An Age of Metabolomics
Obtaining enormous amounts of data on the human metabolome now costs little. Databases of metabolomic data available for analysis have become vast, and continue to grow. Productive analysis trails far behind the production of data, unfortunately, as is true for all of the omics technologies. In this paper, researchers discuss the present state of metabolomic knowledge in the context of aging, and the path forward to producing useful understanding from this deluge of human data, contributing perhaps to the better development of treatments for aging.
Aging is a fundamental part of the human experience, and it has lo...
Source: Fight Aging! - October 27, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Back to Debating Limits to Human Life Span Again
While it is self-evident that longevity is limited in the practical sense, in that one or more degenerative processes of aging eventually make it so unlikely for survival to continue that everyone dies somewhere before age 120, that doesn't mean that longevity is limited in any other sense. If we alter the consequences of the underlying processes of aging, by repairing the damage that they cause, by changing the process, and so forth, then longevity will increase. While the authors of today's open access paper make generally sensible statements about the nature of aging, they seem far too skeptical that anything of practic...
Source: Fight Aging! - October 25, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, October 24th 2022
This study shows the uncoupling of lifespan and healthspan parameters (aerobic fitness and spontaneous activity) and provides new insights into SIRT3 function in CR adaptation, fuel utilization, and aging.
HDL Level, Age, and Smoking are the Largest Determinants of Mortality Risk in Old People
https://www.fightaging.org/archives/2022/10/hdl-level-age-and-smoking-are-the-largest-determinants-of-mortality-risk-in-old-people/
An interesting epidemiological study here stratifies the contributions of various metrics to mortality in later life, age 70 and older. The authors find that the largest effects arise...
Source: Fight Aging! - October 23, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, October 17th 2022
This study investigated whether multimorbidity is associated with incident dementia and whether associations vary by different clusters of disease and genetic risk for dementia. The study used data from the UK Biobank cohort, with baseline data collected between 2006 and 2010 and with up to 15 years of follow-up. Participants included women and men without dementia and aged at least 60 years at baseline. The presence of at least 2 long-term conditions from a preselected list of 42 conditions was used to define multimorbidity.
A total of 206,960 participants (mean age 64.1 years) were included in the final sample, of...
Source: Fight Aging! - October 16, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, October 10th 2022
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Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - October 9, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
TWiV 944: Hacking through Borneo with Kathryn Hanley
Kathryn Hanley joins TWiV to discuss her career and the research in her laboratory on the molecular biology, evolution and ecology of emerging RNA viruses and their insect vectors. (Source: virology blog)
Source: virology blog - October 9, 2022 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology arbovirus blackfly deforestation dengue virus emergence spillover vesicular stomatitis virus viral viruses vsv West Nile virus Source Type: blogs
Magnetic Fields Modestly Extend Life in Nematode Worms via Effects on Mitochondrial Function
Electromagnetic effects on cellular biochemistry, and their potential use as interventions, are little studied in comparison to the use of pharmaceutical agents. That state of affairs shows little sign of changing in the near future, despite the existence of interesting studies on regeneration, or this one on the longevity of nematodes. Researchers pin down a potential mechanism to explain how a magnetic field can alter the activities of cells in ways that modestly extend life in this short-lived species. It is worth noting that nematode life span is very plastic in response to circumstances and interventions. Approaches t...
Source: Fight Aging! - October 6, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, October 3rd 2022
In conclusion, based on the analysis of proteomics and transcriptome, we identified four SRMs that may affect aging and speculated their possible mechanisms, which provides a new target for preventing aging, especially skin aging.
A Popular Science Article on the State of Epigenetic Clocks
https://www.fightaging.org/archives/2022/09/a-popular-science-article-on-the-state-of-epigenetic-clocks/
This popular science article is a good view of the present state of development and use of epigenetic clocks, covering the issues as well as the promise. Epigenetic age can be measured, with many different clocks...
Source: Fight Aging! - October 2, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, September 26th 2022
This study examined the dose-response association between daily step count and intensity and incidence of all-cause dementia among adults in the UK. This was a UK Biobank prospective population-based cohort study (February 2013 to December 2015) with 6.9 years of follow-up (data analysis conducted May 2022). A total of 78,430 of 103,684 eligible adults aged 40 to 79 years with valid wrist accelerometer data were included. Registry-based dementia was ascertained through October 2021.
We found no minimal threshold for the beneficial association of step counts with incident dementia. Our findings suggest that approxima...
Source: Fight Aging! - September 25, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Summarizing the State of Aging Research
Providing a summary of the present state of aging research is a tall order, given the rapid growth in the field, and great breadth of work in both academia and industry, but the authors of this lengthy review paper take a swing at it. They look at areas of interest, new and well-established, apply a loose taxonomy to diverse initiatives, and attempt to draw it all together into a cohesive whole. The thrust of the field nowadays is towards intervention, attempting to slow or reverse aging in order to treat and prevent age-related disease. The important debates are over which strategies are more likely versus less likely to ...
Source: Fight Aging! - September 23, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Rapamycin, Acarbose, and Phenylbutyrate Combination Slows Cognitive Decline in Mice
You might recall that researchers recently reported that the combination of rapamycin, acarbose, and phenylbutyrate appear to meaningfully improve physical function in old mice. Here, the same team reports on the efforts of this intervention on cognitive function in mice. Individually, these treatments, applied over the long term, are all shown to slow aging to some degree in mice. It remains to be seen whether combination treatments of this sort, upregulation of cellular stress responses, mimicking aspects of the cellular response to exercise and calorie restriction, will be as useful in humans. It is the case that life s...
Source: Fight Aging! - September 19, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, September 19th 2022
Conclusion
Use of the Khavinson peptides and melatonin in combination in this way, at this dose, negatively impacts the thymus, producing a reduction in active tissue and increase in atrophy to fatty tissue. The degree to which this atrophy occurred is greater than one would expect to take place over nine months of aging at this stage of life.
Why did this outcome occur, given the animal studies showing thymic regrowth, and the studies showing reduced later life mortality following use of thymogen? We can only speculate. Firstly, the dose makes the poison, and the dosing here may have been too high, too frequ...
Source: Fight Aging! - September 18, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
In the Matter of Human Longevity There Will Be Opportunists and Alchemists
I suspect that a sizable, earnest community of opportunists and alchemists focused on anti-aging and longevity will continue to exist even as we transition from an era in which the only approaches to aging (beyond exercise and calorie restriction) were snake oil, the only service providers frauds, to an era in which therapies to slow aging and produce rejuvenation actually exist and are robustly proven to do what they say on the label. Will reliable, low-cost ways to measure biological age drive out the true believers who try whatever intervention is hyped, fail to gain scientific understanding, and fail to use adequate me...
Source: Fight Aging! - September 16, 2022 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
SENS Research Foundation Annual Reports for 2022
The SENS Research Foundation has published its annual reports for 2022, for those interested. SENS, the Strategies for Engineered Negligible Senescence, is both (a) a laundry list of forms of cell and tissue damage that cause aging, with supporting evidence from the past century of scientific research into aging, and (b) a laundry list methods of intervention that should produce rejuvenation. Aging is damage accumulation, and rejuvenation is repair of that damage.
Funding for SENS programs, and initiatives to produce therapies based on the SENS view of damage repair, remain as relevant as ever. In fact, even more re...
Source: Fight Aging! - September 14, 2022 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
Fight Aging! Newsletter, September 12th 2022
Discussion of Present Drug Development to Target Senescent Cells
Targeting Senescent Cells to Better Address Cancer and Consequences of Cancer Therapy
Calorie Restriction Suppresses Generation of Immune Cells via Changes to the Gut Microbiome
Arguing for an Expansion of the Hallmarks of Aging
https://www.fightaging.org/archives/2022/09/arguing-for-an-expansion-of-the-hallmarks-of-aging/
The hallmarks of aging form a catalog of largely better studied changes in cells and tissues considered relevant, and possibly more important, in the onset and development of age-related degeneration and disease. Thi...
Source: Fight Aging! - September 11, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
