A Genomic Search for Longevity-Associated Genes Points to Iron Metabolism in Human Aging
As a general rule, one should be skeptical about any and all single studies that identify longevity-associated genes from human data. Typically the results cannot be replicated in different study populations, and the effect sizes are in any case small. Identified gene variants confer only small changes in the odds of reaching a given age. Only a handful of gene variants show up reliably in multiple studies carried out in different human populations. So, unfortunately, however interesting or novel the data in a new study, such as the association of longevity with maintenance of normal iron levels noted in today's open acces...
Source: Fight Aging! - July 27, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, June 22nd 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - June 21, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Tears and Growth — in Feldenkrais and Psychotherapy
Nothing is permanent about our behavior patterns except our belief that they are so. – Moshé Feldenkrais
I learned about the Feldenkrais method at a two-day workshop at the Esalen Institute in Big Sur, California, in the mid-1970s. A hot spot for the human potential movement, Esalen featured nude soaking in co-ed hot tubs near a row of outdoor massage tables at which naked masseuses kneaded naked bodies. Also, mixed-gender volleyball games where everyone was, yes, naked.
In this seemingly “anything goes” environment, about twenty-five of us spent the better part of two days in comfortable clothes, lying...
Source: World of Psychology - June 17, 2020 Category: Psychiatry & Psychology Authors: Marcia Naomi Berger, MSW, LCSW Tags: Personal Treatment Feldenkrais method Source Type: blogs
Retraining the Immune System to Turn Off Autoimmunity
This interesting study suggests that it may be possible to turn off many forms of autoimmunity by inducing tolerance, in a comparatively simple manner, to the specific fragment of a protein that is causing an immune reaction. There are autoimmunities in which the specific trigger is poorly understood, including the only vaguely cataloged and no doubt highly variable autoimmunities of aging, but many other conditions for which this might be a useful approach.
Autoimmune diseases are caused when the immune system loses its normal focus on fighting infections or disease within and instead begins to attack otherwise h...
Source: Fight Aging! - June 17, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, June 15th 2020
In this study, we used markers to monitor the formation of SGs in Caenorhabditis elegans. We found that, in addition to acute heat stress, SG formation could also be triggered by dietary changes, such as starvation and dietary restriction (DR). We found that HSF-1 is required for the SG formation in response to acute heat shock and starvation but not DR, whereas the AMPK-eEF2K signaling is required for starvation and DR-induced SG formation but not heat shock. Moreover, our data suggest that this AMPK-eEF2K pathway-mediated SG formation is required for lifespan extension by DR, but dispensable for the longevity by reduced ...
Source: Fight Aging! - June 14, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Transplantion of Glial Progenitor Cells Regenerates Myelin in a Mouse Model of Multiple Sclerosis
Disabling conditions result when the myelin sheathing of nerves is sufficiently degraded, such as via a malfunctioning immune system attacking the body's own tissues, as is the case for multiple sclerosis. All of us suffer loss of myelin with aging to some degree however, due to damage and dysfunction in the oligodendrocyte cell populations responsible for maintaining myelin. There is evidence for this specific issue to contribute to age-related cognitive decline. Thus treatments that focus on boosting remyelination are of general interest: if safe, they should probably be applied to every older person, not just those with...
Source: Fight Aging! - June 8, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Update: The latest research and noninvasive neurotechnologies for brain health and mental fitness
Time for a new edition of SharpBrains’ e‑newsletter!
1. Food for (nonpartisan) Thought: Should heads of state and candidates to high office pass a cognitive/ mental fitness test?
2. A school psychologist shares good tips to support our kids and, yes, manage our own stress. Three Ss to reduce the stress of “homeschooling” our kids: Simplify, Structure, Support.
3. Wow. Mindstrong Health raises $100M to transform how we measure and promote mental health.
4. Great partnership! Kaiser Permanente offers Calm mental fitness app at no cost to millions of members.
5. “Just as you can’t self-introspect to determine...
Source: SharpBrains - May 29, 2020 Category: Neuroscience Authors: SharpBrains Tags: Cognitive Neuroscience Education & Lifelong Learning Health & Wellness Technology app brain health Brain Teasers brain-teaser Calm cognitive test FDA Headsafe Kaiser-Permanente Kernel mental health mental-fitness Mindstrong Source Type: blogs
Portable brain assessment device by Headsafe secures 510(k) FDA clearance
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FDA Clears Nurocheck, Portable Device to Quickly Assess Brain Health (MS News Today):
“A portable device that can quickly measure electrical activity in the brain and relay it to doctors via a smartphone app, called the Nurochek system, has been cleared by the United States Food and Drug Administration (FDA) for use as a medical device.
Its developer, Headsafe, plans to it soon make this brain assessment system available for use with patients in the U.S., ages 14 and older.”
The Announcement:
Headsafe Announces FDA Clearance and U.S. Launch of its NUROCHEK Portable Brain Assessment System (press release):
“Headsaf...
Source: SharpBrains - May 14, 2020 Category: Neuroscience Authors: SharpBrains Tags: Cognitive Neuroscience Health & Wellness Technology 510(k) clearance app brain brain health technology brain-assessment EEG electrical activity FDA Food and Drug Administration Headsafe neurological testing Nurochek portable Source Type: blogs
Podcast: It ’ s See You Later, Not Goodbye
All good things must come to an end. And today is one of those days. In this episode of The Not Crazy Podcast, we say a sad farewell to our amazing cohost, Jackie Zimmerman. Tune in, as Jackie and Gabe reminisce about the good old days, ponder the fate of podcasts, and discuss Jackie’s decision to leave. They also introduce you to Gabe’s new cohost, Lisa, who just happens to be his ex-wife. Yep! You heard that right! Will this divorced duo be an absolute train wreck (as most divorced cohosts would be) or an inspiration to all? You’ll have to stick around to find out.
Join us for a sweet farewell to Jackie and...
Source: World of Psychology - May 4, 2020 Category: Psychiatry & Psychology Authors: Not Crazy Podcast Tags: General Not Crazy Podcast Source Type: blogs
Podcast: What is Mindfulness?
Is your mind constantly preoccupied with the past or the future? What if you could train your brain to just BE in the present moment? This is the essence of mindfulness — simply being in the here-and-now (not worrying about that stupid thing you said last week), and gently noticing your surroundings and thoughts without judgment. In today’s podcast, Jackie enlightens a skeptical Gabe of the value of practicing mindfulness and how it can be a very useful tool in his mental health tool box. And she’s armed with scientific facts to break him down.
When was the last time you truly listened to the rain, enjoye...
Source: World of Psychology - April 27, 2020 Category: Psychiatry & Psychology Authors: Not Crazy Podcast Tags: Anxiety and Panic General LifeHelper Mental Health and Wellness Mindfulness Not Crazy Podcast Source Type: blogs
Podcast: Canceling Plans Due to Anxiety
Does your anxiety take over when it’s time to leave the house — keeping you home more often than not? Do you cancel plans at the last minute due to that feeling of dread in the pit of your stomach? Or maybe you are the friend that keeps getting canceled on. In today’s podcast, Gabe and Jackie discuss why this happens and how both parties — the chronic canceler and the chronically disappointed friend — can navigate this awkward scenario.
Tune in to today’s Not Crazy podcast to get specific tips on how you can feel more in control so you can cancel less.
(Transcript Available Below)
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Source: World of Psychology - April 20, 2020 Category: Psychiatry & Psychology Authors: Not Crazy Podcast Tags: Anxiety and Panic Disorders General Not Crazy Podcast Self-Help Source Type: blogs
Podcast: Setting Boundaries With Your Family
Do you have difficult — or even toxic — family members? How does one go about setting boundaries with them? And is it OK to cut them off? In today’s Not Crazy podcast, Jackie and Gabe tackle these tough questions with Sonya Mastick, a mental health advocate and fellow podcaster of a show called “What Won’t She Say?” Sonya shares her personal story of how she handled her toxic mom and demonstrates how it’s OK, and sometimes even necessary, to set strong boundaries with family members who hurt you. It’s also OK if those boundaries shift and evolve with time.
Tune in for an honest discussion about pro...
Source: World of Psychology - April 13, 2020 Category: Psychiatry & Psychology Authors: Not Crazy Podcast Tags: Family General Interview LifeHelper Mental Health and Wellness Not Crazy Podcast Source Type: blogs
Podcast: Quarantine and Declining Mental Health
Day 1,364 of the COVID-19 quarantine (well, at least it feels like it). How are you holding up? If you’re like most people, you’re not having much fun. But if you already struggle with anxiety, depression or another mental health issue, these days of isolation and uncertainty can feel like absolute torture. In today’s Not Crazy episode, Gabe laments the loss of his routine — those regular activities he clung to religiously to keep his mental health in check. Now what is he supposed to do?
Tune in for a special quarantine episode. Together, we will grieve our old routines and discuss how to start ne...
Source: World of Psychology - April 6, 2020 Category: Psychiatry & Psychology Authors: Not Crazy Podcast Tags: Anxiety and Panic General Health-related Mental Health and Wellness Not Crazy Podcast Self-Help Source Type: blogs
Podcast: Smoking Weed for Anxiety – Fact vs Fiction
Cannabis, weed, marijuana, pot. It goes by several names, but we all know what it smells like. As weed becomes more mainstream, we on the Not Crazy podcast want to know: Is marijuana really an effective treatment for anxiety? Is it just a coping mechanism? Or a vice? In today’s podcast, Gabe and Jackie look at the research and weigh out the evidence. They also interview Eileen Davidson, a rheumatoid arthritis patient who regularly uses marijuana as a medicine to see what she has to say.
What’s your take? Tune in for an open-minded discussion about weed.
(Transcript Available Below)
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Source: World of Psychology - March 30, 2020 Category: Psychiatry & Psychology Authors: Not Crazy Podcast Tags: Anxiety and Panic General Medications Not Crazy Podcast Source Type: blogs
Podcast: Coronavirus – How to Keep it Together
How are you handling the coronavirus pandemic? Most people are struggling right now, but for those of us with mental illness, these days can feel truly overwhelming. Fear, depression, isolation and loss of routine are just a few of the difficulties many of us are facing. In today’s podcast, Gabe and Jackie discuss what we can do right now to make things just a little better, and they share their personal hopes and fears for humanity once this pandemic subsides.
You’re not alone — we’re all in this together. Join us for an important discussion on how we can handle this time of fear and uncertainty.
(T...
Source: World of Psychology - March 23, 2020 Category: Psychiatry & Psychology Authors: Not Crazy Podcast Tags: Anxiety and Panic General LifeHelper Mental Health and Wellness Not Crazy Podcast Source Type: blogs
