Underfunding Research Of Female Health Leaves Huge Amounts Of Money On The Table
“Did you know that at least one-third of women have lower back pain before their periods every month, and yet, nobody seems to fully understand why?” – asked a Medical Futurist team member a little while ago. The question led to a discussion about the differences in research, funding and understanding of male-only and female-only health issues, and consequently, to this article.
It is a well-known fact that some diseases or conditions dominantly affect one gender or the other. There are the trivial ones, like prostate cancer or ovarian, cervical, uterine cancers. But there is a long list of diseases and condit...
Source: The Medical Futurist - May 12, 2022 Category: Information Technology Authors: Andrea Koncz Tags: TMF Future of Medicine Healthcare Policy Medical Education women female health under-reseached gender gap in healthcare Source Type: blogs
Fight Aging! Newsletter, May 2nd 2022
In this study, we tested the therapeutic potential of VHHASC and a newly generated VHH against murine ASC (VHHmASC) to target ASC specks in vitro and in vivo. We show that pre-incubation of extracellular ASC specks with VHHASC abrogated their inflammatory functions in vitro. Recombinant VHHASC rapidly disassembled pre-formed ASC specks and thus inhibited their ability to seed the nucleation of soluble ASC. Notably, VHHASC required prior cytosolic access to prevent inflammasome activation within cells, but it was effective against extracellular ASC specks released following caspase-1-dependent loss of membrane integrity, an...
Source: Fight Aging! - May 1, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Leg Sleeve for Neurological Mobility Issues: Interview with Jeremiah Robison, Cionic CEO
Cionic, a medtech company based in San Francisco, created the Neural Sleeve, a wearable that is designed to enhance movement for those with mobility issues.
The company describes its device as a bionic garment, and it has recently been cleared by the FDA for use in those with neurological conditions that can impair mobility, such as Cerebral Palsy and Multiple Sclerosis.
Walking is an essential activity that many of us take for granted, but for those with mobility issues it can be a taxing process, with the potential for trips and falls ever present.
This risk means that such people put a lot more conscious effo...
Source: Medgadget - April 28, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Exclusive Neurology Rehab Source Type: blogs
Towards Control of Inflammation as an Important Goal in the Treatment of Aging
Today I'll point out a review article that laments the present state of progress towards the control of inflammation in the human body. While acknowledging that great strides have been made in ways to interfere in inflammatory signaling, benefiting many patients, present tools are crude in comparison to the technologies that will most likely be needed in order to truly control unresolved, chronic inflammation and eliminate its contribution to age-related disease. True control of inflammation would imply the ability to (a) trigger resolution mechanisms with specificity, avoiding impairment of the operation of inflammation w...
Source: Fight Aging! - April 25, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
A man in his 60s with chest pain. Cardiologist refuses to take to the lab. Obvious STEMI, even with criteria. Yet final diagnosis " NSTEMI " . This happens far too often.
Submitted by Anonymous MD, edits by MeyersA man in his 60s with past medical history of multiple sclerosis and hypertension was brought in by EMS from home for chest pain thatstarted acutely just prior to arrival. He rated the pain at 9/10, describes as pressure, radiates towards the left arm with associated shortness of breath, diaphoresis and had one episode of emesis. He did not have a prior history of CAD or other cardiac disease. His pain improved to 6/10 after EMS gave him 3 sprays of sublingual nitroglycerin and 324 mg of aspirin. Prehospital ECGs:What do you think?Both ECGs are diagnostic of acute LAD OMI...
Source: Dr. Smith's ECG Blog - April 15, 2022 Category: Cardiology Authors: Pendell Source Type: blogs
A Viral Risk Factor for Multiple Sclerosis
Several new lines of evidence suggest that Epstein-Barr virus infection may be a risk factor for the development of multiple sclerosis. (Source: virology blog)
Source: virology blog - April 7, 2022 Category: Virology Authors: Gertrud U. Rey Tags: Basic virology Gertrud Rey autoimmune disease autoimmunity B cell receptor b cells EBNA1 EBV Epstein-Barr virus GlialCAM herpesvirus kinase molecular mimicry monoclonal antibody multiple sclerosis somatic hypermutation Source Type: blogs
Pithiatism Redux
BY MARTIN SAMUELS
Those of us in medicine have all seen the famous painting of the Tuesday afternoon lessons at the Salpȇtrière in Paris in the 19th century. In Pierre Aristide André Brouillet’s painting, one can clearly see the great professor, Jean-Martin Charcot, holding forth while the patient, Blanche Whitman, is being supported by a tall young man, Joseph Jules Francois Felix Babinski, the Chef de Clinique (the chief resident) and allegedly the favorite to succeed Charcot. He never did as he was failed repeatedly on the exam necessary to become a faculty member at the university by a jealous, xenophobic, anti...
Source: The Health Care Blog - February 25, 2022 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Medical Practice Patients Physicians Andre Brouillet Martin Samuels Mental Health Patient Care Pithiatism Source Type: blogs
TWiV 869: Epstein-Barr virus and MS, a perfect storm
TWiV reviews epidemiological and experimental evidence that infection with Epstein-Barr virus leads to the production of antibodies against a viral protein that cross-react with a human protein, leading to multiple sclerosis. (Source: virology blog)
Source: virology blog - February 25, 2022 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology Epstein-Barr virus molecular mimicry mononucleosis multiple sclerosis viral viruses Source Type: blogs
Kissing disease ’s link to multiple sclerosis
In recent decades, mounting evidence has suggested the Epstein-Barr virus (EBV), a ubiquitous member of the herpes family that causes infectious mononucleosis (a.k.a. the“kissing disease”), can cause multiple sclerosis (MS). Last month, a study published in the journal Science went even further, citing EBV infection as likely the leading cause of MS. It isRead more …Kissing disease’s link to multiple sclerosis originally appeared inKevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - February 21, 2022 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/hoag-memorial-hospital-presbyterian" rel="tag" > Hoag Memorial Hospital Presbyterian < /a > < /span > Tags: Conditions Infectious Disease Source Type: blogs
Digital therapeutics pioneer Akili Interactive plans to go public in mid-2022 at a $1B valuation
Palihapitiya-Led SPAC to Merge With Akili in $1 Billion Deal (Bloomberg):
Akili Interactive, a startup that has developed a video game to help treat attention-deficit disorders in kids, has agreed to go public through a merger with one of Chamath Palihapitiya’s blank-check companies.
The deal, which confirms a Bloomberg News report, values the combined entity at about $1 billion, Akili and Social Capital Suvretta Holdings Corp. I said in a statement seen by Bloomberg. It will provide as much as $412 million in gross cash proceeds, the companies said.
Led by Chief Executive Officer Eddie Martucci, Akili has developed the ...
Source: SharpBrains - January 26, 2022 Category: Neuroscience Authors: SharpBrains Tags: Attention & ADD/ADHD Brain/ Mental Health Technology & Innovation Akili Interactive attention deficit hyperactivity disorder Chamath Palihapitiya cognitive-impairments digital therapeutics EndeavorRx FDA neuropsychiatric neuropsychia Source Type: blogs
Wearable Sensors Track Hand Use in Amputees
Researchers at the University of Missouri-Columbia have developed a system to track hand use in people with a hand prosthesis or patients who have undergone a hand transplant. The technology tracks movement in the hands and arms, and helps to monitor how people use their hands in everyday life. Such data could help to guide personalized treatment for patients, while also enabling clinicians to track recovery and mobility in numerous conditions that can affect hand use, such as multiple sclerosis and stroke.
Losing a hand can make everyday tasks difficult, although researchers have developed an array of technologies and ...
Source: Medgadget - January 13, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Rehab Source Type: blogs
Fight Aging! Newsletter, December 27th 2021
We report that whereas microglia are characterized by marked gene-level alterations related to negative regulation of protein phosphorylation and phagocytic vesicles, astrocytes show activation of enzyme- or peptidase-inhibitor signaling after detectable changes in BBB permeability. We also identify several genes enriched in these pathways that are notably altered after BBB breakdown. Our data reveal that microglia and astrocytes play an active role in maintaining BBB stabilization and corralling infiltrating cells, and thus might potentially function in ameliorating the lesions and neurologic disabilities in CNS diseases....
Source: Fight Aging! - December 26, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
What is the Contribution of Demyelination to Cognitive Decline in Aging?
Myelin is an insulator that sheaths the axons forming nervous system connections. It is essential to the correct electrochemical function of the nervous system. Severe conditions such as multiple sclerosis result when myelin is lost, degrading nervous system function to the point of disability and death. In normal aging, myelin is also lost, though to a lesser degree. It is reasonable to think that this contributes to neurodegeneration and cognitive decline, but the only straightforward way to determine the relative importance of demyelination versus the many other mechanisms at work in the aging brain is to fix the proble...
Source: Fight Aging! - December 23, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, December 13th 2021
In conclusion, there is a good amount of pre-clinical and clinical data showing a strong positive correlation between reduction of senescent cells frequencies and functional improvement of skin. Whether senescence of skin cells makes a significant causal contribution to skin ageing can still not be conclusively decided, however. Nonetheless, there is strong evidence existing today to assume that better understanding of cell senescence in skin may lead to a breakthrough in interventions into skin ageing.
Isomerization of Tau May be Involved in Alzheimer's Disease
https://www.fightaging.org/archives/2021/12/isom...
Source: Fight Aging! - December 12, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Innovation, mRNA, and Public Policy
Chris EdwardsThe main weapons against COVID-19 are the vaccines developed by Moderna and BioNTech after a decade of their research into mRNA technologies. That research was supported by more than $3 billion of private angel investment and venture capital.Democrats and Republicans both support medical research funding, and Republicans tout the Trump administration ’s Operation Warp Speed. But governments were not the key to mRNA development. Instead, we can thank the leaders and scientists at Moderna and BioNTech and the suppliers of private capital to them, as I discusshere andhere.TheWall Street Journal ’s A...
Source: Cato-at-liberty - December 6, 2021 Category: American Health Authors: Chris Edwards Source Type: blogs
