Ways to Block Unwanted Inflammation
Control of chronic inflammation may turn out to be one of the more important themes in the treatment of aging as a medical condition. Senescent cells generate inflammatory signaling, but removing that contribution is likely the easiest aspect of the problem. Many forms of age-related cellular damage and dysfunction generate constant, unwanted, excess inflammation through interactions and signals that are used during a normal, desirable inflammatory reaction, such as to injury or infection. Thus interfering in these mechanisms must be very selective; simply blockading a given signal has undesirable side-effects, such as a w...
Source: Fight Aging! - October 13, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Bonus Features – September 10, 2023 – 77% of clinicians see RPM outpacing traditional inpatient care within five years, Microsoft partnering with Paige on pathology and oncology AI models, and more
This article will be a weekly roundup of interesting stories, product announcements, new hires, partnerships, research studies, awards, sales, and more. Because there’s so much happening out there in healthcare IT we aren’t able to cover in our full articles, we still want to make sure you’re informed of all the latest news, announcements, and stories happening to help you better do your job.
News
Executives for Healthcare Innovation is transferring its assets to the American Telemedicine Association, and ATA will extend engagement opportunities to current EHI members through its various Special Interest Groups.
More...
Source: EMR and HIPAA - September 11, 2023 Category: Information Technology Authors: Brian Eastwood Tags: Healthcare IT Adrian Agostini Alo American Telemedicine Association Andrea Rowe Anki ATA AVIA Black Book Research Canopy Edifecs Experity Healthcare IT Today Bonus Features HITRUST Ibex Medical Analytics iMerit Inovalon K Source Type: blogs
Fight Aging! Newsletter, August 28th 2023
In conclusion, we identified 20 genes with significant evolutionary signals unique to long-lived species, which provided new insight into the lifespan extension of mammals and might bring new strategies to extend human lifespan.
« Back to Top
Trials of Xenotransplantation of Pig Organs into Humans Continue
https://www.fightaging.org/archives/2023/08/trials-of-xenotransplantation-of-pig-organs-into-humans-continue/
Researchers have genetically engineered pigs to overcome the known barriers to transplantation of pig organs into humans, and have reached the stage of conducting transplants i...
Source: Fight Aging! - August 27, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
T Cell Dysfunction in Neurodegenerative Conditions
Chronic inflammation and dysfunction of immune cells is a characteristic of neurodegenerative conditions. Attention is usually given to the innate immune cells of the central nervous system in this context, but it is also the case that the adaptive immune system outside the brain tends towards dysfunction in older individuals suffering from age-related disease. Researchers here review what is known of T cell exhaustion, senescence, and other issues in older individuals. It is hoped that clearing these problematic cells from the immune population, such as via the use of senolytic drugs to destroy senescent cells, will have ...
Source: Fight Aging! - August 25, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, July 24th 2023
In this study, we tested the hypothesis that periodontal disease (PD) as a source of infection alters inflammatory activation and Aβ phagocytosis by the microglial cells.
Experimental PD was induced using ligatures in C57BL/6 mice for 1, 10, 20, and 30 days to assess the progression of PD. Animals without ligatures were used as controls. Ligature placement caused progressive periodontal disease and bone resorption that was already significant on day 1 post-ligation and continued to increase until day 30. The severity of periodontal disease increased the frequency of activated microglia in the brains on day 30 by 36...
Source: Fight Aging! - July 23, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
From medical student to MS warrior: Navigating life with multiple sclerosis
I was diagnosed with multiple sclerosis during my second year of medical school. It happened while I was on a neurology rotation when I approached the neurologist after a lecture and expressed my suspicion of a flare-up. Subsequently, a lumbar puncture and a contrast brain MRI confirmed the diagnosis, leading to my treatment with IV
Read more…
From medical student to MS warrior: Navigating life with multiple sclerosis originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - July 22, 2023 Category: General Medicine Authors: Nesrin Abu Ata, MD Tags: Conditions Neurology Source Type: blogs
Reviewing What is Known of the Biochemistry of Klotho Relevant to Effects on Life Span
Increased klotho expression increases longevity in mice, while reduced klotho expression accelerates aging. The most well studied effects of klotho on organ function involve the kidney and brain, where in both cases it appears protective via a number of different mechanisms. Unfortunately, klotho expression declines with age. Whether treating humans with therapies that increase levels of klotho will produce effects that are as large as those observed in mice remains to be seen. Programs that might lead to treatments remain at a preclinical stage of development, though recently advanced to the point of testing in non-human ...
Source: Fight Aging! - July 21, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Building a Digital Immune System
Credit: Courtesy of Dr. Tomas Helikar.
The power of computer code has been a longtime fascination for Tomas Helikar, Ph.D., a professor of biochemistry at the University of Nebraska-Lincoln (UNL). In college, when he learned he could use that power to help researchers better understand biology and improve human health, Dr. Helikar knew he’d found his ideal career. Since then, he’s built a successful team of scientists studying the ways we can use mathematical models in biomedical research, such as creating a digital replica of the immune system that could predict how a patient will react to infectious microorganisms ...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - June 28, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Cells Tools and Techniques Bioinformatics Computational Biology Cool Tools/Techniques Modeling Profiles Source Type: blogs
Fight Aging! Newsletter, June 26th 2023
This study explored the association between different cooking fuel types and the risk of cancer and all-cause mortality among seniors constructing Cox regression models. Data were obtained by linking waves of 6, 7, and 8 of the Chinese Longitudinal Healthy Longevity Survey, which included a total of 7,269 participants who were 65 years old and over. Cooking fuels were categorized as either biomass, fossil, or clean fuels. And the effects of switching cooking fuels on death risk were also investigated using Cox regression models.
The results indicate that, compared with the users of clean fuels, individuals using bio...
Source: Fight Aging! - June 25, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Towards Treatments for Neurodegenerative Disease via Alteration of the Gut Microbiome
The balance of microbial populations making up the gut microbiome shifts with age, favoring potentially harmful, inflammatory microbes over those that produce beneficial metabolites. This is increasingly associated with the development of disease, and particularly with neurodegenerative conditions, though every age-related condition with a strong inflammatory component to its pathology is likely accelerated by the aging of the gut microbiome. There are ways to adjust the balance of populations to restore a more youthful configuration, such as fecal microbiota transplantation from a young donor, but the research community h...
Source: Fight Aging! - June 21, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Will Success in Reversing Aging Shape the Regulatory System to Accommodate It?
A sizable fraction of the therapies produced by the medical industry are, not to put too fine a point on it, garbage. The benefit is not worth the cost of diverting the resources into the full scale production of the drug, versus those resources going towards some better form of medical research and development. Giving a cancer patient an extra month or two of life, reducing fibrosis in the liver by 10% over a year of treatment, incrementally improving mitophagy to half the degree that exercise achieves, and so forth. Small molecule development in particular excels at producing this sort out outcome, as the effects on gene...
Source: Fight Aging! - June 19, 2023 Category: Research Authors: Reason Tags: Longevity Industry Source Type: blogs
Fight Aging! Newsletter, June 19th 2023
In conclusion, among Swedish middle-aged subjects, nearly two-thirds showed complete fatty degeneration of thymus on CT.
Age-Related Dysfunction of Water Homeostasis
https://www.fightaging.org/archives/2023/06/age-related-dysfunction-of-water-homeostasis/
Dehydration can be an issue in older people. As in every complex system in the body, the mechanisms by which hydration is regulated become dysfunctional with advancing age. Researchers here look at the brain region responsible for regulating some of the response to dehydration, cataloging altered gene expression in search of the more important mechan...
Source: Fight Aging! - June 18, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
