Integrating music, movement and stroke rehabilitation, MedRhythms raises $25M to develop and commercialize digital therapeutic
MedRhythms raises 25m to get patients back in tune after a stroke (TechCrunch):
MedRhythms secured $25 million in Series B funding to advance its digital therapy platform aimed at measuring and improving someone’s ability to walk after they have experienced a neurologic injury or disease … Company co-founder and CEO Brian Harris was a neurologic music fellow at Spaulding Rehabilitation Hospital in Boston, treating people with stroke and brain deficits with music. He began getting questions from patients and families on how they could access similar care outside of the hospital. Not seeing a suitable alternative, h...
Source: SharpBrains - August 2, 2021 Category: Neuroscience Authors: SharpBrains Tags: Brain/ Mental Health Technology & Innovation brain deficits breakthrough device chronic stroke walking deficits digital therapeutics digital therapy platform electrophysiological entrainment neural circuitry neurologic disorders neur Source Type: blogs
Planning Around MS and Incontinence Takes Significant Planning
People living with disabling diseases have as much desire as anyone else to experience traveling to national parks and other getaways. For this couple, it's challenging to pull this off both because of accessibility issues due to multiple sclerosis (MS) and the inconveniences of not being able to change incontinence protection in comfortable surroundings. With good planning, though, it can happen and they mean to be sure it does for them.
Read more on Egosancares blog about how a determined husband is working to make this trip memorable for his wife:
Minding Our Elders: Caregivers Share Their Personal Stories. “I ...
Source: Minding Our Elders - August 2, 2021 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs
Working Around MS and Incontinence Takes Significant Planning
People living with disabling diseases have as much desire as anyone else to experience traveling to national parks and other getaways. For this couple, it's challenging to pull this off both because of accessibility issues due to multiple sclerosis (MS) and the inconveniences of not being able to change incontinence protection in comfortable surroundings. With good planning, though, it can happen and they mean to be sure it does for them.
Read more on Egosancares blog about how a determined husband is working to make this trip memorable for his wife:
Minding Our Elders: Caregivers Share Their Personal Stories. “I ...
Source: Minding Our Elders - August 2, 2021 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs
Future Treatment For Autoimmune Diseases
New digital health tech targeted to fight autoimmune diseases or their symptoms are diverse and creative. These often completely different illnesses, like type 1 diabetes, inflammatory bowel disease, rheumatoid arthritis, and multiple sclerosis, indicate an immune system dysfunction. Immune cells and mechanisms target the body’s own cells and structures, deconstructing it bit by bit and inducing inflammation.
An estimated 24-50 million people in the US alone are living with autoimmune conditions. It affects their day-to-day life, but scientists suggest people living with chronic conditions could also be more suscepti...
Source: The Medical Futurist - July 29, 2021 Category: Information Technology Authors: szandra Tags: Biotechnology Future of Medicine Portable Medical Diagnostics Telemedicine & Smartphones chatbot diabetes digital health sleep optimization chronic pain chronic illness skin coronavirus autoimmune disease Source Type: blogs
On building better brains at any age, treating Depression vs. Dementia, emerging neurotechnologies, psychedelics, and more
Welcome to a new edition of SharpBrains’ e‑newsletter, featuring eleven new research findings and innovative resources for lifelong cognitive and brain health.
#1. Debate: Are depression and dementia two sides of the same coin? And, if they are, how to best approach treatment?
#2. Either way, the earlier the better, but it’s never too late: New book outlines the five lifestyle pillars to “build a better brain at any age”
#3. “If I were a cardiologist evaluating a patient’s chest pain, for instance, I would speak with the patient, but then I would listen to their heart and measure their pulse and blood pr...
Source: SharpBrains - May 28, 2021 Category: Neuroscience Authors: SharpBrains Tags: Brain/ Mental Health Education & Lifelong Learning Technology & Innovation brain health cognitive cognitive healthcare cognitive--disorders cognitive-health Cumulus Neuroscience dementia depression neurotechnologies psychedelics Source Type: blogs
The Informal Carers Who Help People with MS Need Support More Than Ever
The trend within health care services toward remote care and self-management for people with multiple sclerosis has not included adequate support to carers. Greater investment to support the needs of carers could support the informal care they provide, as well as the carer as an individual. (Source: The RAND Blog)
Source: The RAND Blog - May 28, 2021 Category: Health Management Authors: Daniela Rodriguez-Rincon; Brandi Leach Source Type: blogs
Akili Interactive Labs raises $160M in equity and debt to transform cognitive healthcare via prescription videogame treatments
Akili raises $110m to build its digital therapeutics pipeline (pharmaforum):
EndeavorRx became the first and so far only approved prescription video game treatment in the US when it was cleared by the FDA last year to treat attention-deficit hyperactivity disorder (ADHD), and has also been given a green light in Europe.
It is also being tested for other indications including fuzzy thinking in COVID-19 survivors, a condition sometimes known as ‘brain fog’.
The new funding, which is accompanied by a $50 million loan facility, is earmarked for the continued rollout of the app as well as Akili’s pipeline of prescription ...
Source: SharpBrains - May 26, 2021 Category: Neuroscience Authors: SharpBrains Tags: Attention & ADD/ADHD Brain/ Mental Health Technology & Innovation Akili Akili Interactive Labs attention deficit hyperactivity disorder cognitive healthcare cognitive--disorders digital therapeutics EndeavorRx FDA Neuberger Berma Source Type: blogs
Fight Aging! Newsletter, May 3rd 2021
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - May 2, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
B Cell Depletion Reverses Measures of Alzheimer's Progression in Mouse Models
In today's open access paper, researchers report results that suggest the contribution of B cells, a type of immune cell, to the progression of Alzheimer's disease is meaningful. Approaches to the selective destruction of the B cell complement in mice are fairly well developed, given that it is not harmful in the short term to live without B cells, and the B cell population regenerates quite rapidly when it is depleted. Applying such a method to clear B cells in Alzheimer's mouse models resulted in slowing of progression in the early stages and reversal in the later stages of the condition.
The mechanism of interest...
Source: Fight Aging! - April 26, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, March 29th 2021
Discussion of Systemic Inflammation and its Contribution to Dementia
Fisetin Reduces D-Galactose Induced Cognitive Loss in Mice
Reprogramming Cancer Cells into Normal Somatic Cells
Considering Longevity Medicine and the Education of Physicians
Researchers Generate Thyroid Organoids Capable of Restoring Function in Mice
In Search of Transcriptional Signatures of Aging
A Pace of Aging Biomarker Correlates with Manifestations of Aging
Targeting Tissues with Extracellular Vesicles
Calorie Restriction Slows Aging of the Gut Microbiome in Mice
Mitochondrial DNA Heteroplasmy in the Aging Heart
Evidence...
Source: Fight Aging! - March 28, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Insight into the Dysregulation of Myelin Maintenance in the Aging Brain
Today's research materials report on an investigation of the age-related loss of myelin in the nervous system. The insulating sheath that surrounds nerves is made up of myelin. Its presence ensures the proper conduction of nerve impulses along the axons that connect neurons in the nervous system. The structure and maintenance of myelin sheathing has been most studied in the context of demyelinating conditions such as multiple sclerosis, in which the immune system causes a breakdown of myelin. This leads to increasingly severe symptoms as the nervous system loses its ability to function.
Loss of myelin sheathing inte...
Source: Fight Aging! - March 23, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, February 15th 2021
This study assessed cancer risk associations for 3 recently developed methylation-based biomarkers of aging: PhenoAge, GrimAge, and predicted telomere length.
We observed relatively strong associations of age-adjusted PhenoAge with risk of colorectal, kidney, lung, mature B-cell, and urothelial cancers. Similar findings were obtained for age-adjusted GrimAge, but the association with lung cancer risk was much larger, after adjustment for smoking status, pack-years, starting age, time since quitting, and other cancer risk factors. Most associations appeared linear, larger than for the first-generation measures, and w...
Source: Fight Aging! - February 14, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Gut Macrobiome in Chronic Inflammation and Aging
In recent years, a great deal of attention has been devoted to the role of the gut microbiome in aging, as populations shift to include fewer helpful and more harmful microbes. In particular, the ability of the gut microbiome to influence the state of chronic inflammation in aging may be at least as important as lifestyle choices such as degree of exercise. Expanding this line of thinking, researchers here look at the macrobiome, small parasitic animals that dwell in the gut, and their role in age-related inflammation.
A new review looks at the growing evidence to suggest that losing our 'old friend' helminth para...
Source: Fight Aging! - February 9, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
CBD and other medications: Proceed with caution
Products containing cannabidiol (CBD) seem to be all the rage these days, promising relief from a wide range of maladies, from insomnia and hot flashes to chronic pain and seizures. Some of these claims have merit to them, while some of them are just hype. But it won’t hurt to try, right? Well, not so fast. CBD is a biologically active compound, and as such, it may also have unintended consequences. These include known side effects of CBD, but also unintended interactions with supplements, herbal products, and over-the-counter (OTC) and prescription medications.
Doubling up on side effects
While generally considered safe...
Source: Harvard Health Blog - January 11, 2021 Category: Consumer Health News Authors: Katsiaryna Bykov, PharmD, ScD Tags: Drugs and Supplements Marijuana Medical Research Safety Source Type: blogs
Fight Aging! Newsletter, December 21st 2020
In this study, we have found that administration of a specific Sgk1 inhibitor significantly reduces the dysregulated form of tau protein that is a pathological hallmark of AD, restores prefrontal cortical synaptic function, and mitigates memory deficits in an AD model. These results have identified Sgk1 as a potential key target for therapeutic intervention of AD, which may have specific and precise effects."
Targeting histone K4 trimethylation for treatment of cognitive and synaptic deficits in mouse models of Alzheimer's disease
Epigenetic aberration is implicated in aging and neurodegeneration. Using p...
Source: Fight Aging! - December 20, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
