Innovation, mRNA, and Public Policy

Chris EdwardsThe main weapons against COVID-19 are the vaccines developed by Moderna and BioNTech after a decade of their research into mRNA technologies. That research was supported by more than $3 billion of private angel investment and venture capital.Democrats and Republicans both support medical research funding, and Republicans tout the Trump administration ’s Operation Warp Speed. But governments were not the key to mRNA development. Instead, we can thank the leaders and scientists at Moderna and BioNTech and the suppliers of private capital to them, as I discusshere andhere.TheWall Street Journal ’s Allysia Finley discusses mRNA, Moderna, and BioNtechin a new piece. She focuses on the “vast promise of mRNA technology” beyond COVID-19. Numerous companies are developing mRNA vaccines for influenza, which are expected to be more effective than current vaccines. And Finley reports, “Moderna is also advancing vaccines for other infectious diseases, including Zika, HIV, Epstein‐ ​Barr, CMV, human metapneumovirus, parainfluenza virus and respiratory synclinal virus.”There are many applications of mRNA technologies beyond infectious diseases. Finley says these may include regenerating heart tissue for patients with heart failure, addressing aging ‐​related diseases, and stimulating the production of cartilage to ease arthritis. And she notes, “Autoimmune diseases … are another promising area of research. ...
Source: Cato-at-liberty - Category: American Health Authors: Source Type: blogs

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Discussion regarding adjustment of specific PAG values is provided in the footnotes and bases portions of the PAG manual but is often not included in jurisdictional plans or routinely considered in exercises. However, when properly applied, the protective action guidance provides the necessary flexibility for decision-makers to account for additional public health risks or impediments, and jurisdictions can use this guidance to build a more effective response strategy. The authors have applied the full guidance and flexibility provided in the 2017 US Environmental Protection Agency PAG Manual to develop more specific guida...
Source: Health Physics - Category: Radiology Tags: FORUM ARTICLE Source Type: research
This article describes the impacts of food insecurity (FI) on child health, outlines clinical and public policy interventions to mitigate FI in children, and defines new paradigms in population health to ameliorate the harmful effects of FI in children. Recent findings Rates of FI among children have dramatically increased with the onset of the COVID-19 pandemic, with particular adverse impact on low-income children. Population health innovations in screening, referral, and social service integration offer new opportunities to address FI. Summary Despite advances in clinical practice and public policy, FI rem...
Source: Current Opinion in Pediatrics - Category: Pediatrics Tags: POPULATION HEALTH: Edited by Kara Odom Walker Source Type: research
Purpose of review Liquid biopsies have emerged as a noninvasive alternative to tissue biopsy with potential applications during all stages of pediatric oncology care. The purpose of this review is to provide a survey of pediatric cell-free DNA (cfDNA) studies, illustrate their potential applications in pediatric oncology, and to discuss technological challenges and approaches to overcome these hurdles. Recent findings Recent literature has demonstrated liquid biopsies’ ability to inform treatment selection at diagnosis, monitor clonal evolution during treatment, sensitively detect minimum residual disease ...
Source: Current Opinion in Pediatrics - Category: Pediatrics Tags: HEMATOLOGY AND ONCOLOGY: Edited by Brigitte Widemann Source Type: research
Purpose of review The issue of fertility preservation has become increasingly relevant as survival rates of children with cancer exceeds 80% at 5 years. Fertility preservation options are being utilized alongside less gonadotoxic therapeutic regimens in the treatment of these patients. The purpose of this review is to summarize the recent advances in fertility preservation in the pediatric, adolescent, and young adult population. Recent findings Education research involves both patient and provider; to increase understanding on both sides for improved adoption of techniques and higher rates of posttreatment fe...
Source: Current Opinion in Pediatrics - Category: Pediatrics Tags: HEMATOLOGY AND ONCOLOGY: Edited by Brigitte Widemann Source Type: research
Purpose of review Acute ankle sprains frequently occur in active children and adolescents but may be the initial clinical presentation of other less common disorders affecting the lower extremities. There are many conditions that may cause one or multiple episodes of ankle injury that are misdiagnosed as an acute ankle sprain. This manuscript highlights diagnoses that should be considered when evaluating and managing a child or adolescent who presents initially and/or repeatedly with an acute ankle sprain. Recent findings In recent years, various studies have continued to note the prevalence of misdiagnosed ankl...
Source: Current Opinion in Pediatrics - Category: Pediatrics Tags: ORTHOPEDICS: Edited by Daniel W. Green Source Type: research
Purpose of review The COVID-19 pandemic has ushered in great and rapid change in our society. Although children are somewhat less likely to get infected or have severe symptoms from COVID-19, they are being adversely affected by this global public health emergency in many direct and indirect ways. This review focuses on the major areas in which children and adolescents are suffering, and how pediatricians can anticipate and optimize child healthcare and support as the COVID-19 pandemic and its aftermath continues. Recent findings This review provides preliminary insights into the physical, psychological, educati...
Source: Current Opinion in Pediatrics - Category: Pediatrics Tags: OFFICE PEDIATRICS: Edited by Henry H. Bernstein Source Type: research
On Sunday, Australia ’s federal court upheld the cancellation of Djokovic’s visa.
Source: Forbes.com Healthcare News - Category: Pharmaceuticals Authors: Tags: Healthcare /healthcare Innovation /innovation Business /business SportsMoney /sportsmoney pharma Source Type: news
With a 1.1 million jab delivery in Rwanda this weekend, the World Health Organization’s multilateral initiative to provide equal access to vaccines for all reached the one billion milestone.
Source: UN News Centre - Health, Poverty, Food Security - Category: International Medicine & Public Health Source Type: news
After a month at no. 1, “Spider-Man: No Way Home” has finally been overtaken at the box office. Paramount Pictures' “Scream” reboot debuted with $30.6 million in ticket sales over the weekend,... #northamerican #reboot #paramountpictures #spidermannowayhome #scream5
Source: Reuters: Health - Category: Consumer Health News Source Type: news
TWiV reviews findings that increased fitness of the Omicron variant is due to immune evasion, not an increase in intrinsic transmissibility, and determination of infectious viral load in patients infected with wild type, Delta and Omicron viruses reveals lack of correlation with RNA loads determined by RT-PCR, similar levels of shedding among Delta and Omicron, and greatly reduced shedding in vaccinated people. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! L...
Source: This Week in Virology - MP3 Edition - Category: Virology Authors: Source Type: podcasts
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