Pearls Chiari malformation
1.80 percent of patients with cough headache have cm type 1 although only a minority of patients with cm 1 have cough headache. The degree of tonsillar herniation does not correlatevar pageTracker = _gat._getTracker( " UA-3639768-12 " ); pageTracker._initData(); pageTracker._trackPageview();2. Cm1 presents most often from ages 8 to 9 and from 31 to 463. Spinal cord syndrome occurs in 65 to 84 percent and includes weakness and sensory changes.4. Brain stem syndrome occurs in 22 to 38 percent and includes blurred vision, horizontal or downbeating nystagmus, and diplopia (upper) or hoarseness , dysphonia, dysarthria...
Source: neurologyminutiae - July 31, 2022 Category: Neurology Source Type: blogs

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Luna G, Alping P, Burman J et al.  Infection risks among patients with multiple sclerosis  treated with fingolimod, natalizumab, rituximabm  and injectable therapies.  JAMA Neurology2020; 77:184-91.var gaJsHost = (( " https: " == document.location.protocol) ? " https://ssl. " : " http://www. " ); document.write(unescape( " %3Cscript src= ' " + gaJsHost + " google-analytics.com/ga.js ' type= ' text/javascript ' %3E%3C/script%3E " ));var pageTracker = _gat._getTracker( " UA-3639768-12 " ); pageTracker._initData(); pageTracker._trackPageview();Swedish study examines risk of infections severe enough to caus...
Source: neurologyminutiae - November 22, 2020 Category: Neurology Source Type: blogs

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MG after dabrafenib and trametinib in metastatic melanoma.  Case report.  Neurology 2020; 94: 322-3/In this patient, challenge , withdraw and rechallenge brought out MG symptoms and resolved when withdrawn within 24 hours.  {atient was ab positive. These drugs, BRAF and MEK inhibitors  now are standard of care for melanoma.  This is a separate phenomenon from checkpoint inhibitors causing mg var gaJsHost = (( " https: " == document.location.protocol) ? " https://ssl. " : " http://www. " ); document.write(unescape( " %3Cscript src= ' " + gaJsHost + " google-analytics.com/ga.js ' type= ' text/ja...
Source: neurologyminutiae - November 22, 2020 Category: Neurology Source Type: blogs

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A Columbian woman in a kindred of patients who developed Alzheimer ' s disease was homozygote for the Christchurch mutation, which is rare, and maintained cognition into her seventies. She was apo E3 double positive. She had high amyloid but limited tau. This provides a potential target for studies. (Source: neurologyminutiae)
Source: neurologyminutiae - November 22, 2020 Category: Neurology Source Type: blogs

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Atrial fibrillation and falls: a mechanistic or age confounded relationship?  (editorial) Mayo Clinic Proceedings 95; 2020, pp632-4  AuthorsHu T et al.  var pageTracker = _gat._getTracker( " UA-3639768-12 " ); pageTracker._initData(); pageTracker._trackPageview();Meta-analysis shows falls and AF are related,  independently of  age.  Odds ratio is about 1.8.  The relationship exists even after pacemaker placement.  Authors cite an AF complex of symptoms that include cognitive dysfunction, endothelial dysfunction and dysautonomia.   (Source: neurologyminutiae)
Source: neurologyminutiae - November 22, 2020 Category: Neurology Source Type: blogs

Dermatomyositis with and without anti Mi2 autoantibodies
Pinal-Hernandez I, Mecoli CA, Casal-Dominguez Mvar gaJsHost = (( " https: " == document.location.protocol) ? " https://ssl. " : " http://www. " ); document.write(unescape( " %3Cscript src= ' " + gaJsHost + " google-analytics.com/ga.js ' type= ' text/javascript ' %3E%3C/script%3E " )); .  More prominent muscle involvement with dermatomyositis with anti Mi2 autoantibodies. Neurology; 2019; 93e1768-1777(John Hopkins)58 patients with antiMi2 positive DM143 patient with anti Mi2 negative DM162 patients with antisynthetase syndrome170 patients with immune mediated necrotizing myopathy (IMNM).Features of patients with a...
Source: neurologyminutiae - November 13, 2019 Category: Neurology Source Type: blogs

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I ' m on top of the world because of it! http://better.localknead.comDaniel Jacobs (Source: neurologyminutiae)
Source: neurologyminutiae - November 18, 2018 Category: Neurology Source Type: blogs

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Source: neurologyminutiae - October 27, 2018 Category: Neurology Source Type: blogs

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Source: neurologyminutiae - September 27, 2018 Category: Neurology Source Type: blogs

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Source: neurologyminutiae - August 18, 2018 Category: Neurology Source Type: blogs

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Source: neurologyminutiae - July 19, 2018 Category: Neurology Source Type: blogs

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http://win.onemillionhealthywomen.com/review3.phpDaniel Jacobs (Source: neurologyminutiae)
Source: neurologyminutiae - April 19, 2018 Category: Neurology Source Type: blogs

Autoimmune meningoencephalitis associated with GFAP IgG antibodies.
var gaJsHost = (( " https: " == document.location.protocol) ? " https://ssl. " : " http://www. " ); document.write(unescape( " %3Cscript src= ' " + gaJsHost + " google-analytics.com/ga.js ' type= ' text/javascript ' %3E%3C/script%3E " ));var pageTracker = _gat._getTracker( " UA-3639768-12 " ); pageTracker._initData(); pageTracker._trackPageview();Fung B et al.  Autoimmune glial fibrillary acidic protein astrocytopathy: a novel meningoencephalomyelitis.  JAMA Neurol 2016; 73: 1297.Mayo labs has 134 cases out of 100,000 evaluated for autoimmune and paraneoplastic ab ' s as part of routine care.  Clinical prese...
Source: neurologyminutiae - February 7, 2017 Category: Neurology Source Type: blogs

Steroid sparing therapy in neurosarcoidosis
var gaJsHost = (( " https: " == document.location.protocol) ? " https://ssl. " : " http://www. " ); document.write(unescape( " %3Cscript src= ' " + gaJsHost + " google-analytics.com/ga.js ' type= ' text/javascript ' %3E%3C/script%3E " ));var pageTracker = _gat._getTracker( " UA-3639768-12 " ); pageTracker._initData(); pageTracker._trackPageview();Neurology 2016; 13:87:2517 Uncontrolled study of 40 patients with neurosarcoidosis, both central and peripheral nerve.  32 got MTX 20 mg per week, 14 got mycophenolate (MMF) at 2 grams per day (median) 6 had both drugs successively.  In MTX group, 15/32 (46 percent) rela...
Source: neurologyminutiae - February 7, 2017 Category: Neurology Source Type: blogs

Biotinidase deficiency mimicking NMO: initiallyexhibiting symptoms in adulthood
Bottin L, Prud ' honS, Giannesini C et al. Multiple Sclerosis 21 (12) 1604-07 2015. var gaJsHost = (( " https: " == document.location.protocol) ? " https://ssl. " : " http://www. " ); document.write(unescape( " %3Cscript src= ' " + gaJsHost + " google-analytics.com/ga.js ' type= ' text/javascript ' %3E%3C/script%3E " ));var pageTracker = _gat._getTracker( " UA-3639768-12 " ); pageTracker._initData(); pageTracker._trackPageview();Authors present first case of biotinidase deficiency presenting in young adulthood ; children and adolescents may present with vision loss and tetraparesis. It was due in this case t...
Source: neurologyminutiae - November 30, 2016 Category: Neurology Source Type: blogs